David VOLLE
Dr
Resume
During my PhD my work was focused on the role of the nuclear receptors of oxysterols, the Liver X Receptors (LXRalpha and LXRbeta) in steroidogenic tissues. We demonstrate key roles of LXRs in the physiology ofintestine, adrenals, ovaries and testis.
I have identified the nuclear receptor Small Heterodimer partner (SHP, NR0B2) as a main regulator of testicular androgen and retinoic acid metabolisms, making SHP a testicular gatekeeper of the timing of male sexual maturation (post-doc in Pr Auwerx's laboratory)
I have then worked on the impact of Endocrine Disrupters (EDs) in order to understand how in utero and/or neonatal exposure could alter adult testicular physiology. Our data established SHP as a crucial mediator of the deleterious effect of estrogenic EDs, such as diethylstilbestrol, on testicular physiology. These effects seem to be driven through the regulation of the histone methyltransferase EHMT.
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Research
Since 2010, we are now developing an innovative thematic research to identify the molecular mechanisms underlying the links between liver disease (PH) and impaired male fertility. Our studies are mainly focused in understanding the role of the bile acid receptors FXRalpha and TGR5 in context of PH which aree characterized bile increased plasma levels of bile acids. Thanks to our collaboration with PR Auwerx and Schoonjans' laboratory (EPFL, Lausane, SWITZERLAND), we have access to mouse models invalidated for FXRalpha or TGR5. The goal will be to decipher their respective role in testicular physiology.
We are also interested in the impact of environment exposure such as endocrine disrupters (EDs) on testicular pathophysiology. We are mainly working on estogen-like EDs in order to analyze their impact on spermatogenesis. The goal of our group is to better understand the mechanisms involved in generational transmission of anamolies leading to diseases such as altered development, obesity and/or diabetes.
Publications
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2022
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“Identification of the Role of TGR5 in the Regulation of Leydig Cell Homeostasis.”, International journal of molecular sciences, vol. 23 (23) , 2022.
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“Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance.”, Advanced science (Weinheim, Baden-Wurttemberg, Germany), pp. e2200626, 2022.
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“Metallome deregulation and health-related impacts due to long-term exposure to recent volcanic ash deposits: New chemical and isotopic insights.”, The Science of the total environment, pp. 154383, 2022.
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2021
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“When idiopathic male infertility is rooted in maternal malnutrition during the perinatal period in mice.”, Biol Reprod, 2021.
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“Analysis of the Reversible Impact of the Chemodrug Busulfan on Mouse Testes.”, Cells, vol. 10 (9) , 2021.
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“Intestinal microbiota defines the GUT-TESTIS axis.”, Gut, 2021.
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“Molecular and Cellular Endocrinology: Special issue hypothalomo - Pituitary axis: Roles in integrative physiology and pathophysiologies.”, Molecular and cellular endocrinology, vol. 525 , pp. 111198, 2021.
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2020
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“FXRalpha modulates leydig cell endocrine function in mouse.”, Molecular and cellular endocrinology, vol. 518 , pp. 110995, 2020.
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“New perspectives on PPAR, VDR and FXRalpha as new actors in testicular pathophysiology.”, Molecular aspects of medicine, pp. 100886, 2020.
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“Editorial: Bisphenols and Male Reproductive Health.”, Frontiers in endocrinology, vol. 11 , pp. 597609, 2020.
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2019
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“Farnesoid X receptor alpha (FXRalpha) is a critical actor of the development and pathologies of the male reproductive system.”, Cell. Mol. Life Sci., 2019.
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“Fxralpha gene is a target gene of hCG signaling pathway and represses hCG induced steroidogenesis.”, The Journal of steroid biochemistry and molecular biology, pp. 105460, 2019.
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2018
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“Multigenerational impacts of bile exposure are mediated by TGR5 signaling pathways.”, Scientific reports, vol. 8 (1) , pp. 16875, 2018.
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“Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases.”, International journal of molecular sciences, vol. 19 (11) , 2018.
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“Crosstalk between BPA and FXRalpha Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders.”, Stem cell reports, 2018.
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“Cholesterol: A Gatekeeper of Male Fertility?”, Frontiers in endocrinology, vol. 9 , pp. 369, 2018.
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2017
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“Bile acids, roles in integrative physiology and pathophysiology.”, Molecular aspects of medicine, vol. 56 , pp. 1, 2017.
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“The Bile Acid Nuclear Receptor FXRalpha Is a Critical Regulator of Mouse Germ Cell Fate.”, Stem cell reports, 2017.
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“Bile acids and male fertility: From mouse to human?”, Molecular aspects of medicine, 2017.
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“Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha.”, Scientific reports, vol. 7 , pp. 42182, 2017.
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“Bile acids and their receptors.”, Molecular aspects of medicine, 2017.
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2016
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“Nuclear receptors as pharmacological targets, where are we now?”, Cell. Mol. Life Sci., 2016.
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“Once and for all, LXRalpha and LXRbeta are gatekeepers of the endocrine system.”, Molecular aspects of medicine, 2016.
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“Bile acid-FXRalpha pathways regulate male sexual maturation in mice.”, Oncotarget, 2016.
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2015
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“Identification of the functions of Liver X Receptor beta in Sertoli cells using a targeted expression-rescue model.”, Endocrinology, pp. en20151382, 2015.
