Team 10: Translational approach to epithelial injury and repair

Our research team is interested in the membrane receptor called RAGE (Receptor for Advanced glycation Products) which is a multi-ligands (called alarmins) receptor belonging to the immunoglobulin superfamily. Ligands-binding activate, at the cellular level, signalling pathways leading to an inflammatory answer. Our project is particularly focused on this receptor implication in lung and fetal membranes epithelium aggression during two pathologies called respectively: Acute Respiratory Distress Syndrome (ARDS) and Premature Rupture of Membrane (PROM).

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Research

Following endogenous or exogenous aggression, the integrity and functionality of the epithelial barrier could be disrupted as encountered in numerous pathologies. Wound healing ability after such aggression is of primary importance in order to obtain a clinical positive evolution. Situated on the crossroads between metabolic and inflammatory cellular process, the Receptor for Advanced glycation Products (RAGE) seems to be a promising research area in such epithelial defects. The team has already started to demonstrate RAGE’ importance in lung and fetal membranes epithelial aggression models encountered in two pathologies called Acute Respiratory Distress Syndrome (ARDS) and Premature Rupture of Membrane (PROM).  Due to the numerous potential associations between RAGE and its ligands directly linked to pathological state, the importance of each combination and/or the research of new RAGE ligands had to be clarified and identified in ARDS or PROM. By using pharmacological approach and molecular biology tools, our research project aims to identify molecular pathways and target genes that could be implied in pathophysiological cases regarding both pathologies. Furthermore, as the direct interaction of the epithelium with its surrounding environment constitute an important part of the wound evolution; our work will also demonstrate the RAGE pathway implications regarding cell communications. The availability of a RAGE KO mouse in the lab, will permit us to conduct in-vivo studies. At the end, all our results must permit the arising of new diagnostics and therapeutics tools in our both pathologies.

Research thematics

People

Last Name First Name Position Contact
Audrey ANTOINE profile picture ANTOINE Audrey Ph.D Student
Corinne BELVILLE profile picture BELVILLE Corinne Research Engineer
Loic BLANCHON profile picture BLANCHON Loic Associate Professor
Damien BOUVIER profile picture BOUVIER Damien Associate Professor - Clinician
Coline CHARNAY profile picture CHARNAY Coline Ph.D Student
Frederic CHIAMBARETTA profile picture CHIAMBARETTA Frederic Professor - Clinician
Karen COSTE profile picture COSTE Karen Associate Professor - Clinician
Julia EYCHENNE profile picture EYCHENNE Julia Research Fellow
Emmanuel FUTIER profile picture FUTIER Emmanuel Professor - Clinician
Denis GALLOT profile picture GALLOT Denis Professor - Clinician
Fanny HENRIOUX profile picture HENRIOUX Fanny Ph.D Student
Matthieu JABAUDON profile picture JABAUDON Matthieu Professor - Clinician
Samy KAHOUADJI profile picture KAHOUADJI Samy Assistant Clinician
Charlotte LECLAIRE profile picture LECLAIRE Charlotte Research Technician
Woodys Eumenide LENGA MA BONDA profile picture LENGA MA BONDA Woodys Eumenide Post-doctoral Fellow
Geoffroy MARCEAU profile picture MARCEAU Geoffroy Associate Professor - Clinician
Regine MINET-QUINARD profile picture MINET-QUINARD Regine Associate Professor - Clinician
Valentin NAVEL profile picture NAVEL Valentin Ph.D Student
Sebastien PERBET profile picture PERBET Sebastien Ph.D Student
Cedric ROBERT profile picture ROBERT Cedric Intern
Laurence ROSZYK profile picture ROSZYK Laurence Clinician
Cecile Saint-Beat profile picture SAINT-BEAT Cecile Research Technician
Vincent SAPIN profile picture SAPIN Vincent Principal Investigator
MAUD SOR profile picture SOR MAUD Intern
Camille THEILLIERE profile picture THEILLIERE Camille Engineer
Ines TOMASEK profile picture TOMASEK Ines Post-doctoral Fellow

Publications

  • 2020
    • L. Bousset, A. Septier, J. Bunay, A. Voisin, R. Guiton, C. Damon-Soubeyrant, Y. Renaud, A. De Haze, V. Sapin, A. Fogli, A. Rambur, C. De Joussineau, A. Kocer, A. Trousson, J. Henry-Berger, M. Horing, G. Liebisch, S. Matysik, J. Lobaccaro, L. Morel and S. Baron, “Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia.”, PLoS biology, vol. 18 (12) , pp. e3000948, 2020.
    • D. Bouvier, C. Oris, M. Brailova, J. Durif and V. Sapin, “Interest of blood biomarkers to predict lesions in medical imaging in the context of mild traumatic brain injury.”, Clinical biochemistry, vol. 85 , pp. 5–11, 2020.
    • G. Chanques, J. Constantin, J. Devlin, E. Ely, G. Fraser, C. Gelinas, T. Girard, C. Guerin, M. Jabaudon, S. Jaber, S. Mehta, T. Langer, M. Murray, P. Pandharipande, B. Patel, J. Payen, K. Puntillo, B. Rochwerg, Y. Shehabi, T. Strom, H. Olsen and J. Kress, “Analgesia and sedation in patients with ARDS.”, Intensive care medicine, 2020.
