Charles WHITEChef d'équipe
Charles White is a Directeur de Recherche (DR1, senior scientist) at the Centre National de la Recherche Scientifique, and directs a CNRS/University/INSERM research group studying the mechanisms by which cells maintain the integrity of their genomes. Following an Honours BSc. degree in Genetics and Biochemistry at the University of Adelaide (Australia), he carried out his PhD at the MRC (London, U.K.) in the group of Robin Holliday, and a post-doc at Boston in the group of James E. Haber, on the mechanisms of DNA repair and genetic recombination in yeast. Particularly notable results of this work were the establishment of the "Physical Monitoring" of recombination in vivo - establishing the kinetics and two novel molecular intermediates of genetic recombination in eukaryotes (including the resection of 5'-ended DNA strand at DNA breaks, now believed to be the key step in determining the choice of recombination pathway). In 1994 he was recruited by the CNRS at the University of Paris (Orsay), to establish a research group on molecular mechanisms of genetic recombination in plants. The group moved to the University Blaise Pascal at Clermont-Ferrand in 1998 and actively pursues research into the molecular mechanisms responsible for the maintenance of genome integrity in the model plant, Arabidopsis thaliana and the yeast Saccharomyces cerevisiae.
President of the Société Française de Génétique from 2015-2020, he has participated in numerous review committees at international (EU Descartes Prize, FP5, FP7, H2020, Horizon Europe ...) and national levels (scientific commissions of the IRD and the INSERM, CEA, Institut Pasteur, Génoplante, AERES, HCERES thesis and habilitation juries ...). He has organised a number of international scientific meetings (notably the "Genetic stability and Change" EMBO workshop series), coordinated two, and participated in four other European Framework and Marie-Curie network grants, as well as numerous public and industry funded projects in France.
Published on 30 Aug 2022 in PLoS genetics , vol. 18 - pp e1010322
Published on 06 Dec 2022 in EMBO reports , vol. 23 - pp e54736
Published on 04 Dec 2021 in International journal of molecular sciences , vol. 22
Martinez-Garcia M, White CI , Franklin FCH, Sanchez-Moran E
Published on 30 May 2021 in PLoS genetics , vol. 17 - pp e1008919
Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae.
Published on 30 Dec 2020 in DNA repair , vol. 96 - pp 102996
Published on 25 Nov 2020 in Genome biology , vol. 21 - pp 283
Bread wheat TaSPO11-1 exhibits evolutionarily conserved function in meiotic recombination across distant plant species.
Published on 30 Sep 2020 in The Plant journal : for cell and molecular biology , vol. 103 - pp 2052-2068
SPO11.2 is essential for programmed double-strand break formation during meiosis in bread wheat (Triticum aestivum L.).
Published on 30 Sep 2020 in The Plant journal : for cell and molecular biology , vol. 104 - pp 30-43
Published on 30 Oct 2019 in Plant physiology , vol. 181 - pp 499-509
Published on 30 May 2018 in Plant physiology , vol. 177 - pp 311-327
Published on 10 Aug 2017 in PloS one , vol. 12 - pp e0183006
Published on 30 Apr 2017 in The Plant journal : for cell and molecular biology , vol. 90 - pp 372-382
Hirakawa T, Hasegawa J, White CI , Matsunaga S
CRISPR-Cas9-mediated efficient directed mutagenesis and RAD51-dependent and RAD51-independent gene targeting in the moss Physcomitrella patens.
Published on 30 Jan 2017 in Plant biotechnology journal , vol. 15 - pp 122-131
Collonnier C, Epert A, Mara K, Maclot F, Guyon-Debast A, Charlot F, White C , Schaefer DG, Nogué F
Published on 30 Jun 2016 in Virology , vol. 493 - pp 113-27
Role of the Polymerase ϵ sub-unit DPB2 in DNA replication, cell cycle regulation and DNA damage response in Arabidopsis.
Published on 06 Sep 2016 in Nucleic acids research , vol. 44 - pp 7251-66
Pedroza-Garcia JA, Domenichini S, Mazubert C, Bourge M, White C , Hudik E, Bounon R, Tariq Z, Delannoy E, Del Olmo I, Piñeiro M, Jarillo JA, Bergounioux C, Benhamed M, Raynaud C
Published on 09 Sep 2015 in Annual review of genetics , vol. 49 - pp 95-114
Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound.
