Team 11: Nuclear receptors and prostate diseases
“Lipids, nuclear receptors and male disorders”
The primary goal of our group is to understand and discriminate the respective roles of the lipid related nuclear receptors (namely LXR, FXR and SHP) in the control of the endocrine activity in males. For that purpose we use complementary as well as parallel approaches to answer these questions: new or already available mouse models and various cell models. The research project is focused on two complementary topics: 1) Control of the lipid homeostasis in the reproductive functions by studying the physiologic role of LXRs in the testis and the impact of bile acids on male reproductive functions. 2) Impact of lipids on prostate physiology and pathology (benign prostate hyperplasia and prostate cancer).
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Research
Projet de l'équipe de L. Morel
Research thematics
People
| Last Name | First Name | Position | Contact | |
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BAABDATY | Elissa | Ph.D Student | |
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BARNIER | Corentin | Intern | |
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BARON | Silvere | Principal Investigator | |
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BOUCHAREB | Erwan | Ph.D Student | |
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CHAGH | Nada | Intern | |
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DALLEL | Sarah | Clinician | |
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DAMON-SOUBEYRAND | Christelle | Assistant Engineer | |
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DEGOUL | Francoise | Research Fellow | |
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DEHAY | Sabrina | Research Engineer | |
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DE JOUSSINEAU | Cyrille | Associate Professor | |
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DELPORTE | Norberta | Ph.D Student | |
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EYA | Hamzaoui | Intern | |
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GONTHIER | Celine | Assistant Engineer | |
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KOCER | Ayhan | Associate Professor | |
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LAGARDE | Aurelie | Post-doctoral Fellow | |
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LOBACCARO | Jean-Marc | Principal Investigator | |
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MOREL | Laurent | Professor | |
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TAMISIER | Christelle | Research Technician | |
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TROUSSON | Amalia | Associate Professor | |
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VIALAT | Marine | Ph.D Student | |
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WU | Siming | Intern |
Publications
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2021
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“Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer.”, Cells, vol. 10 (9) , 2021.
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“LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames.”, Communications biology, vol. 4 (1) , pp. 691, 2021.
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“Three-Dimensional Confocal Analysis of Chromosome Positioning Coupled with Immunofluorescence in Mouse Sperm Nuclei.”, Meth. Mol. Biol., vol. 2198 , pp. 255–268, 2021.
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2020
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“Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia.”, PLoS biology, vol. 18 (12) , pp. e3000948, 2020.
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“Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila.”, Nature communications, vol. 11 (1) , pp. 2300, 2020.
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“Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.”, Asian J. Androl., 2020.
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2019
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“Ethanolic extract of Algerian propolis decreases androgen receptor transcriptional activity in cultured LNCaP cells.”, The Journal of steroid biochemistry and molecular biology, vol. 189 , pp. 108–115, 2019.
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“Individual Comparison of Cholesterol Metabolism in Normal and Tumour Areas in Radical Prostatectomy Specimens from Patients with Prostate Cancer: Results of the CHOMECAP Study.”, European urology oncology, vol. 2 (2) , pp. 198–206, 2019.
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2018
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“Nuclear Integrity but Not Topology of Mouse Sperm Chromosome is Affected by Oxidative DNA Damage.”, Genes, vol. 9 (10) , 2018.
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“Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule.”, Biochimie, vol. 153 , pp. 162–170, 2018.
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“New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors.”, International journal of molecular sciences, vol. 19 (9) , 2018.
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“Liver X Receptors: A Possible Link between Lipid Disorders and Female Infertility.”, International journal of molecular sciences, vol. 19 (8) , 2018.
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“Dual extraction of mRNA and lipids from a single biological sample.”, Scientific reports, vol. 8 (1) , pp. 7019, 2018.
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“Cholesterol: A Gatekeeper of Male Fertility?”, Frontiers in endocrinology, vol. 9 , pp. 369, 2018.
