Charles WHITE

Senior Research Scientist. C.N.R.S.


Charles WHITEprofile picture

Charles I. White is a Directeur de Recherche (DR1, senior scientist) at the Centre National de la Recherche Scientifique, and with Maria Gallego co-directs a CNRS/University/INSERM research group studying the mechanisms by which cells maintain the integrity of their genomes. Following an Honours BSc. degree in Genetics and Biochemistry at the University of Adelaide (Australia), he carried out his PhD. at the MRC (London, U.K.) in the group of Robin Holliday, and a post-doc at Boston in the group of James E. Haber, on the mechanisms of DNA repair and genetic recombination in yeast. Particularly notable results of this work were the establishment of the "Physical Monitoring" of recombination in vivo - establishing the kinetics and two novel molecular intermediates of genetic recombination in eukaryotes (including the resection of 5'-ended DNA strand at DNA breaks, now believed to be the key step in determining the choice of recombination pathway). In 1994 he was recruited by the CNRS at the University of Paris (Orsay), to establish a research group on molecular mechanisms of genetic recombination in plants. The group moved to the University Blaise Pascal at Clermont-Ferrand in 1998 and actively pursues research into the molecular mechanisms responsible for the maintenance of genome integrity in the model plant, Arabidopsis thaliana.

He has participated in numerous review committees at international (EU- Descartes Prize, Framework 5; grant and recruitment reviews, scientific journal reviews, ...) and national levels (scientific commission of the IRD (scientific recruitment and review), CEA, Institut Pasteur, Génoplante, AERES,  thesis and habilitation juries ...). He has organised international scientific meetings (most recently the EMBO "Genetic stability and Change"  EMBO workshop and at Roscoff in 2012), coordinated two, and participated in three other European Framework network grants (currently the Marie-Curie network: COMREC), as well as numerous public and industry funded projects in France. 




