Research Team

Translational approach to epithelial injury and repair

Blasto souris
HomeTeamsTranslational approach to epithelial injury and repair

Our team is interested in the membrane receptor called RAGE (advanced glycation end products receptor) which is a multi-ligand receptor (called alarmins) belonging to the immunoglobulin superfamily. The binding of one of its ligands will trigger at the cellular level signalling cascades leading to the arinsing of an inflammatory response. Our project is particularly interested in the involvement of this receptor in the lung and fetal membranes (water pocket) focusing on epithelial cells and their aggression as a result of 2 pathologies: acute respiratory distress syndrome and premature rupture of fetal membranes.

image équipe

Research

Following aggressions resulting from both exogenous and endogenous signals, the achievement of the integrity and functioning of the epithelial barrier is an essential element found in many human pathological situations. The abilities to repair such epithelial aggression condition the pejorative or favorable evolution of these clinical events. Located at the crossroads of many metabolic and/or inflammatory processes, the receptor for advanced glycation end-products (RAGE) appears to be a promising signaling pathway to be investigated in the context of this epithelial dysfunction. The team has begun to demonstrate this on two models of amniotic and pulmonary epithelial aggression present in the wake of two common and serious pathologies, respectively premature rupture of fetal membranes (PROM) and acute respiratory distress syndrome (ARDS). In view of the complexity of the possible combinations «ligands/ RAGE isoforms» associated with the pathological activation of the RAGE pathway, it appears essential to identify the relative importance of these different combinations and to determine whether new ligands cannot be specifically involved in PROM and/or ARDS. Using pharmacological and molecular approaches developed in parallel on our two models of epithelial aggression, this project also aims to identify abnormally modulated molecular pathways and target genes during the activation of the RAGE pathway that may be associated with the cascading of pathophysiological events encountered during these two pathologies. As the interaction of the epithelium with the cells of its immediate environment is a strong determinant of the evolution of aggression, our work also aims to demonstrate the impact of the RAGE pathway in cellular communications. Finally, the availability of KO mice for RAGE will allow to study in vivo, the impacts of a modulation of this route. Our results should make it possible to obtain diagnostic, prognostic and therapeutic advances focused on the RABIES signaling pathway during epithelial aggressions.

Members

Publications

193 publications
2024

Consensus paper on the assessment of adult patients with traumatic brain injury with Glasgow Coma Scale 13-15 at the emergency department: A multidisciplinary overview.

Published on 01 Aug 2024 in European journal of emergency medicine : official journal of the European Society for Emergency Medicine , vol. 31 - pp 240-249

Backus BE, Moustafa F, Skogen K, Sapin V , Rane N, Moya-Torrecilla F, Biberthaler P, Tenovuo O

Balancing patient needs with environmental impacts for best practices in general anesthesia: Narrative review and clinical perspective.

Published on 01 Aug 2024 in Anaesthesia, critical care & pain medicine , vol. 43 - pp 101389

Jabaudon M , Vallabh B, Bacher HP, Badenes R, Kehl F

Very elevated hCGβ (≥10 multiple of the median) in maternal marker screening for Down syndrome: Frequency, etiologies, outcomes, and guidelines.

Published on 01 Jul 2024 in Prenatal diagnosis , vol. 44 - pp 959-964

Dreux S, Rosenblatt J, Massardier J, Benachi A, Voirin-Mathieu E, ABA Study Group, Muller F

Volatile Anesthetic Sedation for Critically Ill Patients.

Published on 01 Jul 2024 in Anesthesiology , vol. 141 - pp 163-174

O'Gara B, Boncyk C, Meiser A, Jerath A, Bellgardt M, Jabaudon M , Beitler JR, Hughes CG

Early-onset neonatal sepsis: Effectiveness of classification based on ante- and intrapartum risk factors and clinical monitoring.

Published on 01 Jun 2024 in Journal of gynecology obstetrics and human reproduction , vol. 53 - pp 102775

Dalut L, Brunhes A, Cambier S, Gallot D , Coste K

COVID-19 pandemic and impact of universal face mask wear on ocular surface health and risk of infection.

Published on 01 Jun 2024 in Journal francais d'ophtalmologie , vol. 47 - pp 104170

Navel V , Labetoulle M, Lazreg S, Brémond-Gignac D, Chiambaretta F

Performance of glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) biomarkers in predicting CT scan results and neurological outcomes in children with traumatic brain injury (BRAINI-2 paediatric study): protocol of a European prospective multicentre study.

Published on 15 May 2024 in BMJ open , vol. 14 - pp e083531

Lorton F, Lagares A, de la Cruz J, Méjan O, Pavlov V, Sapin V , Poca MA, Lehner M, Biberthaler P, Chauviré-Drouard A, Gras-Le-Guen C, Scherdel P, BRAINI–2 paediatric Collaborative group, Collaborators

Serum S100B Level in the Management of Pediatric Minor Head Trauma: A Randomized Clinical Trial.

Published on 04 Mar 2024 in JAMA network open , vol. 7 - pp e242366

Bouvier D , Cantais A, Laspougeas A, Lorton F, Plenier Y, Cottier M, Fournier P, Tran A, Moreau E, Durif J, Sarret C , Mourgues C, Sturtz F, Oudart JB, Raffort J, Gonzalo P, Cristol JP, Masson D, Pereira B, Sapin V

Corticosteroids induce an early but limited decrease in IL-6 dependent pro-inflammatory responses in critically ill COVID-19 patients.

Published on 01 Mar 2024 in Minerva anestesiologica , vol. 90 - pp 172-180

Urbina T, Gabarre P, Bonny V, Lavillegrand JR, Garnier M , Joffre J, Mario N, Dumas G, Hariri G, Turpin M, Pardo E, Fartoukh M, Guidet B, Maury E, Chantran Y, Boelle PY, Voiriot G, Ait-Oufella H

Beyond the Surviving Sepsis Campaign Guidelines: a systematic review of interventions affecting mortality in sepsis.

Published on 01 Mar 2024 in Panminerva medica , vol. 66 - pp 55-62

Sartini C, Landoni G, Belletti A, Kotani Y, Maimeri N, Umbrello M, Yavorovskiy A, Jabaudon M

Sedation with volatile anaesthetics in intensive care.

Published on 01 Mar 2024 in BJA education , vol. 24 - pp 77-80

Jabaudon M , Constantin JM

Ex Vivo Optimization of Donor Lungs with Inhaled Sevoflurane during Normothermic Ex Vivo Lung Perfusion (VITALISE): A Pilot and Feasibility Study in Sheep.

Published on 19 Feb 2024 in International journal of molecular sciences , vol. 25

Steinkühler T, Yang S, Hu MA, Jainandunsing JS, Jager NM, Erasmus ME, Struys MMRF, Bosch DJ, van Meurs M, Jabaudon M , Richard D, Timens W, Leuvenink HGD, Nieuwenhuijs-Moeke GJ

DeepMPTB: a vaginal microbiome-based deep neural network as artificial intelligence strategy for efficient preterm birth prediction.

Published on 14 Feb 2024 in Biomarker research , vol. 12 - pp 25

Chakoory O, Barra V, Rochette E, Blanchon L , Sapin V , Merlin E, Pons M, Gallot D , Comtet-Marre S, Peyret P

CX3CL1/Fractalkine as a biomarker for early pregnancy prediction of preterm premature rupture of membranes.

Published on 26 Jan 2024 in Clinical chemistry and laboratory medicine

Kahouadji S , Giguère Y, Lambert S, Forest JC, Bernard N, Blanchon L , Marceau G , Durif J, Pereira B, Gallot D , Sapin V , Bouvier D

Nanoscale silicate melt textures determine volcanic ash surface chemistry.

Published on 15 Jan 2024 in Nature communications , vol. 15 - pp 531

Hornby AJ, Ayris PM, Damby DE, Diplas S, Eychenne J , Kendrick JE, Cimarelli C, Kueppers U, Scheu B, Utley JEP, Dingwell DB

Prevalence of FGF23 elevation in patients with hypophosphatemia.

