Real-time imaging of a transposable Element (ONSEN)

We are developing innovative microscopy methodologies to monitor the entire life-cycle of the retro-transposable element ONSEN, activate under heat stress, to explore its dynamic with a single-cell resolution. Our system is also able to detect Extra-chromosomal circular DNA (EccDNA) generated upon ONSEN activation and accumulate in the cell.

Staff involved: Petra Barnas (MSCA-DN PhD student 2026-2029), Aurore Sureau (CNRS IE CDD), Myrtille Barrot (PhD student 2025-28), Franziska Buslaps (European Project Manager, CNRS IE CDD)

and Frédéric Pontvianne (CNRS DR2)

Collaborators: Mathieu Ingouff (IRD, Montpellier) and Marie Mirouze (IRD, LGDP, Perpignan)

Funding : MSCA-DN AGILE (Grant Agreement No. 101226536; 2026-2030)