    • G. Kayem, E. Lecarpentier, P. Deruelle, F. Bretelle, E. Azria, J. Blanc, C. Bohec, M. Bornes, P. Ceccaldi, Y. Chalet, C. Chauleur, A. Cordier, R. Desbriere, M. Doret, M. Dreyfus, M. Driessen, M. Fermaut, D. Gallot, C. Garabedian, C. Huissoud, D. Luton, O. Morel, F. Perrotin, O. Picone, P. Rozenberg, L. Sentilhes, J. Sroussi, C. Vayssiere, E. Verspyck, A. Vivanti, N. Winer, V. Alessandrini and T. Schmitz, “A snapshot of the Covid-19 pandemic among pregnant women in France.”, Journal of gynecology obstetrics and human reproduction, vol. 49 (7) , pp. 101826, 2020.
    • V. Navel, F. Chiambaretta and F. Dutheil, “Response to Re: COVID-19, sweat, tears... and myopia?”, Clinical & experimental optometry, vol. 103 (5) , pp. 718, 2020.
    • R. Blondonnet, B. Paquette, J. Audard, R. Guler, F. Roman, R. Zhai, C. Belville, L. Blanchon, T. Godet, E. Futier, J. Bazin, J. Constantin, V. Sapin and M. Jabaudon, “Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device.”, Journal of visualized experiments : JoVE, 2020.
    • M. Jabaudon, J. Audard, B. Pereira, S. Jaber, J. Lefrant, R. Blondonnet, T. Godet, E. Futier, C. Lambert, J. Bazin, J. Bastarache, J. Constantin and L. Ware, “Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS.”, Chest, 2020.
    • R. Zhai, R. Blondonnet, E. Ebrahimi, C. Belville, J. Audard, C. Gross, H. Choltus, F. Henrioux, J. Constantin, B. Pereira, L. Blanchon, V. Sapin and M. Jabaudon, “The receptor for advanced glycation end-products enhances lung epithelial wound repair: An in vitro study.”, Exp. Cell Res., vol. 391 (2) , pp. 112030, 2020.
    • L. Velly, E. Gayat, H. Quintard, E. Weiss, A. De Jong, P. Cuvillon, G. Audibert, J. Amour, M. Beaussier, M. Biais, S. Bloc, M. Bonnet, P. Bouzat, G. Brezac, C. Dahyot-Fizelier, S. Dahmani, M. de Queiroz, S. Di Maria, C. Ecoffey, E. Futier, T. Geeraerts, H. Jaber, L. Heyer, R. Hoteit, O. Joannes-Boyau, D. Kern, O. Langeron, S. Lasocki, Y. Launey, F. le Sache, A. Lukaszewicz, A. Maurice-Szamburski, N. Mayeur, F. Michel, V. Minville, S. Mirek, P. Montravers, E. Morau, L. Muller, J. Muret, K. Nouette-Gaulain, J. Orban, G. Orliaguet, P. Perrigault, F. Plantet, J. Pottecher, C. Quesnel, V. Reubrecht, B. Rozec, B. Tavernier, B. Veber, F. Veyckmans, H. Charbonneau, I. Constant, D. Frasca, M. Fischer, C. Huraux, A. Blet and M. Garnier, “Guidelines: Anaesthesia in the context of COVID-19 pandemic.”, Anaesthesia, critical care & pain medicine, vol. 39 (3) , pp. 395–415, 2020.
    • M. Jabaudon, J. Bastarache and L. Ware, “Eyes wide open on bronchial aeration in acute respiratory distress syndrome.”, Anaesthesia, critical care & pain medicine, vol. 39 (2) , pp. 191–192, 2020.
    • A. Carla, B. Pereira, H. Boukail, J. Audard, N. Pinol-Domenech, M. De Carvalho, R. Blondonnet, R. Zhai, D. Morand, C. Lambert, V. Sapin, L. Ware, C. Calfee, J. Bastarache, J. Laffey, N. Juffermans, L. Bos, A. Artigas, P. Rocco, M. Matthay, D. McAuley, J. Constantin and M. Jabaudon, “Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.”, Respiratory research, vol. 21 (1) , pp. 81, 2020.
    • C. Gross, C. Belville, M. Lavergne, H. Choltus, M. Jabaudon, R. Blondonnet, J. Constantin, F. Chiambaretta, L. Blanchon and V. Sapin, “Advanced Glycation End Products and Receptor (RAGE) Promote Wound Healing of Human Corneal Epithelial Cells.”, Investigative ophthalmology & visual science, vol. 61 (3) , pp. 14, 2020.
    • D. Bouvier, Y. Giguere, B. Pereira, N. Bernard, I. Marc, V. Sapin and J. Forest, “Cord blood S100B: reference ranges and interest for early identification of newborns with brain injury.”, Clinical chemistry and laboratory medicine, vol. 58 (2) , pp. 285–293, 2020.
