Christophe TATOUT

Chef d'équipe
HomeChristophe TATOUT

Chef d'équipe


2021-: Head of Master in Bio-informatics

2017-2021: Coordinator of the European COST-Action CA16212

2013: Professor of Genetics, Principal co-Investigator of Team 3 (GReD)
2009: Professor of Genetics, Blaise Pascal University, Dr Sylvette Tourmente's team (GReD)
1999-2009: Maize genetics and genomics team at Biogemma, Chappes.
2005: Habilitation à Diriger des Recherches (HDR)
1997-1999:  Postdoc, UMR CNRS 6457, Pr  Jean-Marc Deragon's team
1994-1997: Postdoc, Department of Zoology and Animal Biology, Geneva, Dr Vincenzo Pirrotta's team
1990-1993: PhD, URA360, Blaise Pascal University, France, Pr Hubert Pinon's team


Role of the nuclear periphery in chromatin organization

Discover how and why the spatial organization of chromatin impacts gene expression


It is becoming increasingly clear that the 3D organization of the genome within the nucleus has a profound influence on gene expression and several functional nuclear domains have been defined including the nuclear periphery. Many proteins components of the nuclear periphery have been described over the 10 last years (left side of the figure) and mutants affecting these proteins alter nuclear size and shape (right side of the figure) with for some of them significant impact on gene transcription. Despite the fact that the protein composition differs between animals and plants, the concept that the nuclear periphery is a functional interface influencing gene expression is conserved. Yet, the protein composition of the nuclear periphery in plants is still poorly documented and this motivated our research efforts to better understand the impact of the nuclear periphery on chromatin organization and transcription regulation.

Selected reviews : Tatout et al, Chromosome Res, 2014, and Parry et al, J. Cell Science, 2018) and research articles (Graumann et al, J. Exp. Bot., 2014, and Pawar et al 2016


40 publications

Image analysis workflows to reveal the spatial organization of cell nuclei and chromosomes.

Published on 30 Dec 2022 in Nucleus (Austin, Tex.) , vol. 13 - pp 277-299

Randall RS, Jourdain C, Nowicka A, Kaduchová K, Kubová M, Ayoub MA, Schubert V, Tatout C , Colas I, Kalyanikrishna, Desset S , Mermet S , Boulaflous-Stevens A, Kubalová I, Mandáková T, Heckmann S, Lysak MA, Panatta M, Santoro R, Schubert D, Pecinka A, Routh D, Baroux C

Deep learning — promises for 3D nuclear imaging: a guide for biologists.

Published on 01 Apr 2022 in Journal of cell science , vol. 135

Mougeot G , Dubos T , Chausse F, Péry E, Graumann K, Tatout C , Evans DE, Desset S


The Histone Chaperone HIRA Is a Positive Regulator of Seed Germination.

Published on 14 Apr 2021 in International journal of molecular sciences , vol. 22

Layat E , Bourcy M, Cotterell S , Zdzieszyńska J, Desset S , Duc C , Tatout C , Bailly C, Probst AV


Automated 3D bio-imaging analysis of nuclear organization by NucleusJ 2.0.

Published on 30 Dec 2020 in Nucleus (Austin, Tex.) , vol. 11 - pp 315-329

Dubos T , Poulet A , Gonthier-Gueret C, Mougeot G , Vanrobays E , Li Y , Tutois S , Pery E, Chausse F, Probst AV, Tatout C , Desset S

Untangling chromatin interactions.

Published on 17 Aug 2020 in Journal of experimental botany , vol. 71 - pp 5115-5118

Parry G, Pradillo M, Probst AV , Tatout C

The H3 histone chaperone NASP(SIM3) escorts CenH3 in Arabidopsis.

Published on 30 Jan 2020 in The Plant journal : for cell and molecular biology , vol. 101 - pp 71-86

Le Goff S , Keçeli BN, Jeřábková H, Heckmann S, Rutten T, Cotterell S , Schubert V, Roitinger E, Mechtler K, Franklin FCH, Tatout C , Houben A, Geelen D, Probst AV , Lermontova I


Probing the 3D architecture of the plant nucleus with microscopy approaches: challenges and solutions.

