Research Team

ERO: Epigenetic Regulations & Ontogenesis

HomeTeamsERO: Epigenetic Regulations & Ontogenesis

Cell fate choice and differentiation as well as the maintenance of specialized cells function require a tight and coordinated regulation of genome expression. One key layer of regulation takes place at the level of transcription and involves epigenetic enzymes, which act at least in part by covalently modifying DNA or chromatin-associated factors. Our main objective is to shed light on the functions of these enzymes in vivo and to characterize their mode(s) of action.





Our team is interested in the mechanisms which regulate gene expression during development and how alterations in these mechanisms can cause diseases. We focus our researches on a conserved family of epigenetic enzymes whose human homologs are implicated in the development of many pathologies, including blood cell cancer, neurodegenerative diseases or muscular dystrophies. Our objective is to shed light on the functions of these enzymes in vivo and to characterize their mode(s) of action.


Accordingly, our researches revolve along four interconnected axes:

(1) reveal the function of these factors in different biological contexts (blood cell development and response to immune challenges, adult muscle differentiation and maintenance, central nervous system development),

(2) define the impact of these factors on gene expression, chromatin modifications and genome organisation to better understand how they control transcription,

(3) identify their partners to bring further information about their molecular mechanism of action and their regulation,

(4) develop new genetic models to understand how deregulations in the activity of these factors can lead to pathological situations.


To tackle these questions, we use Drosophila melanogaster, a well-established animal model, and we use a broad combination of state-of-the art genetic, molecular and cellular techniques as well as genomic and bioinformatic approaches.




32 publications

Drosophila TET acts with PRC1 to activate gene expression independently of its catalytic activity.

Published on 03 May 2024 in Science advances , vol. 10 - pp eadn5861

Gilbert G , Renaud Y , Teste C , Anglaret N , Bertrand R , Hoehn S, Jurkowski TP, Schuettengruber B, Cavalli G, Waltzer L , Vandel L


Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution.

Published on 24 Jun 2022 in Nucleic acids research , vol. 50 - pp 6284-6299

Bortolin-Cavaillé ML, Quillien A, Thalalla Gamage S, Thomas JM, Sas-Chen A, Sharma S, Plisson-Chastang C, Vandel L , Blader P, Lafontaine DLJ, Schwartz S, Meier JL, Cavaillé J


Patient-matched analysis identifies deregulated networks in prostate cancer to guide personalized therapeutic intervention.

Published on 15 Nov 2021 in American journal of cancer research , vol. 11 - pp 5299-5318

Kumar A, Kasikci Y, Badredine A, Azzag K, Quintyn Ranty ML, Zaidi F, Aragou N, Mazerolles C, Malavaud B, Mendoza-Parra MA, Vandel L , Gronemeyer H

m(6)A RNA methylation regulates promoter- proximal pausing of RNA polymerase II.

Published on 19 Aug 2021 in Molecular cell , vol. 81 - pp 3356-3367.e6

Akhtar J, Renaud Y , Albrecht S, Ghavi-Helm Y, Roignant JY, Silies M, Junion G

Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity.

Published on 30 Jun 2021 in PLoS genetics , vol. 17 - pp e1009641

Quillien A, Gilbert G , Boulet M , Ethuin S, Waltzer L , Vandel L


A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons.

Published on 20 Feb 2020 in Nucleic acids research , vol. 48 - pp 1206-1224

Lepesant JMJ, Iampietro C, Galeota E, Augé B, Aguirrenbengoa M, Mercé C, Chaubet C, Rocher V, Haenlin M, Waltzer L , Pelizzola M, Di Stefano L


CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

Published on 22 Aug 2018 in Scientific reports , vol. 8 - pp 12629

Fauquier L, Azzag K, Parra MAM, Quillien A, Boulet M , Diouf S , Carnac G, Waltzer L , Gronemeyer H, Vandel L

From Drosophila Blood Cells to Human Leukemia.

Published on 01 Jan 2018 in Advances in experimental medicine and biology , vol. 1076 - pp 195-214

Boulet M , Miller M , Vandel L , Waltzer L


Control of RUNX-induced repression of Notch signaling by MLF and its partner DnaJ-1 during Drosophila hematopoiesis.

Published on 30 Jul 2017 in PLoS genetics , vol. 13 - pp e1006932

Miller M , Chen A, Gobert V, Augé B, Beau M, Burlet-Schiltz O, Haenlin M, Waltzer L


Drosophila hematopoiesis under normal conditions and in response to immune stress.

