Silvere BARON
Resume
2011 - Research Management Degree (Habilitation à Diriger les Recherches) Université Clermont Auvergne, Université Blaise Pascal
"LXRs roles in Physiopathology of Prostate Gland"
2005 - Assistant Professor (Maître de Conférences des Universités), Université Clermont Auvergne, Université Blaise Pascal
Pr. JMA Lobaccaro team "Oxysterols, LXRs and steroidogenic tissues", Génétique Reproduction et Développement UMR CNRS6247 INSERM U931 Clermont Université.
2004 - Post-doctoral training, Institut Cochin INSERM U567, Département d'Hématologie
"Identification of new partners of RelB and IKKa in the NF-kB transduction pathway"
2004 - Doctoral training, Molecular Physiology and Genetics - Molecular and Cellular Endocrinology
"Identification of non genomic effects of androgen receptor on PI3K-AKT transduction pathway and survival" Mentoring Pr. Laurent MOREL. Unité Génétique des Eucaryotes Endocrinologie Moléculaire UMR-CNRS 6547 Blaise Pascal University
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Research
Liver X receptors (LXRs) belong to the nuclear receptor superfamily. These receptors are present in both isoforms, LXRα and LXRβ, and are activated by binding with oxidized derivatives of cholesterol, named oxysterols. They behave as transcription factors and thus stimulate expression of a particular set of genes involved in cholesterol homeostasis and fatty acid synthesis. In addition to their roles in tissues that have a very active lipid metabolism such as liver, brain and adipose tissue, our work focuses on prostate gland. Our objective is to decipher, the roles of LXRs in prostate cancer ex vivo, using cell culture models, and in vivo by exploration of transgenic mice. We have recently demonstrated that LXRs act as metabolic gatekeeper against cancer progression. Our goal is to understand and to identify molecular mechanisms targeted by LXRs and that constrain cancer progression.
Publications
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2021
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“Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer.”, Cells, vol. 10 (9) , 2021.
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2020
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“Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia.”, PLoS biology, vol. 18 (12) , pp. e3000948, 2020.
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“Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila.”, Nature communications, vol. 11 (1) , pp. 2300, 2020.
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2019
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“Ethanolic extract of Algerian propolis decreases androgen receptor transcriptional activity in cultured LNCaP cells.”, The Journal of steroid biochemistry and molecular biology, vol. 189 , pp. 108–115, 2019.
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“Individual Comparison of Cholesterol Metabolism in Normal and Tumour Areas in Radical Prostatectomy Specimens from Patients with Prostate Cancer: Results of the CHOMECAP Study.”, European urology oncology, vol. 2 (2) , pp. 198–206, 2019.
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2018
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“Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule.”, Biochimie, vol. 153 , pp. 162–170, 2018.
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“New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors.”, International journal of molecular sciences, vol. 19 (9) , 2018.
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“Liver X Receptors: A Possible Link between Lipid Disorders and Female Infertility.”, International journal of molecular sciences, vol. 19 (8) , 2018.
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2017
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“Role of the liver X receptors in skin physiology: Putative pharmacological targets in human diseases.”, Chem. Phys. Lipids, vol. 207 (Pt B) , pp. 59–68, 2017.
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“Biological properties of propolis extracts: Something new from an ancient product.”, Chem. Phys. Lipids, vol. 207 (Pt B) , pp. 214–222, 2017.
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“The Bile Acid Nuclear Receptor FXRalpha Is a Critical Regulator of Mouse Germ Cell Fate.”, Stem cell reports, 2017.
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“Bile acids and male fertility: From mouse to human?”, Molecular aspects of medicine, 2017.
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“Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha.”, Scientific reports, vol. 7 , pp. 42182, 2017.
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2016
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“EZH2 is overexpressed in Adrenocortical Carcinoma and is associated with disease progression.”, Hum. Mol. Genet., 2016.
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“mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.”, Cell cycle (Georgetown, Tex.), pp. 0, 2016.
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“Once and for all, LXRalpha and LXRbeta are gatekeepers of the endocrine system.”, Molecular aspects of medicine, 2016.
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“Bile acid-FXRalpha pathways regulate male sexual maturation in mice.”, Oncotarget, 2016.