Published on 13 Jan 2024 in Clinica chimica acta; international journal of clinical chemistry , vol. 554 - pp 117782

Oris C , Lautrette A, Dougé A, Bouraima F, Kahouadji S , Pickering ME, Garrouste C, Gagnière J, Guièze R, D'Ostrevy N, Futier E , Grobost V, Buisson A, Batisse M, Bouillon-Minois JB, Pereira B, Durif J, Sapin V , Bouvier D

2023

Volatile Organic Compounds Detected in Amniotic Fluid of Women During Normal Pregnancy

Published on 21 Dec 2023 in Exposure and Health

Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced Peripheral Neuropathy: A Comparative Pilot Study with Oxaliplatin, Paclitaxel, Bortezomib, and Vincristine.

Published on 08 Dec 2023 in Toxics , vol. 11

Balayssac D, Durif J, Lambert C, Dalbos C, Chapuy E, Etienne M, Demiot C, Busserolles J, Martin V, Sapin V

S100B vs. “GFAP and UCH-L1” assays in the management of mTBI patients.

Published on 01 Dec 2023 in Clinical chemistry and laboratory medicine , vol. 62 - pp 891-899

Oris C , Bouillon-Minois JB, Kahouadji S , Pereira B, Dhaiby G, Defrance VB, Durif J, Schmidt J, Moustafa F, Bouvier D , Sapin V

[Calprotectin levels in meconium measured with an automated immunoassay (Liaison(®) XL)].

Published on 20 Oct 2023 in Annales de biologie clinique , vol. 81 - pp 388-394

Oris C , Pons M, Rochette E, Tadrent M, Durif J, Pereira B, Justine P, Troin U, Gallot D , Bouvier D , Merlin É, Sapin V

Tumor-Induced Osteomalacia in Patients With Malignancy: A Meta-analysis and Systematic Review of Case Reports.

Published on 18 Oct 2023 in The Journal of clinical endocrinology and metabolism , vol. 108 - pp 3031-3040

Bouraima F, Sapin V , Kahouadji S , Pickering ME, Pereira B, Bouvier D , Oris C

Body composition and muscle strength at the end of ICU stay are associated with 1-year mortality, a prospective multicenter observational study.

Published on 01 Oct 2023 in Clinical nutrition (Edinburgh, Scotland) , vol. 42 - pp 2070-2079

Ait Hssain A, Farigon N, Merdji H, Guelon D, Bohé J, Cayot S, Chabanne R, Constantin JM , Pereira B, Bouvier D , Andant N, Roth H, Thibault R, Sapin V , Hasselmann M, Souweine B, Cano N, Boirie Y, Dupuis C

Effectiveness and Costs of Molecular Screening and Treatment for Bacterial Vaginosis to Prevent Preterm Birth: The AuTop Randomized Clinical Trial.

Published on 01 Sep 2023 in JAMA pediatrics , vol. 177 - pp 894-902

Bretelle F, Loubière S, Desbriere R, Loundou A, Blanc J, Heckenroth H, Schmitz T, Benachi A, Haddad B, Mauviel F, Danoy X, Mares P, Chenni N, Ménard JP, Cocallemen JF, Slim N, Sénat MV, Chauleur C, Bohec C, Kayem G, Trastour C , Bongain A, Rozenberg P, Serazin V, Fenollar F, Groupe de Recherche en Obstetrique et Gynécologie (GROG) Investigators

Benefits of Premaquick(®) Combined Detection of IL-6/Total IGFBP-1/Native IGFBP-1 to Predict Preterm Delivery.

Published on 01 Sep 2023 in Journal of clinical medicine , vol. 12

Pambet M, Sirodot F, Pereira B, Cahierc R, Delabaere A , Comptour A , Rouzaire M , Sapin V , Gallot D

Efficacy of artificial tears containing trehalose and hyaluronic acid for dry eye disease in women aged 42-54 versus ≥ 55 years.

Published on 01 Aug 2023 in Contact lens & anterior eye : the journal of the British Contact Lens Association , vol. 46 - pp 101845

Mateo-Orobia AJ, Del Prado Sanz E, Blasco-Martínez A, Pablo-Júlvez LE, Farrant S, Chiambaretta F

Sample size estimation in clinical trials using ventilator-free days as the primary outcome: a systematic review.

Published on 01 Aug 2023 in Critical care (London, England) , vol. 27 - pp 303

Renard Triché L, Futier E , De Carvalho M, Piñol-Domenech N, Bodet-Contentin L, Jabaudon M , Pereira B

Management of patients suffering from mild traumatic brain injury 2023.

Published on 01 Aug 2023 in Anaesthesia, critical care & pain medicine , vol. 42 - pp 101260

Gil-Jardiné C, Payen JF, Bernard R, Bobbia X, Bouzat P, Catoire P, Chauvin A, Claessens YE, Douay B, Dubucs X, Galanaud D, Gauss T, Gauvrit JY, Geeraerts T, Glize B, Goddet S, Godier A, Le Borgne P, Rousseau G, Sapin V , Velly L, Viglino D, Vigue B, Cuvillon P, Frasca D, Claret PG

Genetic Characterization of Rat Hepatic Stellate Cell Line PAV-1.

Published on 11 Jun 2023 in Cells , vol. 12

Gäberlein K, Schröder SK, Nanda I, Steinlein C, Haaf T, Buhl EM, Sauvant P, Sapin V , Abergel A, Weiskirchen R

Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial.

Published on 31 May 2023 in Critical care (London, England) , vol. 27 - pp 213

Jabaudon M , Genevrier A, Jaber S, Windisch O, Bulyez S, Laterre PF, Escudier E, Sossou A, Guerci P, Bertrand PM, Danin PE, Bonnassieux M, Bühler L, Heidegger CP, Chabanne R, Godet T, Roszyk L , Sapin V , Futier E , Pereira B, Constantin JM , EPIPAN study group

Impact of storage temperature and time before analysis on electrolytes (Na(+), K(+), Ca(2+)), lactate, glucose, blood gases (pH, pO(2), pCO(2)), tHb, O(2)Hb, COHb and MetHb results.

Published on 21 Apr 2023 in Clinical chemistry and laboratory medicine , vol. 61 - pp 1740-1749

Puravet A, Rieu B , Phere C, Kahouadji S, Pereira B , Jabaudon M, Andanson B , Brailova M, Sapin V, Bouvier D

S100B, Actor and Biomarker of Mild Traumatic Brain Injury.

Published on 01 Apr 2023 in International journal of molecular sciences , vol. 24

Oris C , Kahouadji S , Durif J, Bouvier D , Sapin V

Epidemiology and Outcome of Early-Onset Acute Kidney Injury and Recovery in Critically Ill COVID-19 Patients: A Retrospective Analysis.

Published on 23 Mar 2023 in Biomedicines , vol. 11

Ruault A, Philipponnet C, Sapin V , Evrard B, Bouzgarrou R, Calvet L, Thouy F, Grapin K, Bonnet B, Adda M, Souweine B, Dupuis C

Characterization of RAGE and CK2 Expressions in Human Fetal Membranes.

Published on 17 Feb 2023 in International journal of molecular sciences , vol. 24

Coste K , Bruet S , Chollat-Namy C , Filhol O, Cochet C, Gallot D , Marceau G , Blanchon L , Sapin V , Belville C

Epidemiology, risk factors and prognosis of ventilator-associated pneumonia during severe COVID-19: Multicenter observational study across 149 European Intensive Care Units.

Published on 01 Feb 2023 in Anaesthesia, critical care & pain medicine , vol. 42 - pp 101184

Garnier M , Constantin JM , Heming N, Camous L, Ferré A, Razazi K, Lapidus N, COVID-ICU Investigators

Blood Biomarkers for Return to Play after Concussion in Professional Rugby Players.

Published on 01 Feb 2023 in Journal of neurotrauma , vol. 40 - pp 283-295

Oris C , Durif J, Rouzaire M , Pereira B, Bouvier D , Kahouadji S , Abbot M, Brailova M, Lehmann S, Hirtz C, Decq P, Dusfour B, Marchi N, Sapin V

Inhaled Sedation with Volatile Anesthetics for Mechanically Ventilated Patients in Intensive Care Units: A Narrative Review.

Published on 30 Jan 2023 in Journal of clinical medicine , vol. 12

Yassen KA, Jabaudon M , Alsultan HA, Almousa H, Shahwar DI, Alhejji FY, Aljaziri ZY

Stability of plasma renin concentration based on plasma freezing time, as an adjunct to the stability data reported in the paper by Hepburn and others.

