Publications

• 2022
  • D. Dufour, T. Dumontet, I. Sahut-Barnola, A. Carusi, M. Onzon, E. Pussard, J. Wilmouth, J. Olabe, C. Lucas, A. Levasseur, C. Damon-Soubeyrand, J. Pointud, F. Roucher-Boulez, I. Tauveron, G. Bossis, E. Yeh, D. Breault, P. Val, A. Lefrancois-Martinez and A. Martinez, “Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.”, Nature communications, vol. 13 (1) , pp. 7858, 2022.
  • J. J. Wilmouth, J. Olabe, D. Garcia-Garcia, C. Lucas, R. Guiton, F. Roucher-Boulez, D. Dufour, C. Damon-Soubeyrand, I. Sahut-Barnola, J. Pointud, Y. Renaud, A. Levasseur, I. Tauveron, A. Lefrancois-Martinez, A. Martinez and P. Val, “Sexually dimorphic activation of innate antitumor immunity prevents adrenocortical carcinoma development.”, Science advances, vol. 8 (41) , pp. eadd0422, 2022.
  • M. Omar, D. Byrne, K. Jones, T. Lakey, K. Collins, K. Lee, L. Daly, K. Forbush, H. Lau, M. Golkowski, G. McKnight, D. Breault, A. Lefrancois-Martinez, A. Martinez, C. Eyers, G. Baird, S. Ong, F. Smith, P. Eyers and J. Scott, “Mislocalization of protein kinase A drives pathology in Cushing's syndrome.”, Cell Rep, vol. 40 (2) , pp. 111073, 2022.
  • I. Sahut-Barnola, A. Lefrancois-Martinez, D. Dufour, J. Botto, C. Kamilaris, F. Faucz, C. Stratakis, P. Val and A. Martinez, “Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome.”, The Journal of investigative dermatology, 2022.
  • J. Amaya, E. Viho, H. Sips, R. Lalai, I. Sahut-Barnola, T. Dumontet, N. Montanier, A. Pereira, A. Martinez and O. Meijer, “Gene expression changes in the brain of a Cushing's syndrome mouse model.”, Journal of neuroendocrinology, vol. 34 (4) , pp. e13125, 2022.
  • A. Martinez and A. Schedl, “Dissecting a zonated organ - Special issue on adrenal biology.”, Molecular and cellular endocrinology, vol. 539 , pp. 111486, 2022.
• 2021
  • C. Djari, I. Sahut-Barnola, A. Septier, I. Plotton, N. Montanier, D. Dufour, A. Levasseur, J. J. Wilmouth, J. Pointud, F. Faucz, C. Kamilaris, A. Lopez, F. Guillou, A. Swain, S. Vainio, I. Tauveron, P. Val, H. Lefebvre, C. Stratakis, A. Martinez and A. Lefrancois-Martinez, “Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.”, J. Clin. Invest., vol. 131 (23) , 2021.
  • T. Dumontet and A. Martinez, “Adrenal androgens, adrenarche, and zona reticularis: A human affair?”, Molecular and cellular endocrinology, vol. 528 , pp. 111239, 2021.
  • D. Fudulu, G. Horn, G. Hazell, A. Lefrancois-Martinez, A. Martinez, G. Angelini, S. Lightman and F. Spiga, “Co-culture of monocytes and zona fasciculata adrenal cells: An in vitro model to study the immune-adrenal cross-talk.”, Molecular and cellular endocrinology, vol. 526 , pp. 111195, 2021.
  • D. Watts, J. Stein, A. Meneses, N. Bechmann, A. Neuwirth, D. Kaden, A. Kruger, A. Sinha, V. Alexaki, L. G. Perez-Rivas, S. Kircher, A. Martinez, M. Theodoropoulou, G. Eisenhofer, M. Peitzsch, A. El-Armouche, T. Chavakis and B. Wielockx, “HIF1alpha is a direct regulator of steroidogenesis in the adrenal gland.”, Cell. Mol. Life Sci., vol. 78 (7) , pp. 3577–3590, 2021.
