Thematic 1: Genome dynamics and epigenetic control

Leaders:
Arnaud
Mathieu
Molaro
Probst / Tatout
Brasset
Waltzer
White / Gallego

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The information content of eukaryotic genomes is encoded in both the chromosomal DNA sequence and in epigenetic modifications of the proteins and DNA making up the chromatin. Faithful propagation and interpretation of this genetic and epigenetic information ensures a fine tuning of the balance between genome stability and plasticity, underpinning the dynamics of development and reproduction of all living organisms. Repair and surveillance systems ensure the structural and functional integrity of genomes while flexible epigenetic mechanisms contribute to the dynamics of gene expression pattern and cell fate decision. Combining genetic, cytogenetic, molecular, genomic and imaging approaches, five research groups of the GReD are studying these fundamental cellular processes in both physiological and pathological contexts in mammals, plants and vinegar flies.

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