Team 15: Evolutionary Epigenomics and Genetic Conflicts
Access to genetic information is organized by epigenetic modifications and chromatin pathways. These mechanisms predate the last common ancestor to all eukaryotes and are hypothesized to perform conserved functions. Nevertheless, we find that they are subject to diversification in mammals (see publications). Genetic conflicts are well known to drive genome diversification, however their impact on epigenome evolution is poorly understood. Our team uses phylogenetics to identify chromatin pathways with evolutionary signatures of genetic conflicts, and test their function on the epigenome in vivo.
Recherche soutenue par la FRM, Amorçage de Jeunes Équipes (AJE201912009932).
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Research
Currently, we use mouse models, mammalian cell culture and comparative epigenomics to answer the following questions:
1) What are the functions of protein domains subject to diversification in chromatin modifying enzymes?
2) Which evolutionary forces drive short histone H2A variants diversification in mammals?
3) How do short H2As imprint parental epigenomes during mammalian reproduction?
4) How does epigenome evolution shape normal development and disease progression in humans?
Research thematics
People
Last Name | First Name | Position | Contact | |
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BUISSON | Guillaume | Intern | |
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FRAISSE | Marine | Assistant Engineer | |
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MOLARO | Antoine | Principal Investigator | |
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MORDIER | Joris | Assistant Engineer |
Publications
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2021
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“Short H2A histone variants are expressed in cancer.”, Nature communications, vol. 12 (1) , pp. 490, 2021.
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2020
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“Biparental contributions of the H2A.B histone variant control embryonic development in mice.”, PLoS biology, vol. 18 (12) , pp. e3001001, 2020.
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“Sex and suicide: The curious case of Toll-like receptors.”, PLoS biology, vol. 18 (3) , pp. e3000663, 2020.
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“Dynamic evolution of de novo DNA methyltransferases in rodent and primate genomes.”, Molecular biology and evolution, 2020.
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2018
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“Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals.”, Genome Res., vol. 28 (4) , pp. 460–473, 2018.
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“Evolutionary expansion of DNA hypomethylation in the mammalian germline genome.”, Genome Res., vol. 28 (2) , pp. 145–158, 2018.
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“Studying the Evolution of Histone Variants Using Phylogeny.”, Meth. Mol. Biol., vol. 1832 , pp. 273–291, 2018.
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2017
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“Culture shock.”, eLife, vol. 6 , 2017.
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2016
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“Hide and seek: how chromatin-based pathways silence retroelements in the mammalian germline.”, Current opinion in genetics & development, vol. 37 , pp. 51–58, 2016.
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2014
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“Two waves of de novo methylation during mouse germ cell development.”, Genes Dev., vol. 28 (14) , pp. 1544–9, 2014.
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2013
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“DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.”, Genome biology, vol. 14 (5) , pp. R50, 2013.
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2012
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“Genomic landscape of human allele-specific DNA methylation.”, Proc. Natl. Acad. Sci. U.S.A., vol. 109 (19) , pp. 7332–7, 2012.
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“Production of artificial piRNAs in flies and mice.”, RNA, vol. 18 (1) , pp. 42–52, 2012.
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2011
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“Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment.”, Molecular cell, vol. 44 (1) , pp. 17–28, 2011.
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“Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates.”, Cell, vol. 146 (6) , pp. 1029–41, 2011.
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