Our team is interested in the membrane receptor called RAGE (advanced glycation end products receptor) which is a multi-ligand receptor (called alarmins) belonging to the immunoglobulin superfamily. The binding of one of its ligands will trigger at the cellular level signalling cascades leading to the arinsing of an inflammatory response. Our project is particularly interested in the involvement of this receptor in the lung and fetal membranes (water pocket) focusing on epithelial cells and their aggression as a result of 2 pathologies: acute respiratory distress syndrome and premature rupture of fetal membranes.
Research
Following aggressions resulting from both exogenous and endogenous signals, the achievement of the integrity and functioning of the epithelial barrier is an essential element found in many human pathological situations. The abilities to repair such epithelial aggression condition the pejorative or favorable evolution of these clinical events. Located at the crossroads of many metabolic and/or inflammatory processes, the receptor for advanced glycation end-products (RAGE) appears to be a promising signaling pathway to be investigated in the context of this epithelial dysfunction. The team has begun to demonstrate this on two models of amniotic and pulmonary epithelial aggression present in the wake of two common and serious pathologies, respectively premature rupture of fetal membranes (PROM) and acute respiratory distress syndrome (ARDS). In view of the complexity of the possible combinations «ligands/ RAGE isoforms» associated with the pathological activation of the RAGE pathway, it appears essential to identify the relative importance of these different combinations and to determine whether new ligands cannot be specifically involved in PROM and/or ARDS. Using pharmacological and molecular approaches developed in parallel on our two models of epithelial aggression, this project also aims to identify abnormally modulated molecular pathways and target genes during the activation of the RAGE pathway that may be associated with the cascading of pathophysiological events encountered during these two pathologies. As the interaction of the epithelium with the cells of its immediate environment is a strong determinant of the evolution of aggression, our work also aims to demonstrate the impact of the RAGE pathway in cellular communications. Finally, the availability of KO mice for RAGE will allow to study in vivo, the impacts of a modulation of this route. Our results should make it possible to obtain diagnostic, prognostic and therapeutic advances focused on the RABIES signaling pathway during epithelial aggressions.
Members
Publications
CX3CL1/Fractalkine as a biomarker for early pregnancy prediction of preterm premature rupture of membranes.
Published on 26 Jan 2024 in Clinical chemistry and laboratory medicine
Kahouadji S , Giguère Y, Lambert S, Forest JC, Bernard N, Blanchon L , Marceau G , Durif J, Pereira B, Gallot D , Sapin V , Bouvier D
Nanoscale silicate melt textures determine volcanic ash surface chemistry.
Published on 15 Jan 2024 in Nature communications , vol. 15 - pp 531
Hornby AJ, Ayris PM, Damby DE, Diplas S, Eychenne J , Kendrick JE, Cimarelli C, Kueppers U, Scheu B, Utley JEP, Dingwell DB
Prevalence of FGF23 elevation in patients with hypophosphatemia.
Published on 13 Jan 2024 in Clinica chimica acta; international journal of clinical chemistry , vol. 554 - pp 117782
Oris C , Lautrette A, Dougé A, Bouraima F, Kahouadji S , Pickering ME, Garrouste C, Gagnière J, Guièze R, D'Ostrevy N, Futier E , Grobost V, Buisson A, Batisse M, Bouillon-Minois JB, Pereira B, Durif J, Sapin V , Bouvier D
Effectiveness and Costs of Molecular Screening and Treatment for Bacterial Vaginosis to Prevent Preterm Birth: The AuTop Randomized Clinical Trial.
Published on 01 Sep 2023 in JAMA pediatrics , vol. 177 - pp 894-902
Bretelle F, Loubière S, Desbriere R, Loundou A, Blanc J, Heckenroth H, Schmitz T, Benachi A, Haddad B, Mauviel F, Danoy X, Mares P, Chenni N, Ménard JP, Cocallemen JF, Slim N, Sénat MV, Chauleur C, Bohec C, Kayem G, Trastour C , Bongain A, Rozenberg P, Serazin V, Fenollar F, Groupe de Recherche en Obstetrique et Gynécologie (GROG) Investigators
Inflammation of Dry Eye Syndrome: A Cellular Study of the Epithelial and Macrophagic Involvement of NFAT5 and RAGE.
