In a few words...
The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France ...
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Accéder à l’inaccessible
Les régions hétérochromatiques des génomes eucaryotes, riches en séquences répétées, sont très compactes et peu accessibles, toutefois l'hétérochromatine doit conserver un certain degré d'accessibilité pour permettre à d'importants processus biologiques impliquant les molécules d’ADN de se produire, comme la réplication, la réparation des dommages ou la méthylation. Dans cette étude publiée dans la revue Nature Communications (Bourguet et al., ) , l’équipe SILENT montrent, chez la plante Arabidopsis thaliana, que le variant d’histone H2A.W permet de maintenir une accessibilité optimale de l’hétérochromatine.
JED 2021
The JED SVSAE 2021 are coming up May 27-28th! You can find all the information here: https://svsae.ed.uca.fr/inscription-obligations/obligations/journee-scientifique-de-led-svsae-1
Here is a teaser of what's to come! https://www.youtube.com/watch?v=lRNUEz1CRqE
Diversity matters
Blood cell progenitors play an essential role in the cellular immune response to infection but the importance of their heterogeneity remains elusive. In collaboration with the team of Pr M. Inamdar (JNCASR- Bangalore), the team “Epigenetic regulation and hematopoiesis” revealed that Drosophila larval blood cell progenitors exhibit an unforeseen degree of diversity, which underlies a proper immune response. This study has beeen published (Rodriguez et al., 2021) in elife.
This study has been higlighted on the INSB CNRS website
fixed-term contract for Research Engineer "Towards the development of better tools for the evaluation and conservation of male gametes".
Research Engineer position ( fixed-term contract 24 months) is available from june 2021 in the team "Mechanisms of mammalian post-testicular infertility"
Form more details an dapply , it's here
When LXR plays firefighters….
Chronic inflammation is a precursor mechanism supporting cancer development. Regarding the prostate, although hormone deprivation therapy significantly slows down cancer development, it triggers deep alterations in the tumor microenvironment. In its last studi, published in Genome Biology ( Bousset et al.) the NuReP team shows that the absence of nuclear receptors LXR leads to reprogramming of the tumor microenvironment, in particular the immune landscape.
Labellisation LIGUE de l’équipe MOP@ET
Félicitation à l’équipe MOP@ET qui vient d’obtenir la labélisation de La Ligue Nationale Contre le Cancer pour une période de 5 ans. Ce label prestigieux est une reconnaissance du travail mené depuis plusieurs années par cette équipe sur le cancer de la surrénale.
Ce succés mérité fait l'objet d'un article dans La Montagne
Replicate to repress
Heterochromatin, which states for highly condensed genomics regions, is mainly constituted of transcriptionally repressed repeated elements. In its last study, published in Genome Biology (Bourguet et al., 2020), the SILENT team shows that DNA polymerase epsilon, which is involved in DNA replication, plays a crucial role in maintaining both the structure and the function of heterochromatin.
Post-doc available : “Identification of natural extracts targeting LXR nuclear receptors activity involved in skin wound healing”
A 2 years post-doc position, shared between the GRed and GREENTECH company, is available in the "Nuclear receptors and prostate diseases" from august 2021
For more details and to apply, it’s here.