Équipe de recherche

ERO: Epigenetic Regulations & Ontogenesis

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AccueilÉquipesERO: Epigenetic Regulations & Ontogenesis

Cell fate choice and differentiation as well as the maintenance of specialized cells function require a tight and coordinated regulation of genome expression. One key layer of regulation takes place at the level of transcription and involves epigenetic enzymes, which act at least in part by covalently modifying DNA or chromatin-associated factors. Our main objective is to shed light on the functions of these enzymes in vivo and to characterize their mode(s) of action.


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Recherche

Our team is interested in the mechanisms which regulate gene expression during development and how alterations in these mechanisms can cause diseases. We focus our researches on a conserved family of epigenetic enzymes whose human homologs are implicated in the development of many pathologies, including blood cell cancer, neurodegenerative diseases or muscular dystrophies. Our objective is to shed light on the functions of these enzymes in vivo and to characterize their mode(s) of action.

 

Accordingly, our researches revolve along four interconnected axes:

(1) reveal the function of these factors in different biological contexts (blood cell development and response to immune challenges, adult muscle differentiation and maintenance, central nervous system development),

(2) define the impact of these factors on gene expression, chromatin modifications and genome organisation to better understand how they control transcription,

(3) identify their partners to bring further information about their molecular mechanism of action and their regulation,

(4) develop new genetic models to understand how deregulations in the activity of these factors can lead to pathological situations.

 

To tackle these questions, we use Drosophila melanogaster, a well-established animal model, and we use a broad combination of state-of-the art genetic, molecular and cellular techniques as well as genomic and bioinformatic approaches.

Membres

Publications

32 publications
2024

Drosophila TET acts with PRC1 to activate gene expression independently of its catalytic activity.

Publié le 03 Mai 2024 dans Science advances , vol. 10 - pp eadn5861

Gilbert G , Renaud Y , Teste C , Anglaret N , Bertrand R , Hoehn S, Jurkowski TP, Schuettengruber B, Cavalli G, Waltzer L , Vandel L

drosophila
epigenetics
2022

Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution.

Publié le 24 Juin 2022 dans Nucleic acids research , vol. 50 - pp 6284-6299

Bortolin-Cavaillé ML, Quillien A, Thalalla Gamage S, Thomas JM, Sas-Chen A, Sharma S, Plisson-Chastang C, Vandel L , Blader P, Lafontaine DLJ, Schwartz S, Meier JL, Cavaillé J

2021

Patient-matched analysis identifies deregulated networks in prostate cancer to guide personalized therapeutic intervention.

Publié le 15 Nov 2021 dans American journal of cancer research , vol. 11 - pp 5299-5318

Kumar A, Kasikci Y, Badredine A, Azzag K, Quintyn Ranty ML, Zaidi F, Aragou N, Mazerolles C, Malavaud B, Mendoza-Parra MA, Vandel L , Gronemeyer H

m(6)A RNA methylation regulates promoter- proximal pausing of RNA polymerase II.

Publié le 19 Août 2021 dans Molecular cell , vol. 81 - pp 3356-3367.e6

Akhtar J, Renaud Y , Albrecht S, Ghavi-Helm Y, Roignant JY, Silies M, Junion G

Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity.

Publié le 30 Juin 2021 dans PLoS genetics , vol. 17 - pp e1009641

Quillien A, Gilbert G , Boulet M , Ethuin S, Waltzer L , Vandel L

2020

A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons.

Publié le 20 Fév 2020 dans Nucleic acids research , vol. 48 - pp 1206-1224

Lepesant JMJ, Iampietro C, Galeota E, Augé B, Aguirrenbengoa M, Mercé C, Chaubet C, Rocher V, Haenlin M, Waltzer L , Pelizzola M, Di Stefano L

2018

CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

Publié le 22 Août 2018 dans Scientific reports , vol. 8 - pp 12629

Fauquier L, Azzag K, Parra MAM, Quillien A, Boulet M , Diouf S , Carnac G, Waltzer L , Gronemeyer H, Vandel L

From Drosophila Blood Cells to Human Leukemia.

Publié le 01 Jan 2018 dans Advances in experimental medicine and biology , vol. 1076 - pp 195-214

Boulet M , Miller M , Vandel L , Waltzer L

2017

Epigenetic Regulators Modulate Muscle Damage in Duchenne Muscular Dystrophy Model.

Publié le 21 Déc 2017 dans PLoS currents , vol. 9

Bajanca F, Vandel L

Control of RUNX-induced repression of Notch signaling by MLF and its partner DnaJ-1 during Drosophila hematopoiesis.

Publié le 30 Juil 2017 dans PLoS genetics , vol. 13 - pp e1006932

Miller M , Chen A, Gobert V, Augé B, Beau M, Burlet-Schiltz O, Haenlin M, Waltzer L

2016

Drosophila hematopoiesis under normal conditions and in response to immune stress.