Published on 24 Jan 2023 in Clinical chemistry and laboratory medicine , vol. 61 - pp e115-e117

Oris C , Bouvier D , Pereira B, Saintonge A, Coelho A, Sapin V

Ionized Magnesium: Interpretation and Interest in Atrial Fibrillation.

Published on 03 Jan 2023 in Nutrients , vol. 15

Bouillon-Minois JB, Khaled L, Vitte F, Miraillet L, Eschalier R, Jabaudon M , Sapin V , Derault L, Kahouadji S , Brailova M, Durif J, Schmidt J, Moustafa F, Pereira B, Futier E , Bouvier D

2022

Inhaled Sedation in Patients with COVID-19-Related Acute Respiratory Distress Syndrome: An International Retrospective Study.

Published on 20 Dec 2022 in Journal of clinical medicine , vol. 12

Coupet R , Schläpfer M, Neff TA, Boucher P, Bailly P, Bellgardt M, Badenes R, Carbonell J, Becher T, Varillon C, Morand D, Blondonnet R , Constantin JM , Pereira B, O'Gara B, Jabaudon M , ISCA Study Group

Spatial Distribution and Physicochemical Properties of Respirable Volcanic Ash From the 16-17 August 2006 Tungurahua Eruption (Ecuador), and Alveolar Epithelium Response In-Vitro.

Published on 01 Dec 2022 in GeoHealth , vol. 6 - pp e2022GH000680

Eychenne J , Gurioli L, Damby D, Belville C , Schiavi F, Marceau G , Szczepaniak C, Blavignac C, Laumonier M, Gardés E, Le Pennec JL, Nedelec JM, Blanchon L , Sapin V

COVID-19 acute respiratory distress syndrome promotes a specific alternative macrophage polarization.

Published on 13 Nov 2022 in Immunology letters , vol. 251-252 - pp 107-112

Garnier M , Blanchard F, Mailleux A, Morand-Joubert L, Crestani B, Quesnel C

Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience.

Published on 01 Oct 2022 in Anaesthesia, critical care & pain medicine , vol. 41 - pp 101121

Verdonk F, Feyaerts D, Badenes R, Bastarache JA, Bouglé A, Ely W, Gaudilliere B, Howard C, Kotfis K, Lautrette A, Le Dorze M, Mankidy BJ, Matthay MA, Morgan CK, Mazeraud A, Patel BV, Pattnaik R, Reuter J, Schultz MJ, Sharshar T, Shrestha GS, Verdonk C, Ware LB, Pirracchio R, Jabaudon M

Inhaled sedation in the intensive care unit.

Published on 01 Oct 2022 in Anaesthesia, critical care & pain medicine , vol. 41 - pp 101133

Jabaudon M, Zhai R , Blondonnet R , Bonda WLM

Association between proteinuria trajectories and outcomes in critically ill patients with sepsis or shock.

Published on 24 Aug 2022 in PloS one , vol. 17 - pp e0272835

Monge R, Oris C , Jabaudon M , Braïlova M, Futier E , Sapin V , Pereira B, Lautrette A

Reduced telomere length in amniocytes: an early biomarker of abnormal fetal development?

Published on 23 Aug 2022 in Human molecular genetics , vol. 31 - pp 2669-2677

Goumy C, Veronese L, Stamm R, Domas Q, Hadjab K, Gallot D , Laurichesse H, Delabaere A , Gouas L, Salaun G, Perbel-Richard C, Vago P, Tchirkov A

Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial.

Published on 20 Aug 2022 in Lancet (London, England) , vol. 400 - pp 592-604

Schmitz T, Doret-Dion M, Sentilhes L, Parant O, Claris O, Renesme L, Abbal J, Girault A, Torchin H, Houllier M, Le Saché N, Vivanti AJ, De Luca D, Winer N, Flamant C, Thuillier C , Boileau P, Blanc J , Brevaut V, Bouet PE, Gascoin G, Beucher G, Datin-Dorriere V, Bounan S, Bolot P, Poncelet C, Alberti C, Ursino M, Aupiais C, Baud O, BETADOSE trial study group, Groupe de Recherche en Obstétrique et Gynécologie

Factors Associated with and Prognosis Impact of Perceived Sleep Quality and Estimated Quantity in Patients Receiving Non-Invasive Ventilation for Acute Respiratory Failure.

Published on 08 Aug 2022 in Journal of clinical medicine , vol. 11

Lê Dinh M, Darmon M, Kouatchet A, Jaber S, Meziani F, Perbet S , Chanques G, Azoulay E, Demoule A

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis.

Published on 01 Aug 2022 in American journal of respiratory and critical care medicine , vol. 206 - pp 281-294

Hajage D, Combes A, Guervilly C, Lebreton G, Mercat A, Pavot A, Nseir S, Mekontso-Dessap A, Mongardon N, Mira JP, Ricard JD, Beurton A, Tachon G, Kontar L, Le Terrier C, Richard JC , Mégarbane B, Keogh RH, Belot A, Maringe C, Leyrat C, Schmidt M, COVID-ICU Investigators

Metallome deregulation and health-related impacts due to long-term exposure to recent volcanic ash deposits: New chemical and isotopic insights.

Published on 10 Jul 2022 in The Science of the total environment , vol. 829 - pp 154383

Sauzéat L , Eychenne J , Gurioli L, Boyet M, Jessop DE, Moretti R, Monrose M , Holota H , Beaudoin C , Volle DH

Descemetorhexis Without Endothelial Keratoplasty in Fuchs Endothelial Corneal Dystrophy: A Systematic Review and Meta-Analysis.

Published on 01 Jul 2022 in Cornea , vol. 41 - pp 815-825

Franceschino A, Dutheil F, Pereira B, Watson SL, Chiambaretta F , Navel V

34879044

[Two-year clinico-biological feedback in Overseas France and French-speaking territories during Covid-19 pandemic].

Published on 01 Jul 2022 in Annales de biologie clinique , vol. 80 - pp 311-318

Barguil Y, Busca S, Moury PH, Lamorinière M, Raz M, Chavant A, Duhin M, Chiaradia L, Couadou E, Bérard AM, Sapin V , Beauvieux MC, Sous-groupe de travail SFBC « Outre-mer et Francophonie »

One-year patient outcomes based on lung morphology in acute respiratory distress syndrome: secondary analysis of LIVE trial.

Published on 04 Jun 2022 in Critical care (London, England) , vol. 26 - pp 159

Blanchard F, Godet T, Pons S, Kapandji N, Jabaudon M , Degos V, Borao L, Bougle A, Monsel A, Futier E , Constantin JM , James A

Hypophosphatemia related to a neuro-endocrine tumor of the pancreas: A case report.

Published on 01 Jun 2022 in Clinical biochemistry , vol. 104 - pp 62-65

Pickering ME, Bouvier D , Puravet A , Soubrier M, Sapin V , Oris C

Design and Rationale of the Sevoflurane for Sedation in Acute Respiratory Distress Syndrome (SESAR) Randomized Controlled Trial.

Published on 16 May 2022 in Journal of clinical medicine , vol. 11

Blondonnet R , Simand LA, Vidal P, Borao L, Bourguignon N, Morand D, Bernard L, Roszyk L , Audard J, Godet T, Monsel A, Garnier M , Quesnel C, Bazin JE, Sapin V , Bastarache JA, Ware LB, Hughes CG, Pandharipande PP, Ely EW, Futier E , Pereira B, Constantin JM , Jabaudon M , On Behalf Of The Sesar Collaborative Group

Evaluation of serum neurofilament light in the early management of mTBI patients.

Published on 05 May 2022 in Clinical chemistry and laboratory medicine , vol. 60 - pp 1234-1241

Kahouadji S , Bouillon-Minois JB, Oris C , Durif J, Pereira B, Pinguet J, Rozand A, Schmidt J, Sapin V , Bouvier D

A chronic low-dose magnesium L-lactate administration has a beneficial effect on the myocardium and the skeletal muscles.

Published on 01 May 2022 in Journal of physiology and biochemistry , vol. 78 - pp 501-516

Pinto MM, Dubouchaud H, Jouve C, Rigaudière JP, Patrac V, Bouvier D , Hininger-Favier I, Walrand S, Demaison L

Inhaled Sedation for Invasively Ventilated COVID-19 Patients: A Systematic Review.

