In a few words...
The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France ...Read more
seminar: “mRNA silencing machineries and translation apparatus, a physical intimacy that shapes the human proteome”
Par Clément CHAPAT- Ecole Polytechnique Palaiseau
Tuesday 19 of October, 9:30- Amphi VOLCAN
Les Mardis de l'iGReD Octobre 2021None
Post-doctoral position in Evolutionary Epigenomics
The Molaro Lab - Evolutionary Epigenomics and Genetic Conflicts - is seeking postdoctoral candidates to investigate the function of short H2A histone variants during mouse reproduction. Funded for 1 year renewable once, extensible upon funding.
More information and details to apply are provided here.
Post-doctoral position in Epigenetics
An ANR funded postdoctoral position is available in our research group “ Genetic instabilities and control by the host genome ” . We are looking for an enthusiastic and highly motivated post-doc to investigate the relationship between transposable elements and their host genome.
Funded for 30 months; Reviewing applications until November 2021 for a start date as early as possible.
More information and details to apply are provided here
m6A methylation of mRNA promotes their transcription thought RNA polymerase II
This study, leads by G.Junion ( team Diversification of muscle and heart cells in normal and pathological conditions ), published in the journal Molecular Cell (Akhtar et al.) shows a new mechanism for regulating gene expression through modification of RNA. Using a combination of molecular biology and bioinformatics, they demonstrate that the enzymatic complex called m6A methyltransferase (MTC) enables RNA polymerase II to escape pausing and perform transcription, and thus precisely control the expression of genes responsible for the development of organisms.
Tabagisme et rupture des membranes fœtales: vers un mécanisme moléculaire
La cigarette est depuis longtemps reconnue comme un ennemi lors de la grossesse et ce pour de nombreuses raisons. Par exemple, il s’agit d’un facteur de risque important de rupture prématurée des membranes fœtales (RPM), pathologie responsable d’un tiers des naissances prématurées dans le monde, soit environ 5 millions de bébés affectés par an.
Dans sa derniére étude, publiée dans International Journal of Molecular Sciences (Choltus et al., 2021), l'équipe « Approches translationnelles des lésions épithéliales et de leur réparation » propose un mécanisme moléculaire permettant d’expliquer comment le tabagisme maternel accélère et accentue un processus physiologique et fragilise précocement les membranes fœtales, qui vont rompre avant terme.
The journey of a thousand piRNAs begins with a single Dot
Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of the most mysterious question is how piRNAs are transcribed and processed inside the cell. Now Chantal Vaury’s lab brings new data into the biosynthesis of piRNAs. Their study, published recently in Nature Comm (Dennis & al., Nat Commun, 2016 Dec 8;7:13739. doi: 10.1038/ncomms13739), shows that the precursor transcripts of piRNAs are exported out of the nucleus by specific exporter proteins-Nxt1,Nxf1 and that the export itself directs the assembly of Yb bodies which are the cytoplasmic maturation centres of piRNAs. Chantal’s lab has been actively studying piRNA production for the past years, using the ovarian tissue of the fruit fly Drosophila melanogaster as a model. In 2013, they discovered ‘Dot COM’ – a single bright spot within the nuclei of ovarian follicular cells where piRNA precursor transcripts accumulate before to be processed. This year their new study has revealed that the precursors travel away from the site of transcription in the DNA to DOT COM, with the help of exportins and exon-junction complex (EJC) proteins. The study opens new possibilities of research in the piRNA and transposable element regulation fields.