Published on 04 Jul 2023 in International journal of molecular sciences , vol. 24
Henrioux F , Navel V , Belville C , Charnay C , Antoine A , Chiambaretta F , Sapin V , Blanchon L
Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome.
Published on 18 Jun 2023 in Journal of translational medicine , vol. 21 - pp 397
Zhai R , Lenga Ma Bonda W, Leclaire C , Saint-Béat C , Theilliere C , Belville C , Coupet R, Blondonnet R, Bouvier D , Blanchon L , Sapin V , Jabaudon M
Characterization of RAGE and CK2 Expressions in Human Fetal Membranes.
Published on 17 Feb 2023 in International journal of molecular sciences , vol. 24
Coste K , Bruet S , Chollat-Namy C , Filhol O, Cochet C, Gallot D , Marceau G , Blanchon L , Sapin V , Belville C
Spatial Distribution and Physicochemical Properties of Respirable Volcanic Ash From the 16-17 August 2006 Tungurahua Eruption (Ecuador), and Alveolar Epithelium Response In-Vitro.
Published on 01 Dec 2022 in GeoHealth , vol. 6 - pp e2022GH000680
Eychenne J , Gurioli L, Damby D, Belville C , Schiavi F, Marceau G , Szczepaniak C, Blavignac C, Laumonier M, Gardés E, Le Pennec JL, Nedelec JM, Blanchon L , Sapin V
Dysregulation of the Amniotic PPARγ Pathway by Phthalates: Modulation of the Anti-Inflammatory Activity of PPARγ in Human Fetal Membranes.
Published on 06 Apr 2022 in Life (Basel, Switzerland) , vol. 12
Antoine A , De Sousa Do Outeiro C , Charnay C , Belville C , Henrioux F , Gallot D , Blanchon L , Minet-Quinard R , Sapin V
Dysregulation of Receptor for Advanced Glycation End Products (RAGE) Expression as a Biomarker of Keratoconus.
Published on 15 Jan 2022 in Disease markers , vol. 2022 - pp 1543742
Navel V , Malecaze J , Belville C , Choltus H , Henrioux F , Dutheil F, Malecaze F, Chiambaretta F , Blanchon L , Sapin V
Cigarette Smoke Condensate Exposure Induces Receptor for Advanced Glycation End-Products (RAGE)-Dependent Sterile Inflammation in Amniotic Epithelial Cells.
Published on 03 Aug 2021 in International journal of molecular sciences , vol. 22
Choltus H , Minet-Quinard R , Belville C , Durif J, Gallot D , Blanchon L , Sapin V
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device.
Published on 24 Sep 2020 in Journal of visualized experiments : JoVE
Blondonnet R , Paquette B , Audard J, Guler R, Roman FX, Zhai R , Belville C , Blanchon L , Godet T, Futier E , Bazin JE, Constantin JM , Sapin V , Jabaudon M
Occurrence of a RAGE-Mediated Inflammatory Response in Human Fetal Membranes.
Published on 25 Jun 2020 in Frontiers in physiology , vol. 11 - pp 581
Choltus H , Lavergne M , Belville C , Gallot D , Minet-Quinard R , Durif J, Blanchon L , Sapin V
The receptor for advanced glycation end-products enhances lung epithelial wound repair: An in vitro study.
Published on 15 Jun 2020 in Experimental cell research , vol. 391 - pp 112030
Zhai R , Blondonnet R , Ebrahimi E, Belville C , Audard J, Gross C , Choltus H , Henrioux F , Constantin JM , Pereira B, Blanchon L , Sapin V , Jabaudon M
Risk Factors and Outcomes of Preterm Premature Rupture of Membranes in a Cohort of 6968 Pregnant Women Prospectively Recruited.
Published on 15 Nov 2019 in Journal of clinical medicine , vol. 8
Bouvier D , Forest JC, Blanchon L , Bujold E, Pereira B, Bernard N, Gallot D , Sapin V , Giguère Y
Retinoic Acid Pathway Regulation of Vascular Endothelial Growth Factor in Ovine Amnion.
Published on 30 Oct 2019 in Reproductive sciences (Thousand Oaks, Calif.) , vol. 26 - pp 1351-1359
Cheung CY, Anderson DF, Rouzaire M , Blanchon L , Sapin V , Brace RA
Driving pressure and acute respiratory distress syndrome in critically ill patients.