    • M. Lavergne, C. Belville, H. Choltus, C. Gross, R. Minet-Quinard, D. Gallot, V. Sapin and L. Blanchon, “Human Amnion Epithelial Cells (AECs) Respond to the FSL-1 Lipopeptide by Engaging the NLRP7 Inflammasome.”, Frontiers in immunology, vol. 11 , pp. 1645, 2020.
    • D. Bouvier, Y. Giguere, L. Blanchon, E. Bujold, B. Pereira, N. Bernard, D. Gallot, V. Sapin and J. Forest, “Study of sRAGE, HMGB1, AGE, and S100A8/A9 Concentrations in Plasma and in Serum-Extracted Extracellular Vesicles of Pregnant Women With Preterm Premature Rupture of Membranes.”, Frontiers in physiology, vol. 11 , pp. 609, 2020.
    • H. Choltus, M. Lavergne, C. Belville, D. Gallot, R. Minet-Quinard, J. Durif, L. Blanchon and V. Sapin, “Occurrence of a RAGE-Mediated Inflammatory Response in Human Fetal Membranes.”, Frontiers in physiology, vol. 11 , pp. 581, 2020.
    • S. Kahouadji, P. Salamin, L. Praz, J. Coiffier, V. Frochaux, J. Durif, B. Pereira, L. Arlettaz, C. Oris, V. Sapin and D. Bouvier, “S100B Blood Level Determination for Early Management of Ski-Related Mild Traumatic Brain Injury: A Pilot Study.”, Frontiers in neurology, vol. 11 , pp. 856, 2020.
  • 2019
    • M. Jabaudon, R. Blondonnet and J. Audard, “Encou-RAGE-ing Lung Protection in Patients With Acute Respiratory Distress Syndrome Under Extracorporeal Membrane Oxygenation.”, Critical care medicine, vol. 47 (11) , pp. 1654–1655, 2019.
    • D. Bouvier, J. Forest, L. Blanchon, E. Bujold, B. Pereira, N. Bernard, D. Gallot, V. Sapin and Y. Giguere, “Risk Factors and Outcomes of Preterm Premature Rupture of Membranes in a Cohort of 6968 Pregnant Women Prospectively Recruited.”, Journal of clinical medicine, vol. 8 (11) , 2019.
    • D. Bouvier, J. Forest, E. Dion-Buteau, N. Bernard, E. Bujold, B. Pereira and Y. Giguere, “Association of Maternal Weight and Gestational Weight Gain with Maternal and Neonate Outcomes: A Prospective Cohort Study.”, Journal of clinical medicine, vol. 8 (12) , 2019.
    • C. Oris, R. Chabanne, J. Durif, S. Kahouadji, M. Brailova, V. Sapin and D. Bouvier, “Measurement of S100B protein: evaluation of a new prototype on a bioMerieux Vidas(R) 3 analyzer.”, Clinical chemistry and laboratory medicine, vol. 57 (8) , pp. 1177–1184, 2019.
    • M. Jabaudon, R. Blondonnet and J. Constantin, “ARDS in patients with chest trauma: Better safe than sorry.”, Anaesthesia, critical care & pain medicine, vol. 38 (3) , pp. 221–222, 2019.
    • E. Devillard, A. Delabaere, M. Rouzaire, B. Pereira, M. Accoceberry, C. Houlle, L. Dejou-Bouillet, P. Bouchet and D. Gallot, “Induction of labour in case of premature rupture of membranes at term with an unfavourable cervix: protocol for a randomised controlled trial comparing double balloon catheter (+oxytocin) and vaginal prostaglandin (RUBAPRO) treatments.”, BMJ open, vol. 9 (6) , pp. e026090, 2019.
    • J. Audard, T. Godet, R. Blondonnet, J. Joffredo, B. Paquette, C. Belville, M. Lavergne, C. Gross, J. Pasteur, D. Bouvier, L. Blanchon, V. Sapin, B. Pereira, J. Constantin and M. Jabaudon, “Inhibition of the Receptor for Advanced Glycation End-Products in Acute Respiratory Distress Syndrome: A Randomised Laboratory Trial in Piglets.”, Scientific reports, vol. 9 (1) , pp. 9227, 2019.
    • N. Zabaiou, A. Fouache, A. Trousson, J. Bunay-Noboa, G. Marceau, V. Sapin, A. Zellagui, S. Baron, M. Lahouel and J. Lobaccaro, “Ethanolic extract of Algerian propolis decreases androgen receptor transcriptional activity in cultured LNCaP cells.”, The Journal of steroid biochemistry and molecular biology, vol. 189 , pp. 108–115, 2019.
    • T. Schmitz, L. Sentilhes, E. Lorthe, D. Gallot, H. Madar, M. Doret-Dion, G. Beucher, C. Charlier, C. Cazanave, P. Delorme, C. Garabedian, E. Azria, V. Tessier, M. Senat and G. Kayem, “Preterm premature rupture of the membranes: Guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF).”, European journal of obstetrics, gynecology, and reproductive biology, vol. 236 , pp. 1–6, 2019.
    • D. Bouvier, D. Balayssac, J. Durif, C. Mourgues, C. Sarret, B. Pereira and V. Sapin, “Assessment of the advantage of the serum S100B protein biomonitoring in the management of paediatric mild traumatic brain injury-PROS100B: protocol of a multicentre unblinded stepped wedge cluster randomised trial.”, BMJ open, vol. 9 (5) , pp. e027365, 2019.