Published on 30 Dec 2019 in Nucleus (Austin, Tex.) , vol. 10 - pp 181-212

Dumur T, Duncan S, Graumann K, Desset S , Randall RS, Scheid OM, Prodanov D, Tatout C , Baroux C


Computational Methods for Studying the Plant Nucleus.

Published on 01 Jan 2018 in Methods in molecular biology (Clifton, N.J.) , vol. 1840 - pp 205-219

Poulet A , Zhou X, Tamura K, Meier I, Tatout C , Graumann K, Evans DE

Investigation of Nuclear Periphery Protein Interactions in Plants Using the Membrane Yeast Two-Hybrid (MbY2H) System.

Published on 01 Jan 2018 in Methods in molecular biology (Clifton, N.J.) , vol. 1840 - pp 221-235

Voisin M , Vanrobays E , Tatout C

Quantitative 3D Analysis of Nuclear Morphology and Heterochromatin Organization from Whole-Mount Plant Tissue Using NucleusJ.

Published on 01 Jan 2018 in Methods in molecular biology (Clifton, N.J.) , vol. 1675 - pp 615-632

Desset S , Poulet A , Tatout C

Genetic and epigenetic variation in 5S ribosomal RNA genes reveals genome dynamics in Arabidopsis thaliana.

Published on 06 Apr 2018 in Nucleic acids research , vol. 46 - pp 3019-3033

Simon L , Rabanal FA, Dubos T , Oliver C, Lauber D , Poulet A , Vogt A, Mandlbauer A, Le Goff S , Sommer A, Duborjal H, Tatout C , Probst AV

Spatial organization of chromosome territories in the interphase nucleus of trisomy 21 cells.

Published on 30 Jun 2018 in Chromosoma , vol. 127 - pp 247-259

Kemeny S, Tatout C , Salaun G, Pebrel-Richard C, Goumy C, Ollier N, Maurin E, Pereira B, Vago P, Gouas L

Meeting report – INDEPTH kick-off meeting.

Published on 25 Jun 2018 in Journal of cell science , vol. 131

Parry G, Probst AV, Baroux C, Tatout C


Arabidopsis ATRX Modulates H3.3 Occupancy and Fine-Tunes Gene Expression.

Published on 30 Jul 2017 in The Plant cell , vol. 29 - pp 1773-1793

Duc C , Benoit M , Détourné G , Simon L , Poulet A , Jung M, Veluchamy A, Latrasse D, Le Goff S , Cotterell S , Tatout C , Benhamed M, Probst AV

Exploring the evolution of the proteins of the plant nuclear envelope.

Published on 02 Jan 2017 in Nucleus (Austin, Tex.) , vol. 8 - pp 46-59

Poulet A , Probst AV, Graumann K, Tatout C , Evans D


A novel family of plant nuclear envelope-associated proteins.

Published on 30 Oct 2016 in Journal of experimental botany , vol. 67 - pp 5699-5710

Pawar V, Poulet A , Détourné G , Tatout C , Vanrobays E , Evans DE, Graumann K


Marker gene tethering by nucleoporins affects gene expression in plants.

Published on 01 Jan 2015 in Nucleus (Austin, Tex.) , vol. 6 - pp 471-8

Smith S, Galinha C, Desset S , Tolmie F, Evans D, Tatout C , Graumann K

NucleusJ: an ImageJ plugin for quantifying 3D images of interphase nuclei.

Published on 01 Apr 2015 in Bioinformatics (Oxford, England) , vol. 31 - pp 1144-6

Poulet A , Arganda-Carreras I, Legland D, Probst AV, Andrey P, Tatout C


The plant LINC complex at the nuclear envelope.

Published on 30 Jun 2014 in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology , vol. 22 - pp 241-52

Tatout C , Evans DE, Vanrobays E , Probst AV, Graumann K

Evolutionary history of Methyltransferase 1 genes in hexaploid wheat.

