Nathalie GRANDIN

Chargé de Recherche
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GRANDIN
Nathalie
Chargé de Recherche
CRHC

Research

My research focuses on the mechanisms of telomere maintenance in dividing cells. My primary model organism is the yeast *Saccharomyces cerevisiae*. Between 2016 and 2022, I also participated in experiments involving tumors, primarily gliomas.

Using our preferred model, *S. cerevisiae*, we have continuously deepened our understanding of the functions of the CST telomeric complex—a complex we played a major role in identifying and characterizing over the past 25 years. After defining the complex’s roles at the telomere, we identified additional functions for CST: in transcription during DNA replication, in mechanisms regulating cytokinesis, and, more recently, in the proper progression of mitosis.


Publications

9 publications
2021

The TeloDIAG: how telomeric parameters can help in glioma rapid diagnosis and liquid biopsy approaches.

Published on 30 Dec 2021 in Annals of oncology : official journal of the European Society for Medical Oncology , vol. 32 - pp 1608-1617

Billard P, Guerriau C, Carpentier C, Juillard F, Grandin N , Lomonte P, Kantapareddy P, Dufay N, Barritault M, Rimokh R, Verrelle P, Maucort-Boulch D, Figarella-Branger D, Ducray F, Dehais C, Charbonneau M , Meyronet D, Poncet DA, POLA network

2019

The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription.

Published on 09 Jul 2019 in Nucleic acids research , vol. 47 - pp 6250-6268

Calvo O, Grandin N , Jordán-Pla A, Miñambres E, González-Polo N, Pérez-Ortín JE, Charbonneau M

The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas.

Published on 09 Nov 2019 in Acta neuropathologica communications , vol. 7 - pp 175

Grandin N , Pereira B, Cohen C, Billard P, Dehais C, Carpentier C, Idbaih A, Bielle F, Ducray F, Figarella-Branger D, Delattre JY, Sanson M, Lomonte P, Poncet D, Verrelle P, Charbonneau M , POLA network

2017

Measurement of Telomere Length in Colorectal Cancers for Improved Molecular Diagnosis.

Published on 29 Aug 2017 in International journal of molecular sciences , vol. 18

Balc'h EL, Grandin N , Demattei MV, Guyétant S, Tallet A, Pagès JC, Ouaissi M, Lecomte T, Charbonneau M

Detection of the alternative lengthening of telomeres pathway in malignant gliomas for improved molecular diagnosis.

Published on 30 Nov 2017 in Journal of neuro-oncology , vol. 135 - pp 381-390

Fogli A , Demattei MV, Corset L, Vaurs-Barrière C , Chautard E, Biau J, Kémény JL, Godfraind C, Pereira B, Khalil T, Grandin N , Arnaud P , Charbonneau M , Verrelle P

2015

Genetic Inactivation of ATRX Leads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells.

Published on 30 Aug 2015 in Molecular and cellular biology , vol. 35 - pp 2818-30

Eid R, Demattei MV, Episkopou H, Augé-Gouillou C, Decottignies A, Grandin N , Charbonneau M

Contact
Nathalie GRANDIN

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