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“A Decade of Exploring the Mammalian Sperm Epigenome: Paternal Epigenetic and Transgenerational Inheritance.”, Frontiers in cell and developmental biology, vol. 6 , pp. 50, 2018.
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2017
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“Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease.”, Brain pathology (Zurich, Switzerland), 2017.
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“Role of the liver X receptors in skin physiology: Putative pharmacological targets in human diseases.”, Chem. Phys. Lipids, vol. 207 (Pt B) , pp. 59–68, 2017.
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“Biological properties of propolis extracts: Something new from an ancient product.”, Chem. Phys. Lipids, vol. 207 (Pt B) , pp. 214–222, 2017.
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“Investigation of antioxidant systems in human meibomian gland and conjunctival tissues.”, Experimental eye research, vol. 165 , pp. 99–104, 2017.
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“The Bile Acid Nuclear Receptor FXRalpha Is a Critical Regulator of Mouse Germ Cell Fate.”, Stem cell reports, 2017.
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“SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation.”, Cell death and differentiation, vol. 24 (6) , pp. 1029–1044, 2017.
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“Bile acids and male fertility: From mouse to human?”, Molecular aspects of medicine, 2017.
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“Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha.”, Scientific reports, vol. 7 , pp. 42182, 2017.
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“Bile acids and their receptors.”, Molecular aspects of medicine, 2017.
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2016
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“Mammalian sperm nuclear organization: resiliencies and vulnerabilities”, Basic and Clinical Andrology, vol. 26 (1) , 2016.
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“EZH2 is overexpressed in Adrenocortical Carcinoma and is associated with disease progression.”, Hum. Mol. Genet., 2016.
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“mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.”, Cell cycle (Georgetown, Tex.), pp. 0, 2016.
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“Once and for all, LXRalpha and LXRbeta are gatekeepers of the endocrine system.”, Molecular aspects of medicine, 2016.
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“Bile acid-FXRalpha pathways regulate male sexual maturation in mice.”, Oncotarget, 2016.
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“Oxidative stress in benign prostate hyperplasia.”, Andrologia, vol. 48 (1) , pp. 69–73, 2016.
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“A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models.”, Hum. Reprod., 2016.
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“Lipid Homeostasis and Ligands for Liver X Receptors: Identification and Characterization.”, Meth. Mol. Biol., vol. 1443 , pp. 13–9, 2016.
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2015
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“[Not Available].”, Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, vol. 25 (13) , pp. 727–8, 2015.
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“Identification of the functions of Liver X Receptor beta in Sertoli cells using a targeted expression-rescue model.”, Endocrinology, pp. en20151382, 2015.
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“Liver X Receptor Activation Promotes Polyunsaturated Fatty Acid Synthesis in Macrophages: Relevance in the Context of Atherosclerosis.”, Arteriosclerosis, thrombosis, and vascular biology, 2015.
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“STAT3 serine 727 phosphorylation: a relevant target to radiosensitize human glioblastoma.”, Brain pathology (Zurich, Switzerland), 2015.
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“Identification of the Link Between the Hypothalamo-Pituitary Axis and the Testicular Orphan Nuclear Receptor NR0B2 in Adult Male Mice.”, Endocrinology, vol. 156 (2) , pp. 660–9, 2015.
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“Enolase is regulated by Liver X Receptors.”, Steroids, 2015.
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“Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context.”, PLoS ONE, vol. 10 (10) , pp. e0139946, 2015.
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2014
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“Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP.”, Expert Opin. Ther. Targets, vol. 18 (12) , pp. 1367–76, 2014.
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“Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.”, Hepatology (Baltimore, Md.), vol. 60 (3) , pp. 1054–65, 2014.
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“Levels of liver X receptors in testicular biopsies of patients with azoospermia.”, Fertil. Steril., vol. 102 (2) , pp. 361–371.e5, 2014.
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“'Auto-click' functionalization for diversified copper(I) and gold(I) NHCs.”, Dalton trans., vol. 43 (19) , pp. 6981–9, 2014.