    • N. Bernard, J. Forest, G. Tarabulsy, E. Bujold, D. Bouvier and Y. Giguere, “Use of antidepressants and anxiolytics in early pregnancy and the risk of preeclampsia and gestational hypertension: a prospective study.”, BMC pregnancy and childbirth, vol. 19 (1) , pp. 146, 2019.
    • R. Abi Nahed, D. Reynaud, A. Borg, W. Traboulsi, A. Wetzel, V. Sapin, S. Brouillet, M. Dieudonne, M. Dakouane-Giudicelli, M. Benharouga, P. Murthi and N. Alfaidy, “NLRP7 is increased in human idiopathic fetal growth restriction and plays a critical role in trophoblast differentiation.”, Journal of molecular medicine (Berlin, Germany), vol. 97 (3) , pp. 355–367, 2019.
    • C. Mourgues, A. Rossi, N. Favre, A. Delabaere, L. Roszyk, V. Sapin, A. Debost-Legrand and D. Gallot, “Fetal fibronectin test for threatened preterm delivery 48h after admission: Cost-effectiveness study.”, European journal of obstetrics, gynecology, and reproductive biology, vol. 234 , pp. 75–78, 2019.
    • M. Gouhier, J. Eychenne, N. Azzaoui, A. Guillin, M. Deslandes, M. Poret, A. Costa and P. Husson, “Low efficiency of large volcanic eruptions in transporting very fine ash into the atmosphere.”, Scientific reports, vol. 9 (1) , pp. 1449, 2019.
    • M. Serveaux-Dancer, M. Jabaudon, I. Creveaux, C. Belville, R. Blondonnet, C. Gross, J. Constantin, L. Blanchon and V. Sapin, “Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism.”, Disease markers, vol. 2019 , pp. 2067353, 2019.
  • 2018
    • T. Schmitz, L. Sentilhes, E. Lorthe, D. Gallot, H. Madar, M. Doret-Dion, G. Beucher, C. Charlier, C. Cazanave, P. Delorme, C. Garabedian, E. Azria, V. Tessier, M. Senat and G. Kayem, “[Preterm premature rupture of membranes: CNGOF Guidelines for clinical practice - Short version].”, Gynecologie, obstetrique, fertilite & senologie, vol. 46 (12) , pp. 998–1003, 2018.
    • D. Gallot, “[Diagnosis of rupture of fetal membranes: CNGOF Preterm Premature Rupture of Membranes Guidelines].”, Gynecologie, obstetrique, fertilite & senologie, vol. 46 (12) , pp. 1022–1028, 2018.
    • C. Egron, L. Roszyk, E. Rochette, M. Jabaudon, V. Sapin, A. Mulliez, A. Labbe and K. Coste, “Serum soluble receptor for advanced glycation end-products during acute bronchiolitis in infant: Prospective study in 93 cases.”, Pediatric pulmonology, vol. 53 (10) , pp. 1429–1435, 2018.
    • G. Allouchery, F. Moustafa, J. Roubin, B. Pereira, J. Schmidt, J. Raconnat, D. Pic, V. Sapin and D. Bouvier, “Clinical validation of S100B in the management of a mild traumatic brain injury: issues from an interventional cohort of 1449 adult patients.”, Clinical chemistry and laboratory medicine, vol. 56 (11) , pp. 1897–1904, 2018.
    • R. Blondonnet, B. Paquette, D. Richard, R. Bourg, G. Laplace, R. Segurel, H. Pouvelle, C. Belville, L. Blanchon, T. Godet, J. Constantin, J. Bazin, V. Sapin and M. Jabaudon, “In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells.”, Journal of visualized experiments : JoVE, 2018.
    • M. Jabaudon, R. Blondonnet, B. Pereira, R. Cartin-Ceba, C. Lichtenstern, T. Mauri, R. Determann, T. Drabek, R. Hubmayr, O. Gajic, F. Uhle, A. Coppadoro, A. Pesenti, M. Schultz, M. Ranieri, H. Brodska, S. Mrozek, V. Sapin, M. Matthay, J. Constantin and C. Calfee, “Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.”, Intensive care medicine, vol. 44 (9) , pp. 1388–1399, 2018.
    • R. Blondonnet, E. Joubert, T. Godet, P. Berthelin, T. Pranal, L. Roszyk, R. Chabanne, N. Eisenmann, A. Lautrette, C. Belville, S. Cayot, T. Gillart, B. Souweine, D. Bouvier, L. Blanchon, V. Sapin, B. Pereira, J. Constantin and M. Jabaudon, “Driving pressure and acute respiratory distress syndrome in critically ill patients.”, Respirology (Carlton, Vic.), 2018.
    • J. Constantin, T. Godet and M. Jabaudon, “Understanding Macrophages in Acute Respiratory Distress Syndrome: From Pathophysiology to Precision Medicine.”, Critical care medicine, vol. 46 (7) , pp. 1207–1208, 2018.