Published on 06 Nov 2015 in Scientific reports , vol. 5 - pp 16255
Published on 30 Jan 2015 in The Plant journal : for cell and molecular biology , vol. 81 - pp 198-209
Telomere stability and development of ctc1 mutants are rescued by inhibition of EJ recombination pathways in a telomerase-dependent manner.
Published on 29 Oct 2014 in Nucleic acids research , vol. 42 - pp 11979-91
Arabidopsis thaliana RNase H2 deficiency counteracts the needs for the WEE1 checkpoint kinase but triggers genome instability.
Published on 30 Sep 2014 in The Plant cell , vol. 26 - pp 3680-92
Recombination-independent mechanisms and pairing of homologous chromosomes during meiosis in plants.
Published on 30 Mar 2014 in Molecular plant , vol. 7 - pp 492-501
Multiple host-cell recombination pathways act in Agrobacterium-mediated transformation of plant cells.
Published on 02 Mar 2014 in The Plant journal : for cell and molecular biology , vol. 77 - pp 511-20
Published on 16 Oct 2013 in Frontiers in plant science , vol. 4 - pp 405
Published on 30 Apr 2013 in Plant biotechnology journal , vol. 11 - pp 305-14
Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana.
Published on 19 Apr 2012 in PLoS genetics , vol. 8 - pp e1002636
Published on 30 Mar 2012 in Cell , vol. 149 - pp 101-12
Gene Site-Specific Insertion in Plants.
Published on 21 Jun 2012 in Topics in Current Genetics, Springer, Dordrecht. , vol. 23
Olivier Da Ines & Charles I. White
Published on 10 Jun 2011 in DNA repair , vol. 10 - pp 611-9
Published on 30 Mar 2011 in Current protein & peptide science , vol. 12 - pp 84-92
Published on 30 Oct 2010 in The Plant journal : for cell and molecular biology , vol. 64 - pp 280-90
Rapid repair of DNA double strand breaks in Arabidopsis thaliana is dependent on proteins involved in chromosome structure maintenance.
Published on 01 Mar 2009 in DNA repair , vol. 8 - pp 413-9
Kozak J, West CE, White C , da Costa-Nunes JA, Angelis KJ
Published on 02 Mar 2009 in PLoS genetics , vol. 5 - pp e1000380
Published on 30 Dec 2006 in Plant molecular biology , vol. 62 - pp 859-66
Published on 05 Jan 2006 in DNA repair , vol. 5 - pp 1-12
Published on 01 Mar 2005 in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology , vol. 13 - pp 481-91
Published on 02 Mar 2005 in The Plant journal : for cell and molecular biology , vol. 41 - pp 533-45
Published on 30 Dec 2005 in Trends in biotechnology , vol. 23 - pp 567-9
Tzfira T, White C
Published on 27 Dec 2005 in Proceedings of the National Academy of Sciences of the United States of America , vol. 102 - pp 19231-6
Li J, Vaidya M, White C , Vainstein A, Citovsky V, Tzfira T
Published on 30 Sep 2004 in Plant molecular biology , vol. 56 - pp 217-24
Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination.
Published on 30 Oct 2004 in Chromosoma , vol. 113 - pp 197-203
Published on 28 Jan 2004 in The EMBO journal , vol. 23 - pp 439-49
Bleuyard JY, White CI
Published on 30 Mar 2003 in The Plant cell , vol. 15 - pp 782-9
Ku80 plays a role in non-homologous recombination but is not required for T-DNA integration in Arabidopsis.
Published on 30 Sep 2003 in The Plant journal : for cell and molecular biology , vol. 35 - pp 557-65
Published on 30 Nov 2002 in EMBO reports , vol. 3 - pp 1049-54
Published on 13 Feb 2001 in Proceedings of the National Academy of Sciences of the United States of America , vol. 98 - pp 1711-6
Published on 30 Apr 2001 in EMBO reports , vol. 2 - pp 287-91
Published on 30 Jan 2001 in The Plant journal : for cell and molecular biology , vol. 25 - pp 31-41