Publications

• 2022
  • C. Lucas, K. Sauter, M. Steigert, D. Mallet, J. J. Wilmouth, J. Olabe, I. Plotton, Y. Morel, D. Aeberli, F. Wagner, H. Clevers, A. Pandey, P. Val, F. Roucher-Boulez and C. Fluck, “Loss of LGR4/GPR48 causes severe neonatal salt-wasting due to disrupted WNT signaling altering adrenal zonation.”, J. Clin. Invest., 2022.
  • D. Dufour, T. Dumontet, I. Sahut-Barnola, A. Carusi, M. Onzon, E. Pussard, J. Wilmouth, J. Olabe, C. Lucas, A. Levasseur, C. Damon-Soubeyrand, J. Pointud, F. Roucher-Boulez, I. Tauveron, G. Bossis, E. Yeh, D. Breault, P. Val, A. Lefrancois-Martinez and A. Martinez, “Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.”, Nature communications, vol. 13 (1) , pp. 7858, 2022.
  • J. J. Wilmouth, J. Olabe, D. Garcia-Garcia, C. Lucas, R. Guiton, F. Roucher-Boulez, D. Dufour, C. Damon-Soubeyrand, I. Sahut-Barnola, J. Pointud, Y. Renaud, A. Levasseur, I. Tauveron, A. Lefrancois-Martinez, A. Martinez and P. Val, “Sexually dimorphic activation of innate antitumor immunity prevents adrenocortical carcinoma development.”, Science advances, vol. 8 (41) , pp. eadd0422, 2022.
  • I. Sahut-Barnola, A. Lefrancois-Martinez, D. Dufour, J. Botto, C. Kamilaris, F. Faucz, C. Stratakis, P. Val and A. Martinez, “Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome.”, The Journal of investigative dermatology, 2022.
  • J. Le Mestre, M. Thomas, C. Duparc, P. Val, C. Bures, J. Tuech, J. Sabourin, S. Baert-Desurmont, H. Lefebvre and E. Louiset, “beta-Catenin activation and illicit receptor expression in adrenocortical cells.”, Endocrine-related cancer, vol. 29 (3) , pp. 151–162, 2022.
• 2021
  • C. Djari, I. Sahut-Barnola, A. Septier, I. Plotton, N. Montanier, D. Dufour, A. Levasseur, J. J. Wilmouth, J. Pointud, F. Faucz, C. Kamilaris, A. Lopez, F. Guillou, A. Swain, S. Vainio, I. Tauveron, P. Val, H. Lefebvre, C. Stratakis, A. Martinez and A. Lefrancois-Martinez, “Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.”, J. Clin. Invest., vol. 131 (23) , 2021.
  • J. Francis, J. Gardiner, Y. Renaud, R. Chauhan, Y. Weinstein, C. Gomez-Sanchez, A. Lefrancois-Martinez, J. Bertherat, P. Val and A. Swain, “HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.”, British journal of cancer, vol. 124 (4) , pp. 805–816, 2021.
• 2020
  • J. Francis, J. Gardiner, Y. Renaud, R. Chauhan, Y. Weinstein, C. Gomez-Sanchez, A. Lefrancois-Martinez, J. Bertherat, P. Val and A. Swain, “HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.”, British journal of cancer, 2020.
  • A. Bourdin, I. Adcock, P. Berger, P. Bonniaud, P. Chanson, C. Chenivesse, J. de Blic, A. Deschildre, P. Devilliers, G. Devouassoux, A. Didier, G. Garcia, A. Magnan, Y. Martinat, T. Perez, N. Roche, C. Taille, P. Val and P. Chanez, “How can we minimise the use of regular oral corticosteroids in asthma?”, European respiratory review : an official journal of the European Respiratory Society, vol. 29 (155) , 2020.
• 2019
  • H. Tabbal, A. Septier, M. Mathieu, C. Drelon, S. Rodriguez, C. Djari, M. Batisse-Lignier, I. Tauveron, J. Pointud, I. Sahut-Barnola, B. Ragazzon, G. Assie, J. Bertherat, A. Lefrancois-Martinez, A. Martinez and P. Val, “EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness.”, British journal of cancer, 2019.
  • T. Dumontet, I. Sahut-Barnola, D. Dufour, A. Lefrancois-Martinez, A. Berthon, N. Montanier, B. Ragazzon, C. Djari, J. Pointud, F. Roucher-Boulez, M. Batisse-Lignier, I. Tauveron, J. Bertherat, P. Val and A. Martinez, “Hormonal and spatial control of SUMOylation in the human and mouse adrenal cortex.”, FASEB J., pp. fj201900557R, 2019.
  • K. Basham, S. Rodriguez, A. Turcu, A. Lerario, C. Logan, M. Rysztak, C. Gomez-Sanchez, D. Breault, B. Koo, H. Clevers, R. Nusse, P. Val and G. Hammer, “A ZNRF3-dependent Wnt/beta-catenin signaling gradient is required for adrenal homeostasis.”, Genes Dev., vol. 33 (3-4) , pp. 209–220, 2019.