Publié le 30 Nov 2016 dans FEBS letters , vol. 590 - pp 4034-4051

Letourneau M, Lapraz F, Sharma A, Vanzo N, Waltzer L , Crozatier M

2015

The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche.

Publié le 21 Juil 2015 dans Proceedings of the National Academy of Sciences of the United States of America , vol. 112 - pp 9052-7

Benmimoun B, Polesello C, Haenlin M, Waltzer L

Expression patterns of CREB binding protein (CREBBP) and its methylated species during zebrafish development.

Publié le 01 Jan 2015 dans The International journal of developmental biology , vol. 59 - pp 229-34

Batut J, Duboé C, Vandel L

Haematopoietic progenitor maintenance by EBF/Collier: beyond the Niche.

Publié le 01 Jan 2015 dans Cell cycle (Georgetown, Tex.) , vol. 14 - pp 3517-8

Benmimoun B, Haenlin M, Waltzer L

Blood cell progenitor maintenance: Collier barks out of the niche.

Publié le 01 Jan 2015 dans Fly , vol. 9 - pp 160-4

Benmimoun B, Haenlin M, Waltzer L

2014

Pontin is a critical regulator for AML1-ETO-induced leukemia.

Publié le 30 Juin 2014 dans Leukemia , vol. 28 - pp 1271-9

Breig O, Bras S, Martinez Soria N, Osman D, Heidenreich O, Haenlin M, Waltzer L

2012

Myeloid leukemia factor: a return ticket from human leukemia to fly hematopoiesis.

Publié le 01 Sep 2012 dans Transcription , vol. 3 - pp 250-4

Gobert V, Haenlin M, Waltzer L

Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila.

Publié le 30 Mai 2012 dans Development (Cambridge, England) , vol. 139 - pp 1713-7

Benmimoun B, Polesello C, Waltzer L , Haenlin M

Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis.

Publié le 27 Mar 2012 dans Proceedings of the National Academy of Sciences of the United States of America , vol. 109 - pp 4986-91

Bras S, Martin-Lannerée S, Gobert V, Augé B, Breig O, Sanial M, Yamaguchi M, Haenlin M, Plessis A, Waltzer L

2011

Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin.

Publié le 01 Juin 2011 dans Genes & development , vol. 25 - pp 1132-46

Ceschin DG, Walia M, Wenk SS, Duboé C, Gaudon C, Xiao Y, Fauquier L, Sankar M, Vandel L , Gronemeyer H

The Ly6 protein coiled is required for septate junction and blood brain barrier organisation in Drosophila.

Publié le 15 Mar 2011 dans PloS one , vol. 6 - pp e17763

Hijazi A, Haenlin M, Waltzer L , Roch F

The methyltransferases PRMT4/CARM1 and PRMT5 control differentially myogenesis in zebrafish.

Publié le 01 Jan 2011 dans PloS one , vol. 6 - pp e25427

Batut J, Duboé C, Vandel L

Modeling cancers in Drosophila.

Publié le 01 Jan 2011 dans Progress in molecular biology and translational science , vol. 100 - pp 51-82

Polesello C, Roch F, Gobert V, Haenlin M, Waltzer L

2010

A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.

Publié le 30 Juin 2010 dans Molecular and cellular biology , vol. 30 - pp 2837-48

Gobert V, Osman D, Bras S, Augé B, Boube M, Bourbon HM, Horn T, Boutros M, Haenlin M, Waltzer L

An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis.

Publié le 11 Juin 2010 dans BMC developmental biology , vol. 10 - pp 65

Avet-Rochex A, Boyer K, Polesello C, Gobert V, Osman D, Roch F, Augé B, Zanet J, Haenlin M, Waltzer L

[Drosophila as a new model system for leukaemia].

Publié le 30 Jan 2010 dans Medecine sciences : M/S , vol. 26 - pp 9-11

Osman D, Gobert V, Haenlin M, Waltzer L

Zona pellucida domain proteins remodel the apical compartment for localized cell shape changes.

Publié le 19 Jan 2010 dans Developmental cell , vol. 18 - pp 64-76

Fernandes I, Chanut-Delalande H, Ferrer P, Latapie Y, Waltzer L , Affolter M, Payre F, Plaza S

2009

boudin is required for septate junction organisation in Drosophila and codes for a diffusible protein of the Ly6 superfamily.

Publié le 30 Juil 2009 dans Development (Cambridge, England) , vol. 136 - pp 2199-209

Hijazi A, Masson W, Augé B, Waltzer L , Haenlin M, Roch F

A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO.

Publié le 21 Juil 2009 dans Proceedings of the National Academy of Sciences of the United States of America , vol. 106 - pp 12043-8

Osman D, Gobert V, Ponthan F, Heidenreich O, Haenlin M, Waltzer L

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