Cyrille DE JOUSSINEAU

Maitre de Conférences
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DE JOUSSINEAU
Cyrille
Maitre de Conférences
MCF

Resume

Diplomas

PhD: University of Montpellier II, 1999-2003: "Involvement of cell extensions emitted by the precursors of peripheral sensory organs in a form of remote lateral inhibition in Drosophila: evidence of the role of the Delta protein in their elongation".

Habilitation à Diriger des Recherches : University of Clermont Auvergne, 2021: "Modeling epithelial tumorigenesis in the accessory gland of Drosophila".

Career

Post-doctorate: Cardiff University, 2005-2007: Effect of thiazides on osteoblastic differentiation and mechanisms of osteoporosis.

Post-doctorate: Blaise Pascal University, 2007-2010: Mechanisms of adrenal gland tumorigenesis in a pathophysiological model.

Post-doctorate: University of Auvergne, 2011-2012: Mechanisms of embryonic muscle development.

Senior Lecturer: University of Clermont Auvergne, since 2012: Early epithelial tumorigenesis and pathways to tumor aggressiveness.

Research

Although the ten most frequent cancers are adenocarcinomas, early epithelial tumorigenesis is poorly described and the molecular mechanisms associated with this stage and with the acquisition of tumor aggressiveness remain poorly understood. In this context, we have developed a model specifically dedicated to the study of these stages, in the Drosophila accessory gland. Thus, we benefit from a genetically powerful model, which respects ethical rules (3R compatible model) but which nevertheless allows to follow how tumors appear and evolve in vivo.

Our past and present results show that early epithelial tumorigenesis consists in fact in several distinct steps associated to activation of specific signaling pathways, and that some pathways, but not others, are involved in tumor aggressiveness. Our ambition is to propose a unified model of early epithelial tumorigenesis and to test the importance of the discovered mechanisms in the evolution of epithelial cancers.

Publications

16 publications
2022

Diversification of muscle types in Drosophila embryos.

Published on 01 Jan 2022 in Experimental cell research , vol. 410 - pp 112950

Junion G , Jagla K

2019

Individual Comparison of Cholesterol Metabolism in Normal and Tumour Areas in Radical Prostatectomy Specimens from Patients with Prostate Cancer: Results of the CHOMECAP Study.

Published on 30 Mar 2019 in European urology oncology , vol. 2 - pp 198-206

Celhay O , Bousset L , Guy L, Kemeny JL, Leoni V, Caccia C, Trousson A , Damon-Soubeyrant C, De Haze A , Sabourin L, Godfraind C, de Joussineau C , Pereira B, Morel L , Lobaccaro JM , Baron S

2016

mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.

Published on 18 May 2016 in Cell cycle (Georgetown, Tex.) , vol. 15 - pp 1352-62

Boudra R , Lagrafeuille R, Lours-Calet C, de Joussineau C , Loubeau-Legros G, Chaveroux C, Saru JP , Baron S , Morel L , Beaudoin C

2012

Diversification of muscle types in Drosophila: upstream and downstream of identity genes.

Published on 01 Jan 2012 in Current topics in developmental biology , vol. 98 - pp 277-301

de Joussineau C , Bataillé L, Jagla T , Jagla K

The cAMP pathway and the control of adrenocortical development and growth.

Published on 31 Mar 2012 in Molecular and cellular endocrinology , vol. 351 - pp 28-36

de Joussineau C , Sahut-Barnola I , Levy I, Saloustros E, Val P , Stratakis CA, Martinez A

AKR

Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models.

Published on 28 Aug 2012 in PloS one , vol. 7 - pp e44171

Drelon C , Berthon A , Ragazzon B, Tissier F, Bandiera R, Sahut-Barnola I, de Joussineau C , Batisse-Lignier M , Lefrançois-Martinez AM, Bertherat J, Martinez A , Val P

AKR
2010

Cushing’s syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.

Published on 10 Jun 2010 in PLoS genetics , vol. 6 - pp e1000980

Sahut-Barnola I , de Joussineau C , Val P , Lambert-Langlais S, Damon C, Lefrançois-Martinez AM, Pointud JC , Marceau G , Sapin V , Tissier F, Ragazzon B, Bertherat J, Kirschner LS, Stratakis CA, Martinez A

AKR

Gene dosage effects and transcriptional regulation of early mammalian adrenal cortex development.

Published on 08 Jul 2010 in Molecular and cellular endocrinology , vol. 323 - pp 105-14

Val P , Swain A

AKR

Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.

Published on 15 Apr 2010 in Human molecular genetics , vol. 19 - pp 1561-76

Berthon A , Sahut-Barnola I , Lambert-Langlais S, de Joussineau C , Damon-Soubeyrand C , Louiset E, Taketo MM, Tissier F, Bertherat J, Lefrançois-Martinez AM, Martinez A , Val P

AKR
2009

Mouse model for bilateral adrenal hyperplasia.

Published on 30 Jun 2009 in Annales d'endocrinologie , vol. 70 - pp 194

Sahut-Barnola I , De Joussineau C , Val P , Lambert-Langlais S, Lefrançois-Martinez AM , Pointud JC , Marceau G , Sapin V , Ragazzon B, Bertherat J, Kirschner LS, Stratakis CA, Martinez A

AKR

Diversification of muscle types in Drosophila: upstream and downstream of identity genes.

in Current topics in developmental biology , vol. 98 - pp 277-301

de Joussineau C , Bataillé L, Jagla T , Jagla K

Contact
Cyrille DE JOUSSINEAU

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