Olivier BARDOTMaitre de Conférences
I am Associate Professor in the Biology Department of the University Institute of Technology (Auvergne) since 1995 on the Campus Cezeaux, Aubiere. I am teaching biochemistry.
I mainly studied morphogenesis during development in the Drosophila melanogaster model organism. I have developed for this work, approaches based on genetics, molecular biology and microscopy.
I am currently working on mechanisms that control the size and shape of the cells during development.
I am currently working on mechanisms that control cells size and shape during development. These two parameters must be coordinated during growth and epithelial differentiation. Deregulation of coordination often leads to the formation of tumors, most cancer tumors having an epithelial origin. As model, we use ovarian follicular cells of Drosophila melanogaster. This somatic cell monolayer surrounds the germ cells that will grow up to give a fertilized egg by increasing size during its development. Follicular cells must follow the growth of underneath tissue without loosing their properties. For this work, the approaches used are primarily
genetic and confocal microscopy imaging.
Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation.
Published on 08 Apr 2020 in Development (Cambridge, England) , vol. 147
Cerqueira Campos F , Dennis C , Alégot H , Fritsch C , Isabella A, Pouchin P , Bardot O , Horne-Badovinac S, Mirouse V
Jak-Stat pathway induces Drosophila follicle elongation by a gradient of apical contractility.
Published on 08 Feb 2018 in eLife , vol. 7
Comparative genomics highlights the unique biology of Methanomassiliicoccales, a Thermoplasmatales-related seventh order of methanogenic archaea that encodes pyrrolysine.
Published on 13 Aug 2014 in BMC genomics , vol. 15 - pp 679
Borrel G, Parisot N, Harris HM, Peyretaillade E, Gaci N, Tottey W, Bardot O , Raymann K, Gribaldo S, Peyret P, O'Toole PW, Brugère JF
Genome Sequence of “Candidatus Methanomassiliicoccus intestinalis” Issoire-Mx1, a Third Thermoplasmatales-Related Methanogenic Archaeon from Human Feces.
Published on 11 Jul 2013 in Genome announcements , vol. 1
Borrel G, Harris HM, Parisot N, Gaci N, Tottey W, Mihajlovski A, Deane J, Gribaldo S, Bardot O , Peyretaillade E, Peyret P, O'Toole PW, Brugère JF
Primitive endoderm differentiates via a three-step mechanism involving Nanog and RTK signaling.
Published on 13 Dec 2011 in Developmental cell , vol. 21 - pp 1005-13
Frankenberg S, Gerbe F, Bessonnard S , Belville C , Pouchin P , Bardot O , Chazaud C
HtrA stress protein is involved in intramacrophagic replication of adherent and invasive Escherichia coli strain LF82 isolated from a patient with Crohn’s disease.
Published on 02 Mar 2005 in Infection and immunity , vol. 73 - pp 712-21
Bringer MA, Barnich N, Glasser AL, Bardot O , Darfeuille-Michaud A
The Drosophila melanogaster BTB proteins bric à brac bind DNA through a composite DNA binding domain containing a pipsqueak and an AT-Hook motif.
Published on 15 Sep 2003 in Nucleic acids research , vol. 31 - pp 5389-98
Lours C, Bardot O , Godt D, Laski FA, Couderc JL
Expressing UAS-bab1 and UAS-bab2: a comparative study of gain-of-function effects and the potential to rescue the bric à brac mutant phenotype.
Published on 01 Sep 2002 in Genesis (New York, N.Y. : 2000) , vol. 34 - pp 66-70
Bardot O , Godt D, Laski FA, Couderc JL
Toxicological evaluation of peroxisome proliferators. Further cellular and molecular aspects.
Published on 27 Dec 1996 in Annals of the New York Academy of Sciences , vol. 804 - pp 716-8
Passilly P, Pacot C, Jannin B, Cherkaoui Malki M, Bardot O , Caira F , Clemencet MC, Latruffe N
Delayed effects of ciprofibrate on rat liver peroxisomal properties and proto-oncogene expression.
Published on 28 Sep 1995 in Biochemical pharmacology , vol. 50 - pp 1001-6
Bardot O , Clemencet MC, Cherkaoui Malki M, Latruffe N
Transcriptional and post-transcriptional analysis of peroxisomal protein encoding genes from rat treated with an hypolipemic agent, ciprofibrate. Effect of an intermittent treatment and influence of obesity.
Published on 01 Mar 1995 in Biochemical pharmacology , vol. 49 - pp 611-9
The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs.
Published on 27 Feb 1995 in FEBS letters , vol. 360 - pp 183-6
Bardot O , Clemencet MC, Passilly P, Latruffe N
PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene.
Published on 15 Apr 1993 in Biochemical and biophysical research communications , vol. 192 - pp 37-45
Bardot O , Aldridge TC, Latruffe N, Green S
Effect of different hypolipemic agents on rat liver peroxisomal and mitochondrial functions and biogenesis.
Published on 01 Jan 1991 in Cellular and molecular biology , vol. 37 - pp 723-33
Cherkaoui Malki M, Assaka L, Pacot C, Bardot O , Latruffe N
Molecular analysis of a human liver mitochondrial ornithine transcarbamylase deficiency.
Published on 01 Jan 1991 in Journal of inherited metabolic disease , vol. 14 - pp 29-36
Berrez JM, Bardot O , Thiard MC, Alvarez F, Latruffe N
Expression of liver peroxisomal proteins as compared to other organelle marker enzymes in rats treated with hypolipidemic agents.
Published on 01 Jan 1990 in Biology of the cell , vol. 69 - pp 83-92
Cherkaoui Malki M, Bardot O , Lhuguenot JC, Latruffe N