  • J. Amaya, E. Suidgeest, I. Sahut-Barnola, T. Dumontet, N. Montanier, G. Pages, C. Keller, L. van der Weerd, A. Pereira, A. Martinez and O. Meijer, “Effects of Long-Term Endogenous Corticosteroid Exposure on Brain Volume and Glial Cells in the AdKO Mouse.”, Frontiers in neuroscience, vol. 15 , pp. 604103, 2021.
• 2020
  • L. Smith, V. Huang, M. Olah, L. Trinh, Y. Liu, G. Hazell, B. Conway-Campbell, Z. Zhao, A. Martinez, A. Lefrancois-Martinez, S. Lightman, F. Spiga and G. Aguilera, “Involvement of CREB-regulated transcription coactivators (CRTC) in transcriptional activation of steroidogenic acute regulatory protein (Star) by ACTH.”, Molecular and cellular endocrinology, vol. 499 , pp. 110612, 2020.
• 2019
  • H. Tabbal, A. Septier, M. Mathieu, C. Drelon, S. Rodriguez, C. Djari, M. Batisse-Lignier, I. Tauveron, J. Pointud, I. Sahut-Barnola, B. Ragazzon, G. Assie, J. Bertherat, A. Lefrancois-Martinez, A. Martinez and P. Val, “EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness.”, British journal of cancer, 2019.
  • T. Dumontet, I. Sahut-Barnola, D. Dufour, A. Lefrancois-Martinez, A. Berthon, N. Montanier, B. Ragazzon, C. Djari, J. Pointud, F. Roucher-Boulez, M. Batisse-Lignier, I. Tauveron, J. Bertherat, P. Val and A. Martinez, “Hormonal and spatial control of SUMOylation in the human and mouse adrenal cortex.”, FASEB J., pp. fj201900557R, 2019.
• 2018
  • M. Mathieu, C. Drelon, S. Rodriguez, H. Tabbal, A. Septier, C. Damon-Soubeyrand, T. Dumontet, A. Berthon, I. Sahut-Barnola, C. Djari, M. Batisse-Lignier, J. Pointud, D. Richard, G. Kerdivel, M. Calmejane, V. Boeva, I. Tauveron, A. Lefrancois-Martinez, A. Martinez and P. Val, “Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex.”, Proc. Natl. Acad. Sci. U.S.A., 2018.
  • T. Dumontet, I. Sahut-Barnola, A. Septier, N. Montanier, I. Plotton, F. Roucher-Boulez, V. Ducros, A. Lefrancois-Martinez, J. Pointud, M. Zubair, K. Morohashi, D. Breault, P. Val and A. Martinez, “PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal.”, JCI insight, vol. 3 (2) , 2018.
• 2017
  • M. Batisse-Lignier, I. Sahut-Barnola, F. Tissier, T. Dumontet, M. Mathieu, C. Drelon, J. Pointud, C. Damon-Soubeyrand, G. Marceau, J. Kemeny, J. Bertherat, I. Tauveron, P. Val, A. Martinez and A. Lefrancois-Martinez, “P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model.”, Oncogene, 2017.
• 2016
  • Z. Bram, E. Louiset, B. Ragazzon, S. Renouf, J. Wils, C. Duparc, I. Boutelet, M. Rizk-Rabin, R. Libe, J. Young, D. Carson, M. Vantyghem, E. Szarek, A. Martinez, C. Stratakis, J. Bertherat and H. Lefebvre, “PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease.”, JCI insight, vol. 1 (15) , pp. e87958, 2016.
  • V. Vidal, S. Sacco, A. Rocha, F. da Silva, C. Panzolini, T. Dumontet, T. Doan, J. Shan, A. Rak-Raszewska, T. Bird, S. Vainio, A. Martinez and A. Schedl, “The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3.”, Genes Dev., vol. 30 (12) , pp. 1389–94, 2016.
  • C. Drelon, A. Berthon, M. Mathieu, B. Ragazzon, R. Kuick, H. Tabbal, A. Septier, S. Rodriguez, M. Batisse-Lignier, I. Sahut-Barnola, T. Dumontet, J. Pointud, A. Lefrancois-Martinez, S. Baron, T. Giordano, J. Bertherat, A. Martinez and P. Val, “EZH2 is overexpressed in Adrenocortical Carcinoma and is associated with disease progression.”, Hum. Mol. Genet., 2016.
