Francoise CAIRA
Maitre de Conférences
CAIRA
Francoise
Maitre de Conférences
MCF
Resume
After having worked as a teacher and then lived in Israel in the 1980s, I joined the University of Burgundy in 1987 where I defended a doctorate in Animal Physiology in 1996. I then obtained a research position at the Karolinska Institute in Stockholm before joining Blaise Pascal University in 1999 as a lecturer in the laboratory (now) GReD.
I successively held positions on collective missions as President of the Department of Biology for one term (2011-13), Director of Studies for the First Years (DEPA) in the Pedagogical Service of the Scientific License (SPLS, 2010- 16), Project Manager "Assistance for Student Success" at Blaise Pascal University (2012-2016), Vice-President in charge of Pedagogical Transformation, Digital Pedagogy and Documentary Policy (2017-21) and Director of the Pedagogical Engineering & Audiovisual Production (IPPA) Pole since 2017. In January 2021, the presidency of the EPE-UCA appointed me Strategic Director of the IPPA Pole. This function involves defining a Pedagogical Transformation strategy at UCA and deploying this policy across the establishment by leading the team of pedagogical engineers and audiovisual engineers from the service dedicated to this mission.
Publications
Constitutive Androstane Receptor Regulates Germ Cell Homeostasis, Sperm Quality, and Male Fertility via Akt-Foxo1 Pathway.
Published on 24 Sep 2024 in Advanced science (Weinheim, Baden-Wurttemberg, Germany) - pp e2402082
Monrose M , Holota H , Martinez G, Damon-Soubeyrand C , Thirouard L , Martinot E , Battistelli E , de Haze A , Bravard S , Tamisier C , Caira F , Coutton C, Barbotin AL, Boursier A, Lakhal L, Beaudoin C , Volle DH
Identification of the Role of TGR5 in the Regulation of Leydig Cell Homeostasis.
Published on 06 Dec 2022 in International journal of molecular sciences , vol. 23
Holota H , De Haze A , Martinot E , Monrose M , Saru JP , Caira F , Beaudoin C , Volle DH
Analysis of the Reversible Impact of the Chemodrug Busulfan on Mouse Testes.
Published on 13 Sep 2021 in Cells , vol. 10
Thirouard L , Holota H , Monrose M , Garcia M , De Haze A , Saru JP , Caira F , Beaudoin C , Volle DH
New perspectives on PPAR, VDR and FXRα as new actors in testicular pathophysiology.
Published on 30 Apr 2021 in Molecular aspects of medicine , vol. 78 - pp 100886
Monrose M , Thirouard L , Garcia M , Holota H , De Haze A , Caira F , Beaudoin C , Volle DH
Farnesoid X receptor alpha (FXRα) is a critical actor of the development and pathologies of the male reproductive system.
Published on 30 Dec 2019 in Cellular and molecular life sciences : CMLS , vol. 76 - pp 4849-4859
Garcia M , Thirouard L , Monrose M , Holota H , De Haze A , Caira F , Beaudoin C , Volle DH
Fxralpha gene is a target gene of hCG signaling pathway and represses hCG induced steroidogenesis.
Published on 30 Nov 2019 in The Journal of steroid biochemistry and molecular biology , vol. 194 - pp 105460
Holota H , Thirouard L , Garcia M , Monrose M , de Haze A , Saru JP , Caira F , Beaudoin C , Volle DH
Cholesterol: A Gatekeeper of Male Fertility?
Published on 01 Jul 2018 in Frontiers in endocrinology , vol. 9 - pp 369
Sèdes L , Thirouard L , Maqdasy S , Garcia M , Caira F , Lobaccaro JA, Beaudoin C , Volle DH
Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders.
Published on 09 Oct 2018 in Stem cell reports , vol. 11 - pp 944-958
Sèdes L , Desdoits-Lethimonier C, Rouaisnel B , Holota H , Thirouard L , Lesne L, Damon-Soubeyrand C, Martinot E , Saru JP , Mazaud-Guittot S, Caira F , Beaudoin C , Jégou B, Volle DH
Multigenerational impacts of bile exposure are mediated by TGR5 signaling pathways.