• 2018
  • M. Mathieu, C. Drelon, S. Rodriguez, H. Tabbal, A. Septier, C. Damon-Soubeyrand, T. Dumontet, A. Berthon, I. Sahut-Barnola, C. Djari, M. Batisse-Lignier, J. Pointud, D. Richard, G. Kerdivel, M. Calmejane, V. Boeva, I. Tauveron, A. Lefrancois-Martinez, A. Martinez and P. Val, “Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex.”, Proc. Natl. Acad. Sci. U.S.A., 2018.
  • T. Dumontet, I. Sahut-Barnola, A. Septier, N. Montanier, I. Plotton, F. Roucher-Boulez, V. Ducros, A. Lefrancois-Martinez, J. Pointud, M. Zubair, K. Morohashi, D. Breault, P. Val and A. Martinez, “PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal.”, JCI insight, vol. 3 (2) , 2018.
• 2017
  • M. Batisse-Lignier, I. Sahut-Barnola, F. Tissier, T. Dumontet, M. Mathieu, C. Drelon, J. Pointud, C. Damon-Soubeyrand, G. Marceau, J. Kemeny, J. Bertherat, I. Tauveron, P. Val, A. Martinez and A. Lefrancois-Martinez, “P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model.”, Oncogene, 2017.
• 2016
  • C. Drelon, A. Berthon, M. Mathieu, B. Ragazzon, R. Kuick, H. Tabbal, A. Septier, S. Rodriguez, M. Batisse-Lignier, I. Sahut-Barnola, T. Dumontet, J. Pointud, A. Lefrancois-Martinez, S. Baron, T. Giordano, J. Bertherat, A. Martinez and P. Val, “EZH2 is overexpressed in Adrenocortical Carcinoma and is associated with disease progression.”, Hum. Mol. Genet., 2016.
  • A. Berthon, C. Drelon and P. Val, “Pregnancy, Primary Aldosteronism, and Somatic CTNNB1 Mutations.”, The New England journal of medicine, vol. 374 (15) , pp. 1493–4, 2016.
  • P. Val and A. Martinez, “Editorial: Adrenal Cortex: From Physiology to Disease.”, Frontiers in endocrinology, vol. 7 , pp. 51, 2016.
  • F. Leccia, M. Batisse-Lignier, I. Sahut-Barnola, P. Val, A. Lefrancois-Martinez and A. Martinez, “Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?”, Frontiers in endocrinology, vol. 7 , pp. 93, 2016.
  • C. Drelon, A. Berthon, I. Sahut-Barnola, M. Mathieu, T. Dumontet, S. Rodriguez, M. Batisse-Lignier, H. Tabbal, I. Tauveron, A. Lefrancois-Martinez, J. Pointud, C. Gomez-Sanchez, S. Vainio, J. Shan, S. Sacco, A. Schedl, C. Stratakis, A. Martinez and P. Val, “PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development.”, Nature communications, vol. 7 , pp. 12751, 2016.
• 2015
  • E. Pastel, J. Pointud, G. Loubeau, C. Dani, K. Slim, G. Martin, F. Volat, I. Sahut-Barnola, P. Val, A. Martinez and A. Lefrancois-Martinez, “Aldose reductases influence prostaglandin f2alpha levels and adipocyte differentiation in male mouse and human species.”, Endocrinology, vol. 156 (5) , pp. 1671–84, 2015.
  • L. Lefevre, H. Omeiri, L. Drougat, C. Hantel, M. Giraud, P. Val, S. Rodriguez, K. Perlemoine, C. Blugeon, F. Beuschlein, A. de Reynies, M. Rizk-Rabin, J. Bertherat and B. Ragazzon, “Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of beta-catenin in adrenocortical carcinoma.”, Oncogenesis, vol. 4 , pp. e161, 2015.
• 2014
  • C. Drelon, A. Berthon, M. Mathieu, A. Martinez and P. Val, “Adrenal cortex tissue homeostasis and zonation: A WNT perspective.”, Molecular and cellular endocrinology, 2014.
  • C. de Joussineau, I. Sahut-Barnola, F. Tissier, T. Dumontet, C. Drelon, M. Batisse-Lignier, I. Tauveron, J. Pointud, A. Lefrancois-Martinez, C. Stratakis, J. Bertherat, P. Val and A. Martinez, “mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD).”, Hum. Mol. Genet., 2014.
  • A. Berthon, C. Drelon, B. Ragazzon, S. Boulkroun, F. Tissier, L. Amar, B. Samson-Couterie, M. Zennaro, P. Plouin, S. Skah, M. Plateroti, H. Lefebvre, I. Sahut-Barnola, M. Batisse-Lignier, G. Assie, A. Lefrancois-Martinez, J. Bertherat, A. Martinez and P. Val, “WNT/beta-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production.”, Hum. Mol. Genet., vol. 23 (4) , pp. 889–905, 2014.