Published on 02 Mar 2019 in Respirology (Carlton, Vic.) , vol. 24 - pp 137-145
Blondonnet R , Joubert E, Godet T, Berthelin P, Pranal T, Roszyk L , Chabanne R, Eisenmann N, Lautrette A, Belville C , Cayot S, Gillart T, Souweine B, Bouvier D , Blanchon L , Sapin V , Pereira B, Constantin JM , Jabaudon M
Serum soluble receptor for advanced glycation end-products during acute bronchiolitis in infant: Prospective study in 93 cases.
Published on 30 Oct 2018 in Pediatric pulmonology , vol. 53 - pp 1429-1435
Egron C, Roszyk L , Rochette E, Jabaudon M , Sapin V , Mulliez A, Labbé A, Coste K
Clinical validation of S100B in the management of a mild traumatic brain injury: issues from an interventional cohort of 1449 adult patients.
Published on 25 Oct 2018 in Clinical chemistry and laboratory medicine , vol. 56 - pp 1897-1904
Allouchery G, Moustafa F, Roubin J, Pereira B, Schmidt J, Raconnat J, Pic D, Sapin V , Bouvier D
Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.
Published on 30 Sep 2018 in Intensive care medicine , vol. 44 - pp 1388-1399
Jabaudon M , Blondonnet R , Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V , Matthay MA, Constantin JM , Calfee CS
Understanding Macrophages in Acute Respiratory Distress Syndrome: From Pathophysiology to Precision Medicine.
Published on 30 Jul 2018 in Critical care medicine , vol. 46 - pp 1207-1208
Constantin JM , Godet T, Jabaudon M
The Biomarker S100B and Mild Traumatic Brain Injury: A Meta-analysis.
Published on 30 Jun 2018 in Pediatrics , vol. 141
Oris C , Pereira B, Durif J, Simon-Pimmel J, Castellani C, Manzano S, Sapin V , Bouvier D
Retinoic acid and tracheal occlusion for diaphragmatic hernia treatment in rabbit fetuses.
Published on 30 Jun 2018 in Prenatal diagnosis , vol. 38 - pp 482-492
Delabaere A , Blanchon L , Coste K , Clairefond G , Belville C , Blanc P , Marceau G , Sapin V , Gallot D
Recent directions in personalised acute respiratory distress syndrome medicine.
Published on 30 Jun 2018 in Anaesthesia, critical care & pain medicine , vol. 37 - pp 251-258
Jabaudon M , Blondonnet R , Audard J, Fournet M , Godet T, Sapin V , Constantin JM
Clinical and Biological Predictors of Plasma Levels of Soluble RAGE in Critically Ill Patients: Secondary Analysis of a Prospective Multicenter Observational Study.
Published on 10 May 2018 in Disease markers , vol. 2018 - pp 7849675
Pranal T, Pereira B, Berthelin P, Roszyk L , Godet T, Chabanne R, Eisenmann N, Lautrette A, Belville C , Blondonnet R , Cayot S, Gillart T, Skrzypczak Y, Souweine B, Bouvier D , Blanchon L , Sapin V , Constantin JM , Jabaudon M
Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study.
Published on 08 Feb 2018 in Scientific reports , vol. 8 - pp 2603
Jabaudon M , Berthelin P, Pranal T, Roszyk L , Godet T, Faure JS, Chabanne R, Eisenmann N, Lautrette A, Belville C , Blondonnet R , Cayot S, Gillart T, Pascal J, Skrzypczak Y, Souweine B, Blanchon L , Sapin V , Pereira B, Constantin JM
Vitamin A status in healthy women eating traditionally prepared spirulina (Dihé) in the Chad Lake area.
Published on 29 Jan 2018 in PloS one , vol. 13 - pp e0191887
Soudy ID, Minet-Quinard R , Mahamat AD, Ngoua HF, Izzedine AA, Tidjani A, Ngo Bum E, Lambert C, Pereira B, Desjeux JF, Sapin V
High frequency percussive ventilation increases alveolar recruitment in early acute respiratory distress syndrome: an experimental, physiological and CT scan study.
Published on 11 Jan 2018 in Critical care (London, England) , vol. 22 - pp 3
Godet T, Jabaudon M , Blondonnet R , Tremblay A, Audard J, Rieu B, Pereira B, Garcier JM, Futier E , Constantin JM
Cigarette smoke condensate affects the retinoid pathway in human amnion.