Published on 15 Nov 2018 in Scientific reports , vol. 8 - pp 16875
Baptissart M , Sèdes L , Holota H , Thirouard L , Martinot E , de Haze A , Rouaisnel B , Caira F , Beaudoin C , Volle DH
Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases.
Published on 17 Nov 2018 in International journal of molecular sciences , vol. 19
Garcia M , Thirouard L , Sedès L , Monrose M , Holota H , Caira F , Volle DH , Beaudoin C
Bile acids and male fertility: From mouse to human?
Published on 01 Aug 2017 in Molecular aspects of medicine , vol. 56 - pp 101-109
Sèdes L , Martinot E , Baptissart M , Baron S , Caira F , Beaudoin C , Volle DH
The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate.
Published on 11 Jul 2017 in Stem cell reports , vol. 9 - pp 315-328
Martinot E , Sèdes L , Baptissart M , Holota H , Rouaisnel B , Damon-Soubeyrand C , De Haze A , Saru JP , Thibault-Carpentier C, Keime C, Lobaccaro JA, Baron S , Benoit G, Caira F , Beaudoin C , Volle DH
Bile acids and their receptors.
Published on 30 Aug 2017 in Molecular aspects of medicine , vol. 56 - pp 2-9
Martinot E , Sèdes L , Baptissart M , Lobaccaro JM , Caira F , Beaudoin C , Volle DH
Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha.
Published on 09 Feb 2017 in Scientific reports , vol. 7 - pp 42182
Martinot E , Baptissart M , Véga A , Sèdes L , Rouaisnel B , Vaz F, Saru JP , de Haze A , Baron S , Caira F , Beaudoin C , Volle DH
The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate.
Published on 11 Jul 2017 in Stem cell reports , vol. 9 - pp 315-328
Martinot E , Sèdes L , Baptissart M , Holota H , Rouaisnel B , Damon-Soubeyrand C, De Haze A , Saru JP , Thibault-Carpentier C, Keime C, Lobaccaro JA, Baron S , Benoit G, Caira F , Beaudoin C , Volle DH
Bile acids and male fertility: From mouse to human?
Published on 30 Aug 2017 in Molecular aspects of medicine , vol. 56 - pp 101-109
Sèdes L , Martinot E , Baptissart M , Baron S , Caira F , Beaudoin C , Volle DH
Bile acid-FXRα pathways regulate male sexual maturation in mice.
Published on 12 Apr 2016 in Oncotarget , vol. 7 - pp 19468-82
Baptissart M , Martinot E , Vega A , Sédes L , Rouaisnel B , de Haze A , Baron S , Schoonjans K, Caira F , Volle DH
Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context.
Published on 01 Oct 2015 in PloS one , vol. 10 - pp e0139946
Vega A , Martinot E , Baptissart M , De Haze A , Vaz F, Kulik W, Damon-Soubeyrand C, Baron S , Caira F , Volle DH
Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice.
Published on 02 Mar 2015 in Endocrinology , vol. 156 - pp 660-9
Vega A , Martinot E , Baptissart M , De Haze A , Saru JP , Baron S , Caira F , Schoonjans K, Lobaccaro JM , Volle DH
Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.
Published on 11 Apr 2014 in Biochemical and biophysical research communications , vol. 446 - pp 656-62
Oumeddour A , Viennois E, Caira F , Decourbey C, Maqdasy S , Tahraoui A, Baron S , Volle DH , Lobaccaro JM
Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.
Published on 30 May 2013 in PLoS genetics , vol. 9 - pp e1003483
Pommier AJ, Dufour J , Alves G, Viennois E, De Boussac H , Trousson A , Volle DH , Caira F , Val P , Arnaud P , Lobaccaro JM , Baron S
LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.
Published on 01 Mar 2013 in American journal of cancer research , vol. 3 - pp 58-69
de Boussac H , Pommier AJ, Dufour J , Trousson A , Caira F , Volle DH , Baron S , Lobaccaro JM
Bile acids: from digestion to cancers.
Published on 30 Mar 2013 in Biochimie , vol. 95 - pp 504-17
Baptissart M , Vega A , Maqdasy S , Caira F , Baron S , Lobaccaro JM , Volle DH
Emerging roles for LXRs and LRH-1 in female reproduction.
