Pierre VAL

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HomePierre VAL


2016 Group Leader MOP@ET team

2016 Research Director CNRS

2007 Research Associate CNRS

2003-2007 Post-doctoral Researcher, Institute of Cancer Research, London UK

1999-2003 PhD Student, Blaise Pascal University Clermont-Ferrand


I am interested in the molecular mechanisms involved in the control of adrenal gland homeostasis and how their deregulation contributes to the development of pathologies. My group has demonstrated the key role of an equilibrium between WNT/b-catenin and PKA signalling pathways and of the histone methyltransferase EZH2, in establishing and maintaining the zonal differentiation pattern of the adrenal cortex. We have also shown involvement of these pathways in adrenal pathophysiology, including insufficiency (LGR4 mutations), formation of hormonally active adenomas (b-catenin and PKA), and development of aggressive cancers (alterations of b-catenin, ZNRF3 and TP53 and overexpression of EZH2). I currently investigate the role of the immune microenvironment and in particular macrophages, in the control of endocrine differentiation and cortical cell renewal, as well as in tumour initiation and progression. In this context, we have recently shown that macrophages play a central role in preventing adrenocortical carcinoma progression and in the sexual dimorphism of this cancer.


40 publications

Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.

Published on 21 Dec 2022 in Nature communications , vol. 13 - pp 7858

Dufour D , Dumontet T , Sahut-Barnola I, Carusi A, Onzon M , Pussard E, Wilmouth JJ , Olabe J , Lucas C , Levasseur A , Damon-Soubeyrand C , Pointud JC , Roucher-Boulez F , Tauveron I , Bossis G, Yeh ET, Breault DT, Val P , Lefrançois-Martinez AM, Martinez A


β-Catenin activation and illicit receptor expression in adrenocortical cells.

Published on 07 Feb 2022 in Endocrine-related cancer , vol. 29 - pp 151-162

Le Mestre J, Thomas M, Duparc C, Val P , Bures C, Tuech JJ, Sabourin JC, Baert-Desurmont S, Lefebvre H, Louiset E


Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome.

Published on 12 Nov 2022 in The Journal of investigative dermatology , vol. 142 - pp 2949-2957.e9

Sahut-Barnola I , Lefrançois-Martinez AM , Dufour D , Botto JM, Kamilaris C, Faucz FR, Stratakis CA, Val P , Martinez A


Loss of LGR4/GPR48 causes severe neonatal salt-wasting due to disrupted WNT signaling altering adrenal zonation.

Published on 20 Dec 2022 in The Journal of clinical investigation

Lucas C , Sauter KS, Steigert M, Mallet D, Wilmouth J Jr , Olabe J , Plotton I, Morel Y, Aeberli D, Wagner F, Clevers H, Pandey AV, Val P , Roucher-Boulez F , Fluck CE


Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.

Published on 01 Dec 2021 in The Journal of clinical investigation , vol. 131

Djari C , Sahut-Barnola I , Septier A , Plotton I, Montanier N , Dufour D , Levasseur A , Wilmouth J Jr , Pointud JC , Faucz FR, Kamilaris C, Lopez AG, Guillou F, Swain A, Vainio SJ, Tauveron I , Val P , Lefebvre H, Stratakis CA, Martinez A , Lefrançois-Martinez AM


How can we minimise the use of regular oral corticosteroids in asthma?

Published on 31 Mar 2020 in European respiratory review : an official journal of the European Respiratory Society , vol. 29

Bourdin A, Adcock I, Berger P, Bonniaud P, Chanson P, Chenivesse C, de Blic J, Deschildre A, Devillier P, Devouassoux G, Didier A, Garcia G, Magnan A, Martinat Y, Perez T, Roche N, Taillé C, Val P , Chanez P


A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.

Published on 01 Feb 2019 in Genes & development , vol. 33 - pp 209-220

Basham KJ, Rodriguez S , Turcu AF, Lerario AM, Logan CY, Rysztak MR, Gomez-Sanchez CE, Breault DT, Koo BK, Clevers H, Nusse R, Val P , Hammer GD


Hormonal and spatial control of SUMOylation in the human and mouse adrenal cortex.

Published on 12 Sep 2019 in FASEB journal : official publication of the Federation of American Societies for Experimental Biology , vol. 33 - pp 10218-10230

Dumontet T , Sahut-Barnola I , Dufour D , Lefrançois-Martinez AM , Berthon A , Montanier N , Ragazzon B, Djari C , Pointud JC , Roucher-Boulez F , Batisse-Lignier M , Tauveron I , Bertherat J, Val P , Martinez A


Editorial: Adrenal Cortex: From Physiology to Disease.

Published on 01 Jun 2016 in Frontiers in endocrinology , vol. 7 - pp 51

Val P , Martinez A


Pregnancy, Primary Aldosteronism, and Somatic CTNNB1 Mutations.

Published on 14 Apr 2016 in The New England journal of medicine , vol. 374 - pp 1493-4

Berthon A , Drelon C , Val P


EZH2 is overexpressed in adrenocortical carcinoma and is associated with disease progression.