Published on 30 Oct 2017 in Placenta , vol. 58 - pp 98-104
Rouzaire M , Comptour A , Belville C , Bouvier D , Sapin V , Gallot D , Blanchon L
Rationale, study design and analysis plan of the lung imaging morphology for ventilator settings in acute respiratory distress syndrome study (LIVE study): Study protocol for a randomised controlled trial.
Published on 30 Oct 2017 in Anaesthesia, critical care & pain medicine , vol. 36 - pp 301-306
Jabaudon M , Godet T, Futier E , Bazin JÉ, Sapin V , Roszyk L , Pereira B, Constantin JM , AZUREA group
RAGE inhibition reduces acute lung injury in mice.
Published on 03 Aug 2017 in Scientific reports , vol. 7 - pp 7208
Blondonnet R , Audard J, Belville C , Clairefond G , Lutz J, Bouvier D , Roszyk L , Gross C , Lavergne M , Fournet M , Blanchon L , Vachias C , Damon-Soubeyrand C , Sapin V , Constantin JM , Jabaudon M
Recruitment maneuvers in acute respiratory distress syndrome.
Published on 30 Jul 2017 in Annals of translational medicine , vol. 5 - pp 290
Constantin JM , Godet T, Jabaudon M , Bazin JE, Futier E
Retinoic Acid Engineered Amniotic Membrane Used as Graft or Homogenate: Positive Effects on Corneal Alkali Burns.
Published on 01 Jul 2017 in Investigative ophthalmology & visual science , vol. 58 - pp 3513-3518
Joubert R, Daniel E, Bonnin N, Comptour A , Gross C , Belville C , Chiambaretta F , Blanchon L , Sapin V
[Premature rupture of membranes≥37 weeks of gestation: Predictive factors for labour onset within 24hours].
Published on 30 Jun 2017 in Gynecologie, obstetrique, fertilite & senologie , vol. 45 - pp 348-352
Huret C, Pereira B, Collange V, Delabaere A , Rouzaire M , Lemery D, Sapin V , Gallot D
Effects of tracheal occlusion with retinoic acid administration on normal lung development.
Published on 30 May 2017 in Prenatal diagnosis , vol. 37 - pp 427-434
Delabaere A , Marceau G , Coste K , Blanchon L , Déchelotte PJ, Blanc P , Sapin V , Gallot D
Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol.
Published on 29 May 2017 in BMJ open , vol. 7 - pp e015280
Bulyez S, Pereira B, Caumon E, Imhoff E, Roszyk L , Bernard L, Bühler L, Heidegger C, Jaber S, Lefrant JY, Chabanne R, Bertrand PM, Laterre PF, Guerci P, Danin PE, Escudier E, Sossou A, Morand D, Sapin V , Constantin JM , Jabaudon M , EPIPAN Study Group, AzuRea network
Utility of S100B Serum Level for the Determination of Concussion in Male Rugby Players.
Published on 30 Apr 2017 in Sports medicine (Auckland, N.Z.) , vol. 47 - pp 781-789
Bouvier D , Duret T, Abbot M, Stiernon T, Pereira B, Coste A, Chazal J, Sapin V
Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study.
Published on 15 Mar 2017 in American journal of respiratory and critical care medicine , vol. 195 - pp 792-800
Jabaudon M , Boucher P, Imhoff E, Chabanne R, Faure JS, Roszyk L , Thibault S, Blondonnet R , Clairefond G , Guérin R, Perbet S , Cayot S, Godet T, Pereira B, Sapin V , Bazin JE, Futier E , Constantin JM
Myocilin expression is regulated by retinoic acid in the trabecular meshwork-derived cellular environment.
Published on 02 Mar 2017 in Experimental eye research , vol. 155 - pp 91-98
Prat C , Belville C , Comptour A , Marceau G , Clairefond G , Chiambaretta F , Sapin V , Blanchon L
All-trans retinoic acid promotes wound healing of primary amniocytes through the induction of LOXL4, a member of the lysyl oxidase family.
Published on 30 Dec 2016 in The international journal of biochemistry & cell biology , vol. 81 - pp 10-19
Rouzaire M , Comptour A , Belville C , Bouvier D , Clairefond G , Ponelle F, Sapin V , Gallot D , Blanchon L
Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS: A Prospective Multicenter Study.
