Jean-Christophe POINTUD
Maitre de Conférences
POINTUD
Jean-Christophe
Maitre de Conférences
MCF
Publications
Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.
Published on 21 Dec 2022 in Nature communications , vol. 13 - pp 7858
Dufour D , Dumontet T , Sahut-Barnola I, Carusi A, Onzon M , Pussard E, Wilmouth JJ , Olabe J , Lucas C , Levasseur A , Damon-Soubeyrand C , Pointud JC , Roucher-Boulez F , Tauveron I , Bossis G, Yeh ET, Breault DT, Val P , Lefrançois-Martinez AM, Martinez A
EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness.
Published on 30 Aug 2019 in British journal of cancer , vol. 121 - pp 384-394
Tabbal H , Septier A , Mathieu M , Drelon C , Rodriguez S , Djari C , Batisse-Lignier M , Tauveron I , Pointud JC , Sahut-Barnola I , Ragazzon B, Assié G, Bertherat J, Lefrançois-Martinez AM , Martinez A , Val P
Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex.
Published on 26 Dec 2018 in Proceedings of the National Academy of Sciences of the United States of America , vol. 115 - pp E12265-E12274
Mathieu M , Drelon C , Rodriguez S , Tabbal H , Septier A , Damon-Soubeyrand C , Dumontet T , Berthon A , Sahut-Barnola I , Djari C , Batisse-Lignier M , Pointud JC , Richard D, Kerdivel G, Calméjane MA, Boeva V, Tauveron I , Lefrançois-Martinez AM , Martinez A , Val P
P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model.
Published on 30 Aug 2017 in Oncogene , vol. 36 - pp 4445-4456
Batisse-Lignier M , Sahut-Barnola I , Tissier F, Dumontet T , Mathieu M , Drelon C , Pointud JC , Damon-Soubeyrand C , Marceau G , Kemeny JL, Bertherat J, Tauveron I , Val P , Martinez A , Lefrançois-Martinez AM
Aldose reductases influence prostaglandin F2α levels and adipocyte differentiation in male mouse and human species.
Published on 12 May 2015 in Endocrinology , vol. 156 - pp 1671-84
Pastel E , Pointud JC , Loubeau G , Dani C, Slim K, Martin G, Volat F, Sahut-Barnola I , Val P , Martinez A , Lefrançois-Martinez AM
‘Auto-click’ functionalization for diversified copper(I) and gold(I) NHCs.
Published on 21 May 2014 in Dalton transactions (Cambridge, England : 2003) , vol. 43 - pp 6981-9
Ibrahim H, Gibard C, Hesling C , Guillot R, Morel L , Gautier A, Cisnetti F
Aldo-Keto Reductases 1B in Endocrinology and Metabolism.
Published on 02 Aug 2012 in Frontiers in pharmacology , vol. 3 - pp 148
Pastel E , Pointud JC , Volat F, Martinez A , Lefrançois-Martinez AM
Depressed levels of prostaglandin F2α in mice lacking Akr1b7 increase basal adiposity and predispose to diet-induced obesity.
Published on 30 Nov 2012 in Diabetes , vol. 61 - pp 2796-806
Volat FE, Pointud JC , Pastel E , Morio B, Sion B, Hamard G, Guichardant M, Colas R, Lefrançois-Martinez AM , Martinez A
Transcriptional control of adrenal steroidogenesis: novel connection between Janus kinase (JAK) 2 protein and protein kinase A (PKA) through stabilization of cAMP response element-binding protein (CREB) transcription factor.
Published on 23 Sep 2011 in The Journal of biological chemistry , vol. 286 - pp 32976-85
Lefrancois-Martinez AM , Blondet-Trichard A, Binart N, Val P , Chambon C, Sahut-Barnola I , Pointud JC , Martinez A
Cushing’s syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.
Published on 10 Jun 2010 in PLoS genetics , vol. 6 - pp e1000980
Sahut-Barnola I , de Joussineau C , Val P , Lambert-Langlais S, Damon C, Lefrançois-Martinez AM, Pointud JC , Marceau G , Sapin V , Tissier F, Ragazzon B, Bertherat J, Kirschner LS, Stratakis CA, Martinez A
Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions.
Published on 07 Oct 2009 in PloS one , vol. 4 - pp e7309
Lambert-Langlais S, Pointud JC , Lefrançois-Martinez AM , Volat F, Manin M, Coudoré F, Val P , Sahut-Barnola I , Ragazzon B, Louiset E, Delarue C, Lefebvre H, Urade Y, Martinez A
Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7.
Published on 02 Mar 2009 in Journal of biochemistry , vol. 145 - pp 161-8
Kabututu Z, Manin M, Pointud JC , Maruyama T, Nagata N, Lambert S , Lefrançois-Martinez AM, Martinez A , Urade Y
Mouse model for bilateral adrenal hyperplasia.
Published on 30 Jun 2009 in Annales d'endocrinologie , vol. 70 - pp 194
Sahut-Barnola I , De Joussineau C , Val P , Lambert-Langlais S, Lefrançois-Martinez AM , Pointud JC , Marceau G , Sapin V , Ragazzon B, Bertherat J, Kirschner LS, Stratakis CA, Martinez A
