Philippe ARNAUD

Chef d'équipe
institute
HomePhilippe ARNAUD
P1004502

ARNAUD
Philippe
Chef d'équipe
DR2 CNRS

Publications

53 publications
2024

Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment.

Published on 30 Jan 2024 in HGG advances , vol. 5 - pp 100271

Rengifo Rojas C , Cercy J , Perillous S , Gonthier-Guéret C, Montibus B , Maupetit-Méhouas S, Espinadel A , Dupré M , Hong CC, Hata K, Nakabayashi K, Plagge A, Bouschet T, Arnaud P , Vaillant I , Court F

2022

L1 chimeric transcripts are expressed in healthy brain and their deregulation in glioma follows that of their host locus.

Published on 17 Aug 2022 in Human molecular genetics , vol. 31 - pp 2606-2622

Pinson ME , Court F , Masson A , Renaud Y , Fantini A , Bacoeur-Ouzillou O, Barriere M, Pereira B, Guichet PO, Chautard E, Karayan-Tapon L, Verrelle P, Arnaud P , Vaurs-Barrière C

The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation.

Published on 25 Apr 2022 in International journal of molecular sciences , vol. 23

Le Boiteux E , Guichet PO, Masliantsev K, Montibus B , Vaurs-Barriere C, Gonthier-Gueret C, Chautard E, Verrelle P, Karayan-Tapon L, Fogli A , Court F , Arnaud P

Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells.

Published on 12 Oct 2022 in Frontiers in cell and developmental biology , vol. 10 - pp 1022422

Claxton M, Pulix M, Seah MKY, Bernardo R, Zhou P, Aljuraysi S, Liloglou T, Arnaud P , Kelsey G, Messerschmidt DM, Plagge A

2021

Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage.

Published on 30 Aug 2021 in Molecular oncology , vol. 15 - pp 1995-2010

Le Boiteux E , Court F , Guichet PO, Vaurs-Barrière C , Vaillant I , Chautard E, Verrelle P, Costa BM, Karayan-Tapon L, Fogli A , Arnaud P

DNA
Gliome
H3K27me3
HOX

TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment.

Published on 30 Jan 2021 in Cellular and molecular life sciences : CMLS , vol. 78 - pp 757-768

Montibus B , Cercy J , Bouschet T, Charras A, Maupetit-Méhouas S , Nury D , Gonthier-Guéret C, Chauveau S , Allegre N , Chariau C, Hong CC, Vaillant I , Marques CJ, Court F , Arnaud P

2020

HOX gene cluster (de)regulation in brain: from neurodevelopment to malignant glial tumours.

Published on 30 Oct 2020 in Cellular and molecular life sciences : CMLS , vol. 77 - pp 3797-3821

Gonçalves CS, Le Boiteux E , Arnaud P , Costa BM

2019

Transcriptional alterations in glioma result primarily from DNA methylation-independent mechanisms.

Published on 30 Oct 2019 in Genome research , vol. 29 - pp 1605-1621

Court F , Le Boiteux E , Fogli A , Müller-Barthélémy M, Vaurs-Barrière C , Chautard E, Pereira B, Biau J, Kemeny JL, Khalil T, Karayan-Tapon L, Verrelle P, Arnaud P

2018

CLIFinder: identification of LINE-1 chimeric transcripts in RNA-seq data.

Published on 15 Feb 2018 in Bioinformatics (Oxford, England) , vol. 34 - pp 688-690

Pinson ME , Pogorelcnik R , Court F , Arnaud P , Vaurs-Barrière C

The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma.

Published on 20 Mar 2018 in Oncotarget , vol. 9 - pp 15740-15756

Xavier-Magalhães A, Gonçalves CS, Fogli A , Lourenço T, Pojo M, Pereira B, Rocha M, Lopes MC, Crespo I, Rebelo O, Tão H, Lima J, Moreira R, Pinto AA, Jones C, Reis RM, Costello JF, Arnaud P , Sousa N, Costa BM

DNA methylation profiling reveals a pathological signature that contributes to transcriptional defects of CD34(+) CD15(-) cells in early chronic-phase chronic myeloid leukemia.

