Team 12: Molecular Pathophysiology of Adrenal & Endocrine Tissues
Molecular Pathophysiology of Adrenal & Endocrine Tissues (team leaders: A. Martinez, DR CNRS, P. Val, DR CNRS). Our team is interested in the pathophysiology of the adrenal cortex and endocrine tissues. We focus on the molecular mechanisms involved in adrenal and gonads differentiation and how their deregulation results in tumorigenesis and disease. Our team is internationally recognized for its expertise on transgenic mouse models of adrenal and gonadal diseases.
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Research
We develop two projects that rely on genetically engineered mice. These two projects explore the common and diverging signalling pathways, involved in the differentiation and pathophysiology of the adrenal cortex and gonads.
Research thematics
People
| Last Name | First Name | Position | Contact | |
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BARNOLA | Isabelle | Engineer | |
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CHALEIL | Florian | Ph.D Student | |
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DAMON-SOUBEYRAND | Christelle | Assistant Engineer | |
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DEHAY | Sabrina | Research Engineer | |
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GARCIA GARCIA | Diana | Post-doctoral Fellow | |
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LEFRANCOIS-MARTINEZ | Anne-Marie | Professor | |
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MARTINEZ | Antoine | Principal Investigator | |
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PINIGINA | Iuliia | Intern | |
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POINTUD | Jean-Christophe | Associate Professor | |
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TAUVERON | Igor | Professor - Clinician | |
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VAL | Pierre | Principal Investigator | |
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VIGIER | Antoine | Intern |
Publications
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2022
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“Loss of LGR4/GPR48 causes severe neonatal salt-wasting due to disrupted WNT signaling altering adrenal zonation.”, J. Clin. Invest., 2022.
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“Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.”, Nature communications, vol. 13 (1) , pp. 7858, 2022.
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“Sexually dimorphic activation of innate antitumor immunity prevents adrenocortical carcinoma development.”, Science advances, vol. 8 (41) , pp. eadd0422, 2022.
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“Mislocalization of protein kinase A drives pathology in Cushing's syndrome.”, Cell Rep, vol. 40 (2) , pp. 111073, 2022.
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“Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome.”, The Journal of investigative dermatology, 2022.
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“Gene expression changes in the brain of a Cushing's syndrome mouse model.”, Journal of neuroendocrinology, vol. 34 (4) , pp. e13125, 2022.
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“beta-Catenin activation and illicit receptor expression in adrenocortical cells.”, Endocrine-related cancer, vol. 29 (3) , pp. 151–162, 2022.
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“Dissecting a zonated organ - Special issue on adrenal biology.”, Molecular and cellular endocrinology, vol. 539 , pp. 111486, 2022.
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2021
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“Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.”, J. Clin. Invest., vol. 131 (23) , 2021.
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“Adrenal androgens, adrenarche, and zona reticularis: A human affair?”, Molecular and cellular endocrinology, vol. 528 , pp. 111239, 2021.
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“Co-culture of monocytes and zona fasciculata adrenal cells: An in vitro model to study the immune-adrenal cross-talk.”, Molecular and cellular endocrinology, vol. 526 , pp. 111195, 2021.
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“HIF1alpha is a direct regulator of steroidogenesis in the adrenal gland.”, Cell. Mol. Life Sci., vol. 78 (7) , pp. 3577–3590, 2021.
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“HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.”, British journal of cancer, vol. 124 (4) , pp. 805–816, 2021.
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“Effects of Long-Term Endogenous Corticosteroid Exposure on Brain Volume and Glial Cells in the AdKO Mouse.”, Frontiers in neuroscience, vol. 15 , pp. 604103, 2021.
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2020
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“HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.”, British journal of cancer, 2020.
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“How can we minimise the use of regular oral corticosteroids in asthma?”, European respiratory review : an official journal of the European Respiratory Society, vol. 29 (155) , 2020.
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“Involvement of CREB-regulated transcription coactivators (CRTC) in transcriptional activation of steroidogenic acute regulatory protein (Star) by ACTH.”, Molecular and cellular endocrinology, vol. 499 , pp. 110612, 2020.
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2019
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“EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness.”, British journal of cancer, 2019.
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“Hormonal and spatial control of SUMOylation in the human and mouse adrenal cortex.”, FASEB J., pp. fj201900557R, 2019.
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“A ZNRF3-dependent Wnt/beta-catenin signaling gradient is required for adrenal homeostasis.”, Genes Dev., vol. 33 (3-4) , pp. 209–220, 2019.
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2018
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“Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex.”, Proc. Natl. Acad. Sci. U.S.A., 2018.
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“PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal.”, JCI insight, vol. 3 (2) , 2018.
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2017
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“P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model.”, Oncogene, 2017.
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2016
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“PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease.”, JCI insight, vol. 1 (15) , pp. e87958, 2016.
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“The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3.”, Genes Dev., vol. 30 (12) , pp. 1389–94, 2016.
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“EZH2 is overexpressed in Adrenocortical Carcinoma and is associated with disease progression.”, Hum. Mol. Genet., 2016.