Published on 30 Nov 2016 in Chest , vol. 150 - pp 998-1007
Mrozek S, Jabaudon M , Jaber S, Paugam-Burtz C, Lefrant JY, Rouby JJ, Asehnoune K, Allaouchiche B, Baldesi O, Leone M, Lu Q, Bazin JE, Roszyk L , Sapin V , Futier E , Pereira B, Constantin JM , Azurea network
Lung ultrasonography for assessment of oxygenation response to prone position ventilation in ARDS.
Published on 30 Oct 2016 in Intensive care medicine , vol. 42 - pp 1546-1556
Haddam M, Zieleskiewicz L, Perbet S , Baldovini A, Guervilly C, Arbelot C, Noel A, Vigne C, Hammad E, Antonini F, Lehingue S, Peytel E, Lu Q, Bouhemad B, Golmard JL, Langeron O, Martin C, Muller L, Rouby JJ, Constantin JM , Papazian L, Leone M, CAR’Echo Collaborative Network, AzuRea Collaborative Network
Nuclear retinoid receptors and pregnancy: placental transfer, functions, and pharmacological aspects.
Published on 30 Oct 2016 in Cellular and molecular life sciences : CMLS , vol. 73 - pp 3823-37
Comptour A , Rouzaire M , Belville C , Bouvier D , Gallot D , Blanchon L , Sapin V
Different dose rate-dependent responses of human melanoma cells and fibroblasts to low dose fast neutrons.
Published on 30 Sep 2016 in International journal of radiation biology , vol. 92 - pp 527-35
Dionet C, Müller-Barthélémy M, Marceau G , Denis JM, Averbeck D, Gueulette J, Sapin V , Pereira B, Tchirkov A, Chautard E, Verrelle P
Lysyl oxidase-like 4 involvement in retinoic acid epithelial wound healing.
Published on 06 Sep 2016 in Scientific reports , vol. 6 - pp 32688
Comptour A , Rouzaire M , Belville C , Bonnin N, Daniel E, Chiambaretta F , Blanchon L , Sapin V
Effect of non-invasive oxygenation strategies in immunocompromised patients with severe acute respiratory failure: a post-hoc analysis of a randomised trial.
Published on 30 Aug 2016 in The Lancet. Respiratory medicine , vol. 4 - pp 646-652
Frat JP, Ragot S, Girault C, Perbet S , Prat G, Boulain T, Demoule A, Ricard JD, Coudroy R, Robert R, Mercat A, Brochard L, Thille AW, REVA network
Preanalytical, analytical, gestational and pediatric aspects of the S100B immuno-assays.
Published on 30 May 2016 in Clinical chemistry and laboratory medicine , vol. 54 - pp 833-42
Bouvier D , Duret T, Rouzaire P, Jabaudon M , Rouzaire M , Nourrisson C, Bourgne C, Pereira B, Evrard B, Sapin V
Net alveolar fluid clearance is associated with lung morphology phenotypes in acute respiratory distress syndrome.
Published on 30 Apr 2016 in Anaesthesia, critical care & pain medicine , vol. 35 - pp 81-6
Jabaudon M , Blondonnet R , Lutz J, Roszyk L , Bouvier D , Guérin R, Perbet S , Cayot S, Godet T, Blanchon L , Bazin JE, Futier E , Sapin V , Constantin JM
Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery: A Randomized Clinical Trial.
Published on 05 Apr 2016 in JAMA , vol. 315 - pp 1345-53
Jaber S, Lescot T, Futier E , Paugam-Burtz C, Seguin P, Ferrandiere M, Lasocki S, Mimoz O, Hengy B, Sannini A, Pottecher J, Abback PS, Riu B, Belafia F, Constantin JM , Masseret E, Beaussier M, Verzilli D, De Jong A, Chanques G, Brochard L, Molinari N, NIVAS Study Group
A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome.
Published on 01 Jan 2016 in Disease markers , vol. 2016 - pp 3501373
Association between intraoperative ventilator settings and plasma levels of soluble receptor for advanced glycation end-products in patients without pre-existing lung injury.