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“Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.”, Biochemical and biophysical research communications, vol. 446 (3) , pp. 656–62, 2014.
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“Environmental estrogen exposure during fetal life: a time bomb for prostate cancer.”, Endocrinology, vol. 155 (3) , pp. 656–8, 2014.
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“NPM1 Silencing Reduces Tumour Growth and MAPK Signalling in Prostate Cancer Cells.”, PLoS ONE, vol. 9 (5) , pp. e96293, 2014.
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“Chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils of plants from Burkina Faso.”, PLoS ONE, vol. 9 (3) , pp. e92122, 2014.
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“Anticancer activity of essential oils and their chemical components - a review.”, Am J Cancer Res, vol. 4 (6) , pp. 591–607, 2014.
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2013
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“Monodisperse silica nanoparticles doped with dipicolinic acid-based luminescent lanthanide(iii) complexes for bio-labelling.”, Journal of materials chemistry. B, vol. 1 (34) , pp. 4306–4312, 2013.
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“DNA oxidative damage in mammalian spermatozoa: where and why is the male nucleus affected?”, Free Radic. Biol. Med., vol. 65 , pp. 719–23, 2013.
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“Oxysterol receptors and their therapeutic applications in cancer conditions.”, Expert Opin. Ther. Targets, vol. 17 (9) , pp. 1029–38, 2013.
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“Lipids, LXRs and prostate cancer: are HDACs a new link?”, Biochemical pharmacology, vol. 86 (1) , pp. 168–74, 2013.
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“Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?”, Cell. Mol. Life Sci., vol. 70 (23) , pp. 4511–26, 2013.
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“Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.”, PLoS Genet., vol. 9 (5) , pp. e1003483, 2013.
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“Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.”, J. Hepatol., vol. 58 (5) , pp. 984–92, 2013.
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“LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.”, Am J Cancer Res, vol. 3 (1) , pp. 58–69, 2013.
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“Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell.”, PLoS ONE, vol. 8 (3) , pp. e58876, 2013.
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“Liver X Receptors and female reproduction: when cholesterol meets fertility!”, Journal of endocrinological investigation, vol. 36 (1) , pp. 55–60, 2013.
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2012
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“A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARalpha.”, Biochimie, vol. 95 (3) , pp. 556–67, 2012.
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“Vitamin E: potential therapeutical approach for prevention of liver cancer development.”, Chinese clinical oncology, vol. 1 (1) , pp. 6, 2012.
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“Bile acids: from digestion to cancers.”, Biochimie, vol. 95 (3) , pp. 504–17, 2012.
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“Cholesterol and male fertility: what about orphans and adopted?”, Molecular and cellular endocrinology, vol. 368 (1-2) , pp. 30–46, 2012.
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“Oxysterol receptors, AKT and prostate cancer.”, Curr Opin Pharmacol, vol. 12 (6) , pp. 724–8, 2012.
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“Emerging roles for LXRs and LRH-1 in female reproduction.”, Molecular and cellular endocrinology, vol. 368 (1-2) , pp. 47–58, 2012.
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“Lxralpha regulates the androgen response in prostate epithelium.”, Endocrinology, vol. 153 (7) , pp. 3211–23, 2012.
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“Anticancer activity of silver-N-heterocyclic carbene complexes: caspase-independent induction of apoptosis via mitochondrial apoptosis-inducing factor (AIF).”, ChemMedChem, vol. 7 (5) , pp. 805–14, 2012.
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“Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.”, PLoS ONE, vol. 7 (6) , pp. e38565, 2012.
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“Epigenetic: a molecular link between testicular cancer and environmental exposures.”, Frontiers in endocrinology, vol. 3 , pp. 150, 2012.
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2011
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“Selective liver X receptor modulators (SLiMs): what use in human health?”, Molecular and cellular endocrinology, vol. 351 (2) , pp. 129–41, 2011.