    • M. Jabaudon, R. Blondonnet, J. Audard, M. Fournet, T. Godet, V. Sapin and J. Constantin, “Recent directions in personalised acute respiratory distress syndrome medicine.”, Anaesthesia, critical care & pain medicine, vol. 37 (3) , pp. 251–258, 2018.
    • M. Jabaudon, R. Blondonnet and J. Constantin, “Distinct Biological Effects of Time-Controlled Adaptive Ventilation in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome: "One Small Step for Rats, One Giant Leap for Humans?"”, Critical care medicine, vol. 46 (6) , pp. 1038–1040, 2018.
    • C. Oris, B. Pereira, J. Durif, J. Simon-Pimmel, C. Castellani, S. Manzano, V. Sapin and D. Bouvier, “The Biomarker S100B and Mild Traumatic Brain Injury: A Meta-analysis.”, Pediatrics, 2018.
    • A. Delabaere, L. Blanchon, K. Coste, G. Clairefond, C. Belville, P. Blanc, G. Marceau, V. Sapin and D. Gallot, “Retinoic acid and tracheal occlusion for diaphragmatic hernia treatment in rabbit fetuses.”, Prenatal diagnosis, 2018.
    • R. Blondonnet, T. Godet, E. Futier, J. Bazin, J. Constantin and M. Jabaudon, “Reply to Riche et al.: Sevoflurane in Acute Respiratory Distress Syndrome: Are Lung Protection and Anesthesia Depth Influenced by Pulmonary Morphology?”, American journal of respiratory and critical care medicine, vol. 197 (6) , pp. 832–834, 2018.
    • M. Jabaudon, P. Berthelin, T. Pranal, L. Roszyk, T. Godet, J. Faure, R. Chabanne, N. Eisenmann, A. Lautrette, C. Belville, R. Blondonnet, S. Cayot, T. Gillart, J. Pascal, Y. Skrzypczak, B. Souweine, L. Blanchon, V. Sapin, B. Pereira and J. Constantin, “Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study.”, Scientific reports, vol. 8 (1) , pp. 2603, 2018.
    • T. Godet, M. Jabaudon, R. Blondonnet, A. Tremblay, J. Audard, B. Rieu, B. Pereira, J. Garcier, E. Futier and J. Constantin, “High frequency percussive ventilation increases alveolar recruitment in early acute respiratory distress syndrome: an experimental, physiological and CT scan study.”, Critical care (London, England), vol. 22 (1) , pp. 3, 2018.
    • I. Soudy, R. Minet-Quinard, A. Mahamat, H. Ngoua, A. Izzedine, A. Tidjani, E. Ngo Bum, C. Lambert, B. Pereira, J. Desjeux and V. Sapin, “Vitamin A status in healthy women eating traditionally prepared spirulina (Dihe) in the Chad Lake area.”, PLoS ONE, vol. 13 (1) , pp. e0191887, 2018.
    • C. Cheung, D. Anderson, M. Rouzaire, L. Blanchon, V. Sapin and R. Brace, “Retinoic Acid Pathway Regulation of Vascular Endothelial Growth Factor in Ovine Amnion.”, Reproductive sciences (Thousand Oaks, Calif.), pp. 1933719118765979, 2018.
    • T. Pranal, B. Pereira, P. Berthelin, L. Roszyk, T. Godet, R. Chabanne, N. Eisenmann, A. Lautrette, C. Belville, R. Blondonnet, S. Cayot, T. Gillart, Y. Skrzypczak, B. Souweine, D. Bouvier, L. Blanchon, V. Sapin, J. Constantin and M. Jabaudon, “Clinical and Biological Predictors of Plasma Levels of Soluble RAGE in Critically Ill Patients: Secondary Analysis of a Prospective Multicenter Observational Study.”, Disease markers, vol. 2018 , pp. 7849675, 2018.
    • C. Burillon, F. Chiambaretta and P. Pisella, “Efficacy and safety of glycyrrhizin 2.5% eye drops in the treatment of moderate dry eye disease: results from a prospective, open-label pilot study.”, Clinical ophthalmology (Auckland, N.Z.), vol. 12 , pp. 2629–2636, 2018.
  • 2017
  • 2016
    • M. Rouzaire, A. Comptour, C. Belville, D. Bouvier, G. Clairefond, F. Ponelle, V. Sapin, D. Gallot and L. Blanchon, “All-trans retinoic acid promotes wound healing of primary amniocytes through the induction of LOXL4, a member of the lysyl oxidase family.”, The international journal of biochemistry & cell biology, vol. 81 (Pt A) , pp. 10–19, 2016.
    • S. Mrozek, M. Jabaudon, S. Jaber, C. Paugam-Burtz, J. Lefrant, J. Rouby, K. Asehnoune, B. Allaouchiche, O. Baldesi, M. Leone, Q. Lu, J. Bazin, L. Roszyk, V. Sapin, E. Futier, B. Pereira and J. Constantin, “Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS: A Prospective Multicenter Study.”, Chest, vol. 150 (5) , pp. 998–1007, 2016.