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“Identification of the Link Between the Hypothalamo-Pituitary Axis and the Testicular Orphan Nuclear Receptor NR0B2 in Adult Male Mice.”, Endocrinology, vol. 156 (2) , pp. 660–9, 2015.
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“Enolase is regulated by Liver X Receptors.”, Steroids, 2015.
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“Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context.”, PLoS ONE, vol. 10 (10) , pp. e0139946, 2015.
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2014
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“Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP.”, Expert Opin. Ther. Targets, vol. 18 (12) , pp. 1367–76, 2014.
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“Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.”, Hepatology (Baltimore, Md.), vol. 60 (3) , pp. 1054–65, 2014.
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“Levels of liver X receptors in testicular biopsies of patients with azoospermia.”, Fertil. Steril., vol. 102 (2) , pp. 361–371.e5, 2014.
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“Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.”, Biochemical and biophysical research communications, vol. 446 (3) , pp. 656–62, 2014.
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2013
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“Oxysterol receptors and their therapeutic applications in cancer conditions.”, Expert Opin. Ther. Targets, vol. 17 (9) , pp. 1029–38, 2013.
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“Lipids, LXRs and prostate cancer: are HDACs a new link?”, Biochemical pharmacology, vol. 86 (1) , pp. 168–74, 2013.
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“Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?”, Cell. Mol. Life Sci., vol. 70 (23) , pp. 4511–26, 2013.
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“Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.”, PLoS Genet., vol. 9 (5) , pp. e1003483, 2013.
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“Male fertility: Is spermiogenesis the critical step for answering biomedical issues?”, Spermatogenesis, vol. 3 (2) , pp. e24114, 2013.
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“LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.”, Am J Cancer Res, vol. 3 (1) , pp. 58–69, 2013.
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“Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell.”, PLoS ONE, vol. 8 (3) , pp. e58876, 2013.
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2012
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“Vitamin E: potential therapeutical approach for prevention of liver cancer development.”, Chinese clinical oncology, vol. 1 (1) , pp. 6, 2012.
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“Bile acids: from digestion to cancers.”, Biochimie, vol. 95 (3) , pp. 504–17, 2012.
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“Cholesterol and male fertility: what about orphans and adopted?”, Molecular and cellular endocrinology, vol. 368 (1-2) , pp. 30–46, 2012.
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“Emerging roles for LXRs and LRH-1 in female reproduction.”, Molecular and cellular endocrinology, vol. 368 (1-2) , pp. 47–58, 2012.
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“Epigenetic: a molecular link between testicular cancer and environmental exposures.”, Frontiers in endocrinology, vol. 3 , pp. 150, 2012.
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2011
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“Regenerating I messenger RNA and protein expression in the failing human testis: a potential molecular prognostic marker of seminoma.”, Human pathology, vol. 42 (12) , pp. 1841–8, 2011.
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“Liver X receptors, lipids and their reproductive secrets in the male.”, Biochim. Biophys. Acta, vol. 1812 (8) , pp. 974–81, 2011.
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“Targeting liver X receptors in human health: deadlock or promising trail?”, Expert Opin. Ther. Targets, vol. 15 (2) , pp. 219–32, 2011.
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2010
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“[Endocrine disruptors and fertility: NR0B2, a new therapeutic target?].”, Med Sci (Paris), vol. 26 (4) , pp. 359–61, 2010.
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2009
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“The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice.”, J. Clin. Invest., vol. 119 (12) , pp. 3752–64, 2009.
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“Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.”, Endocrinology, vol. 150 (7) , pp. 3369–75, 2009.
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2008
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“Liver receptor homolog 1 is essential for ovulation.”, Genes Dev., vol. 22 (14) , pp. 1871–6, 2008.
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2007
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“In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.”, Molecular endocrinology (Baltimore, Md.), vol. 21 (6) , pp. 1312–23, 2007.
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“Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility.”, Molecular endocrinology (Baltimore, Md.), vol. 21 (5) , pp. 1014–27, 2007.
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“Oxysterol nuclear receptor LXRbeta regulates cholesterol homeostasis and contractile function in mouse uterus.”, J. biol. chem., vol. 282 (7) , pp. 4693–701, 2007.
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“Role of the nuclear receptors for oxysterols LXRs in steroidogenic tissues: beyond the "foie gras", the steroids and sex?”, Molecular and cellular endocrinology, vol. 265-266 , pp. 183–9, 2007.
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“The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice.”, Genes Dev., vol. 21 (3) , pp. 303–15, 2007.
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2006
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“Liver X receptors regulate adrenal cholesterol balance.”, J. Clin. Invest., vol. 116 (7) , pp. 1902–12, 2006.
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2005
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“Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development.”, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, vol. 283 (1) , pp. 175–81, 2005.
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2004
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“Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.”, Journal of molecular endocrinology, vol. 33 (2) , pp. 361–75, 2004.
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“Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.”, Molecular endocrinology (Baltimore, Md.), vol. 18 (4) , pp. 888–98, 2004.
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“[Oxysterols: metabolism, biological role and associated diseases].”, Gastroenterologie clinique et biologique, vol. 28 (3) , pp. 279–93, 2004.
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“Alpha1beta1-integrin is an essential signal for neurite outgrowth induced by thrombospondin type 1 repeats of SCO-spondin.”, Cell Tissue Res., vol. 315 (1) , pp. 15–25, 2004.
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2001
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“[Regulation of lipid metabolism by the orphan nuclear receptors].”, Annales d'endocrinologie, vol. 62 (3) , pp. 239–47, 2001.
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