Chef d'équipe
HomeClaire CHAZAUD


Present: PI of the team: Molecular mechanisms of cell lineage differentiation in the preimplantation embryo.

2012: DR2 INSERM, PI at the GReD

2005 : CR1 INSERM, PI at the GReD

2003 to present: PI of team n°5 at the GReD (Clermont-Fd)

2002: Recipient of an "AVENIR" grant.

February 1999 to June 2003: post-doctoral fellow in Dr. Janet RossantLaboratory (Toronto, Canada). Research topics: 1- Cell lineage specification in the preimplantation mouse embryo. 2-Involvement of the Wnt/beta-Catenin pathway during A-P axis formation in the mouse.

1994-1998: PhD Université L. Pasteur,IGBMC (Strasbourg), director Dr. P. Dollé. Research topic: Characterisation of RA inducible genes expressed during  mouse development (supervisors Dr. P. Dollé and Prof. P. Chambon).


22 publications

Regionally specific levels and patterns of keratin 8 expression in the mouse embryo visceral endoderm emerge upon anterior-posterior axis determination.

Published on 01 Dec 2022 in Frontiers in cell and developmental biology , vol. 10 - pp 1037041

Despin-Guitard E, Quenec'Hdu R , Nahaboo W, Schwarz N, Leube RE, Chazaud C , Migeotte I

NANOG initiates epiblast fate through the coordination of pluripotency genes expression.

Published on 21 Jun 2022 in Nature communications , vol. 13 - pp 3550

Allègre N , Chauveau S , Dennis C , Renaud Y , Meistermann D, Estrella LV, Pouchin P , Cohen-Tannoudji M, David L, Chazaud C


Computational models for the dynamics of early mouse embryogenesis.

Published on 01 Jan 2019 in The International journal of developmental biology , vol. 63 - pp 131-142

Tosenberger A, Gonze D, Chazaud C , Dupont G

Regulation of the ERK signalling pathway in the developing mouse blastocyst.

Published on 25 Jul 2019 in Development (Cambridge, England) , vol. 146

Azami T, Bassalert C , Allègre N , Valverde Estrella L , Pouchin P , Ema M, Chazaud C


Primitive Endoderm Differentiation: From Specification to Epithelialization.

Published on 01 Jan 2018 in Current topics in developmental biology , vol. 128 - pp 81-104

Bassalert C , Valverde-Estrella L, Chazaud C


A multiscale model of early cell lineage specification including cell division.

Published on 09 Jun 2017 in NPJ systems biology and applications , vol. 3 - pp 16

Tosenberger A, Gonze D, Bessonnard S , Cohen-Tannoudji M, Chazaud C , Dupont G


Cell Fate Specification Based on Tristability in the Inner Cell Mass of Mouse Blastocysts.

Published on 02 Feb 2016 in Biophysical journal , vol. 110 - pp 710-722

De Mot L, Gonze D, Bessonnard S , Chazaud C , Goldbeter A, Dupont G

Lineage specification in the mouse preimplantation embryo.

Published on 01 Apr 2016 in Development (Cambridge, England) , vol. 143 - pp 1063-74

Chazaud C , Yamanaka Y

Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency.

Published on 02 Sep 2016 in Nature communications , vol. 7 - pp 12589

Fiorenzano A, Pascale E, D'Aniello C, Acampora D, Bassalert C , Russo F, Andolfi G, Biffoni M, Francescangeli F, Zeuner A, Angelini C, Chazaud C , Patriarca EJ, Fico A, Minchiotti G


Assessment of cell lineages and cell death in blastocysts by immunostaining.

Published on 01 Jan 2015 in Methods in molecular biology (Clifton, N.J.) , vol. 1222 - pp 175-80

Chauveau S , Chazaud C


A close look at the mammalian blastocyst: epiblast and primitive endoderm formation.

Published on 30 Sep 2014 in Cellular and molecular life sciences : CMLS , vol. 71 - pp 3327-38

Artus J, Chazaud C

Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network.

Published on 30 Oct 2014 in Development (Cambridge, England) , vol. 141 - pp 3637-48

Bessonnard S , De Mot L, Gonze D, Barriol M, Dennis C , Goldbeter A, Dupont G, Chazaud C

Primitive endoderm differentiation: from specification to epithelium formation.

Published on 05 Dec 2014 in Philosophical transactions of the Royal Society of London. Series B, Biological sciences , vol. 369

Hermitte S , Chazaud C


Fluorescent mRNA labeling through cytoplasmic FISH.

Published on 30 Dec 2013 in Nature protocols , vol. 8 - pp 2538-47

Gasnier M , Dennis C , Vaurs-Barrière C , Chazaud C


Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.

Published on 01 Jul 2012 in Genes & development , vol. 26 - pp 1445-58

Lavial F, Bessonnard S , Ohnishi Y, Tsumura A, Chandrashekran A, Fenwick MA, Tomaz RA, Hosokawa H, Nakayama T, Chambers I, Hiiragi T, Chazaud C , Azuara V


Primitive endoderm differentiates via a three-step mechanism involving Nanog and RTK signaling.

Published on 13 Dec 2011 in Developmental cell , vol. 21 - pp 1005-13

Frankenberg S, Gerbe F, Bessonnard S , Belville C , Pouchin P , Bardot O , Chazaud C

The RNA-binding protein Unr prevents mouse embryonic stem cells differentiation toward the primitive endoderm lineage.

Published on 30 Oct 2011 in Stem cells (Dayton, Ohio) , vol. 29 - pp 1504-16

Elatmani H, Dormoy-Raclet V, Dubus P, Dautry F, Chazaud C , Jacquemin-Sablon H


Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst.

Published on 15 Jan 2008 in Developmental biology , vol. 313 - pp 594-602

Gerbe F, Cox B, Rossant J, Chazaud C

[Early embryogenesis in mammals: stem cells and first commitment steps].

Published on 30 Dec 2008 in Medecine sciences : M/S , vol. 24 - pp 1043-8

Chazaud C


Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway.

Published on 30 May 2006 in Developmental cell , vol. 10 - pp 615-24

Chazaud C , Yamanaka Y, Pawson T, Rossant J

Disruption of early proximodistal patterning and AVE formation in Apc mutants.

Published on 30 Sep 2006 in Development (Cambridge, England) , vol. 133 - pp 3379-87

Chazaud C , Rossant J


Lineage allocation and asymmetries in the early mouse embryo.

Published on 29 Aug 2003 in Philosophical transactions of the Royal Society of London. Series B, Biological sciences , vol. 358 - pp 1341-8; discussion 1349

Rossant J, Chazaud C , Yamanaka Y


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