David VOLLEprofile picture

During my PhD my work was focused on the role of the nuclear receptors of oxysterols, the Liver X Receptors (LXRalpha and LXRbeta) in steroidogenic tissues. We demonstrate key roles of LXRs in the physiology ofintestine, adrenals, ovaries and testis.
 I have identified the nuclear receptor Small Heterodimer partner (SHP, NR0B2) as a main regulator of testicular androgen and retinoic acid metabolisms, making SHP a testicular gatekeeper of the timing of male sexual maturation (post-doc in Pr Auwerx's laboratory)

I have then worked on the impact of Endocrine Disrupters (EDs)  in order to understand how in utero and/or neonatal exposure could alter adult testicular physiology. Our data established SHP as a crucial mediator of the deleterious effect of estrogenic EDs, such as diethylstilbestrol, on testicular physiology. These effects seem to be driven through the regulation of the histone methyltransferase EHMT.



Since 2010, we are now developing an innovative thematic research to identify the molecular mechanisms underlying the links between liver disease (PH) and impaired male fertility. Our studies are mainly focused in understanding the role of the bile acid receptors FXRalpha and TGR5 in context of PH which aree characterized bile increased plasma levels of bile acids. Thanks to our collaboration with PR Auwerx and Schoonjans' laboratory (EPFL, Lausane, SWITZERLAND), we have access to mouse models invalidated for FXRalpha or TGR5. The goal will be to decipher their respective role in testicular physiology.

We are also interested in the impact of environment exposure such as endocrine disrupters (EDs) on testicular pathophysiology. We are mainly working on estogen-like EDs in order to analyze their impact on spermatogenesis. The goal of our group is to better understand the mechanisms involved in generational transmission of anamolies leading to diseases such as altered development, obesity and/or diabetes.