• 2013
  • A. Pommier, J. Dufour, G. Alves, E. Viennois, H. De Boussac, A. Trousson, DH. Volle, F. Caira, P. Val, P. Arnaud, JM. Lobaccaro and S. Baron, “Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.”, PLoS Genet., vol. 9 (5) , pp. e1003483, 2013.
  • C. Drelon, A. Berthon and P. Val, “Adrenocortical cancer and IGF2: is the game over or our experimental models limited?”, J. Clin. Endocrinol. Metab., vol. 98 (2) , pp. 505–7, 2013.
• 2012
  • F. Buaas, J. Gardiner, S. Clayton, P. Val and A. Swain, “In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland.”, Development, vol. 139 (24) , pp. 4561–70, 2012.
  • C. Drelon, A. Berthon, B. Ragazzon, F. Tissier, R. Bandiera, I. Sahut-Barnola, C. de Joussineau, M. Batisse-Lignier, A. Lefrancois-Martinez, J. Bertherat, A. Martinez and P. Val, “Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models.”, PLoS ONE, vol. 7 (8) , pp. e44171, 2012.
• 2011
  • C. de Joussineau, I. Sahut-Barnola, I. Levy, E. Saloustros, P. Val, C. Stratakis and A. Martinez, “The cAMP pathway and the control of adrenocortical development and growth.”, Molecular and cellular endocrinology, vol. 351 (1) , pp. 28–36, 2011.
  • A. Berthon, A. Martinez, J. Bertherat and P. Val, “Wnt/beta-catenin signalling in adrenal physiology and tumour development.”, Molecular and cellular endocrinology, vol. 351 (1) , pp. 87–95, 2011.
  • A. Lefrancois-Martinez, A. Blondet-Trichard, N. Binart, P. Val, C. Chambon, I. Sahut-Barnola, J. Pointud and A. Martinez, “Transcriptional control of adrenal steroidogenesis: novel connection between Janus kinase (JAK) 2 protein and protein kinase A (PKA) through stabilization of cAMP response element-binding protein (CREB) transcription factor.”, J. biol. chem., vol. 286 (38) , pp. 32976–85, 2011.
• 2010
  • I. Sahut-Barnola, C. de Joussineau, P. Val, S. Lambert-Langlais, C. Damon, A. Lefrancois-Martinez, J. Pointud, G. Marceau, V. Sapin, F. Tissier, B. Ragazzon, J. Bertherat, L. Kirschner, C. Stratakis and A. Martinez, “Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.”, PLoS Genet., vol. 6 (6) , pp. e1000980, 2010.
  • A. Berthon, I. Sahut-Barnola, S. Lambert-Langlais, C. de Joussineau, C. Damon-Soubeyrand, E. Louiset, M. Taketo, F. Tissier, J. Bertherat, A. Lefrancois-Martinez, A. Martinez and P. Val, “Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.”, Hum. Mol. Genet., vol. 19 (8) , pp. 1561–76, 2010.
• 2009
  • P. Val and A. Swain, “Gene dosage effects and transcriptional regulation of early mammalian adrenal cortex development.”, Molecular and cellular endocrinology, vol. 323 (1) , pp. 105–14, 2009.
  • I. Sahut-Barnola, C. De Joussineau, P. Val, S. Lambert-Langlais, A. Lefrancois-Martinez, J. Pointud, G. Marceau, V. Sapin, B. Ragazzon, J. Bertherat, L. Kirschner, C. Stratakis and A. Martinez, “Mouse model for bilateral adrenal hyperplasia.”, Annales d'endocrinologie, vol. 70 (3) , pp. 194, 2009.
  • F. Buaas, P. Val and A. Swain, “The transcription co-factor CITED2 functions during sex determination and early gonad development.”, Hum. Mol. Genet., vol. 18 (16) , pp. 2989–3001, 2009.
  • S. Lambert-Langlais, J. Pointud, A. Lefrancois-Martinez, F. Volat, M. Manin, F. Coudore, P. Val, I. Sahut-Barnola, B. Ragazzon, E. Louiset, C. Delarue, H. Lefebvre, Y. Urade and A. Martinez, “Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions.”, PLoS ONE, vol. 4 (10) , pp. e7309, 2009.
• 2008
  • S. Lambert-Langlais, P. Val, S. Guyot, B. Ragazzon, I. Sahut-Barnola, A. De Haze, A. Lefrancois-Martinez and A. Martinez, “A transgenic mouse line with specific Cre recombinase expression in the adrenal cortex.”, Molecular and cellular endocrinology, vol. 300 (1-2) , pp. 197–204, 2008.
• 2004
  • D. Volle, J. Repa, A. Mazur, C. Cummins, P. Val, J. Henry-Berger, F. Caira, G. Veyssiere, D. Mangelsdorf and JM. Lobaccaro, “Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.”, Molecular endocrinology (Baltimore, Md.), vol. 18 (4) , pp. 888–98, 2004.