  • P. Val and A. Martinez, “Editorial: Adrenal Cortex: From Physiology to Disease.”, Frontiers in endocrinology, vol. 7 , pp. 51, 2016.
  • F. Leccia, M. Batisse-Lignier, I. Sahut-Barnola, P. Val, A. Lefrancois-Martinez and A. Martinez, “Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?”, Frontiers in endocrinology, vol. 7 , pp. 93, 2016.
  • C. Drelon, A. Berthon, I. Sahut-Barnola, M. Mathieu, T. Dumontet, S. Rodriguez, M. Batisse-Lignier, H. Tabbal, I. Tauveron, A. Lefrancois-Martinez, J. Pointud, C. Gomez-Sanchez, S. Vainio, J. Shan, S. Sacco, A. Schedl, C. Stratakis, A. Martinez and P. Val, “PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development.”, Nature communications, vol. 7 , pp. 12751, 2016.
• 2015
  • E. Pastel, J. Pointud, G. Loubeau, C. Dani, K. Slim, G. Martin, F. Volat, I. Sahut-Barnola, P. Val, A. Martinez and A. Lefrancois-Martinez, “Aldose reductases influence prostaglandin f2alpha levels and adipocyte differentiation in male mouse and human species.”, Endocrinology, vol. 156 (5) , pp. 1671–84, 2015.
• 2014
  • C. Drelon, A. Berthon, M. Mathieu, A. Martinez and P. Val, “Adrenal cortex tissue homeostasis and zonation: A WNT perspective.”, Molecular and cellular endocrinology, 2014.
  • C. de Joussineau, I. Sahut-Barnola, F. Tissier, T. Dumontet, C. Drelon, M. Batisse-Lignier, I. Tauveron, J. Pointud, A. Lefrancois-Martinez, C. Stratakis, J. Bertherat, P. Val and A. Martinez, “mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD).”, Hum. Mol. Genet., 2014.
  • A. Berthon, C. Drelon, B. Ragazzon, S. Boulkroun, F. Tissier, L. Amar, B. Samson-Couterie, M. Zennaro, P. Plouin, S. Skah, M. Plateroti, H. Lefebvre, I. Sahut-Barnola, M. Batisse-Lignier, G. Assie, A. Lefrancois-Martinez, J. Bertherat, A. Martinez and P. Val, “WNT/beta-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production.”, Hum. Mol. Genet., vol. 23 (4) , pp. 889–905, 2014.
• 2013
  • R. Bandiera, V. Vidal, F. Motamedi, M. Clarkson, I. Sahut-Barnola, A. von Gise, W. Pu, P. Hohenstein, A. Martinez and A. Schedl, “WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.”, Dev. Cell, vol. 27 (1) , pp. 5–18, 2013.
  • W. Kanczkowski, V. Alexaki, N. Tran, S. Grossklaus, K. Zacharowski, A. Martinez, P. Popovics, N. Block, T. Chavakis, A. Schally and S. Bornstein, “Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation.”, Proc. Natl. Acad. Sci. U.S.A., vol. 110 (36) , pp. 14801–6, 2013.
• 2012
  • F. Volat, J. Pointud, E. Pastel, B. Morio, B. Sion, G. Hamard, M. Guichardant, R. Colas, A. Lefrancois-Martinez and A. Martinez, “Depressed levels of prostaglandin F2alpha in mice lacking Akr1b7 increase basal adiposity and predispose to diet-induced obesity.”, Diabetes, vol. 61 (11) , pp. 2796–806, 2012.
  • E. Pastel, J. Pointud, F. Volat, A. Martinez and A. Lefrancois-Martinez, “Aldo-Keto Reductases 1B in Endocrinology and Metabolism.”, Front Pharmacol, vol. 3 , pp. 148, 2012.
  • C. Drelon, A. Berthon, B. Ragazzon, F. Tissier, R. Bandiera, I. Sahut-Barnola, C. de Joussineau, M. Batisse-Lignier, A. Lefrancois-Martinez, J. Bertherat, A. Martinez and P. Val, “Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models.”, PLoS ONE, vol. 7 (8) , pp. e44171, 2012.
