Ayhan KOCER
Maitre de Conférences
KOCER
Ayhan
Maitre de Conférences
Associate Professor
Research
After focusing my research (more than 15 years) in the field of reproductive biology and development. I acquired insight in sperm maturation and more particularly in the compaction of sperm nuclear chromatin and the epigenetic marks . In 2019, I decided to focus my research on the metastatic process of cancer cells in a context of deregulation of cholesterol metabolism
Publications
Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis.
Published on 06 Jun 2024 in Cancers , vol. 16
Vialat M , Baabdaty E , Trousson A , Kocer A , Lobaccaro JA, Baron S , Morel L , de Joussineau C
Liver X Receptors Enhance Epithelial to Mesenchymal Transition in Metastatic Prostate Cancer Cells.
Published on 06 Aug 2024 in Cancers , vol. 16
Bouchareb E , Dallel S , De Haze A , Damon-Soubeyrand C , Renaud Y , Baabdaty E , Vialat M , Fabre J , Pouchin P , De Joussineau C , Degoul F , Sanmukh S , Gendronneau J , Sanchez P , Gonthier-Gueret C , Trousson A , Morel L , Lobaccaro JM , Kocer A , Baron S
Persistent organic pollutants promote aggressiveness in prostate cancer.
Published on 01 Sep 2023 in Oncogene , vol. 42 - pp 2854-2867
Buñay J, Kossai M, Damon-Soubeyrant C, De Haze A , Saru JP , Trousson A , de Joussineau C , Bouchareb E , Kocer A , Vialat M , Dallel S , Degoul F , Bost F, Clavel S, Penault-Llorca F, Valli MP, Guy L, Matthews J, Renaud Y , Ittmann M, Jones J, Morel L , Lobaccaro JM , Baron S
Three-dimensional imaging of vascular development in the mouse epididymis.
Published on 13 Jun 2023 in eLife , vol. 12
Damon-Soubeyrand C , Bongiovanni A, Chorfa A , Goubely C , Pirot N, Pardanaud L, Piboin-Fragner L, Vachias C , Bravard S , Guiton R , Thomas JL, Saez F , Kocer A , Tardivel M, Drevet JR , Henry-Berger J
Screening for liver X receptor modulators: Where are we and for what use?
Published on 01 Aug 2021 in British journal of pharmacology , vol. 178 - pp 3277-3293
Buñay J, Fouache A , Trousson A , de Joussineau C , Bouchareb E , Zhu Z , Kocer A , Morel L , Baron S , Lobaccaro JA
Three-dimensional confocal analysis of chromosome positioning coupled with immunofluorescence in mouse sperm nuclei
Published on 01 Jan 2021 in Methods in molecular biology (Clifton, N.J.) , vol. 2198 - pp 255-268
Champroux A , Goubely C , Henry-Berger J , Drevet JR , Kocer A
LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames.
Published on 07 Jun 2021 in Communications biology , vol. 4 - pp 691
Blythe MJ, Kocer A , Rubio-Roldan A, Giles T, Abakir A, Ialy-Radio C, Wheldon LM, Bereshchenko O, Bruscoli S, Kondrashov A, Drevet JR , Emes RD, Johnson AD, McCarrey JR, Gackowski D, Olinski R, Cocquet J, Garcia-Perez JL, Ruzov A
Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia.
Published on 07 Dec 2020 in PLoS biology , vol. 18 - pp e3000948
Bousset L , Septier A , Bunay J, Voisin A , Guiton R , Damon-Soubeyrant C, Renaud Y , De Haze A , Sapin V , Fogli A , Rambur A , De Joussineau C , Kocer A , Trousson A , Henry-Berger J , Höring M, Liebisch G, Matysik S, Lobaccaro JA, Morel L , Baron S
Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.
Published on 01 Nov 2020 in Asian journal of andrology , vol. 22 - pp 590-601
Chu C, Yu L, Henry-Berger J , Ru YF, Kocer A , Champroux A , Li ZT, He M, Xie SS, Ma WB, Ni MJ, Ni ZM, Guo YL, Fei ZL, Gou LT, Liu Q, Sharma S, Zhou Y, Liu MF, Chen CD, Eamens AL, Nixon B, Zhou YC, Drevet JR , Zhang YL
Comprehensive overview of murine epididymal mononuclear phagocytes and lymphocytes: Unexpected populations arise.