Published on 29 Apr 2022 in Journal of clinical medicine , vol. 11

Landoni G, Belloni O, Russo G, Bonaccorso A, Carà G, Jabaudon M

Open the lungs, keep them open and… take a break?

Published on 01 Apr 2022 in Anaesthesia, critical care & pain medicine , vol. 41 - pp 101057

Jabaudon M , Neto AS

Identification of low fluoride areas using conceptual groundwater flow model and hydrogeochemical system analysis in the aquifer system on the flanks of an active volcano: Mount Meru, Northern Tanzania.

Published on 25 Mar 2022 in The Science of the total environment , vol. 814 - pp 152682

Bennett G, Van Reybrouck J, Shemsanga C, Kisaka M, Tomašek I , Fontijn K, Kervyn M, Walraevens K

Spatial variability of the sources and distribution of fluoride in groundwater of the Sanya alluvial plain aquifers in northern Tanzania.

Published on 01 Mar 2022 in The Science of the total environment , vol. 810 - pp 152153

Ijumulana J, Ligate F, Irunde R, Bhattacharya P, Ahmad A, Tomašek I , Maity JP, Mtalo F

Intravenous immunoglobulins in patients with COVID-19-associated moderate-to-severe acute respiratory distress syndrome (ICAR): multicentre, double-blind, placebo-controlled, phase 3 trial.

Published on 01 Feb 2022 in The Lancet. Respiratory medicine , vol. 10 - pp 158-166

Mazeraud A, Jamme M, Mancusi RL, Latroche C, Megarbane B, Siami S, Zarka J, Moneger G, Santoli F, Argaud L, Chillet P, Muller G, Bruel C, Asfar P, Beloncle F, Reignier J, Vinsonneau C, Schimpf C, Amour J, Goulenok C, Lemaitre C, Rohaut B, Mateu P, De Rudnicki S, Mourvillier B, Declercq PL, Schwebel C, Stoclin A, Garnier M , Madeux B, Gaudry S, Bailly K, Lamer C, Aegerter P, Rieu C, Sylla K, Lucas B, Sharshar T

Decision support system to evaluate ventilation in the acute respiratory distress syndrome (DeVENT study)-trial protocol.

Published on 17 Jan 2022 in Trials , vol. 23 - pp 47

Patel B, Mumby S, Johnson N, Falaschetti E, Hansen J, Adcock I, McAuley D, Takata M, Karbing DS, Jabaudon M , Schellengowski P, Rees SE, DeVENT study group

Benefits of using corneal topography to choose subjective refraction technique in keratoconus (RE-CON): a prospective comparative crossover clinical study.

Published on 01 Jan 2022 in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie , vol. 260 - pp 197-207

Metzger M, Navel V , Barrière JV, Kwiatkowski F, Hébraud J, Mulliez A, Béral L, Chiambaretta F , Dutheil F

2021

Amniotic Aaquaporins (AQP) in Normal and Pathological Pregnancies: Interest in Polyhydramnios.

Published on 01 Oct 2021 in Reproductive sciences (Thousand Oaks, Calif.) , vol. 28 - pp 2929-2938

Guibourdenche J, Bonnet-Serrano F, Younes Chaouch L, Sapin V , Tsatsaris V, Combarel D, Laguillier C, Grange G

Tocolysis in the management of preterm prelabor rupture of membranes at 22-33 weeks of gestation: study protocol for a multicenter, double-blind, randomized controlled trial comparing nifedipine with placebo (TOCOPROM).

Published on 08 Sep 2021 in BMC pregnancy and childbirth , vol. 21 - pp 614

Lorthe E , Kayem G, TOCOPROM Study Group and the GROG (Groupe de Recherche en Obstétrique et Gynécologie)

Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta-analysis.

Published on 01 Sep 2021 in Acta ophthalmologica , vol. 99 - pp e777-e794

Navel V , Malecaze J , Pereira B, Baker JS, Malecaze F, Sapin V , Chiambaretta F , Dutheil F

French multicentre observational study on SARS-CoV-2 infections intensive care initial management: the FRENCH CORONA study.

Published on 01 Aug 2021 in Anaesthesia, critical care & pain medicine , vol. 40 - pp 100931

Roger C, Collange O, Mezzarobba M, Abou-Arab O, Teule L, Garnier M , Hoffmann C, Muller L, Lefrant JY, Guinot PG, Novy E, Abraham P, Clavier T, Bourenne J, Besch G, Favier L, Fiani M, Ouattara A, Joannes-Boyau O, Fischer MO, Leone M, Ait Tamlihat Y, Pottecher J, Cordier PY, Aussant P, Moussa MD, Hautin E, Bouex M, Julia JM, Cady J, Danguy Des Déserts M, Mayeur N, Mura T, Allaouchiche B, AZUREA group

Importance of Lung Epithelial Injury in COVID-19-associated Acute Respiratory Distress Syndrome: Value of Plasma Soluble Receptor for Advanced Glycation End-Products.

Published on 01 Aug 2021 in American journal of respiratory and critical care medicine , vol. 204 - pp 359-362

Kapandji N, Yvin E, Devriese M, de Margerie-Mellon C, Moratelli G, Lemiale V, Jabaudon M , Azoulay E, Constantin JM , Dumas G

Predictive Performance of Blood S100B in the Management of Patients Over 65 Years Old With Mild Traumatic Brain Injury.

Published on 13 Jul 2021 in The journals of gerontology. Series A, Biological sciences and medical sciences , vol. 76 - pp 1471-1479

Oris C , Bouillon-Minois JB, Pinguet J, Kahouadji S , Durif J, Meslé V, Pereira B, Schmidt J, Sapin V , Bouvier D

Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia.

Published on 08 Jul 2021 in The New England journal of medicine , vol. 385 - pp 107-118

Deprest JA, Nicolaides KH, Benachi A, Gratacos E, Ryan G, Persico N, Sago H, Johnson A, Wielgoś M, Berg C, Van Calster B, Russo FM, TOTAL Trial for Severe Hypoplasia Investigators

Randomized Trial of Fetal Surgery for Moderate Left Diaphragmatic Hernia.

Published on 08 Jul 2021 in The New England journal of medicine , vol. 385 - pp 119-129

Deprest JA, Benachi A, Gratacos E, Nicolaides KH, Berg C, Persico N, Belfort M, Gardener GJ, Ville Y, Johnson A, Morini F, Wielgoś M, Van Calster B, DeKoninck PLJ, TOTAL Trial for Moderate Hypoplasia Investigators

NLRP7 Promotes Choriocarcinoma Growth and Progression through the Establishment of an Immunosuppressive Microenvironment.

Published on 15 Jun 2021 in Cancers , vol. 13

Reynaud D, Abi Nahed R, Lemaitre N, Bolze PA, Traboulsi W, Sergent F, Battail C, Filhol O, Sapin V , Boufettal H, Hoffmann P, Aboussaouira T, Murthi P, Slim R, Benharouga M, Alfaidy N

Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a translational study.

Published on 01 Jun 2021 in American journal of physiology. Endocrinology and metabolism , vol. 320 - pp E1119-E1137

Chavanelle V, Otero YF, Le Joubioux F, Ripoche D, Bargetto M, Vluggens A, Montaurier C, Pickering G, Ducheix G, Dubray C, Dualé C, Boulliau S, Macian N, Marceau G , Sapin V , Dutheil F, Guigas B, Maugard T, Boisseau N, Cazaubiel M, Peltier SL, Sirvent P

[The world after].

Published on 01 Jun 2021 in Annales de biologie clinique , vol. 79 - pp 213-214

Piéroni L, Sapin V

[Myocardial injury in coronavirus disease 19 (Covid-19): main pathophysiological mechanisms and clinical utility of cardiac biomarkers].

Published on 01 Jun 2021 in Annales de biologie clinique , vol. 79 - pp 219-231

Kamel S, Raynor A, Zozor S, Lacape G, Brunel V, Nivet-Antoine V, Collin-Chavagnac D, Peoc'h K, Cohen A, Lassoued AB, Chévrier M, Alemann M, Lessinger JM, Bérard AM, Sapin V , Beauvieux MC, Levy P, Pour le Groupe de Travail de la SFBC « Marqueurs Biochimiques de la pathologie Covid-19 »

[8th international symposium “Alain Feuillu” – Emergency biology and blood gases].