Published on 30 Jun 2018 in Molecular oncology , vol. 12 - pp 814-829

Maupetit-Mehouas S , Court F , Bourgne C, Guerci-Bresler A, Cony-Makhoul P, Johnson H, Etienne G, Rousselot P, Guyotat D, Janel A, Hermet E, Saugues S, Berger J, Arnaud P , Berger MG

2017

In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression.

Published on 01 Mar 2017 in Cerebral cortex (New York, N.Y. : 1991) , vol. 27 - pp 2418-2433

Bouschet T, Dubois E, Reynès C, Kota SK, Rialle S, Maupetit-Méhouas S , Pezet M, Le Digarcher A, Nidelet S, Demolombe V, Cavelier P, Meusnier C, Maurizy C, Sabatier R, Feil R, Arnaud P , Journot L, Varrault A

Detection of the alternative lengthening of telomeres pathway in malignant gliomas for improved molecular diagnosis.

Published on 30 Nov 2017 in Journal of neuro-oncology , vol. 135 - pp 381-390

Fogli A , Demattei MV, Corset L, Vaurs-Barrière C , Chautard E, Biau J, Kémény JL, Godfraind C, Pereira B, Khalil T, Grandin N , Arnaud P , Charbonneau M , Verrelle P

2016

Imprinting control regions (ICRs) are marked by mono-allelic bivalent chromatin when transcriptionally inactive.

Published on 29 Jan 2016 in Nucleic acids research , vol. 44 - pp 621-35

Maupetit-Méhouas S , Montibus B , Nury D , Tayama C, Wassef M, Kota SK, Fogli A , Cerqueira Campos F , Hata K, Feil R, Margueron R, Nakabayashi K, Court F , Arnaud P

The tumoral A genotype of the MGMT rs34180180 single-nucleotide polymorphism in aggressive gliomas is associated with shorter patients’ survival.

Published on 01 Mar 2016 in Carcinogenesis , vol. 37 - pp 169-176

Fogli A , Chautard E, Vaurs-Barrière C , Pereira B, Müller-Barthélémy M, Court F , Biau J, Pinto AA, Kémény JL, Khalil T, Karayan-Tapon L, Verrelle P, Costa BM, Arnaud P

2015

Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape.

Published on 25 Sep 2015 in Genome biology , vol. 16 - pp 209

Veselovska L, Smallwood SA, Saadeh H, Stewart KR, Krueger F, Maupetit-Méhouas S , Arnaud P , Tomizawa S, Andrews S, Kelsey G

2014

ICR noncoding RNA expression controls imprinting and DNA replication at the Dlk1-Dio3 domain.

Published on 13 Oct 2014 in Developmental cell , vol. 31 - pp 19-33

Kota SK, Llères D, Bouschet T, Hirasawa R, Marchand A, Begon-Pescia C, Sanli I, Arnaud P , Journot L, Girardot M, Feil R

2012

Characterization of novel paternal ncRNAs at the Plagl1 locus, including Hymai, predicted to interact with regulators of active chromatin.

Published on 01 Jan 2012 in PloS one , vol. 7 - pp e38907

Iglesias-Platas I, Martin-Trujillo A, Cirillo D, Court F , Guillaumet-Adkins A, Camprubi C, Bourc'his D, Hata K, Feil R, Tartaglia G, Arnaud P , Monk D

Transcription and histone methylation changes correlate with imprint acquisition in male germ cells.

Published on 01 Feb 2012 in The EMBO journal , vol. 31 - pp 606-15

Henckel A, Chebli K, Kota SK, Arnaud P , Feil R

Characterization of novel paternal ncRNAs at the Plagl1 locus, including Hymai, predicted to interact with regulators of active chromatin.

Published on 19 Jun 2012 in PloS one , vol. 7 - pp e38907

Iglesias-Platas I, Martin-Trujillo A, Cirillo D, Court F , Guillaumet-Adkins A, Camprubi C, Bourc'his D, Hata K, Feil R, Tartaglia G, Arnaud P , Monk D

2011

Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes.

