Nathalie GRANDINChargé de Recherche
Chargé de Recherche
Since joining the CNRS, I have been interested in the maintenance mechanisms of telomeres in dividing cells, always in collaboration with Michel Charbonneau. My main model is the yeast Saccharomyces cerevisiae. Between 2016 and 2022 I also participated in experiments on tumours, mainly gliomas.
In our favorite model, S. cerevisiae, we are constantly investigating the functions of the telomeric complex CST, a complex that we have greatly contributed to identifying and characterizing over the past 25 years. After clarifying the roles of this complex at the telomeric level, we identified other roles of CST: in transcription during DNA replication, then in mechanisms regulating cytokinesis. To be continued…
The TeloDIAG: how telomeric parameters can help in glioma rapid diagnosis and liquid biopsy approaches.
Published on 30 Dec 2021 in Annals of oncology : official journal of the European Society for Medical Oncology , vol. 32 - pp 1608-1617
Billard P, Guerriau C, Carpentier C, Juillard F, Grandin N , Lomonte P, Kantapareddy P, Dufay N, Barritault M, Rimokh R, Verrelle P, Maucort-Boulch D, Figarella-Branger D, Ducray F, Dehais C, Charbonneau M , Meyronet D, Poncet DA, POLA network
Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae.
Published on 30 Dec 2020 in DNA repair , vol. 96 - pp 102996
The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription.
Published on 09 Jul 2019 in Nucleic acids research , vol. 47 - pp 6250-6268
Calvo O, Grandin N , Jordán-Pla A, Miñambres E, González-Polo N, Pérez-Ortín JE, Charbonneau M
The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas.
Published on 09 Nov 2019 in Acta neuropathologica communications , vol. 7 - pp 175
Grandin N , Pereira B, Cohen C, Billard P, Dehais C, Carpentier C, Idbaih A, Bielle F, Ducray F, Figarella-Branger D, Delattre JY, Sanson M, Lomonte P, Poncet D, Verrelle P, Charbonneau M , POLA network
Measurement of Telomere Length in Colorectal Cancers for Improved Molecular Diagnosis.
Published on 29 Aug 2017 in International journal of molecular sciences , vol. 18
Balc'h EL, Grandin N , Demattei MV, Guyétant S, Tallet A, Pagès JC, Ouaissi M, Lecomte T, Charbonneau M
Detection of the alternative lengthening of telomeres pathway in malignant gliomas for improved molecular diagnosis.
Published on 30 Nov 2017 in Journal of neuro-oncology , vol. 135 - pp 381-390
Fogli A , Demattei MV, Corset L, Vaurs-Barrière C , Chautard E, Biau J, Kémény JL, Godfraind C, Pereira B, Khalil T, Grandin N , Arnaud P , Charbonneau M , Verrelle P
Genetic Inactivation of ATRX Leads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells.
Published on 30 Aug 2015 in Molecular and cellular biology , vol. 35 - pp 2818-30
Eid R, Demattei MV, Episkopou H, Augé-Gouillou C, Decottignies A, Grandin N , Charbonneau M