    • M. Haddam, L. Zieleskiewicz, S. Perbet, A. Baldovini, C. Guervilly, C. Arbelot, A. Noel, C. Vigne, E. Hammad, F. Antonini, S. Lehingue, E. Peytel, Q. Lu, B. Bouhemad, J. Golmard, O. Langeron, C. Martin, L. Muller, J. Rouby, J. Constantin, L. Papazian and M. Leone, “Lung ultrasonography for assessment of oxygenation response to prone position ventilation in ARDS.”, Intensive care medicine, vol. 42 (10) , pp. 1546–56, 2016.
    • A. Comptour, M. Rouzaire, C. Belville, D. Bouvier, D. Gallot, L. Blanchon and V. Sapin, “Nuclear retinoid receptors and pregnancy: placental transfer, functions, and pharmacological aspects.”, Cell. Mol. Life Sci., vol. 73 (20) , pp. 3823–37, 2016.
    • A. Comptour, M. Rouzaire, C. Belville, N. Bonnin, E. Daniel, F. Chiambaretta, L. Blanchon and V. Sapin, “Lysyl oxidase-like 4 involvement in retinoic acid epithelial wound healing.”, Scientific reports, vol. 6 , pp. 32688, 2016.
    • C. Dionet, M. Muller-Barthelemy, G. Marceau, J. Denis, D. Averbeck, J. Gueulette, V. Sapin, B. Pereira, A. Tchirkov, E. Chautard and P. Verrelle, “Different dose rate-dependent responses of human melanoma cells and fibroblasts to low dose fast neutrons.”, International journal of radiation biology, vol. 92 (9) , pp. 527–35, 2016.
    • J. Frat, S. Ragot, C. Girault, S. Perbet, G. Prat, T. Boulain, A. Demoule, J. Ricard, R. Coudroy, R. Robert, A. Mercat, L. Brochard and A. Thille, “Effect of non-invasive oxygenation strategies in immunocompromised patients with severe acute respiratory failure: a post-hoc analysis of a randomised trial.”, The Lancet. Respiratory medicine, vol. 4 (8) , pp. 646–52, 2016.
    • D. Bouvier, T. Duret, P. Rouzaire, M. Jabaudon, M. Rouzaire, C. Nourrisson, C. Bourgne, B. Pereira, B. Evrard and V. Sapin, “Preanalytical, analytical, gestational and pediatric aspects of the S100B immuno-assays.”, Clinical chemistry and laboratory medicine, vol. 54 (5) , pp. 833–42, 2016.
    • S. Jaber, T. Lescot, E. Futier, C. Paugam-Burtz, P. Seguin, M. Ferrandiere, S. Lasocki, O. Mimoz, B. Hengy, A. Sannini, J. Pottecher, P. Abback, B. Riu, F. Belafia, J. Constantin, E. Masseret, M. Beaussier, D. Verzilli, A. De Jong, G. Chanques, L. Brochard and N. Molinari, “Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery: A Randomized Clinical Trial.”, JAMA, vol. 315 (13) , pp. 1345–53, 2016.
    • M. Jabaudon, R. Blondonnet, J. Lutz, L. Roszyk, D. Bouvier, R. Guerin, S. Perbet, S. Cayot, T. Godet, L. Blanchon, J. Bazin, E. Futier, V. Sapin and J. Constantin, “Net alveolar fluid clearance is associated with lung morphology phenotypes in acute respiratory distress syndrome.”, Anaesthesia, critical care & pain medicine, vol. 35 (2) , pp. 81–6, 2016.
    • R. Blondonnet, J. Constantin, V. Sapin and M. Jabaudon, “A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome.”, Disease markers, vol. 2016 , pp. 3501373, 2016.
  • 2015
    • M. Jabaudon, E. Futier, L. Roszyk, V. Sapin, B. Pereira and J. Constantin, “Association between intraoperative ventilator settings and plasma levels of soluble receptor for advanced glycation end-products in patients without pre-existing lung injury.”, Respirology (Carlton, Vic.), vol. 20 (7) , pp. 1131–8, 2015.
    • D. Bouvier, M. Rouzaire, G. Marceau, C. Prat, B. Pereira, R. Lemarie, P. Deruelle, I. Fajardy, D. Gallot, L. Blanchon, A. Vambergue and V. Sapin, “Aquaporins and Fetal Membranes From Diabetic Parturient Women: Expression Abnormalities and Regulation by Insulin.”, J. Clin. Endocrinol. Metab., vol. 100 (10) , pp. E1270–9, 2015.
    • C. Prat, D. Bouvier, A. Comptour, G. Marceau, C. Belville, G. Clairefond, P. Blanc, D. Gallot, L. Blanchon and V. Sapin, “All-trans-retinoic acid regulates aquaporin-3 expression and related cellular membrane permeability in the human amniotic environment.”, Placenta, vol. 36 (8) , pp. 881–7, 2015.
    • M. Jabaudon, R. Blondonnet, L. Roszyk, D. Bouvier, J. Audard, G. Clairefond, M. Fournier, G. Marceau, P. Dechelotte, B. Pereira, V. Sapin and J. Constantin, “Soluble Receptor for Advanced Glycation End-Products Predicts Impaired Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome.”, American journal of respiratory and critical care medicine, vol. 192 (2) , pp. 191–9, 2015.