Published on 01 Jun 2021 in Annales de biologie clinique , vol. 79 - pp 277-299

Aussel C, Delacour H, Merzouk M, Cohen R, Oueidat N, Hausfater P, Planche V, Satre-Buisson L, Wehler M, Blanchecotte F, Gruson D, Scaillierez AL, Bouvier D , Izopet J, Bereder JM, Robach P, Millet S, Boutherre C, Kuentz M, Monange JB, Dempsey F, Sollier CBD, Plessis P, Vaubourdolle M

[Blood biomarkers of early diagnosis for neonatal bacterial infections: back from Senegal cohort].

Published on 01 Jun 2021 in Annales de biologie clinique , vol. 79 - pp 241-252

Coly NFG, Durif J, Bass I, Pereira B, Thiam S, Samba A, Ndiaye A, Soumah IY, Diedhiou F, Cissé F, Djité M, Gueye PM, Gueye NRD, Ndiaye HD, Coste K , Sapin V , Agne FD

Changes in Plasma Soluble Receptor for Advanced Glycation End-Products Are Associated with Survival in Patients with Acute Respiratory Distress Syndrome.

Published on 12 May 2021 in Journal of clinical medicine , vol. 10

Jabaudon M , Pereira B, Laroche E, Roszyk L , Blondonnet R , Audard J, Godet T, Futier E , Bazin JE, Sapin V , Bastarache JA, Ware LB, Constantin JM , On Behalf Of The Live Study Group And The Azurea Network

Blood biomarkers of mild traumatic brain injury: State of art.

Published on 01 May 2021 in Neuro-Chirurgie , vol. 67 - pp 249-254

Sapin V, Gaulmin R , Aubin R, Walrand S, Coste A, Abbot M

Nutritional factors in sport-related concussion.

Published on 01 May 2021 in Neuro-Chirurgie , vol. 67 - pp 255-258

Walrand S, Gaulmin R, Aubin R, Sapin V , Coste A, Abbot M

Use of volatile agents for sedation in the intensive care unit: A national survey in France.

Published on 15 Apr 2021 in PloS one , vol. 16 - pp e0249889

Blondonnet R , Quinson A, Lambert C, Audard J, Godet T, Zhai R , Pereira B, Futier E , Bazin JE, Constantin JM , Jabaudon M

Impact of disease activity and treatments on ovarian reserve in patients with rheumatoid arthritis in the ESPOIR cohort.

Published on 06 Apr 2021 in Rheumatology (Oxford, England) , vol. 60 - pp 1863-1870

Valdeyron C, Soubrier M, Pereira B, Constantin A, Morel J, Gaudin P, Combe B, Gremeau AS, Dejou-Bouillet L, Pouly JL, Sapin V , Oris C , Brugnon F

The ‘ephemeral’ intensive care units that saved the French healthcare system, a new concept to be preserved.

Published on 01 Apr 2021 in European journal of anaesthesiology , vol. 38 - pp 441-442

Verdonk F, Garnier M , Bonnet F, Jabaudon M

Sudden cardiac death risk in contact sports increased by myocarditis: a case series.

Published on 01 Mar 2021 in European heart journal. Case reports , vol. 5 - pp ytab054

Massoullié G, Boyer B, Sapin V , Jean F, Andronache M, Peoc'h M, Clerfond G, Eschalier R

Cervical ripening in prolonged pregnancies by silicone double balloon catheter versus vaginal dinoprostone slow release system: The MAGPOP randomised controlled trial.

Published on 11 Feb 2021 in PLoS medicine , vol. 18 - pp e1003448

Diguisto C, Le Gouge A, Arthuis C, Winer N, Parant O, Poncelet C, Chauleur C, Hannigsberg J, Ducarme G, Gallot D , Gabriel R, Desbriere R, Beucher G, Faraguet C, Isly H, Rozenberg P, Giraudeau B, Perrotin F, Groupe de Recherche en Obstétrique et Gynécologie (GROG)

[SARS-CoV-2 and neurological disorders: the revelance of biomarkers?].

Published on 01 Feb 2021 in Annales de biologie clinique , vol. 79 - pp 7-16

Bigot-Corbel E, Lanore A, Raulet C, Delorme C, Azulay JP, Lehmann S, Beaudeux JL, Beauvieux MC, Sapin V , Peoc'h K, Rucheton B, Membres du groupe de travail « SFBC Marqueurs biochimiques COVID-19 »

Biomarkers in acute respiratory distress syndrome.

Published on 01 Feb 2021 in Current opinion in critical care , vol. 27 - pp 46-54

Jabaudon M, Blondonnet R , Ware LB

Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: inflammatory response of SARS-CoV-2 patients.

Published on 13 Jan 2021 in Annals of intensive care , vol. 11 - pp 9

Lavillegrand JR, Garnier M , Spaeth A, Mario N, Hariri G, Pilon A, Berti E, Fieux F, Thietart S, Urbina T, Turpin M, Darrivere L, Fartoukh M, Verdonk F, Dumas G, Tedgui A, Guidet B, Maury E, Chantran Y, Voiriot G, Ait-Oufella H

Predictors of Short Latency Period Exceeding 48 h after Preterm Premature Rupture of Membranes.

Published on 04 Jan 2021 in Journal of clinical medicine , vol. 10

Rouzaire M , Corvaisier M, Roumeau V, Mulliez A, Sendy F, Delabaere A , Gallot D

2020

Impact of maternal prenatal psychological stress on birth weight.

Published on 01 Dec 2020 in Health psychology : official journal of the Division of Health Psychology, American Psychological Association , vol. 39 - pp 1100-1108

Mélançon J, Bernard N, Forest JC, Tessier R, Tarabulsy GM, Bouvier D , Giguère Y

Analgesia and sedation in patients with ARDS.

Published on 01 Dec 2020 in Intensive care medicine , vol. 46 - pp 2342-2356

Chanques G, Constantin JM , Devlin JW, Ely EW, Fraser GL, Gélinas C, Girard TD, Guérin C, Jabaudon M , Jaber S, Mehta S, Langer T, Murray MJ, Pandharipande P, Patel B, Payen JF, Puntillo K, Rochwerg B, Shehabi Y, Strøm T, Olsen HT, Kress JP

Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS.

Published on 01 Dec 2020 in Chest , vol. 158 - pp 2394-2403

Jabaudon M , Audard J, Pereira B, Jaber S, Lefrant JY, Blondonnet R , Godet T, Futier E , Lambert C, Bazin JE, Bastarache JA, Constantin JM , Ware LB, LIVE Study Group and the AZUREA Network

A proposed Common Training Framework for Specialists in Laboratory Medicine under EU Directive 2013/55/EC (The Recognition of Professional Qualifications).

Published on 30 Nov 2020 in Clinical chemistry and laboratory medicine , vol. 59 - pp 505-512

Wieringa G, Queraltó J, Homšak E, Jassam N, Cavalier E, Svinarov D, Krleža JL, Christou S, Pikner R, Larsen TR, Tomberg K, Linko-Parvinen A, Sapin V , Baum H, Kroupis C, Bagoly Z, Costelloe S, Sciacovelli L, Stasulans J, Vitkus D, Meunier D, Solnica B, Reguengo H, Mambet C, Kovac G, Krhin B, Ohlson M, Buhagiar G, Simundic AM

A proposed Common Training Framework for Specialists in Laboratory Medicine under EU Directive 2013/55/EC (The Recognition of Professional Qualifications).

Published on 30 Nov 2020 in Clinical chemistry and laboratory medicine , vol. 59 - pp 505-512

Wieringa G, Queraltó J, Homšak E, Jassam N, Cavalier E, Svinarov D, Krleža JL, Christou S, Pikner R, Larsen TR, Tomberg K, Linko-Parvinen A, Sapin V , Baum H, Kroupis C, Bagoly Z, Costelloe S, Sciacovelli L, Stasulans J, Vitkus D, Meunier D, Solnica B, Reguengo H, Mambet C, Kovac G, Krhin B, Ohlson M, Buhagiar G, Simundic AM

Interest of blood biomarkers to predict lesions in medical imaging in the context of mild traumatic brain injury.

Published on 01 Nov 2020 in Clinical biochemistry , vol. 85 - pp 5-11

Bouvier D , Oris C , Brailova M, Durif J, Sapin V

[COVID-19, an atypical acute respiratory distress syndrome].

