In a few words...

The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France ...

Read more

News

seminar:  “mRNA silencing machineries and translation apparatus, a physical intimacy that shapes the human proteome”

seminar: “mRNA silencing machineries and translation apparatus, a physical intimacy that shapes the human proteome”

Par Clément CHAPAT- Ecole Polytechnique Palaiseau

Tuesday  19 of  October,  9:30- Amphi VOLCAN

Read more

Euréka! Que d'émotions!

Euréka! Que d'émotions!

Pour la fête de la science, le GReD partage avec vous les émotions de la découverte grâce à Guillaume, doctorant.

Pour voir les autres vidéos "Eureka! que d'émotions!" proposées par Astu'sciences

Read more

iGReD goes green...

iGReD goes green...

iGReD days 2021  (4th and 5th of october) will be held  at the holiday village of Parent , near Clermont.

In the programme (here) : Science sand recreation...Quoi de plus ?!

Read more

A new team joins the iGRED

A new team joins the iGRED

Charléne GUILLOT, I-SITE CAP2025 call laureate , joined the i-GReD in september 2021 to set up her team " Dynamic regulation of body axis regulation".

To know more, it's here.

Read more

Les Mardis de l'iGReD Octobre 2021

Les Mardis de l'iGReD Octobre 2021

None

Read more

Post-doctoral position in Evolutionary Epigenomics

Post-doctoral position in Evolutionary Epigenomics

The Molaro Lab - Evolutionary Epigenomics and Genetic Conflicts - is seeking postdoctoral candidates to investigate the function of short H2A histone variants during mouse reproduction. Funded for 1 year renewable once, extensible upon funding.

More information and details to apply are provided here.

Read more

Post-doctoral position in Epigenetics

Post-doctoral position in Epigenetics

An  ANR funded  postdoctoral position is available in our research group “ Genetic instabilities and control  by the host genome ” . We are looking for an enthusiastic and highly motivated post-doc to investigate the relationship between  transposable elements and their host genome.

Funded for 30 months; Reviewing applications until November 2021 for a start date as early as possible.

More information and details to apply are provided here

Read more

m6A methylation of mRNA  promotes their transcription thought RNA polymerase II

m6A methylation of mRNA promotes their transcription thought RNA polymerase II

This study, leads by G.Junion ( team  Diversification of muscle and heart cells in normal and pathological conditions ),  published in the journal Molecular Cell (Akhtar et al.) shows a new mechanism for regulating gene expression through modification of RNA. Using a combination of molecular biology and bioinformatics, they demonstrate that the enzymatic complex called m6A methyltransferase (MTC) enables RNA polymerase II to escape pausing and perform transcription, and thus precisely control the expression of genes responsible for the development of organisms.

Read more

Tabagisme et rupture des membranes fœtales: vers un mécanisme moléculaire

Tabagisme et rupture des membranes fœtales: vers un mécanisme moléculaire

La cigarette est depuis longtemps reconnue comme un ennemi lors de la grossesse et ce  pour de nombreuses raisons. Par exemple, il s’agit d’un facteur de risque important de rupture prématurée des membranes fœtales (RPM), pathologie responsable d’un tiers des naissances prématurées dans le monde, soit environ 5 millions de bébés affectés par an.

Dans sa derniére étude, publiée dans International Journal of Molecular Sciences (Choltus et al., 2021), l'équipe « Approches translationnelles des lésions épithéliales et de leur réparation » propose un mécanisme moléculaire permettant d’expliquer comment le tabagisme maternel accélère et accentue un processus physiologique et fragilise précocement les membranes fœtales, qui vont rompre avant terme. 

Read more

The journey of a thousand piRNAs begins with a single Dot

The journey of a thousand piRNAs begins with a single Dot

Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of the most mysterious question is how piRNAs are transcribed and processed inside the cell. Now  Chantal Vaury’s lab brings new data into the biosynthesis of piRNAs. Their study, published recently in Nature Comm (Dennis & al., Nat Commun, 2016 Dec 8;7:13739. doi: 10.1038/ncomms13739), shows that the precursor transcripts of piRNAs are exported out of the nucleus by specific exporter proteins-Nxt1,Nxf1 and that the export itself directs the assembly of Yb bodies which are the cytoplasmic maturation centres of piRNAs. Chantal’s lab has been actively studying piRNA production for the past years, using the ovarian tissue of the fruit fly Drosophila melanogaster as a model. In 2013, they discovered ‘Dot COM’ – a single bright spot within the nuclei of ovarian follicular cells where piRNA precursor transcripts accumulate before to be processed. This year their new study has revealed that the precursors travel away from the site of transcription in the DNA to DOT COM, with the help of exportins and exon-junction complex (EJC) proteins. The study opens new possibilities of research in the piRNA and transposable element regulation fields.

Read more