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“Lipid Homeostasis and Ligands for Liver X Receptors: Identification and Characterization.”, Meth. Mol. Biol., vol. 1443 , pp. 13–9, 2016.
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2015
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“[Not Available].”, Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, vol. 25 (13) , pp. 727–8, 2015.
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“Identification of the functions of Liver X Receptor beta in Sertoli cells using a targeted expression-rescue model.”, Endocrinology, pp. en20151382, 2015.
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“Identification of the Link Between the Hypothalamo-Pituitary Axis and the Testicular Orphan Nuclear Receptor NR0B2 in Adult Male Mice.”, Endocrinology, vol. 156 (2) , pp. 660–9, 2015.
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“Enolase is regulated by Liver X Receptors.”, Steroids, 2015.
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“Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context.”, PLoS ONE, vol. 10 (10) , pp. e0139946, 2015.
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2014
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“Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP.”, Expert Opin. Ther. Targets, vol. 18 (12) , pp. 1367–76, 2014.
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“Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.”, Hepatology (Baltimore, Md.), vol. 60 (3) , pp. 1054–65, 2014.
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“Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.”, Biochemical and biophysical research communications, vol. 446 (3) , pp. 656–62, 2014.
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2013
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“Oxysterol receptors and their therapeutic applications in cancer conditions.”, Expert Opin. Ther. Targets, vol. 17 (9) , pp. 1029–38, 2013.
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“Lipids, LXRs and prostate cancer: are HDACs a new link?”, Biochemical pharmacology, vol. 86 (1) , pp. 168–74, 2013.
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“Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?”, Cell. Mol. Life Sci., vol. 70 (23) , pp. 4511–26, 2013.
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“Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.”, PLoS Genet., vol. 9 (5) , pp. e1003483, 2013.
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“Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.”, J. Hepatol., vol. 58 (5) , pp. 984–92, 2013.
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“LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.”, Am J Cancer Res, vol. 3 (1) , pp. 58–69, 2013.
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“Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell.”, PLoS ONE, vol. 8 (3) , pp. e58876, 2013.
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2012
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“Bile acids: from digestion to cancers.”, Biochimie, vol. 95 (3) , pp. 504–17, 2012.
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“Cholesterol and male fertility: what about orphans and adopted?”, Molecular and cellular endocrinology, vol. 368 (1-2) , pp. 30–46, 2012.
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“Oxysterol receptors, AKT and prostate cancer.”, Curr Opin Pharmacol, vol. 12 (6) , pp. 724–8, 2012.
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“Emerging roles for LXRs and LRH-1 in female reproduction.”, Molecular and cellular endocrinology, vol. 368 (1-2) , pp. 47–58, 2012.
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“Lxralpha regulates the androgen response in prostate epithelium.”, Endocrinology, vol. 153 (7) , pp. 3211–23, 2012.
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2011
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“Selective liver X receptor modulators (SLiMs): what use in human health?”, Molecular and cellular endocrinology, vol. 351 (2) , pp. 129–41, 2011.
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“A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity.”, J. biol. chem., vol. 286 (37) , pp. 32277–88, 2011.
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“Liver X receptors, lipids and their reproductive secrets in the male.”, Biochim. Biophys. Acta, vol. 1812 (8) , pp. 974–81, 2011.
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“Targeting liver X receptors in human health: deadlock or promising trail?”, Expert Opin. Ther. Targets, vol. 15 (2) , pp. 219–32, 2011.
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“A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia.”, BMC medical genetics, vol. 12 , pp. 145, 2011.
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2010
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“Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.”, Oncogene, vol. 29 (18) , pp. 2712–23, 2010.
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2009
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“Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.”, Endocrinology, vol. 150 (7) , pp. 3369–75, 2009.
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“[Nuclear liver X receptors are involved in the biology of reproduction].”, Med Sci (Paris), vol. 25 (2) , pp. 141–4, 2009.
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2008
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“Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.”, Biol Reprod, vol. 78 (6) , pp. 968–75, 2008.
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2007
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“Liver X receptors and epididymal epithelium physiology.”, Asian J. Androl., vol. 9 (4) , pp. 574–82, 2007.
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