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“A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity.”, J. biol. chem., vol. 286 (37) , pp. 32277–88, 2011.
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“A platinum Chugaev carbene complex as a potent anticancer agent.”, Chemical communications (Cambridge, England), vol. 47 (27) , pp. 7830–2, 2011.
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“Liver X Receptor: an oxysterol sensor and a major player in the control of lipogenesis.”, Chem. Phys. Lipids, vol. 164 (6) , pp. 500–14, 2011.
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“Interplay between LXR and Wnt/beta-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols.”, J. Neurosci., vol. 31 (26) , pp. 9620–9, 2011.
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“Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis.”, J. Neurosci., vol. 31 (10) , pp. 3729–42, 2011.
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“Liver X receptors, lipids and their reproductive secrets in the male.”, Biochim. Biophys. Acta, vol. 1812 (8) , pp. 974–81, 2011.
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“Targeting liver X receptors in human health: deadlock or promising trail?”, Expert Opin. Ther. Targets, vol. 15 (2) , pp. 219–32, 2011.
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“Dietary cholesterol-induced post-testicular infertility.”, PLoS ONE, vol. 6 (11) , pp. e26966, 2011.
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“A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia.”, BMC medical genetics, vol. 12 , pp. 145, 2011.
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2010
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“Estrogens repress PGC1-alpha expression in the uterus.”, Molecular and cellular endocrinology, vol. 330 (1-2) , pp. 33–40, 2010.
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“Thyroid hormone receptor beta (TRbeta) and liver X receptor (LXR) regulate carbohydrate-response element-binding protein (ChREBP) expression in a tissue-selective manner.”, J. biol. chem., vol. 285 (36) , pp. 28156–63, 2010.
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“Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells.”, The American journal of clinical nutrition, vol. 91 (6) , pp. 1716–24, 2010.
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“Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.”, Oncogene, vol. 29 (18) , pp. 2712–23, 2010.
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“Akt signaling pathway: a target for radiosensitizing human malignant glioma.”, Neuro-oncology, vol. 12 (5) , pp. 434–43, 2010.
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2009
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“Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages.”, Circulation research, vol. 105 (4) , pp. 393–401, 2009.
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“Metal-NHC complexes: a survey of anti-cancer properties.”, Dalton trans., pp. 6894–902, 2009.
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“25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.”, Journal of neurochemistry, vol. 109 (4) , pp. 945–58, 2009.
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“LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner.”, J. Lipid Res., vol. 50 (9) , pp. 1766–75, 2009.
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“Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.”, Endocrinology, vol. 150 (7) , pp. 3369–75, 2009.
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“[Nuclear liver X receptors are involved in the biology of reproduction].”, Med Sci (Paris), vol. 25 (2) , pp. 141–4, 2009.
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“LXR regulate cholesterol homeostasis in the proximal mouse epididymis.”, Folia Histochem. Cytobiol., vol. 47 (5) , pp. S75–9, 2009.
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“Toxicity of copper(I)-NHC complexes against human tumor cells: induction of cell cycle arrest, apoptosis, and DNA cleavage.”, Chemistry (Weinheim an der Bergstrasse, Germany), vol. 15 (2) , pp. 314–8, 2009.
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“[NPM: a new player in prostate cancer?].”, Med Sci (Paris), vol. 25 (1) , pp. 19–21, 2009.
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2008
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“Attempt to rescue sex-reversal by transgenic expression of the PISRT1 gene in XX PIS-/- goats.”, Sex. Dev., vol. 2 (3) , pp. 142–51, 2008.
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“R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation.”, BMC Dev. Biol., vol. 8 , pp. 36, 2008.
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“A specialized cDNA microarray (Mouse Lipid Chip) reveals hepatic overexpression of serum amyloid a in high-fat diet-fed mice.”, Horm. Metab. Res., vol. 40 (3) , pp. 228–30, 2008.
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“Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.”, Biol Reprod, vol. 78 (6) , pp. 968–75, 2008.
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