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“Pregnancy, Primary Aldosteronism, and Somatic CTNNB1 Mutations.”, The New England journal of medicine, vol. 374 (15) , pp. 1493–4, 2016.
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“Editorial: Adrenal Cortex: From Physiology to Disease.”, Frontiers in endocrinology, vol. 7 , pp. 51, 2016.
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“Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?”, Frontiers in endocrinology, vol. 7 , pp. 93, 2016.
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“PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development.”, Nature communications, vol. 7 , pp. 12751, 2016.
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2015
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“Aldose reductases influence prostaglandin f2alpha levels and adipocyte differentiation in male mouse and human species.”, Endocrinology, vol. 156 (5) , pp. 1671–84, 2015.
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“Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of beta-catenin in adrenocortical carcinoma.”, Oncogenesis, vol. 4 , pp. e161, 2015.
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2014
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“Adrenal cortex tissue homeostasis and zonation: A WNT perspective.”, Molecular and cellular endocrinology, 2014.
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“mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD).”, Hum. Mol. Genet., 2014.
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“WNT/beta-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production.”, Hum. Mol. Genet., vol. 23 (4) , pp. 889–905, 2014.
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“Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial.”, Reproductive biology and endocrinology : RB&E, vol. 12 , pp. 65, 2014.
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2013
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“WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.”, Dev. Cell, vol. 27 (1) , pp. 5–18, 2013.
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“Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation.”, Proc. Natl. Acad. Sci. U.S.A., vol. 110 (36) , pp. 14801–6, 2013.
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“Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.”, PLoS Genet., vol. 9 (5) , pp. e1003483, 2013.
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“Adrenocortical cancer and IGF2: is the game over or our experimental models limited?”, J. Clin. Endocrinol. Metab., vol. 98 (2) , pp. 505–7, 2013.
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2012
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“In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland.”, Development, vol. 139 (24) , pp. 4561–70, 2012.
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“Depressed levels of prostaglandin F2alpha in mice lacking Akr1b7 increase basal adiposity and predispose to diet-induced obesity.”, Diabetes, vol. 61 (11) , pp. 2796–806, 2012.
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“Aldo-Keto Reductases 1B in Endocrinology and Metabolism.”, Front Pharmacol, vol. 3 , pp. 148, 2012.
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“Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models.”, PLoS ONE, vol. 7 (8) , pp. e44171, 2012.
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2011
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“Identification, cloning and regulation of cDNA encoding aldo-keto reductase 1B7 in the adrenal gland of two Saharan rodents Meriones libycus (Libyan jird) and Gerbillus gerbillus (gerbil).”, General and comparative endocrinology, vol. 174 (3) , pp. 292–300, 2011.
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“The cAMP pathway and the control of adrenocortical development and growth.”, Molecular and cellular endocrinology, vol. 351 (1) , pp. 28–36, 2011.
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“Wnt/beta-catenin signalling in adrenal physiology and tumour development.”, Molecular and cellular endocrinology, vol. 351 (1) , pp. 87–95, 2011.
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“Transcriptional control of adrenal steroidogenesis: novel connection between Janus kinase (JAK) 2 protein and protein kinase A (PKA) through stabilization of cAMP response element-binding protein (CREB) transcription factor.”, J. biol. chem., vol. 286 (38) , pp. 32976–85, 2011.
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2010
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“Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.”, PLoS Genet., vol. 6 (6) , pp. e1000980, 2010.
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“Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.”, Hum. Mol. Genet., vol. 19 (8) , pp. 1561–76, 2010.
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“Akt signaling pathway: a target for radiosensitizing human malignant glioma.”, Neuro-oncology, vol. 12 (5) , pp. 434–43, 2010.
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2009
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“Gene dosage effects and transcriptional regulation of early mammalian adrenal cortex development.”, Molecular and cellular endocrinology, vol. 323 (1) , pp. 105–14, 2009.
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“Pasture-feeding of Charolais steers influences skeletal muscle metabolism and gene expression.”, J. Physiol. Pharmacol., vol. 60 Suppl 3 , pp. 83–90, 2009.
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“Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.”, Cancer research, vol. 69 (18) , pp. 7278–84, 2009.
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“24-dehydrocholesterol reductase/seladin-1: a key protein differentially involved in adrenocorticotropin effects observed in human and rat adrenal cortex.”, Endocrinology, vol. 150 (9) , pp. 4180–90, 2009.
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“Mouse model for bilateral adrenal hyperplasia.”, Annales d'endocrinologie, vol. 70 (3) , pp. 194, 2009.
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“The transcription co-factor CITED2 functions during sex determination and early gonad development.”, Hum. Mol. Genet., vol. 18 (16) , pp. 2989–3001, 2009.
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“Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions.”, PLoS ONE, vol. 4 (10) , pp. e7309, 2009.
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2008
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“Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7.”, J. Biochem., vol. 145 (2) , pp. 161–8, 2008.
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“A transgenic mouse line with specific Cre recombinase expression in the adrenal cortex.”, Molecular and cellular endocrinology, vol. 300 (1-2) , pp. 197–204, 2008.
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