  • 2022
    • A. Meschichi, L. Zhao, S. Reeck, C. White, O. Da Ines, A. Sicard, F. Pontvianne and S. Rosa, “The plant-specific DDR factor SOG1 increases chromatin mobility in response to DNA damage.”, EMBO Rep., pp. e54736, 2022.
    • O. Da Ines, J. Bazile, M. Gallego and C. White, “DMC1 attenuates RAD51-mediated recombination in Arabidopsis.”, PLoS Genet., vol. 18 (8) , pp. e1010322, 2022.
  • 2021
    • M. Martinez-Garcia, C. White, F. Franklin and E. Sanchez-Moran, “The Role of Topoisomerase II in DNA Repair and Recombination in Arabidopsis thaliana.”, International journal of molecular sciences, vol. 22 (23) , 2021.
    • M. Hernandez Sanchez-Rebato, A. Bouatta, M. Gallego, C. White and O. Da Ines, “RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis.”, PLoS Genet., vol. 17 (5) , pp. e1008919, 2021.
  • 2020
    • P. Bourguet, L. Lopez-Gonzalez, A. Gomez-Zambrano, T. Pelissier, A. Hesketh, M. Potok, M. Pouch-Pelissier, M. Perez, O. Da Ines, D. Latrasse, C. White, S. Jacobsen, M. Benhamed and O. Mathieu, “DNA polymerase epsilon is required for heterochromatin maintenance in Arabidopsis.”, Genome biology, vol. 21 (1) , pp. 283, 2020.
    • N. Grandin, M. Gallego, C. White and M. Charbonneau, “Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae.”, DNA Repair (Amst.), vol. 96 , pp. 102996, 2020.
    • O. Da Ines, R. Michard, I. Fayos, G. Bastianelli, A. Nicolas, E. Guiderdoni, C. White and P. Sourdille, “Bread Wheat TaSPO11-1 exhibits evolutionary conserved function in meiotic recombination across distant plant species.”, Plant J., 2020.
    • F. Benyahya, I. Nadaud, O. Da Ines, H. Rimbert, C. White and P. Sourdille, “SPO11.2 is essential for programmed double strand break formation during meiosis in bread wheat (Triticum aestivum L.).”, Plant J., 2020.
  • 2019
    • T. Hirakawa, K. Kuwata, M. Gallego, C. White, M. Nomoto, Y. Tada and S. Matsunaga, “LSD1-LIKE1-mediated H3K4me2 demethylation is required for homologous recombination repair.”, Plant physiology, 2019.
  • 2018
  • 2017
    • T. Hirakawa, J. Hasegawa, C. White and S. Matsunaga, “RAD54 forms DNA repair foci in response to DNA damage in living plant cells.”, Plant J., 2017.
    • G. Singh, O. Da Ines, M. Gallego and C. White, “Analysis of the impact of the absence of RAD51 strand exchange activity in Arabidopsis meiosis.”, PLoS ONE, vol. 12 (8) , pp. e0183006, 2017.
  • 2016
    • C. Collonnier, A. Epert, K. Mara, F. Maclot, A. Guyon-Debast, F. Charlot, C. White, D. Schaefer and F. Nogue, “CRISPR-Cas9-mediated efficient directed mutagenesis and RAD51-dependent and RAD51-independent gene targeting in the moss Physcomitrella patens.”, Plant Biotechnol. J., 2016.
    • J. Pedroza-Garcia, S. Domenichini, C. Mazubert, M. Bourge, C. White, E. Hudik, R. Bounon, Z. Tariq, E. Delannoy, I. Del Olmo, M. Pineiro, J. Jarillo Quiroga, C. Bergounioux, M. Benhamed and C. Raynaud, “Role of the Polymerase sub-unit DPB2 in DNA replication, cell cycle regulation and DNA damage response in Arabidopsis.”, Nucleic Acids Res., 2016.
    • K. Richter, H. Serra, C. White and H. Jeske, “The recombination mediator RAD51D promotes geminiviral infection.”, Virology, vol. 493 , pp. 113–127, 2016.
    • M. Olivier, O. Da Ines, S. Amiard, H. Serra, C. Goubely, C. White and M. Gallego, “The Structure-Specific Endonucleases MUS81 and SEND1 Are Essential for Telomere Stability in Arabidopsis.”, Plant Cell, vol. 28 (1) , pp. 74–86, 2016.
  • 2015
    • O. Da Ines and C. White, “Centromere Associations in Meiotic Chromosome Pairing.”, Annual review of genetics, 2015.
    • V. Muchova, S. Amiard, I. Mozgova, M. Dvorackova, M. Gallego, C. White and J. Fajkus, “Homology-dependent repair is involved in 45S rDNA loss in plant CAF-1 mutants.”, Plant J., vol. 81 (2) , pp. 198–209, 2015.
    • P. Merle, M. Gueugneau, M. Teulade-Fichou, M. Muller-Barthelemy, S. Amiard, E. Chautard, C. Guetta, V. Dedieu, Y. Communal, J. Mergny, M. Gallego, C. White, P. Verrelle and A. Tchirkov, “Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound.”, Scientific reports, vol. 5 , pp. 16255, 2015.
  • 2014
    • S. Amiard, M. Olivier, E. Allain, K. Choi, R. Smith-Unna, I. Henderson, C. White and M. Gallego, “Telomere stability and development of ctc1 mutants are rescued by inhibition of EJ recombination pathways in a telomerase-dependent manner.”, Nucleic Acids Res., vol. 42 (19) , pp. 11979–91, 2014.
    • P. Kalhorzadeh, Z. Hu, T. Cools, S. Amiard, E. Willing, N. De Winne, K. Gevaert, G. De Jaeger, K. Schneeberger, C. White and L. De Veylder, “Arabidopsis thaliana RNase H2 deficiency counteracts the needs for the WEE1 checkpoint kinase but triggers genome instability.”, Plant Cell, vol. 26 (9) , pp. 3680–92, 2014.