Published on 01 Sep 2020 in Le praticien en anesthesie reanimation , vol. 24 - pp 225-229

Tirolien JA, Garnier M

S100B Blood Level Determination for Early Management of Ski-Related Mild Traumatic Brain Injury: A Pilot Study.

Published on 14 Aug 2020 in Frontiers in neurology , vol. 11 - pp 856

Kahouadji S , Salamin P, Praz L, Coiffier J, Frochaux V, Durif J, Pereira B, Arlettaz L, Oris C , Sapin V , Bouvier D

Methyl-donor supplementation prevents intestinal colonization by Adherent-Invasive E. coli in a mouse model of Crohn’s disease.

Published on 31 Jul 2020 in Scientific reports , vol. 10 - pp 12922

Gimier E, Chervy M, Agus A, Sivignon A, Billard E, Privat M, Viala S, Minet-Quinard R , Buisson A, Vazeille E, Barnich N, Denizot J

Variation of faecal calprotectin level within the first three months after bowel resection is predictive of endoscopic postoperative recurrence in Crohn’s disease.

Published on 01 Jul 2020 in Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver , vol. 52 - pp 740-744

Boube M, Laharie D, Nancey S, Hebuterne X, Fumery M, Pariente B, Roblin X, Peyrin-Biroulet L, Minet-Quinard R , Pereira B, Bommelaer G, Buisson A, POPCUR study group

Is laterality of congenital diaphragmatic hernia a reliable prognostic factor? French national cohort study.

Published on 01 Jul 2020 in Prenatal diagnosis , vol. 40 - pp 949-957

Pinton A, Boubnova J, Becmeur F, Kuhn P, Senat MV, Stirnemann J, Capelle M, Rosenblatt J, Massardier J, Vaast P, Le Bouar G, Desrumaux A, Connant L, Begue L, Parmentier B, Perrotin F, Diguet A, Benoist G, Muszynski C, Scalabre A, Winer N, Michel JL, Casagrandre-Magne F, Jouannic JM, Gallot D , Coste Mazeau P, Sapin E, Maatouk A, Saliou AH, Sentilhes L, Biquard F, Mottet N, Favre R, Benachi A, Sananès N

Coronavirus: good or bad news for ocular diseases?

Published on 09 Jun 2020 in BMJ open ophthalmology , vol. 5 - pp e000495

Navel V , Chiambaretta F , Dutheil F

Guidelines: Anaesthesia in the context of COVID-19 pandemic.

Published on 01 Jun 2020 in Anaesthesia, critical care & pain medicine , vol. 39 - pp 395-415

Velly L, Gayat E, Quintard H, Weiss E, De Jong A, Cuvillon P, Audibert G, Amour J, Beaussier M, Biais M, Bloc S, Bonnet MP, Bouzat P, Brezac G, Dahyot-Fizelier C, Dahmani S, de Queiroz M, Di Maria S, Ecoffey C, Futier E , Geeraerts T, Jaber H, Heyer L, Hoteit R, Joannes-Boyau O, Kern D, Langeron O, Lasocki S, Launey Y, le Saché F, Lukaszewicz AC, Maurice-Szamburski A, Mayeur N, Michel F, Minville V, Mirek S, Montravers P, Morau E, Muller L, Muret J, Nouette-Gaulain K, Orban JC, Orliaguet G, Perrigault PF, Plantet F, Pottecher J, Quesnel C, Reubrecht V, Rozec B, Tavernier B, Veber B, Veyckmans F, Charbonneau H, Constant I, Frasca D, Fischer MO, Huraux C, Blet A, Garnier M

A procedure to extract functional isolated mitochondria from small-sized human atrial samples. Application to obesity with a partial characterisation of the organelles.

Published on 01 Jun 2020 in Free radical biology & medicine , vol. 153 - pp 71-79

Leger T, Jouve C, Patrac V, Batel V, Bouvier D , Sapin V , Miguel B, Demaison L, Azarnoush K

Minimal alveolar concentration for deep sedation (MAC-DS) in intensive care unit patients sedated with sevoflurane: A physiological study.

Published on 01 Jun 2020 in Anaesthesia, critical care & pain medicine , vol. 39 - pp 429-434

Blanchard F, Perbet S , James A, Verdonk F, Godet T, Bazin JE, Pereira B, Lambert C, Constantin JM

Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.

Published on 07 Apr 2020 in Respiratory research , vol. 21 - pp 81

Carla A, Pereira B, Boukail H, Audard J, Pinol-Domenech N, De Carvalho M, Blondonnet R , Zhai R , Morand D, Lambert C, Sapin V , Ware LB, Calfee CS, Bastarache JA, Laffey JG, Juffermans NP, Bos LD, Artigas A, Rocco PRM, Matthay MA, McAuley DF, Constantin JM , Jabaudon M , ESICM Translational Biology Group of the Acute Respiratory Failure section

Eyes wide open on bronchial aeration in acute respiratory distress syndrome.

Published on 01 Apr 2020 in Anaesthesia, critical care & pain medicine , vol. 39 - pp 191-192

Jabaudon M , Bastarache JA, Ware LB

Cord blood S100B: reference ranges and interest for early identification of newborns with brain injury.

Published on 28 Jan 2020 in Clinical chemistry and laboratory medicine , vol. 58 - pp 285-293

Bouvier D , Giguère Y, Pereira B, Bernard N, Marc I, Sapin V , Forest JC

2019

Risk Factors and Outcomes of Preterm Premature Rupture of Membranes in a Cohort of 6968 Pregnant Women Prospectively Recruited.

Published on 15 Nov 2019 in Journal of clinical medicine , vol. 8

Bouvier D , Forest JC, Blanchon L , Bujold E, Pereira B, Bernard N, Gallot D , Sapin V , Giguère Y

Risk Factors and Outcomes of Preterm Premature Rupture of Membranes in a Cohort of 6968 Pregnant Women Prospectively Recruited.

Published on 15 Nov 2019 in Journal of clinical medicine , vol. 8

Bouvier D , Forest JC, Blanchon L , Bujold E, Pereira B, Bernard N, Gallot D , Sapin V , Giguère Y

Retinoic Acid Pathway Regulation of Vascular Endothelial Growth Factor in Ovine Amnion.

Published on 30 Oct 2019 in Reproductive sciences (Thousand Oaks, Calif.) , vol. 26 - pp 1351-1359

Cheung CY, Anderson DF, Rouzaire M , Blanchon L , Sapin V , Brace RA

Driving pressure and acute respiratory distress syndrome in critically ill patients.

Published on 02 Mar 2019 in Respirology (Carlton, Vic.) , vol. 24 - pp 137-145

Blondonnet R , Joubert E, Godet T, Berthelin P, Pranal T, Roszyk L , Chabanne R, Eisenmann N, Lautrette A, Belville C , Cayot S, Gillart T, Souweine B, Bouvier D , Blanchon L , Sapin V , Pereira B, Constantin JM , Jabaudon M

Fetal fibronectin test for threatened preterm delivery 48h after admission: Cost-effectiveness study.

Published on 01 Mar 2019 in European journal of obstetrics, gynecology, and reproductive biology , vol. 234 - pp 75-78

Mourgues C, Rossi A, Favre N, Delabaere A , Roszyk L , Sapin V , Debost-Legrand A, Gallot D

NLRP7 is increased in human idiopathic fetal growth restriction and plays a critical role in trophoblast differentiation.

Published on 01 Mar 2019 in Journal of molecular medicine (Berlin, Germany) , vol. 97 - pp 355-367

Abi Nahed R, Reynaud D, Borg AJ, Traboulsi W, Wetzel A, Sapin V , Brouillet S, Dieudonné MN, Dakouane-Giudicelli M, Benharouga M, Murthi P, Alfaidy N

2018

Serum soluble receptor for advanced glycation end-products during acute bronchiolitis in infant: Prospective study in 93 cases.

Published on 30 Oct 2018 in Pediatric pulmonology , vol. 53 - pp 1429-1435

Egron C, Roszyk L , Rochette E, Jabaudon M , Sapin V , Mulliez A, Labbé A, Coste K

Clinical validation of S100B in the management of a mild traumatic brain injury: issues from an interventional cohort of 1449 adult patients.

