Cyrille DE JOUSSINEAU
Maitre de Conférences
DE JOUSSINEAU
Cyrille
Maitre de Conférences
MCF
Resume
Diplomas
PhD: University of Montpellier II, 1999-2003: "Involvement of cell extensions emitted by the precursors of peripheral sensory organs in a form of remote lateral inhibition in Drosophila: evidence of the role of the Delta protein in their elongation".
Habilitation à Diriger des Recherches : University of Clermont Auvergne, 2021: "Modeling epithelial tumorigenesis in the accessory gland of Drosophila".
Career
Post-doctorate: Cardiff University, 2005-2007: Effect of thiazides on osteoblastic differentiation and mechanisms of osteoporosis.
Post-doctorate: Blaise Pascal University, 2007-2010: Mechanisms of adrenal gland tumorigenesis in a pathophysiological model.
Post-doctorate: University of Auvergne, 2011-2012: Mechanisms of embryonic muscle development.
Senior Lecturer: University of Clermont Auvergne, since 2012: Early epithelial tumorigenesis and pathways to tumor aggressiveness.
Research
Although the ten most frequent cancers are adenocarcinomas, early epithelial tumorigenesis is poorly described and the molecular mechanisms associated with this stage and with the acquisition of tumor aggressiveness remain poorly understood. In this context, we have developed a model specifically dedicated to the study of these stages, in the Drosophila accessory gland. Thus, we benefit from a genetically powerful model, which respects ethical rules (3R compatible model) but which nevertheless allows to follow how tumors appear and evolve in vivo.
Our past and present results show that early epithelial tumorigenesis consists in fact in several distinct steps associated to activation of specific signaling pathways, and that some pathways, but not others, are involved in tumor aggressiveness. Our ambition is to propose a unified model of early epithelial tumorigenesis and to test the importance of the discovered mechanisms in the evolution of epithelial cancers.
Publications
Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis.
Published on 06 Jun 2024 in Cancers , vol. 16
Vialat M , Baabdaty E , Trousson A , Kocer A , Lobaccaro JA, Baron S , Morel L , de Joussineau C
Liver X Receptors Enhance Epithelial to Mesenchymal Transition in Metastatic Prostate Cancer Cells.
Published on 06 Aug 2024 in Cancers , vol. 16
Bouchareb E , Dallel S , De Haze A , Damon-Soubeyrand C , Renaud Y , Baabdaty E , Vialat M , Fabre J , Pouchin P , De Joussineau C , Degoul F , Sanmukh S, Gendronneau J , Sanchez P, Gonthier-Gueret C, Trousson A , Morel L , Lobaccaro JM , Kocer A , Baron S
Persistent organic pollutants promote aggressiveness in prostate cancer.
Published on 01 Sep 2023 in Oncogene , vol. 42 - pp 2854-2867
Buñay J, Kossai M, Damon-Soubeyrant C, De Haze A , Saru JP , Trousson A , de Joussineau C , Bouchareb E , Kocer A , Vialat M , Dallel S , Degoul F , Bost F, Clavel S, Penault-Llorca F, Valli MP, Guy L, Matthews J, Renaud Y , Ittmann M, Jones J, Morel L , Lobaccaro JM , Baron S
Diversification of muscle types in Drosophila embryos.
Published on 01 Jan 2022 in Experimental cell research , vol. 410 - pp 112950
Screening for liver X receptor modulators: Where are we and for what use?
Published on 01 Aug 2021 in British journal of pharmacology , vol. 178 - pp 3277-3293
Buñay J, Fouache A , Trousson A , de Joussineau C , Bouchareb E , Zhu Z , Kocer A , Morel L , Baron S , Lobaccaro JA
MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin.
Published on 26 Aug 2021 in Journal of experimental & clinical cancer research : CR , vol. 40 - pp 270
Luo Y, Vlaeminck-Guillem V, Baron S , Dallel S , Zhang CX, Le Romancer M
Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer.
Published on 10 Sep 2021 in Cells , vol. 10
Rambur A , Vialat M , Beaudoin C , Lours-Calet C, Lobaccaro JM , Baron S , Morel L , de Joussineau C
Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives.
Published on 23 May 2020 in International journal of molecular sciences , vol. 21
Bayala B , Zoure AA, Baron S , de Joussineau C , Simpore J, Lobaccaro JM
Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia.
Published on 07 Dec 2020 in PLoS biology , vol. 18 - pp e3000948
Bousset L , Septier A , Bunay J, Voisin A , Guiton R , Damon-Soubeyrant C, Renaud Y , De Haze A , Sapin V , Fogli A , Rambur A , De Joussineau C , Kocer A , Trousson A , Henry-Berger J , Höring M, Liebisch G, Matysik S, Lobaccaro JA, Morel L , Baron S
Multiple functions of the scaffold protein Discs large 5 in the control of growth, cell polarity and cell adhesion in Drosophila melanogaster.
