Testosterone is an ally of macrophages in the battle against adrenal cancers
Why are cancers of the adrenal glands more common among women? Why are prognoses worse for them? The team "Molecular Pathophysiology of Adrenal & Endocrine Tissues" answers these questions in an article published in Science Advances (Wilmouth J Jr, Olabe J et al., 2022). They demonstrate that, in male mice, there is greater recruitment of immune cells known as macrophages, which can eliminate tumour cells. Hence, aggressive tumour progression is scarcely seen in male mice; while in female miles, macrophages do not slow the growth of tumours, which eventually metastasize.
CNRS press release on this study can be find here
Last modified: 01/04/2023