Published on 01 Jul 2016 in Human molecular genetics , vol. 25 - pp 2789-2800

Drelon C, Berthon A, Mathieu M, Ragazzon B, Kuick R, Tabbal H, Septier A, Rodriguez S, Batisse-Lignier M, Sahut-Barnola I, Dumontet T, Pointud JC, Lefrançois-Martinez AM, Baron S , Giordano TJ, Bertherat J, Martinez A, Val P


Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma.

Published on 27 Jul 2015 in Oncogenesis , vol. 4 - pp e161

Lefèvre L, Omeiri H, Drougat L, Hantel C, Giraud M, Val P , Rodriguez S , Perlemoine K, Blugeon C, Beuschlein F, de Reyniès A, Rizk-Rabin M, Bertherat J, Ragazzon B


Adrenal cortex tissue homeostasis and zonation: A WNT perspective.

Published on 15 Jun 2015 in Molecular and cellular endocrinology , vol. 408 - pp 156-64

Drelon C , Berthon A , Mathieu M , Martinez A , Val P


WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production.

Published on 15 Feb 2014 in Human molecular genetics , vol. 23 - pp 889-905

Berthon A , Drelon C , Ragazzon B, Boulkroun S, Tissier F, Amar L, Samson-Couterie B, Zennaro MC, Plouin PF, Skah S, Plateroti M, Lefèbvre H, Sahut-Barnola I , Batisse-Lignier M , Assié G, Lefrançois-Martinez AM , Bertherat J, Martinez A , Val P


Adrenocortical cancer and IGF2: is the game over or our experimental models limited?

Published on 12 Feb 2013 in The Journal of clinical endocrinology and metabolism , vol. 98 - pp 505-7

Drelon C , Berthon A , Val P


The cAMP pathway and the control of adrenocortical development and growth.

Published on 31 Mar 2012 in Molecular and cellular endocrinology , vol. 351 - pp 28-36

de Joussineau C , Sahut-Barnola I , Levy I, Saloustros E, Val P , Stratakis CA, Martinez A


Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models.

Published on 28 Aug 2012 in PloS one , vol. 7 - pp e44171

Drelon C , Berthon A , Ragazzon B, Tissier F, Bandiera R, Sahut-Barnola I, de Joussineau C , Batisse-Lignier M , Lefrançois-Martinez AM, Bertherat J, Martinez A , Val P


Wnt/β-catenin signalling in adrenal physiology and tumour development.

Published on 31 Mar 2012 in Molecular and cellular endocrinology , vol. 351 - pp 87-95

Berthon A , Martinez A , Bertherat J, Val P


In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland.

Published on 12 Dec 2012 in Development (Cambridge, England) , vol. 139 - pp 4561-70

Buaas FW, Gardiner JR, Clayton S, Val P , Swain A


Cushing’s syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.

Published on 10 Jun 2010 in PLoS genetics , vol. 6 - pp e1000980

Sahut-Barnola I , de Joussineau C , Val P , Lambert-Langlais S, Damon C, Lefrançois-Martinez AM, Pointud JC , Marceau G , Sapin V , Tissier F, Ragazzon B, Bertherat J, Kirschner LS, Stratakis CA, Martinez A


Gene dosage effects and transcriptional regulation of early mammalian adrenal cortex development.

Published on 08 Jul 2010 in Molecular and cellular endocrinology , vol. 323 - pp 105-14

Val P , Swain A


Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.

Published on 15 Apr 2010 in Human molecular genetics , vol. 19 - pp 1561-76

Berthon A , Sahut-Barnola I , Lambert-Langlais S, de Joussineau C , Damon-Soubeyrand C , Louiset E, Taketo MM, Tissier F, Bertherat J, Lefrançois-Martinez AM, Martinez A , Val P


Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions.

Published on 07 Oct 2009 in PloS one , vol. 4 - pp e7309

Lambert-Langlais S, Pointud JC , Lefrançois-Martinez AM , Volat F, Manin M, Coudoré F, Val P , Sahut-Barnola I , Ragazzon B, Louiset E, Delarue C, Lefebvre H, Urade Y, Martinez A


The transcription co-factor CITED2 functions during sex determination and early gonad development.

Published on 15 Aug 2009 in Human molecular genetics , vol. 18 - pp 2989-3001

Buaas FW, Val P , Swain A


A transgenic mouse line with specific Cre recombinase expression in the adrenal cortex.

Published on 05 Mar 2009 in Molecular and cellular endocrinology , vol. 300 - pp 197-204

Lambert-Langlais S, Val P , Guyot S, Ragazzon B, Sahut-Barnola I , De Haze A , Lefrançois-Martinez AM , Martinez A


Mouse model for bilateral adrenal hyperplasia.

Published on 30 Jun 2009 in Annales d'endocrinologie , vol. 70 - pp 194

Sahut-Barnola I , De Joussineau C , Val P , Lambert-Langlais S, Lefrançois-Martinez AM , Pointud JC , Marceau G , Sapin V , Ragazzon B, Bertherat J, Kirschner LS, Stratakis CA, Martinez A


Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage.

Published on 30 Jun 2007 in Development (Cambridge, England) , vol. 134 - pp 2349-58

Val P , Martinez-Barbera JP, Swain A


Identification of a novel population of adrenal-like cells in the mammalian testis.

Published on 01 Nov 2006 in Developmental biology , vol. 299 - pp 250-6

Val P , Jeays-Ward K, Swain A


Pierre VAL

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