David VOLLEChef d'équipe
During my PhD my work was focused on the role of the nuclear receptors of oxysterols, the Liver X Receptors (LXRalpha and LXRbeta) in steroidogenic tissues. We demonstrate key roles of LXRs in the physiology ofintestine, adrenals, ovaries and testis.
I have identified the nuclear receptor Small Heterodimer partner (SHP, NR0B2) as a main regulator of testicular androgen and retinoic acid metabolisms, making SHP a testicular gatekeeper of the timing of male sexual maturation (post-doc in Pr Auwerx's laboratory)
Then I have been recruited as INSERM researcher in 2007. I have then worked on the impact of Endocrine Disrupters (EDs) in order to understand how in utero and/or neonatal exposure could alter adult testicular physiology. Our data established SHP as a crucial mediator of the deleterious effect of estrogenic EDs, such as diethylstilbestrol, on testicular physiology. These effects seem to be driven through the regulation of the histone methyltransferase EHMT.
Since 2010, we are now developing an innovative thematic research to identify the molecular mechanisms underlying the links between liver disease (PH) and impaired male fertility. Our studies are mainly focused in understanding the role of the bile acid receptors FXRalpha and TGR5 in context of PH which aree characterized bile increased plasma levels of bile acids. Thanks to our collaboration with PR Auwerx and Schoonjans’ laboratory (EPFL, Lausane, SWITZERLAND), we have access to mouse models invalidated for FXRalpha or TGR5. The goal will be to decipher their respective role in testicular physiology.
We are also interested in the impact of environment exposure such as endocrine disrupters (EDs) on testicular pathophysiology. We are mainly working on estrogen-like EDs in order to analyze their impact on spermatogenesis. The goal of our group is to better understand the mechanisms involved in generational transmission of anomalies leading to diseases such as altered development, obesity and/or diabetes.
When idiopathic male infertility is rooted in maternal malnutrition during the perinatal period in mice†.
Published on 19 Mar 2022 in Biology of reproduction , vol. 106 - pp 463-476
Muranishi Y, Parry L, Vachette-Dit-Martin M, Saez F , Coudy-Gandilhon C, Sauvanet P, Volle DH , Tournayre J, Bottari S, Carpentiero F, Martinez G, Muroňová J, Escoffier J, Bruhat A, Maurin AC, Averous J, Arnoult C, Fafournoux P, Jousse C
Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance.
Published on 30 Jun 2022 in Advanced science (Weinheim, Baden-Wurttemberg, Germany) , vol. 9 - pp e2200626
Metallome deregulation and health-related impacts due to long-term exposure to recent volcanic ash deposits: New chemical and isotopic insights.
Published on 10 Jul 2022 in The Science of the total environment , vol. 829 - pp 154383
Published on 30 Apr 2021 in Molecular aspects of medicine , vol. 78 - pp 100956
Molecular and Cellular Endocrinology: Special issue hypothalomo – Pituitary axis: Roles in integrative physiology and pathophysiologies.
Published on 05 Apr 2021 in Molecular and cellular endocrinology , vol. 525 - pp 111198
Farnesoid X receptor alpha (FXRα) is a critical actor of the development and pathologies of the male reproductive system.
Published on 30 Dec 2019 in Cellular and molecular life sciences : CMLS , vol. 76 - pp 4849-4859
Published on 30 Nov 2019 in The Journal of steroid biochemistry and molecular biology , vol. 194 - pp 105460
Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders.
Published on 09 Oct 2018 in Stem cell reports , vol. 11 - pp 944-958
Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases.
Published on 17 Nov 2018 in International journal of molecular sciences , vol. 19
Published on 30 Aug 2017 in Molecular aspects of medicine , vol. 56 - pp 1
Published on 11 Jul 2017 in Stem cell reports , vol. 9 - pp 315-328
Martinot E , Sèdes L , Baptissart M , Holota H , Rouaisnel B , Damon-Soubeyrand C, De Haze A , Saru JP , Thibault-Carpentier C, Keime C, Lobaccaro JA, Baron S , Benoit G, Caira F , Beaudoin C , Volle DH
Published on 30 Oct 2016 in Cellular and molecular life sciences : CMLS , vol. 73 - pp 3777-80
Identification of the Functions of Liver X Receptor-β in Sertoli Cells Using a Targeted Expression-Rescue Model.
Published on 30 Dec 2015 in Endocrinology , vol. 156 - pp 4545-57
Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice.
Published on 02 Mar 2015 in Endocrinology , vol. 156 - pp 660-9
Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.
Published on 30 Sep 2014 in Hepatology (Baltimore, Md.) , vol. 60 - pp 1054-65
Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.
Published on 11 Apr 2014 in Biochemical and biophysical research communications , vol. 446 - pp 656-62
Published on 01 Jul 2013 in Biochemical pharmacology , vol. 86 - pp 168-74
Published on 01 Apr 2013 in Spermatogenesis , vol. 3 - pp e24114
Regenerating I messenger RNA and protein expression in the failing human testis: a potential molecular prognostic marker of seminoma.
Published on 30 Dec 2011 in Human pathology , vol. 42 - pp 1841-8
Mauro V, Volle DH , Chevallier D, Haudebourg J, Sénégas-Balas F, Pointis G
The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice.
Published on 30 Dec 2009 in The Journal of clinical investigation , vol. 119 - pp 3752-64
Volle DH , Decourteix M, Garo E, McNeilly J, Fenichel P, Auwerx J, McNeilly AS, Schoonjans K, Benahmed M
Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.
Published on 30 Jul 2009 in Endocrinology , vol. 150 - pp 3369-75
Published on 15 Jul 2008 in Genes & development , vol. 22 - pp 1871-6
Duggavathi R, Volle DH , Mataki C, Antal MC, Messaddeq N, Auwerx J, Murphy BD, Schoonjans K
Published on 01 Feb 2007 in Genes & development , vol. 21 - pp 303-15
In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.
Published on 30 Jun 2007 in Molecular endocrinology (Baltimore, Md.) , vol. 21 - pp 1312-23
Houten SM, Volle DH , Cummins CL, Mangelsdorf DJ, Auwerx J
Role of the nuclear receptors for oxysterols LXRs in steroidogenic tissues: beyond the “foie gras”, the steroids and sex?
Published on 02 Mar 2007 in Molecular and cellular endocrinology , vol. 265-266 - pp 183-9
Published on 30 May 2007 in Molecular endocrinology (Baltimore, Md.) , vol. 21 - pp 1014-27
Published on 30 Jul 2006 in The Journal of clinical investigation , vol. 116 - pp 1902-12
Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development.
Published on 30 Mar 2005 in The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology , vol. 283 - pp 175-81
Alpha1beta1-integrin is an essential signal for neurite outgrowth induced by thrombospondin type 1 repeats of SCO-spondin.
Published on 30 Jan 2004 in Cell and tissue research , vol. 315 - pp 15-25
Bamdad M, Volle D, Dastugue B, Meiniel A
Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.
Published on 30 Oct 2004 in Journal of molecular endocrinology , vol. 33 - pp 361-75
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.
Published on 30 Apr 2004 in Molecular endocrinology (Baltimore, Md.) , vol. 18 - pp 888-98
Published on 30 Mar 2004 in Gastroenterologie clinique et biologique , vol. 28 - pp 279-93
Published on 30 Jun 2001 in Annales d'endocrinologie , vol. 62 - pp 239-47