    • D. Gallot, F. Goffinet, V. Sapin, J. Guibourdenche, M. Jouannic, B. Langer, M. Doret, D. Subtil and H. Fernandez, “Comment and reply on: Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth.”, The journal of maternal-fetal & neonatal medicine, pp. 1–2, 2015.
    • J. Frat, A. Thille, A. Mercat, C. Girault, S. Ragot, S. Perbet, G. Prat, T. Boulain, E. Morawiec, A. Cottereau, J. Devaquet, S. Nseir, K. Razazi, J. Mira, L. Argaud, J. Chakarian, J. Ricard, X. Wittebole, S. Chevalier, A. Herbland, M. Fartoukh, J. Constantin, J. Tonnelier, M. Pierrot, A. Mathonnet, G. Beduneau, C. Deletage-Metreau, J. Richard, L. Brochard and R. Robert, “High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure.”, The New England journal of medicine, vol. 372 (23) , pp. 2185–96, 2015.
    • M. Jabaudon, N. Hamroun, L. Roszyk, R. Guerin, J. Bazin, V. Sapin, B. Pereira and J. Constantin, “Effects of a recruitment maneuver on plasma levels of soluble RAGE in patients with diffuse acute respiratory distress syndrome: a prospective randomized crossover study.”, Intensive care medicine, vol. 41 (5) , pp. 846–55, 2015.
    • R. Blondonnet, J. Aliane, T. Godet, B. Souweine and J. Constantin, “High-frequency percussive ventilation as a rescue therapy for ARDS patients under ECMO: About a case.”, Anaesthesia, critical care & pain medicine, vol. 34 (2) , pp. 105–7, 2015.
    • S. Barbaux, J. Erwich, P. Favaron, S. Gil, D. Gallot, T. Golos, A. Gonzalez-Bulnes, J. Guibourdenche, A. Heazell, T. Jansson, O. Laprevote, R. Lewis, R. Miller, D. Monk, B. Novakovic, C. Oudejans, M. Parast, P. Peugnet, C. Pfarrer, H. Pinar, C. Roberts, W. Robinson, R. Saffery, C. Salomon, A. Sexton, A. Staff, M. Suter, A. Tarrade, J. Wallace, C. Vaillancourt, D. Vaiman, S. Worton and G. Lash, “IFPA meeting 2014 workshop report: Animal models to study pregnancy pathologies; new approaches to study human placental exposure to xenobiotics; biomarkers of pregnancy pathologies; placental genetics and epigenetics; the placenta and stillbirth and fetal growth restriction.”, Placenta, vol. 36 Suppl 1 , pp. S5–10, 2015.
    • K. Coste, L. Beurskens, P. Blanc, D. Gallot, A. Delabaere, L. Blanchon, D. Tibboel, A. Labbe, R. Rottier and V. Sapin, “Metabolic disturbances of the vitamin A pathway in human diaphragmatic hernia.”, American journal of physiology. Lung cellular and molecular physiology, vol. 308 (2) , pp. L147–57, 2015.
    • M. Jabaudon, R. Blondonnet, L. Roszyk, B. Pereira, R. Guerin, S. Perbet, S. Cayot, D. Bouvier, L. Blanchon, V. Sapin and J. Constantin, “Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study.”, PLoS ONE, vol. 10 (8) , pp. e0135857, 2015.
  • 2014
    • D. Menshykau, P. Blanc, E. Unal, V. Sapin and D. Iber, “An interplay of geometry and signaling enables robust lung branching morphogenesis.”, Development, vol. 141 (23) , pp. 4526–36, 2014.
    • A. Rossi, A. Delabaere, H. Delmas-Laurichesse, A. Beaufrere, D. Lemery and D. Gallot, “The challenge of prenatal identification of congenital diaphragmatic hernia in the context of hydrops.”, European journal of obstetrics, gynecology, and reproductive biology, vol. 182 , pp. 238–9, 2014.
    • R. Chabanne, S. Perbet, E. Futier, N. Ben Said, S. Jaber, J. Bazin, B. Pereira and J. Constantin, “Impact of the anesthetic conserving device on respiratory parameters and work of breathing in critically ill patients under light sedation with sevoflurane.”, Anesthesiology, vol. 121 (4) , pp. 808–16, 2014.
    • C. Dunand, P. Hoffmann, V. Sapin, L. Blanchon, A. Salomon, F. Sergent, M. Benharouga, S. Sabra, J. Guibourdenche, S. Lye, J. Feige and N. Alfaidy, “Endocrine gland-derived endothelial growth factor (EG-VEGF) is a potential novel regulator of human parturition.”, Biol Reprod, vol. 91 (3) , pp. 73, 2014.
    • N. Bonnin, C. Belville, F. Chiambaretta, V. Sapin and L. Blanchon, “DNA methyl transferases are differentially expressed in the human anterior eye segment.”, Acta ophthalmologica, vol. 92 (5) , pp. e366–71, 2014.
    • R. Deplus, L. Blanchon, A. Rajavelu, A. Boukaba, M. Defrance, J. Luciani, F. Rothe, S. Dedeurwaerder, H. Denis, A. Brinkman, F. Simmer, F. Muller, B. Bertin, M. Berdasco, P. Putmans, E. Calonne, D. Litchfield, Y. de Launoit, T. Jurkowski, H. Stunnenberg, C. Bock, C. Sotiriou, M. Fraga, M. Esteller, A. Jeltsch and F. Fuks, “Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a.”, Cell Rep, vol. 8 (3) , pp. 743–53, 2014.
