The elongation of Mest transcript into MestXL sustains, but does not initiate, the maternal allele bias of its convergent gene Copg2 during neurogenesis.
Auteurs : Perillous S , Fromaget AC, Gonthier-Guéret C , Clerici O , Espenel M , Murigneux A , Phan S , Feit L , Vaurs-Barriére C , Slimani F, Lemmers C, Normanno D, Ha A, Ashworth N, Bogutz AB, Kamura H, Gumpangseth N, Hata K, Montibus B , Nakabayashi K, Lefebvre L, Bouschet T, Court F , Arnaud P
The authors show how two imprinted convergent genes, Mest and Copg2, are coregulated in the developing mouse brain: first through joint co-activation, then, at later stages, via elongation of Mest into MestXL, which silences the paternal Copg2 allele.
dans Nature communications , vol. 17
