In a few words...

The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France ...

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News

Accéder à l’inaccessible

Accéder à l’inaccessible

Les régions hétérochromatiques des génomes eucaryotes, riches en séquences répétées,   sont très compactes et peu accessibles, toutefois l'hétérochromatine doit conserver un certain degré d'accessibilité pour permettre à d'importants processus biologiques impliquant les molécules d’ADN de se produire, comme la réplication, la réparation des dommages ou la méthylation. Dans cette étude publiée dans la revue Nature Communications (Bourguet et al., ) , l’équipe SILENT montrent, chez la plante Arabidopsis thaliana, que le variant d’histone H2A.W permet de maintenir une accessibilité optimale de l’hétérochromatine.

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JED 2021

JED 2021

The JED SVSAE 2021 are coming up May 27-28th! You can find all the information here: https://svsae.ed.uca.fr/inscription-obligations/obligations/journee-scientifique-de-led-svsae-1

Here is a teaser of what's to come!  https://www.youtube.com/watch?v=lRNUEz1CRqE

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Les Mardis of iGReD May 2021

Les Mardis of iGReD May 2021

12H45 – 13H45
WEBINARS via Teams

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 Diversity matters

Diversity matters

Blood cell progenitors play an essential role in the cellular immune response to infection but the importance of their heterogeneity remains elusive. In collaboration with the team of Pr M. Inamdar (JNCASR- Bangalore), the team “Epigenetic regulation and hematopoiesis” revealed that Drosophila larval blood cell progenitors exhibit an unforeseen degree of diversity, which underlies a proper immune response. This study has beeen published  (Rodriguez et al., 2021) in elife.

 This study has been higlighted on the  INSB CNRS website

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fixed-term contract for Research Engineer "Towards the development of better tools for the evaluation and conservation of male gametes".

fixed-term contract for Research Engineer "Towards the development of better tools for the evaluation and conservation of male gametes".

Research Engineer position ( fixed-term contract 24 months) is available from june 2021 in the team "Mechanisms of mammalian post-testicular infertility"

Form more details an dapply , it's here

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When LXR plays firefighters….

When LXR plays firefighters….

Chronic inflammation is a precursor mechanism supporting cancer development. Regarding the prostate, although hormone deprivation therapy significantly slows down cancer development, it triggers deep alterations in the tumor microenvironment. In its last studi, published in Genome Biology ( Bousset et al.) the NuReP team shows that the absence of nuclear receptors LXR leads to reprogramming of the tumor microenvironment, in particular the immune landscape.

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Labellisation LIGUE de l’équipe MOP@ET

Labellisation LIGUE de l’équipe MOP@ET

Félicitation à l’équipe MOP@ET qui vient d’obtenir la labélisation de La Ligue Nationale Contre le Cancer pour une période de 5 ans. Ce label prestigieux est une reconnaissance du travail mené depuis plusieurs années par cette équipe sur le cancer de la surrénale.

Ce succés mérité fait l'objet d'un article dans La Montagne

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 Replicate to repress

Replicate to repress

Heterochromatin, which states for highly condensed genomics regions, is mainly constituted of transcriptionally repressed repeated elements.  In its last study, published in  Genome Biology (Bourguet et al., 2020),  the SILENT team  shows that DNA polymerase epsilon, which is involved in DNA replication, plays a crucial role in maintaining both the structure and the function of heterochromatin.

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Post-doc available :  “Identification  of  natural  extracts  targeting  LXR  nuclear  receptors  activity  involved  in  skin wound healing”

Post-doc available : “Identification of natural extracts targeting LXR nuclear receptors activity involved in skin wound healing”

A  2 years post-doc position, shared between the GRed and GREENTECH company, is available in the "Nuclear receptors and prostate diseases" from august 2021

For more details and to apply, it’s here.

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GReD internal meeting 2017

The GReD internal meeting 2017 will be held thursday the 9th and friday the 10th of february  at "amplhi de Physique" on Cézeaux Campus.

Please,click  here to download the program.

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