Published on 25 Oct 2018 in Clinical chemistry and laboratory medicine , vol. 56 - pp 1897-1904

Allouchery G, Moustafa F, Roubin J, Pereira B, Schmidt J, Raconnat J, Pic D, Sapin V , Bouvier D

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells.

Published on 23 Oct 2018 in Journal of visualized experiments : JoVE

Blondonnet R , Paquette B , Richard D, Bourg R, Laplace G, Segurel R, Pouvelle H, Belville C , Blanchon L , Godet T, Constantin JM , Bazin JE, Sapin V , Jabaudon M

Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.

Published on 30 Sep 2018 in Intensive care medicine , vol. 44 - pp 1388-1399

Jabaudon M , Blondonnet R , Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V , Matthay MA, Constantin JM , Calfee CS

The Biomarker S100B and Mild Traumatic Brain Injury: A Meta-analysis.

Published on 30 Jun 2018 in Pediatrics , vol. 141

Oris C , Pereira B, Durif J, Simon-Pimmel J, Castellani C, Manzano S, Sapin V , Bouvier D

Recent directions in personalised acute respiratory distress syndrome medicine.

Published on 30 Jun 2018 in Anaesthesia, critical care & pain medicine , vol. 37 - pp 251-258

Jabaudon M , Blondonnet R , Audard J, Fournet M , Godet T, Sapin V , Constantin JM

Clinical and Biological Predictors of Plasma Levels of Soluble RAGE in Critically Ill Patients: Secondary Analysis of a Prospective Multicenter Observational Study.

Published on 10 May 2018 in Disease markers , vol. 2018 - pp 7849675

Pranal T, Pereira B, Berthelin P, Roszyk L , Godet T, Chabanne R, Eisenmann N, Lautrette A, Belville C , Blondonnet R , Cayot S, Gillart T, Skrzypczak Y, Souweine B, Bouvier D , Blanchon L , Sapin V , Constantin JM , Jabaudon M

Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study.

Published on 08 Feb 2018 in Scientific reports , vol. 8 - pp 2603

Jabaudon M , Berthelin P, Pranal T, Roszyk L , Godet T, Faure JS, Chabanne R, Eisenmann N, Lautrette A, Belville C , Blondonnet R , Cayot S, Gillart T, Pascal J, Skrzypczak Y, Souweine B, Blanchon L , Sapin V , Pereira B, Constantin JM

Vitamin A status in healthy women eating traditionally prepared spirulina (Dihé) in the Chad Lake area.

Published on 29 Jan 2018 in PloS one , vol. 13 - pp e0191887

Soudy ID, Minet-Quinard R , Mahamat AD, Ngoua HF, Izzedine AA, Tidjani A, Ngo Bum E, Lambert C, Pereira B, Desjeux JF, Sapin V

Vitamin A status in healthy women eating traditionally prepared spirulina (Dihé) in the Chad Lake area.

Published on 29 Jan 2018 in PloS one , vol. 13 - pp e0191887

Soudy ID, Minet-Quinard R , Mahamat AD, Ngoua HF, Izzedine AA, Tidjani A, Ngo Bum E, Lambert C, Pereira B, Desjeux JF, Sapin V

High frequency percussive ventilation increases alveolar recruitment in early acute respiratory distress syndrome: an experimental, physiological and CT scan study.

Published on 11 Jan 2018 in Critical care (London, England) , vol. 22 - pp 3

Godet T, Jabaudon M , Blondonnet R , Tremblay A, Audard J, Rieu B, Pereira B, Garcier JM, Futier E , Constantin JM

2017

Recruitment maneuvers in acute respiratory distress syndrome.

Published on 30 Jul 2017 in Annals of translational medicine , vol. 5 - pp 290

Constantin JM , Godet T, Jabaudon M , Bazin JE, Futier E

Retinoic Acid Engineered Amniotic Membrane Used as Graft or Homogenate: Positive Effects on Corneal Alkali Burns.

Published on 01 Jul 2017 in Investigative ophthalmology & visual science , vol. 58 - pp 3513-3518

Joubert R, Daniel E, Bonnin N, Comptour A , Gross C , Belville C , Chiambaretta F , Blanchon L , Sapin V

[Premature rupture of membranes≥37 weeks of gestation: Predictive factors for labour onset within 24hours].

Published on 30 Jun 2017 in Gynecologie, obstetrique, fertilite & senologie , vol. 45 - pp 348-352

Huret C, Pereira B, Collange V, Delabaere A , Rouzaire M , Lemery D, Sapin V , Gallot D

Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol.

Published on 29 May 2017 in BMJ open , vol. 7 - pp e015280

Bulyez S, Pereira B, Caumon E, Imhoff E, Roszyk L , Bernard L, Bühler L, Heidegger C, Jaber S, Lefrant JY, Chabanne R, Bertrand PM, Laterre PF, Guerci P, Danin PE, Escudier E, Sossou A, Morand D, Sapin V , Constantin JM , Jabaudon M , EPIPAN Study Group, AzuRea network

Utility of S100B Serum Level for the Determination of Concussion in Male Rugby Players.

Published on 30 Apr 2017 in Sports medicine (Auckland, N.Z.) , vol. 47 - pp 781-789

Bouvier D , Duret T, Abbot M, Stiernon T, Pereira B, Coste A, Chazal J, Sapin V

Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study.

Published on 15 Mar 2017 in American journal of respiratory and critical care medicine , vol. 195 - pp 792-800

Jabaudon M , Boucher P, Imhoff E, Chabanne R, Faure JS, Roszyk L , Thibault S, Blondonnet R , Clairefond G , Guérin R, Perbet S , Cayot S, Godet T, Pereira B, Sapin V , Bazin JE, Futier E , Constantin JM

2016

Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS: A Prospective Multicenter Study.

Published on 30 Nov 2016 in Chest , vol. 150 - pp 998-1007

Mrozek S, Jabaudon M , Jaber S, Paugam-Burtz C, Lefrant JY, Rouby JJ, Asehnoune K, Allaouchiche B, Baldesi O, Leone M, Lu Q, Bazin JE, Roszyk L , Sapin V , Futier E , Pereira B, Constantin JM , Azurea network

Lung ultrasonography for assessment of oxygenation response to prone position ventilation in ARDS.

Published on 30 Oct 2016 in Intensive care medicine , vol. 42 - pp 1546-1556

Haddam M, Zieleskiewicz L, Perbet S , Baldovini A, Guervilly C, Arbelot C, Noel A, Vigne C, Hammad E, Antonini F, Lehingue S, Peytel E, Lu Q, Bouhemad B, Golmard JL, Langeron O, Martin C, Muller L, Rouby JJ, Constantin JM , Papazian L, Leone M, CAR’Echo Collaborative Network, AzuRea Collaborative Network

Different dose rate-dependent responses of human melanoma cells and fibroblasts to low dose fast neutrons.

Published on 30 Sep 2016 in International journal of radiation biology , vol. 92 - pp 527-35

Dionet C, Müller-Barthélémy M, Marceau G , Denis JM, Averbeck D, Gueulette J, Sapin V , Pereira B, Tchirkov A, Chautard E, Verrelle P

Lysyl oxidase-like 4 involvement in retinoic acid epithelial wound healing.

Published on 06 Sep 2016 in Scientific reports , vol. 6 - pp 32688

Comptour A , Rouzaire M , Belville C , Bonnin N, Daniel E, Chiambaretta F , Blanchon L , Sapin V

Effect of non-invasive oxygenation strategies in immunocompromised patients with severe acute respiratory failure: a post-hoc analysis of a randomised trial.

Published on 30 Aug 2016 in The Lancet. Respiratory medicine , vol. 4 - pp 646-652

Frat JP, Ragot S, Girault C, Perbet S , Prat G, Boulain T, Demoule A, Ricard JD, Coudroy R, Robert R, Mercat A, Brochard L, Thille AW, REVA network

Preanalytical, analytical, gestational and pediatric aspects of the S100B immuno-assays.

Published on 30 May 2016 in Clinical chemistry and laboratory medicine , vol. 54 - pp 833-42

Bouvier D , Duret T, Rouzaire P, Jabaudon M , Rouzaire M , Nourrisson C, Bourgne C, Pereira B, Evrard B, Sapin V

Net alveolar fluid clearance is associated with lung morphology phenotypes in acute respiratory distress syndrome.