Published on 23 Oct 2014 in BMC genomics , vol. 15 - pp 922

Thomas M, Pingault L, Poulet A , Duarte J, Throude M, Faure S, Pichon JP, Paux E, Probst AV, Tatout C


Characterization of a cinnamoyl-CoA reductase 1 (CCR1) mutant in maize: effects on lignification, fibre development, and global gene expression.

Published on 30 Jul 2011 in Journal of experimental botany , vol. 62 - pp 3837-48

Tamasloukht B, Wong Quai Lam MS, Martinez Y, Tozo K, Barbier O, Jourda C, Jauneau A, Borderies G, Balzergue S, Renou JP, Huguet S, Martinant JP, Tatout C , Lapierre C, Barrière Y, Goffner D, Pichon M


empty pericarp4 encodes a mitochondrion-targeted pentatricopeptide repeat protein necessary for seed development and plant growth in maize.

Published on 30 Jan 2007 in The Plant cell , vol. 19 - pp 196-210

Gutiérrez-Marcos JF, Dal Prà M, Giulini A, Costa LM, Gavazzi G, Cordelier S, Sellam O, Tatout C , Paul W, Perez P, Dickinson HG, Consonni G


Two cytosolic glutamine synthetase isoforms of maize are specifically involved in the control of grain production.

Published on 30 Nov 2006 in The Plant cell , vol. 18 - pp 3252-74

Martin A, Lee J, Kichey T, Gerentes D, Zivy M, Tatout C , Dubois F, Balliau T, Valot B, Davanture M, Tercé-Laforgue T, Quilleré I, Coque M, Gallais A, Gonzalez-Moro MB, Bethencourt L, Habash DZ, Lea PJ, Charcosset A, Perez P, Murigneux A , Sakakibara H, Edwards KJ, Hirel B


UDP-glucose dehydrogenases of maize: a role in cell wall pentose biosynthesis.

Published on 15 Oct 2005 in The Biochemical journal , vol. 391 - pp 409-15

Kärkönen A, Murigneux A , Martinant JP, Pepey E, Tatout C , Dudley BJ, Fry SC


Extensive conservation of sequences and chromatin structures in the bxd polycomb response element among Drosophilid species.

Published on 30 Jan 2002 in The International journal of developmental biology , vol. 46 - pp 133-41

Dellino GI, Tatout C , Pirrotta V


Target sites for SINE integration in Brassica genomes display nuclear matrix binding activity.

Published on 01 Jan 2001 in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology , vol. 9 - pp 325-37

Tikhonov AP, Lavie L, Tatout C , Bennetzen JL, Avramova Z, Deragon JM


Structure of a polycomb response element and in vitro binding of polycomb group complexes containing GAGA factor.

Published on 30 May 2000 in Molecular and cellular biology , vol. 20 - pp 3187-97

Horard B, Tatout C , Poux S, Pirrotta V

P-element transposition in Drosophila melanogaster: influence of size and arrangement in pairs.

Published on 30 Apr 2000 in Molecular & general genetics : MGG , vol. 263 - pp 445-54

Delattre M, Tatout C , Coen D

Artificial and epigenetic regulation of the I factor, a nonviral retrotransposon of Drosophila melanogaster.

Published on 30 Dec 2000 in Genetics , vol. 156 - pp 1867-78

Gauthier E, Tatout C , Pinon H


Similar target site selection occurs in integration of plant and mammalian retroposons.

Published on 30 Oct 1998 in Journal of molecular evolution , vol. 47 - pp 463-70

Tatout C , Lavie L, Deragon JM

Rapid evaluation in Escherichia coli of antisense RNAs and ribozymes.

Published on 30 Nov 1998 in Letters in applied microbiology , vol. 27 - pp 297-301

Tatout C , Gauthier E, Pinon H


Germ-line expression of a functional LINE from Drosophila melanogaster: fine characterization allows for potential investigations of trans-regulators.

Published on 30 Mar 1994 in The International journal of developmental biology , vol. 38 - pp 27-33

Tatout C , Docquier M, Lachaume P, Mesure M, Lécher P, Pinon H

Christophe TATOUT

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