Published on 01 Apr 2018 in Journal of reproductive immunology , vol. 126 - pp 11-17
Voisin A , Whitfield M , Damon-Soubeyrand C , Goubely C , Henry-Berger J , Saez F , Kocer A , Drevet JR , Guiton R
A Decade of Exploring the Mammalian Sperm Epigenome: Paternal Epigenetic and Transgenerational Inheritance.
Published on 15 May 2018 in Frontiers in cell and developmental biology , vol. 6 - pp 50
Champroux A , Cocquet J, Henry-Berger J , Drevet JR , Kocer A
Accuracy of human sperm DNA oxidation quantification and threshold determination using an 8-OHdG immuno-detection assay.
Published on 01 Apr 2018 in Human reproduction (Oxford, England) , vol. 33 - pp 553-562
Vorilhon S , Brugnon F , Kocer A , Dollet S, Bourgne C, Berger M, Janny L , Pereira B, Aitken RJ, Moazamian A , Gharagozloo P, Drevet J , Pons-Rejraji H
Nuclear Integrity but Not Topology of Mouse Sperm Chromosome is Affected by Oxidative DNA Damage.
Published on 17 Oct 2018 in Genes , vol. 9
Champroux A , Damon-Soubeyrand C , Goubely C , Bravard S , Henry-Berger J , Guiton R , Saez F , Drevet J , Kocer A
SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation.
Published on 01 Jun 2017 in Cell death and differentiation , vol. 24 - pp 1029-1044
Moretti C, Serrentino ME, Ialy-Radio C, Delessard M, Soboleva TA, Tores F, Leduc M, Nitschké P, Drevet JR , Tremethick DJ, Vaiman D, Kocer A , Cocquet J
Investigation of antioxidant systems in human meibomian gland and conjunctival tissues.
Published on 01 Dec 2017 in Experimental eye research , vol. 165 - pp 99-104
Nezzar H, Mbekeani JN, Noblanc A , Chiambaretta F , Drevet JR , Kocer A
Dyslipidemia alters sperm maturation and capacitation in LXR-null mice.
Published on 01 Dec 2017 in Reproduction (Cambridge, England) , vol. 154 - pp 827-842
Whitfield M , Guiton R , Rispal J , Acar N, Kocer A , Drevet JR , Saez F
A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models.
Published on 01 Feb 2016 in Human reproduction (Oxford, England) , vol. 31 - pp 252-62
Gharagozloo P, Gutiérrez-Adán A, Champroux A , Noblanc A , Kocer A , Calle A, Pérez-Cerezales S, Pericuesta E, Polhemus A, Moazamian A , Drevet JR , Aitken RJ
Liver X Receptors (LXRs) Alpha and Beta Play Distinct Roles in the Mouse Epididymis.
Published on 01 Mar 2016 in Biology of reproduction , vol. 94 - pp 55
Whitfield M , Ouvrier A, Cadet R , Damon-Soubeyrand C , Guiton R , Janny L , Kocer A , Marceau G , Pons-Rejraji H , Trousson A , Drevet JR , Saez F
Mammalian sperm nuclear organization: resiliencies and vulnerabilities.
Published on 21 Dec 2016 in Basic and clinical andrology , vol. 26 - pp 17
Champroux A , Torres-Carreira J , Gharagozloo P, Drevet JR , Kocer A
Oxidative DNA damage in mouse sperm chromosomes: Size matters.
Published on 01 Dec 2015 in Free radical biology & medicine , vol. 89 - pp 993-1002
Kocer A , Henry-Berger J , Noblanc A , Champroux A , Pogorelcnik R , Guiton R , Janny L , Pons-Rejraji H , Saez F , Johnson GD, Krawetz SA, Alvarez JG, Aitken RJ, Drevet JR
Recent knowledge concerning mammalian sperm chromatin organization and its potential weaknesses when facing oxidative challenge.
Published on 01 Apr 2014 in Basic and clinical andrology , vol. 24 - pp 6
Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment.
Published on 20 Jun 2013 in PloS one , vol. 8 - pp e66494
Jrad-Lamine A , Henry-Berger J , Damon-Soubeyrand C , Saez F , Kocer A , Janny L , Pons-Rejraji H , Munn DH, Mellor AL, Gharbi N, Cadet R , Guiton R , Aitken RJ, Drevet JR
DNA oxidative damage in mammalian spermatozoa: where and why is the male nucleus affected?