Published on 30 Oct 2015 in Respirology (Carlton, Vic.) , vol. 20 - pp 1131-8
Jabaudon M , Futier E , Roszyk L , Sapin V , Pereira B, Constantin JM
Aquaporins and Fetal Membranes From Diabetic Parturient Women: Expression Abnormalities and Regulation by Insulin.
Published on 30 Oct 2015 in The Journal of clinical endocrinology and metabolism , vol. 100 - pp E1270-9
Bouvier D , Rouzaire M , Marceau G , Prat C , Pereira B, Lemarié R, Deruelle P, Fajardy I, Gallot D , Blanchon L , Vambergue A, Sapin V
All-trans-retinoic acid regulates aquaporin-3 expression and related cellular membrane permeability in the human amniotic environment.
Published on 30 Aug 2015 in Placenta , vol. 36 - pp 881-7
Prat C , Bouvier D , Comptour A , Marceau G , Belville C , Clairefond G , Blanc P , Gallot D , Blanchon L , Sapin V
Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study.
Published on 14 Aug 2015 in PloS one , vol. 10 - pp e0135857
Jabaudon M , Blondonnet R , Roszyk L , Pereira B, Guérin R, Perbet S , Cayot S, Bouvier D , Blanchon L , Sapin V , Constantin JM
Soluble Receptor for Advanced Glycation End-Products Predicts Impaired Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome.
Published on 15 Jul 2015 in American journal of respiratory and critical care medicine , vol. 192 - pp 191-9
Jabaudon M , Blondonnet R , Roszyk L , Bouvier D , Audard J, Clairefond G , Fournier M, Marceau G , Déchelotte P , Pereira B, Sapin V , Constantin JM
Comment and reply on: Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth.
Published on 17 Jun 2015 in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - pp 1-2
Gallot D , Goffinet F, Sapin V , Guibourdenche J, Jouannic M, Langer B, Doret M, Subtil D, Fernandez H
High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure.
Published on 04 Jun 2015 in The New England journal of medicine , vol. 372 - pp 2185-96
Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S , Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM , Tonnelier JM, Pierrot M, Mathonnet A, Béduneau G, Delétage-Métreau C, Richard JC, Brochard L, Robert R, FLORALI Study Group, REVA Network
Effects of a recruitment maneuver on plasma levels of soluble RAGE in patients with diffuse acute respiratory distress syndrome: a prospective randomized crossover study.
Published on 30 May 2015 in Intensive care medicine , vol. 41 - pp 846-55
Jabaudon M , Hamroun N, Roszyk L , Guérin R, Bazin JE, Sapin V , Pereira B, Constantin JM
IFPA meeting 2014 workshop report: Animal models to study pregnancy pathologies; new approaches to study human placental exposure to xenobiotics; biomarkers of pregnancy pathologies; placental genetics and epigenetics; the placenta and stillbirth and fetal growth restriction.
Published on 30 Apr 2015 in Placenta , vol. 36 Suppl 1 - pp S5-10
Barbaux S, Erwich JJ, Favaron PO, Gil S, Gallot D , Golos TG, Gonzalez-Bulnes A, Guibourdenche J, Heazell AE, Jansson T, Laprévote O, Lewis RM, Miller RK, Monk D, Novakovic B, Oudejans C, Parast M, Peugnet P, Pfarrer C, Pinar H, Roberts CT, Robinson W, Saffery R, Salomon C, Sexton A, Staff AC, Suter M, Tarrade A, Wallace J, Vaillancourt C, Vaiman D, Worton SA, Lash GE
Metabolic disturbances of the vitamin A pathway in human diaphragmatic hernia.
Published on 15 Jan 2015 in American journal of physiology. Lung cellular and molecular physiology , vol. 308 - pp L147-57
Coste K , Beurskens LW, Blanc P , Gallot D , Delabaere A , Blanchon L , Tibboel D, Labbé A, Rottier RJ, Sapin V
An interplay of geometry and signaling enables robust lung branching morphogenesis.
Published on 30 Dec 2014 in Development (Cambridge, England) , vol. 141 - pp 4526-36
The challenge of prenatal identification of congenital diaphragmatic hernia in the context of hydrops.
Published on 30 Nov 2014 in European journal of obstetrics, gynecology, and reproductive biology , vol. 182 - pp 238-9
Rossi A, Delabaere A , Delmas-Laurichesse H, Beaufrère AM, Lémery D, Gallot D
Impact of the anesthetic conserving device on respiratory parameters and work of breathing in critically ill patients under light sedation with sevoflurane.
