Team: Environment, Metabolism, spermatogenesis, pathophysiology and inheritance
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We have an available post-doc position in our lab open.
Our team has been laureate of 3 years funding from Plan Cancer Contrat for the 3R call.
Welcome to Lucie who is starting her post-doc, and will start working on the impacts of ashes on health.
Welcome to Alexis who is starting his master-2 research in our team, and who will work on C. Elegans and Dafachronic.
Rencontre patients/chercheur Inserm
http://www.auvergne-rhone-alpes.inserm.fr/rubriques/ao/sante-et-environnement-les-chercheurs-accueillent-les-malades-a-clermont-ferrand-13-nov-2019
Thrusday 27th of February 2020 3:00 pm; Dr DavidVOLLE (Inserm U 1103, CNRS UMR6293–Université Clermont Auvergne) will present his work on "Bile acid signaling in male reproduction at the Inserm Unit 1185, PARIS
13th November 2019, Our team will present his work on Environment and Healthto patient associatons. (CRBC, Clermont, Ferrand).
Congratulation to Hélène for her article In The Journal of Steroid Biochemistry and Molecular Biology. Fxralpha gene is a target gene of hCG signaling pathway and represses hCG induced steroidogenesis
Congratulation to Manon and Laura for their article review in Cell Mol Life Sci.. Farnesoid X receptor alpha (FXRα) is a critical actor of the development and pathologies of the male reproductive system.
Congratulation to Laura who was awarded at the Doctoral School Days 2019. She received the prize for the best poster.
Welcome to Guerric who is starting his master-2 research in our team, and who will work on C. Elegans and Dafachronic.
Congratulations to Mélusine who won the Junior Prize of the Society of French-speaking Andrology for her M2 work in our team.
Féliciations à Marine pour son papierdansScientific Reports "Multigenerational impacts of bile exposure are mediated by TGR5 signaling pathways."
Félicitations à Manon pour sa revue "Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases." dans Int J Mol Sci.
Congratulation to Claude who obtain funding from the Ligue contre le cancer for his work on FXRalpha in the etiology of testicular germ cell cancer.
Féliciations à Lauriane pour son papier dans Stem Cell Reports "Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders."
Congratulation to Mélusine who succeed in her MASTER-2R and will start PhD with us in October 2018.
Wellcome to Melusine, Master-2R student, working on molecular mechanisms of spermatogenesis.
We will start studying spermatogenesis using C ELegans thanks to our financial support from the French government IDEX-ISITE initiative 16-IDEX-0001 (CAP 20-25)/ Emergence program.
Félicitations à Manon et Claude pour l'obtention d'une bourse de thèse de la FRM.
Félicitations à Laura pour l'obtention de son contrat doctoral, nous serons heureux de la retrouver en Septembre prochaine avec nous!
Félicitations à Manon pour son prix de thèse de la Ligue contre le cancer
Féliciations à Emmanuelle pour son papier dans Stem Cell Reports "The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate"
Research thematics
People
| Last Name | First Name | Position | Contact | |
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BEAUDOIN | Claude | Professor | |
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CAIRA | Francoise | Associate Professor | |
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DAMON-SOUBEYRAND | Christelle | Assistant Engineer | |
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DEHAY | Sabrina | Research Engineer | |
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DE HAZE | Angelique | Assistant Engineer | |
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GARCIA | Manon | Ph.D Student | |
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HOLOTA | Helene | Engineer | |
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JOUVE | Mickael | Intern | |
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MARTINOT | Emmanuelle | Post-doctoral Fellow | |
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MONROSE | Melusine | Ph.D Student | |
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SARU | Jean-Paul | Research Technician | |
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SAUZEAT | Lucie | Post-doctoral Fellow | |
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THIROUARD | Laura | Ph.D Student | |
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VOLLE | David | Principal Investigator |
Publications
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2020
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“New perspectives on PPAR, VDR and FXRalpha as new actors in testicular pathophysiology.”, Molecular aspects of medicine, pp. 100886, 2020.
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“Editorial: Bisphenols and Male Reproductive Health.”, Frontiers in endocrinology, vol. 11 , pp. 597609, 2020.
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2019
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“Farnesoid X receptor alpha (FXRalpha) is a critical actor of the development and pathologies of the male reproductive system.”, Cell. Mol. Life Sci., 2019.
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“Fxralpha gene is a target gene of hCG signaling pathway and represses hCG induced steroidogenesis.”, The Journal of steroid biochemistry and molecular biology, pp. 105460, 2019.
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2018
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“Multigenerational impacts of bile exposure are mediated by TGR5 signaling pathways.”, Scientific reports, vol. 8 (1) , pp. 16875, 2018.
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“Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases.”, International journal of molecular sciences, vol. 19 (11) , 2018.
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“Crosstalk between BPA and FXRalpha Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders.”, Stem cell reports, 2018.
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“Cholesterol: A Gatekeeper of Male Fertility?”, Frontiers in endocrinology, vol. 9 , pp. 369, 2018.
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2017
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“Bile acids, roles in integrative physiology and pathophysiology.”, Molecular aspects of medicine, vol. 56 , pp. 1, 2017.
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“The Bile Acid Nuclear Receptor FXRalpha Is a Critical Regulator of Mouse Germ Cell Fate.”, Stem cell reports, 2017.
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“Bile acids and male fertility: From mouse to human?”, Molecular aspects of medicine, 2017.