Published on 30 Jun 2011 in Nucleic acids research , vol. 39 - pp 4577-86

Monk D, Arnaud P , Frost JM, Wood AJ, Cowley M, Martin-Trujillo A, Guillaumet-Adkins A, Iglesias Platas I, Camprubi C, Bourc'his D, Feil R, Moore GE, Oakey RJ

Synergic reprogramming of mammalian cells by combined exposure to mitotic Xenopus egg extracts and transcription factors.

Published on 18 Oct 2011 in Proceedings of the National Academy of Sciences of the United States of America , vol. 108 - pp 17331-6

Ganier O, Bocquet S, Peiffer I, Brochard V, Arnaud P , Puy A, Jouneau A, Feil R, Renard JP, Méchali M

2010

Genomic imprinting in germ cells: imprints are under control.

Published on 30 Sep 2010 in Reproduction (Cambridge, England) , vol. 140 - pp 411-23

Arnaud P

Genome-wide identification of new imprinted genes.

Published on 30 Jul 2010 in Briefings in functional genomics , vol. 9 - pp 304-14

Henckel A, Arnaud P

Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.

Published on 01 Aug 2010 in Development (Cambridge, England) , vol. 137 - pp 2483-92

Alder O, Lavial F, Helness A, Brookes E, Pinho S, Chandrashekran A, Arnaud P , Pombo A, O'Neill L, Azuara V

2009

Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression.

Published on 15 Aug 2009 in Human molecular genetics , vol. 18 - pp 3066-74

Monk D, Arnaud P , Frost J, Hills FA, Stanier P, Feil R, Moore GE

Histone methylation is mechanistically linked to DNA methylation at imprinting control regions in mammals.

Published on 15 Sep 2009 in Human molecular genetics , vol. 18 - pp 3375-83

Henckel A, Nakabayashi K, Sanz LA, Feil R, Hata K, Arnaud P

2008

Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.

Published on 30 Aug 2008 in Genome research , vol. 18 - pp 1270-81

Monk D, Wagschal A, Arnaud P , Müller PS, Parker-Katiraee L, Bourc'his D, Scherer SW, Feil R, Stanier P, Moore GE

A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10.

Published on 08 Oct 2008 in The EMBO journal , vol. 27 - pp 2523-32

Sanz LA, Chamberlain S, Sabourin JC, Henckel A, Magnuson T, Hugnot JP, Feil R, Arnaud P

2007

Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.

Published on 04 May 2007 in PLoS genetics , vol. 3 - pp e65

Parker-Katiraee L, Carson AR, Yamada T, Arnaud P , Feil R, Abu-Amero SN, Moore GE, Kaneda M, Perry GH, Stone AC, Lee C, Meguro-Horike M, Sasaki H, Kobayashi K, Nakabayashi K, Scherer SW

Early mouse embryo development: could epigenetics influence cell fate determination?

Published on 30 Jun 2007 in BioEssays : news and reviews in molecular, cellular and developmental biology , vol. 29 - pp 520-4

Henckel A, Tóth S, Arnaud P

Chromatin Immunoprecipitation (ChIP) on Unfixed Chromatin from Cells and Tissues to Analyze Histone Modifications.

Published on 01 Jun 2007 in CSH protocols , vol. 2007 - pp pdb.prot4767

Wagschal A, Delaval K, Pannetier M, Arnaud P , Feil R

PCR-Based Analysis of Immunoprecipitated Chromatin.

Published on 01 Jun 2007 in CSH protocols , vol. 2007 - pp pdb.prot4768

Wagschal A, Delaval K, Pannetier M, Arnaud P , Feil R

2006

Stochastic imprinting in the progeny of Dnmt3L-/- females.

Published on 15 Feb 2006 in Human molecular genetics , vol. 15 - pp 589-98

Arnaud P , Hata K, Kaneda M, Li E, Sasaki H, Feil R, Kelsey G

Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.