    • O. Da Ines, M. Gallego and C. White, “Recombination-independent mechanisms and pairing of homologous chromosomes during meiosis in plants.”, Mol Plant, vol. 7 (3) , pp. 492–501, 2014.
    • I. Mestiri, F. Norre, M. Gallego and C. White, “Multiple host-cell recombination pathways act in Agrobacterium-mediated transformation of plant cells.”, Plant J., vol. 77 (4) , pp. 511–20, 2014.
    • S. Amiard, O. Da Ines, M. Gallego and C. White, “Responses to telomere erosion in plants.”, PLoS ONE, vol. 9 (1) , pp. e86220, 2014.
  • 2013
  • 2012
    • A. Ayar, S. Wehrkamp-Richter, J. Laffaire, S. Le Goff, J. Levy, S. Chaignon, H. Salmi, A. Lepicard, C. Sallaud, M. Gallego, C. White and W. Paul, “Gene targeting in maize by somatic ectopic recombination.”, Plant Biotechnol. J., vol. 11 (3) , pp. 305–14, 2012.
    • W. Wei, Z. Ba, M. Gao, Y. Wu, Y. Ma, S. Amiard, C. White, J. Rendtlew Danielsen, Y. Yang and Y. Qi, “A role for small RNAs in DNA double-strand break repair.”, Cell, vol. 149 (1) , pp. 101–12, 2012.
    • O. Da Ines, K. Abe, C. Goubely, M. Gallego and C. White, “Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana.”, PLoS Genet., vol. 8 (4) , pp. e1002636, 2012.
  • 2011
  • 2010
  • 2009
    • J. Vannier, A. Depeiges, C. White and M. Gallego, “ERCC1/XPF protects short telomeres from homologous recombination in Arabidopsis thaliana.”, PLoS Genet., vol. 5 (2) , pp. e1000380, 2009.
  • 2008
    • J. Kozak, C. West, C. White, J. da Costa-Nunes and K. Angelis, “Rapid repair of DNA double strand breaks in Arabidopsis thaliana is dependent on proteins involved in chromosome structure maintenance.”, DNA Repair (Amst.), vol. 8 (3) , pp. 413–9, 2008.
    • C. White, “News from Arabidopsis on the meiotic roles of Blap75/Rmi1 and Top3alpha.”, PLoS Genet., vol. 4 (12) , pp. e1000306, 2008.
  • 2006
    • G. Maillet, C. White and M. Gallego, “Telomere-length regulation in inter-ecotype crosses of Arabidopsis.”, Plant molecular biology, vol. 62 (6) , pp. 859–66, 2006.
    • J. Vannier, A. Depeiges, C. White and M. Gallego, “Two roles for Rad50 in telomere maintenance.”, EMBO J., vol. 25 (19) , pp. 4577–85, 2006.
    • J. Bleuyard, M. Gallego and C. White, “Recent advances in understanding of the DNA double-strand break repair machinery of plants.”, DNA Repair (Amst.), vol. 5 (1) , pp. 1–12, 2006.
  • 2005
    • T. Tzfira and C. White, “Towards targeted mutagenesis and gene replacement in plants.”, Trends in biotechnology, vol. 23 (12) , pp. 567–9, 2005.
    • J. Li, M. Vaidya, C. White, A. Vainstein, V. Citovsky and T. Tzfira, “Involvement of KU80 in T-DNA integration in plant cells.”, Proc. Natl. Acad. Sci. U.S.A., vol. 102 (52) , pp. 19231–6, 2005.
    • J. Bleuyard, M. Gallego, F. Savigny and C. White, “Differing requirements for the Arabidopsis Rad51 paralogs in meiosis and DNA repair.”, Plant J., vol. 41 (4) , pp. 533–45, 2005.
    • M. Gallego and C. White, “DNA repair and recombination functions in Arabidopsis telomere maintenance.”, Chromosome Res., vol. 13 (5) , pp. 481–91, 2005.
  • 2004
    • J. Bleuyard, M. Gallego and C. White, “Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination.”, Chromosoma, vol. 113 (4) , pp. 197–203, 2004.
    • J. Bleuyard, M. Gallego and C. White, “The atspo11-1 mutation rescues atxrcc3 meiotic chromosome fragmentation.”, Plant molecular biology, vol. 56 (2) , pp. 217–24, 2004.
    • S. Dubest, M. Gallego and C. White, “Roles of the AtErcc1 protein in recombination.”, Plant J., vol. 39 (3) , pp. 334–42, 2004.
    • J. Bleuyard and C. White, “The Arabidopsis homologue of Xrcc3 plays an essential role in meiosis.”, EMBO J., vol. 23 (2) , pp. 439–49, 2004.
  • 2003
    • M. Gallego, J. Bleuyard, S. Daoudal-Cotterell, N. Jallut and C. White, “Ku80 plays a role in non-homologous recombination but is not required for T-DNA integration in Arabidopsis.”, Plant J., vol. 35 (5) , pp. 557–65, 2003.
  • 2002
    • S. Dubest, M. Gallego and C. White, “Role of the AtRad1p endonuclease in homologous recombination in plants.”, EMBO Rep., vol. 3 (11) , pp. 1049–54, 2002.
    • S. Daoudal-Cotterell, M. Gallego and C. White, “The plant Rad50-Mre11 protein complex.”, FEBS Lett., vol. 516 (1-3) , pp. 164–6, 2002.
  • 2001
    • H. Gherbi, M. Gallego, N. Jalut, J. Lucht, B. Hohn and C. White, “Homologous recombination in planta is stimulated in the absence of Rad50.”, EMBO Rep., vol. 2 (4) , pp. 287–91, 2001.
    • M. Gallego and C. White, “RAD50 function is essential for telomere maintenance in Arabidopsis.”, Proc. Natl. Acad. Sci. U.S.A., vol. 98 (4) , pp. 1711–6, 2001.
    • M. Gallego, M. Jeanneau, F. Granier, D. Bouchez, N. Bechtold and C. White, “Disruption of the Arabidopsis RAD50 gene leads to plant sterility and MMS sensitivity.”, Plant J., vol. 25 (1) , pp. 31–41, 2001.