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“ERRalpha induces H3K9 demethylation by LSD1 to promote cell invasion.”, Proc. Natl. Acad. Sci. U.S.A., 2017.
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“Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha.”, Scientific reports, vol. 7 , pp. 42182, 2017.
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“Bile acids and their receptors.”, Molecular aspects of medicine, 2017.
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2016
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“Nuclear receptors as pharmacological targets, where are we now?”, Cell. Mol. Life Sci., 2016.
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“mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.”, Cell cycle (Georgetown, Tex.), pp. 0, 2016.
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“Once and for all, LXRalpha and LXRbeta are gatekeepers of the endocrine system.”, Molecular aspects of medicine, 2016.
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“Bile acid-FXRalpha pathways regulate male sexual maturation in mice.”, Oncotarget, 2016.
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2015
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“Identification of the functions of Liver X Receptor beta in Sertoli cells using a targeted expression-rescue model.”, Endocrinology, pp. en20151382, 2015.
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“STAT3 serine 727 phosphorylation: a relevant target to radiosensitize human glioblastoma.”, Brain pathology (Zurich, Switzerland), 2015.
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“Identification of the Link Between the Hypothalamo-Pituitary Axis and the Testicular Orphan Nuclear Receptor NR0B2 in Adult Male Mice.”, Endocrinology, vol. 156 (2) , pp. 660–9, 2015.
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“Enolase is regulated by Liver X Receptors.”, Steroids, 2015.
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“Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context.”, PLoS ONE, vol. 10 (10) , pp. e0139946, 2015.
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2014
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“Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP.”, Expert Opin. Ther. Targets, vol. 18 (12) , pp. 1367–76, 2014.
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“Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.”, Hepatology (Baltimore, Md.), vol. 60 (3) , pp. 1054–65, 2014.
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“Levels of liver X receptors in testicular biopsies of patients with azoospermia.”, Fertil. Steril., vol. 102 (2) , pp. 361–371.e5, 2014.
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“Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.”, Biochemical and biophysical research communications, vol. 446 (3) , pp. 656–62, 2014.
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2013
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“Oxysterol receptors and their therapeutic applications in cancer conditions.”, Expert Opin. Ther. Targets, vol. 17 (9) , pp. 1029–38, 2013.
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“Lipids, LXRs and prostate cancer: are HDACs a new link?”, Biochemical pharmacology, vol. 86 (1) , pp. 168–74, 2013.
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“Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?”, Cell. Mol. Life Sci., vol. 70 (23) , pp. 4511–26, 2013.
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“Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.”, PLoS Genet., vol. 9 (5) , pp. e1003483, 2013.
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“Male fertility: Is spermiogenesis the critical step for answering biomedical issues?”, Spermatogenesis, vol. 3 (2) , pp. e24114, 2013.
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“LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.”, Am J Cancer Res, vol. 3 (1) , pp. 58–69, 2013.
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“Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell.”, PLoS ONE, vol. 8 (3) , pp. e58876, 2013.
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“Monodisperse silica nanoparticles doped with dipicolinic acid-based luminescent lanthanide(iii) complexes for bio-labelling”, Journal of Materials Chemistry B, vol. 1 (34) , pp. 4306, 2013.
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2012
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“Vitamin E: potential therapeutical approach for prevention of liver cancer development.”, Chinese clinical oncology, vol. 1 (1) , pp. 6, 2012.
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“Bile acids: from digestion to cancers.”, Biochimie, vol. 95 (3) , pp. 504–17, 2012.
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“Cholesterol and male fertility: what about orphans and adopted?”, Molecular and cellular endocrinology, vol. 368 (1-2) , pp. 30–46, 2012.
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“Emerging roles for LXRs and LRH-1 in female reproduction.”, Molecular and cellular endocrinology, vol. 368 (1-2) , pp. 47–58, 2012.
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“Epigenetic: a molecular link between testicular cancer and environmental exposures.”, Frontiers in endocrinology, vol. 3 , pp. 150, 2012.
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2011
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“Regenerating I messenger RNA and protein expression in the failing human testis: a potential molecular prognostic marker of seminoma.”, Human pathology, vol. 42 (12) , pp. 1841–8, 2011.
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“Liver X receptors, lipids and their reproductive secrets in the male.”, Biochim. Biophys. Acta, vol. 1812 (8) , pp. 974–81, 2011.
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“Targeting liver X receptors in human health: deadlock or promising trail?”, Expert Opin. Ther. Targets, vol. 15 (2) , pp. 219–32, 2011.
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2010
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“[Endocrine disruptors and fertility: NR0B2, a new therapeutic target?].”, Med Sci (Paris), vol. 26 (4) , pp. 359–61, 2010.
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2009
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“The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice.”, J. Clin. Invest., vol. 119 (12) , pp. 3752–64, 2009.
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“Metal-NHC complexes: a survey of anti-cancer properties.”, Dalton trans., pp. 6894–902, 2009.
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“Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.”, Endocrinology, vol. 150 (7) , pp. 3369–75, 2009.
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“Toxicity of copper(I)-NHC complexes against human tumor cells: induction of cell cycle arrest, apoptosis, and DNA cleavage.”, Chemistry (Weinheim an der Bergstrasse, Germany), vol. 15 (2) , pp. 314–8, 2009.
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2008
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“Liver receptor homolog 1 is essential for ovulation.”, Genes Dev., vol. 22 (14) , pp. 1871–6, 2008.
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“Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.”, Biol Reprod, vol. 78 (6) , pp. 968–75, 2008.
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