Published on 15 Apr 2006 in Human molecular genetics , vol. 15 - pp 1259-69

Monk D, Sanches R, Arnaud P , Apostolidou S, Hills FA, Abu-Amero S, Murrell A, Friess H, Reik W, Stanier P, Constância M, Moore GE

Limited evolutionary conservation of imprinting in the human placenta.

Published on 25 Apr 2006 in Proceedings of the National Academy of Sciences of the United States of America , vol. 103 - pp 6623-8

Monk D, Arnaud P , Apostolidou S, Hills FA, Kelsey G, Stanier P, Feil R, Moore GE

MEDEA takes control of its own imprinting.

Published on 10 Feb 2006 in Cell , vol. 124 - pp 468-70

Arnaud P , Feil R

2005

Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproduction.

Published on 30 Jun 2005 in Birth defects research. Part C, Embryo today : reviews , vol. 75 - pp 81-97

Arnaud P , Feil R

2004

Identification and properties of imprinted genes and their control elements.

Published on 01 Jan 2004 in Cytogenetic and genome research , vol. 105 - pp 335-45

Smith RJ, Arnaud P , Kelsey G

Identification and properties of imprinted genes and their control elements.

Published on 14 Jul 2004 in Cytogenetic and genome research , vol. 105 - pp 335-45

Smith RJ, Arnaud P, Kelsey G

22723905
2003

Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark.

Published on 01 May 2003 in Human molecular genetics , vol. 12 - pp 1005-19

Arnaud P , Monk D, Hitchins M, Gordon E, Dean W, Beechey CV, Peters J, Craigen W, Preece M, Stanier P, Moore GE, Kelsey G

Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus.

Published on 30 Aug 2003 in Molecular and cellular biology , vol. 23 - pp 5475-88

Coombes C, Arnaud P , Gordon E, Dean W, Coar EA, Williamson CM, Feil R, Peters J, Kelsey G

Imprinted methylation profiles for proximal mouse chromosomes 11 and 7 as revealed by methylation-sensitive representational difference analysis.

Published on 30 Dec 2003 in Mammalian genome : official journal of the International Mammalian Genome Society , vol. 14 - pp 805-16

Monk D, Smith R, Arnaud P , Preece MA, Stanier P, Beechey CV, Peters J, Kelsey G, Moore GE

2002

The mouse Zac1 locus: basis for imprinting and comparison with human ZAC.

Published on 12 Jun 2002 in Gene , vol. 292 - pp 101-12

Smith RJ, Arnaud P , Konfortova G, Dean WL, Beechey CV, Kelsey G

2001

Analysis of the SINE S1 Pol III promoter from Brassica; impact of methylation and influence of external sequences.

Published on 30 May 2001 in The Plant journal : for cell and molecular biology , vol. 26 - pp 295-305

Arnaud P , Yukawa Y, Lavie L, Pélissier T , Sugiura M, Deragon JM

2000

SINE retroposons can be used in vivo as nucleation centers for de novo methylation.

Published on 30 May 2000 in Molecular and cellular biology , vol. 20 - pp 3434-41

Arnaud P , Goubely C , Pélissier T , Deragon JM

1997

Plant S1 SINEs as a model to study retroposition.

Published on 01 Jan 1997 in Genetica , vol. 100 - pp 155-60

Gilbert N, Arnaud P , Lenoir A , Warwick SI, Picard G, Deragon JM

Plant S1 SINEs as a model to study retroposition.

Published on 17 Mar 1997 in Genetica , vol. 100 - pp 155-60

Gilbert N, Arnaud P, Lenoir A , Warwick SI, Picard G, Deragon JM

1996

A transcriptional analysis of the S1Bn (Brassica napus) family of SINE retroposons.

Published on 30 Dec 1996 in Plant molecular biology , vol. 32 - pp 869-78

Deragon JM, Gilbert N, Rouquet L, Lenoir A , Arnaud P , Picard G

Improved thermostability of the North American firefly luciferase: saturation mutagenesis at position 354.

Published on 15 Oct 1996 in The Biochemical journal , vol. 319 ( Pt 2) - pp 343-50

White PJ, Squirrell DJ, Arnaud P , Lowe CR, Murray JA

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Philippe ARNAUD

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