Published on 18 Jun 2020 in BMC developmental biology , vol. 20 - pp 10
Venugopal P , Veyssière H , Couderc JL , Richard G , Vachias C , Mirouse V
Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation.
Published on 08 Apr 2020 in Development (Cambridge, England) , vol. 147
Cerqueira Campos F , Dennis C , Alégot H , Fritsch C , Isabella A, Pouchin P , Bardot O , Horne-Badovinac S, Mirouse V
Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila.
Published on 08 May 2020 in Nature communications , vol. 11 - pp 2300
Rambur A , Lours-Calet C, Beaudoin C , Buñay J, Vialat M , Mirouse V , Trousson A , Renaud Y , Lobaccaro JA, Baron S , Morel L , de Joussineau C
Flavonoids differentially modulate liver X receptors activity-Structure-function relationship analysis.
Published on 01 Jun 2019 in The Journal of steroid biochemistry and molecular biology , vol. 190 - pp 173-182
Fouache A , Zabaiou N , De Joussineau C , Morel L , Silvente-Poirot S, Namsi A, Lizard G, Poirot M, Makishima M, Baron S , Lobaccaro JA, Trousson A
Individual Comparison of Cholesterol Metabolism in Normal and Tumour Areas in Radical Prostatectomy Specimens from Patients with Prostate Cancer: Results of the CHOMECAP Study.
Published on 30 Mar 2019 in European urology oncology , vol. 2 - pp 198-206
Celhay O , Bousset L , Guy L, Kemeny JL, Leoni V, Caccia C, Trousson A , Damon-Soubeyrant C, De Haze A , Sabourin L, Godfraind C, de Joussineau C , Pereira B, Morel L , Lobaccaro JM , Baron S
New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors.
Published on 28 Aug 2018 in International journal of molecular sciences , vol. 19
Bousset L , Rambur A , Fouache A , Bunay J, Morel L , Lobaccaro JA, Baron S , Trousson A , de Joussineau C
mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.
Published on 18 May 2016 in Cell cycle (Georgetown, Tex.) , vol. 15 - pp 1352-62
Boudra R , Lagrafeuille R, Lours-Calet C, de Joussineau C , Loubeau-Legros G, Chaveroux C, Saru JP , Baron S , Morel L , Beaudoin C
mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD).
Published on 15 Oct 2014 in Human molecular genetics , vol. 23 - pp 5418-28
de Joussineau C , Sahut-Barnola I , Tissier F, Dumontet T , Drelon C , Batisse-Lignier M , Tauveron I , Pointud JC , Lefrançois-Martinez AM , Stratakis CA, Bertherat J, Val P , Martinez A
Diversification of muscle types in Drosophila: upstream and downstream of identity genes.
Published on 01 Jan 2012 in Current topics in developmental biology , vol. 98 - pp 277-301
de Joussineau C , Bataillé L, Jagla T , Jagla K
The cAMP pathway and the control of adrenocortical development and growth.
Published on 31 Mar 2012 in Molecular and cellular endocrinology , vol. 351 - pp 28-36
de Joussineau C , Sahut-Barnola I , Levy I, Saloustros E, Val P , Stratakis CA, Martinez A
Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models.
Published on 28 Aug 2012 in PloS one , vol. 7 - pp e44171
Drelon C , Berthon A , Ragazzon B, Tissier F, Bandiera R, Sahut-Barnola I, de Joussineau C , Batisse-Lignier M , Lefrançois-Martinez AM, Bertherat J, Martinez A , Val P
Cushing’s syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.
Published on 10 Jun 2010 in PLoS genetics , vol. 6 - pp e1000980
Sahut-Barnola I , de Joussineau C , Val P , Lambert-Langlais S, Damon C, Lefrançois-Martinez AM, Pointud JC , Marceau G , Sapin V , Tissier F, Ragazzon B, Bertherat J, Kirschner LS, Stratakis CA, Martinez A
Gene dosage effects and transcriptional regulation of early mammalian adrenal cortex development.
Published on 08 Jul 2010 in Molecular and cellular endocrinology , vol. 323 - pp 105-14
Val P , Swain A
Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.
Published on 15 Apr 2010 in Human molecular genetics , vol. 19 - pp 1561-76
Berthon A , Sahut-Barnola I , Lambert-Langlais S, de Joussineau C , Damon-Soubeyrand C , Louiset E, Taketo MM, Tissier F, Bertherat J, Lefrançois-Martinez AM, Martinez A , Val P
Mouse model for bilateral adrenal hyperplasia.
Published on 30 Jun 2009 in Annales d'endocrinologie , vol. 70 - pp 194
Sahut-Barnola I , De Joussineau C , Val P , Lambert-Langlais S, Lefrançois-Martinez AM , Pointud JC , Marceau G , Sapin V , Ragazzon B, Bertherat J, Kirschner LS, Stratakis CA, Martinez A
Diversification of muscle types in Drosophila: upstream and downstream of identity genes.
in Current topics in developmental biology , vol. 98 - pp 277-301
de Joussineau C , Bataillé L, Jagla T , Jagla K