Published on 30 Nov 2016 in FEBS letters , vol. 590 - pp 4034-4051

Letourneau M, Lapraz F, Sharma A, Vanzo N, Waltzer L , Crozatier M


The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche.

Published on 21 Jul 2015 in Proceedings of the National Academy of Sciences of the United States of America , vol. 112 - pp 9052-7

Benmimoun B, Polesello C, Haenlin M, Waltzer L

Expression patterns of CREB binding protein (CREBBP) and its methylated species during zebrafish development.

Published on 01 Jan 2015 in The International journal of developmental biology , vol. 59 - pp 229-34

Batut J, Duboé C, Vandel L

Haematopoietic progenitor maintenance by EBF/Collier: beyond the Niche.

Published on 01 Jan 2015 in Cell cycle (Georgetown, Tex.) , vol. 14 - pp 3517-8

Benmimoun B, Haenlin M, Waltzer L

Blood cell progenitor maintenance: Collier barks out of the niche.

Published on 01 Jan 2015 in Fly , vol. 9 - pp 160-4

Benmimoun B, Haenlin M, Waltzer L


Pontin is a critical regulator for AML1-ETO-induced leukemia.

Published on 30 Jun 2014 in Leukemia , vol. 28 - pp 1271-9

Breig O, Bras S, Martinez Soria N, Osman D, Heidenreich O, Haenlin M, Waltzer L


Myeloid leukemia factor: a return ticket from human leukemia to fly hematopoiesis.

Published on 01 Sep 2012 in Transcription , vol. 3 - pp 250-4

Gobert V, Haenlin M, Waltzer L

Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila.

Published on 30 May 2012 in Development (Cambridge, England) , vol. 139 - pp 1713-7

Benmimoun B, Polesello C, Waltzer L , Haenlin M

Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis.

Published on 27 Mar 2012 in Proceedings of the National Academy of Sciences of the United States of America , vol. 109 - pp 4986-91

Bras S, Martin-Lannerée S, Gobert V, Augé B, Breig O, Sanial M, Yamaguchi M, Haenlin M, Plessis A, Waltzer L


Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin.

Published on 01 Jun 2011 in Genes & development , vol. 25 - pp 1132-46

Ceschin DG, Walia M, Wenk SS, Duboé C, Gaudon C, Xiao Y, Fauquier L, Sankar M, Vandel L , Gronemeyer H

The Ly6 protein coiled is required for septate junction and blood brain barrier organisation in Drosophila.

Published on 15 Mar 2011 in PloS one , vol. 6 - pp e17763

Hijazi A, Haenlin M, Waltzer L , Roch F

The methyltransferases PRMT4/CARM1 and PRMT5 control differentially myogenesis in zebrafish.

Published on 01 Jan 2011 in PloS one , vol. 6 - pp e25427

Batut J, Duboé C, Vandel L

Modeling cancers in Drosophila.

Published on 01 Jan 2011 in Progress in molecular biology and translational science , vol. 100 - pp 51-82

Polesello C, Roch F, Gobert V, Haenlin M, Waltzer L


A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.

Published on 30 Jun 2010 in Molecular and cellular biology , vol. 30 - pp 2837-48

Gobert V, Osman D, Bras S, Augé B, Boube M, Bourbon HM, Horn T, Boutros M, Haenlin M, Waltzer L

An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis.

Published on 11 Jun 2010 in BMC developmental biology , vol. 10 - pp 65

Avet-Rochex A, Boyer K, Polesello C, Gobert V, Osman D, Roch F, Augé B, Zanet J, Haenlin M, Waltzer L

[Drosophila as a new model system for leukaemia].

Published on 30 Jan 2010 in Medecine sciences : M/S , vol. 26 - pp 9-11

Osman D, Gobert V, Haenlin M, Waltzer L

Zona pellucida domain proteins remodel the apical compartment for localized cell shape changes.

Published on 19 Jan 2010 in Developmental cell , vol. 18 - pp 64-76

Fernandes I, Chanut-Delalande H, Ferrer P, Latapie Y, Waltzer L , Affolter M, Payre F, Plaza S


boudin is required for septate junction organisation in Drosophila and codes for a diffusible protein of the Ly6 superfamily.

Published on 30 Jul 2009 in Development (Cambridge, England) , vol. 136 - pp 2199-209

Hijazi A, Masson W, Augé B, Waltzer L , Haenlin M, Roch F

A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO.

Published on 21 Jul 2009 in Proceedings of the National Academy of Sciences of the United States of America , vol. 106 - pp 12043-8

Osman D, Gobert V, Ponthan F, Heidenreich O, Haenlin M, Waltzer L


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