Published on 10 Apr 2013 in Molecular and cellular endocrinology , vol. 368 - pp 47-58
Mouzat K, Baron S , Marceau G , Caira F , Sapin V , Volle DH , Lumbroso S, Lobaccaro JM
Epigenetic: a molecular link between testicular cancer and environmental exposures.
Published on 01 Nov 2012 in Frontiers in endocrinology , vol. 3 - pp 150
Vega A , Baptissart M , Caira F , Brugnon F , Lobaccaro JM , Volle DH
Liver X receptors, lipids and their reproductive secrets in the male.
Published on 01 Aug 2011 in Biochimica et biophysica acta , vol. 1812 - pp 974-81
El-Hajjaji FZ, Oumeddour A , Pommier AJ, Ouvrier A, Viennois E, Dufour J , Caira F , Drevet JR , Volle DH, Baron S , Saez F , Lobaccaro JM
Liver X receptors, lipids and their reproductive secrets in the male.
Published on 30 Aug 2011 in Biochimica et biophysica acta , vol. 1812 - pp 974-81
El-Hajjaji FZ, Oumeddour A , Pommier AJ, Ouvrier A, Viennois E, Dufour J , Caira F , Drevet JR, Volle DH , Baron S , Saez F , Lobaccaro JM
Targeting liver X receptors in human health: deadlock or promising trail?
Published on 02 Mar 2011 in Expert opinion on therapeutic targets , vol. 15 - pp 219-32
Viennois E, Pommier AJ, Mouzat K, Oumeddour A , El Hajjaji FZ, Dufour J , Caira F , Volle DH , Baron S , Lobaccaro JM
Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.
Published on 06 May 2010 in Oncogene , vol. 29 - pp 2712-23
Pommier AJ, Alves G, Viennois E, Bernard S, Communal Y, Sion B, Marceau G , Damon C, Mouzat K, Caira F , Baron S , Lobaccaro JM
Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.
Published on 30 Jul 2009 in Endocrinology , vol. 150 - pp 3369-75
Mouzat K, Volat F, Baron S , Alves G, Pommier AJ, Volle DH , Marceau G , DeHaze A, Déchelotte P , Duggavathi R, Caira F , Lobaccaro JM
[Nuclear liver X receptors are involved in the biology of reproduction].
Published on 02 Mar 2009 in Medecine sciences : M/S , vol. 25 - pp 141-4
Mouzat K, Alves G, Pommier A, Viennois E, Pihen T, Caira F , Baron S , A Lobaccaro JM
Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.
Published on 30 Jun 2008 in Biology of reproduction , vol. 78 - pp 968-75
Henry-Berger J , Mouzat K, Baron S , Bernabeu C, Marceau G , Saru JP , Sapin V , Lobaccaro JM , Caira F
Liver X receptors regulate adrenal cholesterol balance.
Published on 30 Jul 2006 in The Journal of clinical investigation , vol. 116 - pp 1902-12
Cummins CL, Volle DH , Zhang Y, McDonald JG, Sion B, Lefrançois-Martinez AM , Caira F , Veyssière G, Mangelsdorf DJ, Lobaccaro JM
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.
Published on 30 Apr 2004 in Molecular endocrinology (Baltimore, Md.) , vol. 18 - pp 888-98
Volle DH , Repa JJ, Mazur A, Cummins CL, Val P , Henry-Berger J , Caira F , Veyssiere G, Mangelsdorf DJ, Lobaccaro JM
[Regulation of lipid metabolism by the orphan nuclear receptors].
Published on 30 Jun 2001 in Annales d'endocrinologie , vol. 62 - pp 239-47
Lobaccaro JM , Repa JJ, Lu TT, Caira F , Henry-Berger J , Volle DH , Mangelsdorf DJ
Toxicological evaluation of peroxisome proliferators. Further cellular and molecular aspects.
Published on 27 Dec 1996 in Annals of the New York Academy of Sciences , vol. 804 - pp 716-8
Passilly P, Pacot C, Jannin B, Cherkaoui Malki M, Bardot O , Caira F , Clemencet MC, Latruffe N
Transcriptional and post-transcriptional analysis of peroxisomal protein encoding genes from rat treated with an hypolipemic agent, ciprofibrate. Effect of an intermittent treatment and influence of obesity.
Published on 01 Mar 1995 in Biochemical pharmacology , vol. 49 - pp 611-9