Published on 01 Dec 2013 in Free radical biology & medicine , vol. 65 - pp 719-723
Noblanc A , Damon-Soubeyrand C , Karrich B, Henry-Berger J , Cadet R , Saez F , Guiton R , Janny L , Pons-Rejraji H , Alvarez JG, Drevet JR , Kocer A
Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.
Published on 01 Jan 2012 in PloS one , vol. 7 - pp e38565
Noblanc A , Peltier M, Damon-Soubeyrand C , Kerchkove N, Chabory E, Vernet P, Saez F , Cadet R , Janny L , Pons-Rejraji H , Conrad M, Drevet JR , Kocer A
[Post-testicular protection of male gametes from oxidative damage. The role of the epididymis].
Published on 30 May 2012 in Medecine sciences : M/S , vol. 28 - pp 519-25
Dietary cholesterol-induced post-testicular infertility.
Published on 01 Jan 2011 in PloS one , vol. 6 - pp e26966
Ouvrier A, Alves G, Damon-Soubeyrand C , Marceau G , Cadet R , Janny L , Brugnon F , Kocer A , Pommier A, Lobaccaro JM , Drevet JR , Saez F
Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability.
Published on 01 Nov 2011 in Journal of andrology , vol. 32 - pp 641-50
Noblanc A , Kocer A , Chabory E, Vernet P, Saez F , Cadet R , Conrad M, Drevet JR
Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state.
Published on 11 Mar 2011 in The Journal of biological chemistry , vol. 286 - pp 8030-8042
Jrad-Lamine A , Henry-Berger J , Gourbeyre P, Damon-Soubeyrand C , Lenoir A , Combaret L, Saez F , Kocer A , Tone S, Fuchs D, Zhu W, Oefner PJ, Munn DH, Mellor AL, Gharbi N, Cadet R , Aitken RJ, Drevet JR
[Role of reactive oxygen species (ROS) on human spermatozoa and male infertility].
Published on 30 Jun 2009 in Gynecologie, obstetrique & fertilite , vol. 37 - pp 529-35
Pons-Rejraji H , Sion B, Saez F , Brugnon F , Janny L , Grizard G
Attempt to rescue sex-reversal by transgenic expression of the PISRT1 gene in XX PIS-/- goats.
Published on 01 Jan 2008 in Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation , vol. 2 - pp 142-51
Boulanger L, Kocer A , Daniel N, Pannetier M, Chesné P, Heyman Y, Renault L, Mandon-Pépin B, Chavatte-Palmer P, Vignon X, Vilotte JL, Cotinot C, Renard JP, Pailhoux E
GPX5, the selenium-independent glutathione peroxidase-encoding single copy gene is differentially expressed in mouse epididymis.
Published on 01 Jan 2008 in Reproduction, fertility, and development , vol. 20 - pp 615-25
Zhang T, Chabory E, Britan A, Grignard E, Pitiot O, Saez F , Cadet R , Henry-Berger J , Vernet P, Drevet JR
Differential aggregation and functional impairment induced by polyalanine expansions in FOXL2, a transcription factor involved in cranio-facial and ovarian development.
Published on 01 Apr 2008 in Human molecular genetics , vol. 17 - pp 1010-9
Moumné L, Dipietromaria A, Batista F, Kocer A , Fellous M, Pailhoux E, Veitia RA
R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation.
Published on 02 Apr 2008 in BMC developmental biology , vol. 8 - pp 36
Kocer A , Pinheiro I, Pannetier M, Renault L, Parma P, Radi O, Kim KA, Camerino G, Pailhoux E
Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.
Published on 01 Oct 2004 in Journal of molecular endocrinology , vol. 33 - pp 361-75
Frenoux JM, Vernet P, Volle DH, Britan A, Saez F , Kocer A , Henry-Berger J , Mangelsdorf DJ, Lobaccaro JM , Drevet JR
Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.
Published on 30 Oct 2004 in Journal of molecular endocrinology , vol. 33 - pp 361-75
Frenoux JM, Vernet P, Volle DH , Britan A, Saez F , Kocer A , Henry-Berger J , Mangelsdorf DJ, Lobaccaro JM , Drevet JR