• 2011
  • H. Mataoui-Mazari, Z. Amirat, F. Khammar and A. Martinez, “Identification, cloning and regulation of cDNA encoding aldo-keto reductase 1B7 in the adrenal gland of two Saharan rodents Meriones libycus (Libyan jird) and Gerbillus gerbillus (gerbil).”, General and comparative endocrinology, vol. 174 (3) , pp. 292–300, 2011.
  • C. de Joussineau, I. Sahut-Barnola, I. Levy, E. Saloustros, P. Val, C. Stratakis and A. Martinez, “The cAMP pathway and the control of adrenocortical development and growth.”, Molecular and cellular endocrinology, vol. 351 (1) , pp. 28–36, 2011.
  • A. Berthon, A. Martinez, J. Bertherat and P. Val, “Wnt/beta-catenin signalling in adrenal physiology and tumour development.”, Molecular and cellular endocrinology, vol. 351 (1) , pp. 87–95, 2011.
  • A. Lefrancois-Martinez, A. Blondet-Trichard, N. Binart, P. Val, C. Chambon, I. Sahut-Barnola, J. Pointud and A. Martinez, “Transcriptional control of adrenal steroidogenesis: novel connection between Janus kinase (JAK) 2 protein and protein kinase A (PKA) through stabilization of cAMP response element-binding protein (CREB) transcription factor.”, J. biol. chem., vol. 286 (38) , pp. 32976–85, 2011.
• 2010
  • I. Sahut-Barnola, C. de Joussineau, P. Val, S. Lambert-Langlais, C. Damon, A. Lefrancois-Martinez, J. Pointud, G. Marceau, V. Sapin, F. Tissier, B. Ragazzon, J. Bertherat, L. Kirschner, C. Stratakis and A. Martinez, “Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.”, PLoS Genet., vol. 6 (6) , pp. e1000980, 2010.
  • A. Berthon, I. Sahut-Barnola, S. Lambert-Langlais, C. de Joussineau, C. Damon-Soubeyrand, E. Louiset, M. Taketo, F. Tissier, J. Bertherat, A. Lefrancois-Martinez, A. Martinez and P. Val, “Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.”, Hum. Mol. Genet., vol. 19 (8) , pp. 1561–76, 2010.
• 2009
  • B. Ragazzon, L. Cazabat, M. Rizk-Rabin, G. Assie, L. Groussin, H. Fierrard, K. Perlemoine, A. Martinez and J. Bertherat, “Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.”, Cancer research, vol. 69 (18) , pp. 7278–84, 2009.
  • M. Battista, C. Roberge, A. Martinez and N. Gallo-Payet, “24-dehydrocholesterol reductase/seladin-1: a key protein differentially involved in adrenocorticotropin effects observed in human and rat adrenal cortex.”, Endocrinology, vol. 150 (9) , pp. 4180–90, 2009.
  • I. Sahut-Barnola, C. De Joussineau, P. Val, S. Lambert-Langlais, A. Lefrancois-Martinez, J. Pointud, G. Marceau, V. Sapin, B. Ragazzon, J. Bertherat, L. Kirschner, C. Stratakis and A. Martinez, “Mouse model for bilateral adrenal hyperplasia.”, Annales d'endocrinologie, vol. 70 (3) , pp. 194, 2009.
  • S. Lambert-Langlais, J. Pointud, A. Lefrancois-Martinez, F. Volat, M. Manin, F. Coudore, P. Val, I. Sahut-Barnola, B. Ragazzon, E. Louiset, C. Delarue, H. Lefebvre, Y. Urade and A. Martinez, “Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions.”, PLoS ONE, vol. 4 (10) , pp. e7309, 2009.
• 2008
  • Z. Kabututu, M. Manin, J. Pointud, T. Maruyama, N. Nagata, S. Lambert, A. Lefrancois-Martinez, A. Martinez and Y. Urade, “Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7.”, J. Biochem., vol. 145 (2) , pp. 161–8, 2008.
  • S. Lambert-Langlais, P. Val, S. Guyot, B. Ragazzon, I. Sahut-Barnola, A. De Haze, A. Lefrancois-Martinez and A. Martinez, “A transgenic mouse line with specific Cre recombinase expression in the adrenal cortex.”, Molecular and cellular endocrinology, vol. 300 (1-2) , pp. 197–204, 2008.