    • F. Dutheil, G. Walther, R. Chapier, G. Mnatzaganian, B. Lesourd, G. Naughton, J. Verney, A. Fogli, V. Sapin, M. Duclos, A. Vinet, P. Obert, D. Courteix and G. Lac, “Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet - the RESOLVE trial.”, Lipids in health and disease, vol. 13 , pp. 112, 2014.
    • A. Ravinet, S. Perbet, R. Guieze, R. Lemal, R. Guerin, G. Gayraud, J. Aliane, A. Tremblay, J. Pascal, A. Ledoux, C. Chaleteix, P. Dechelotte, J. Bay, J. Bazin and J. Constantin, “Lung postmortem autopsy revealing extramedullary involvement in multiple myeloma causing acute respiratory distress syndrome.”, Case reports in hematology, vol. 2014 , pp. 635237, 2014.
  • 2013
    • JM. Lobaccaro, D. Gallot, S. Lumbroso and K. Mouzat, “Liver X Receptors and female reproduction: when cholesterol meets fertility!”, Journal of endocrinological investigation, vol. 36 (1) , pp. 55–60, 2013.
    • M. Jabaudon, S. Perbet, B. Pereira, A. Soummer, L. Roszyk, R. Guerin, E. Futier, Q. Lu, J. Bazin, V. Sapin, J. Rouby and J. Constantin, “Plasma levels of sRAGE, loss of aeration and weaning failure in ICU patients: a prospective observational multicenter study.”, PLoS ONE, vol. 8 (5) , pp. e64083, 2013.
  • 2012
  • 2010
    • A. Albert, M. Gaume, S. Ughetto, V. Sapin and A. Fogli, “[Coupling proteinemia and serum protein electrophoresis: evaluation of the capillary technique (Capillarys 2, Sebia), experience from Clermont-Ferrand].”, Ann. Biol. Clin. (Paris), vol. 68 (6) , pp. 657–67, 2010.
    • I. Sahut-Barnola, C. de Joussineau, P. Val, S. Lambert-Langlais, C. Damon, A. Lefrancois-Martinez, J. Pointud, G. Marceau, V. Sapin, F. Tissier, B. Ragazzon, J. Bertherat, L. Kirschner, C. Stratakis and A. Martinez, “Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.”, PLoS Genet., vol. 6 (6) , pp. e1000980, 2010.
    • J. Talvas, C. Caris-Veyrat, L. Guy, M. Rambeau, B. Lyan, R. Minet-Quinard, JM. Lobaccaro, M. Vasson, S. George, A. Mazur and E. Rock, “Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells.”, The American journal of clinical nutrition, vol. 91 (6) , pp. 1716–24, 2010.
    • C. Goumy, L. Gouas, G. Marceau, K. Coste, L. Veronese, D. Gallot, V. Sapin, P. Vago and A. Tchirkov, “Retinoid pathway and congenital diaphragmatic hernia: hypothesis from the analysis of chromosomal abnormalities.”, Fetal. Diagn. Ther., vol. 28 (3) , pp. 129–39, 2010.
    • C. Goumy, K. Coste, G. Marceau, L. Gouas, A. Tchirkov, P. Vago, D. Gallot and V. Sapin, “Fetal skin fibroblasts: a cell model for studying the retinoid pathway in congenital diaphragmatic hernia.”, Birth Defects Res. Part A Clin. Mol. Teratol., vol. 88 (3) , pp. 195–200, 2010.
  • 2009
    • P. Labauge, L. Horzinski, X. Ayrignac, P. Blanc, S. Vukusic, D. Rodriguez, F. Mauguiere, L. Peter, C. Goizet, F. Bouhour, C. Denier, C. Confavreux, M. Obadia, F. Blanc, J. de Seze, A. Fogli and O. Boespflug-Tanguy, “Natural history of adult-onset eIF2B-related disorders: a multi-centric survey of 16 cases.”, Brain, vol. 132 (Pt 8) , pp. 2161–9, 2009.
    • I. Sahut-Barnola, C. De Joussineau, P. Val, S. Lambert-Langlais, A. Lefrancois-Martinez, J. Pointud, G. Marceau, V. Sapin, B. Ragazzon, J. Bertherat, L. Kirschner, C. Stratakis and A. Martinez, “Mouse model for bilateral adrenal hyperplasia.”, Annales d'endocrinologie, vol. 70 (3) , pp. 194, 2009.
    • C. Belville, J. Marechal, S. Pennetier, P. Carmillo, L. Masgrau, L. Messika-Zeitoun, J. Galey, G. Machado, D. Treton, J. Gonzales, J. Picard, N. Josso, R. Cate and N. di Clemente, “Natural mutations of the anti-Mullerian hormone type II receptor found in persistent Mullerian duct syndrome affect ligand binding, signal transduction and cellular transport.”, Hum. Mol. Genet., vol. 18 (16) , pp. 3002–13, 2009.
  • 2008