Published on 30 Oct 2014 in Anesthesiology , vol. 121 - pp 808-16
Chabanne R, Perbet S , Futier E , Ben Said NA, Jaber S, Bazin JE, Pereira B, Constantin JM
Endocrine gland-derived endothelial growth factor (EG-VEGF) is a potential novel regulator of human parturition.
Published on 30 Sep 2014 in Biology of reproduction , vol. 91 - pp 73
Dunand C, Hoffmann P, Sapin V , Blanchon L , Salomon A, Sergent F, Benharouga M, Sabra S, Guibourdenche J, Lye SJ, Feige JJ, Alfaidy N
DNA methyl transferases are differentially expressed in the human anterior eye segment.
Published on 30 Aug 2014 in Acta ophthalmologica , vol. 92 - pp e366-71
Bonnin N, Belville C , Chiambaretta F , Sapin V , Blanchon L
Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a.
Published on 07 Aug 2014 in Cell reports , vol. 8 - pp 743-53
Deplus R, Blanchon L , Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B , Berdasco M, Putmans P, Calonne E, Litchfield DW, de Launoit Y, Jurkowski TP, Stunnenberg HG, Bock C, Sotiriou C, Fraga MF, Esteller M, Jeltsch A, Fuks F
Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet – the RESOLVE trial.
Published on 11 Jul 2014 in Lipids in health and disease , vol. 13 - pp 112
Dutheil F, Walther G, Chapier R, Mnatzaganian G, Lesourd B, Naughton G, Verney J, Fogli A , Sapin V , Duclos M, Vinet A, Obert P, Courteix D, Lac G
Lung postmortem autopsy revealing extramedullary involvement in multiple myeloma causing acute respiratory distress syndrome.
Published on 01 Jan 2014 in Case reports in hematology , vol. 2014 - pp 635237
Ravinet A, Perbet S , Guièze R, Lemal R, Guérin R, Gayraud G, Aliane J, Tremblay A, Pascal J, Ledoux A, Chaleteix C, Dechelotte P , Bay JO, Bazin JE, Constantin JM
Plasma levels of sRAGE, loss of aeration and weaning failure in ICU patients: a prospective observational multicenter study.
Published on 27 May 2013 in PloS one , vol. 8 - pp e64083
Jabaudon M , Perbet S , Pereira B, Soummer A, Roszyk L , Guérin R, Futier E , Lu Q, Bazin JE, Sapin V , Rouby JJ, Constantin JM
A role for mesenchyme dynamics in mouse lung branching morphogenesis.
Published on 01 Jan 2012 in PloS one , vol. 7 - pp e41643
Blanc P , Coste K , Pouchin P , Azaïs JM, Blanchon L , Gallot D , Sapin V
[Coupling proteinemia and serum protein electrophoresis: evaluation of the capillary technique (Capillarys 2, Sebia), experience from Clermont-Ferrand].
Published on 01 Nov 2010 in Annales de biologie clinique , vol. 68 - pp 657-67
Fetal skin fibroblasts: a cell model for studying the retinoid pathway in congenital diaphragmatic hernia.
Published on 30 Mar 2010 in Birth defects research. Part A, Clinical and molecular teratology , vol. 88 - pp 195-200
Goumy C, Coste K , Marceau G , Gouas L, Tchirkov A, Vago P, Gallot D , Sapin V
Retinoid pathway and congenital diaphragmatic hernia: hypothesis from the analysis of chromosomal abnormalities.
Published on 01 Jan 2010 in Fetal diagnosis and therapy , vol. 28 - pp 129-39
Goumy C, Gouas L, Marceau G , Coste K , Veronese L, Gallot D , Sapin V , Vago P, Tchirkov A
Natural mutations of the anti-Mullerian hormone type II receptor found in persistent Mullerian duct syndrome affect ligand binding, signal transduction and cellular transport.
Published on 15 Aug 2009 in Human molecular genetics , vol. 18 - pp 3002-13
Belville C , Maréchal JD, Pennetier S, Carmillo P, Masgrau L, Messika-Zeitoun L, Galey J, Machado G, Treton D, Gonzalès J, Picard JY, Josso N, Cate RL, di Clemente N