Published on 30 Apr 2016 in Anaesthesia, critical care & pain medicine , vol. 35 - pp 81-6

Jabaudon M , Blondonnet R , Lutz J, Roszyk L , Bouvier D , Guérin R, Perbet S , Cayot S, Godet T, Blanchon L , Bazin JE, Futier E , Sapin V , Constantin JM

Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery: A Randomized Clinical Trial.

Published on 05 Apr 2016 in JAMA , vol. 315 - pp 1345-53

Jaber S, Lescot T, Futier E , Paugam-Burtz C, Seguin P, Ferrandiere M, Lasocki S, Mimoz O, Hengy B, Sannini A, Pottecher J, Abback PS, Riu B, Belafia F, Constantin JM , Masseret E, Beaussier M, Verzilli D, De Jong A, Chanques G, Brochard L, Molinari N, NIVAS Study Group

2015

Aquaporins and Fetal Membranes From Diabetic Parturient Women: Expression Abnormalities and Regulation by Insulin.

Published on 30 Oct 2015 in The Journal of clinical endocrinology and metabolism , vol. 100 - pp E1270-9

Bouvier D , Rouzaire M , Marceau G , Prat C , Pereira B, Lemarié R, Deruelle P, Fajardy I, Gallot D , Blanchon L , Vambergue A, Sapin V

Comment and reply on: Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth.

Published on 17 Jun 2015 in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - pp 1-2

Gallot D , Goffinet F, Sapin V , Guibourdenche J, Jouannic M, Langer B, Doret M, Subtil D, Fernandez H

High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure.

Published on 04 Jun 2015 in The New England journal of medicine , vol. 372 - pp 2185-96

Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S , Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM , Tonnelier JM, Pierrot M, Mathonnet A, Béduneau G, Delétage-Métreau C, Richard JC, Brochard L, Robert R, FLORALI Study Group, REVA Network

IFPA meeting 2014 workshop report: Animal models to study pregnancy pathologies; new approaches to study human placental exposure to xenobiotics; biomarkers of pregnancy pathologies; placental genetics and epigenetics; the placenta and stillbirth and fetal growth restriction.

Published on 30 Apr 2015 in Placenta , vol. 36 Suppl 1 - pp S5-10

Barbaux S, Erwich JJ, Favaron PO, Gil S, Gallot D , Golos TG, Gonzalez-Bulnes A, Guibourdenche J, Heazell AE, Jansson T, Laprévote O, Lewis RM, Miller RK, Monk D, Novakovic B, Oudejans C, Parast M, Peugnet P, Pfarrer C, Pinar H, Roberts CT, Robinson W, Saffery R, Salomon C, Sexton A, Staff AC, Suter M, Tarrade A, Wallace J, Vaillancourt C, Vaiman D, Worton SA, Lash GE

Metabolic disturbances of the vitamin A pathway in human diaphragmatic hernia.

Published on 15 Jan 2015 in American journal of physiology. Lung cellular and molecular physiology , vol. 308 - pp L147-57

Coste K , Beurskens LW, Blanc P , Gallot D , Delabaere A , Blanchon L , Tibboel D, Labbé A, Rottier RJ, Sapin V

2014

An interplay of geometry and signaling enables robust lung branching morphogenesis.

Published on 30 Dec 2014 in Development (Cambridge, England) , vol. 141 - pp 4526-36

Menshykau D, Blanc P , Unal E, Sapin V , Iber D

The challenge of prenatal identification of congenital diaphragmatic hernia in the context of hydrops.

Published on 30 Nov 2014 in European journal of obstetrics, gynecology, and reproductive biology , vol. 182 - pp 238-9

Rossi A, Delabaere A , Delmas-Laurichesse H, Beaufrère AM, Lémery D, Gallot D

Endocrine gland-derived endothelial growth factor (EG-VEGF) is a potential novel regulator of human parturition.

Published on 30 Sep 2014 in Biology of reproduction , vol. 91 - pp 73

Dunand C, Hoffmann P, Sapin V , Blanchon L , Salomon A, Sergent F, Benharouga M, Sabra S, Guibourdenche J, Lye SJ, Feige JJ, Alfaidy N

Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a.

Published on 07 Aug 2014 in Cell reports , vol. 8 - pp 743-53

Deplus R, Blanchon L , Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B , Berdasco M, Putmans P, Calonne E, Litchfield DW, de Launoit Y, Jurkowski TP, Stunnenberg HG, Bock C, Sotiriou C, Fraga MF, Esteller M, Jeltsch A, Fuks F

Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet – the RESOLVE trial.

Published on 11 Jul 2014 in Lipids in health and disease , vol. 13 - pp 112

Dutheil F, Walther G, Chapier R, Mnatzaganian G, Lesourd B, Naughton G, Verney J, Fogli A , Sapin V , Duclos M, Vinet A, Obert P, Courteix D, Lac G

Lung postmortem autopsy revealing extramedullary involvement in multiple myeloma causing acute respiratory distress syndrome.

Published on 01 Jan 2014 in Case reports in hematology , vol. 2014 - pp 635237

Ravinet A, Perbet S , Guièze R, Lemal R, Guérin R, Gayraud G, Aliane J, Tremblay A, Pascal J, Ledoux A, Chaleteix C, Dechelotte P , Bay JO, Bazin JE, Constantin JM

2013

Plasma levels of sRAGE, loss of aeration and weaning failure in ICU patients: a prospective observational multicenter study.

Published on 27 May 2013 in PloS one , vol. 8 - pp e64083

Jabaudon M , Perbet S , Pereira B, Soummer A, Roszyk L , Guérin R, Futier E , Lu Q, Bazin JE, Sapin V , Rouby JJ, Constantin JM

2012
2010

Fetal skin fibroblasts: a cell model for studying the retinoid pathway in congenital diaphragmatic hernia.

Published on 30 Mar 2010 in Birth defects research. Part A, Clinical and molecular teratology , vol. 88 - pp 195-200

Goumy C, Coste K , Marceau G , Gouas L, Tchirkov A, Vago P, Gallot D , Sapin V

Retinoid pathway and congenital diaphragmatic hernia: hypothesis from the analysis of chromosomal abnormalities.

Published on 01 Jan 2010 in Fetal diagnosis and therapy , vol. 28 - pp 129-39

Goumy C, Gouas L, Marceau G , Coste K , Veronese L, Gallot D , Sapin V , Vago P, Tchirkov A

2009

Natural mutations of the anti-Mullerian hormone type II receptor found in persistent Mullerian duct syndrome affect ligand binding, signal transduction and cellular transport.

Published on 15 Aug 2009 in Human molecular genetics , vol. 18 - pp 3002-13

Belville C , Maréchal JD, Pennetier S, Carmillo P, Masgrau L, Messika-Zeitoun L, Galey J, Machado G, Treton D, Gonzalès J, Picard JY, Josso N, Cate RL, di Clemente N

Theses

11 theses
2023
Subject:
Effects of sevoflurane in the treatment of Acute respiratory Distress Syndrome : a translational approach
Realized by :
Ruoyang Zhai
Defense date:
24/03/2023
Subject:
Dérégulation de l’expression du Récepteur aux Produits Avancés de Glycation (RAGE) dans la pathologie de la Surface oculaire
Realized by :
Valentin NAVEL
Defense date:
31/05/2023
Subject:
Inflammation du syndrome de l’oeil sec : implications épithéliales et macrophagiques de NFAT5 et RAGE
Realized by :
Fanny HENRIOUX
Defense date:
01/06/2023
2022
Subject:
Effects of sevoflurane on RAGE-mediated pathways of lung injury and repair : a translational approach
Realized by :
Raïko BLONDONNET
Defense date:
08/09/2022
2021
Subject:
Implications du récepteur aux produits avancés de glycation, RAGE, dans la physiopathologie de la rupture des membranes fœtales humaines
Supervisor:
Realized by :
Helena Choltus
Defense date:
13/09/2021
2019
Subject:
Role des protéines NLRP dans la physopathologie des membranes foetales humaines
Supervisor:
Realized by :
Marilyne LAVERGNE
Defense date:
15/11/2019
2018
Subject:
Etude de l’implication des produits de glycation avancés et de leur récepteur RAGE dans la cicatrisation de l’épithélium cornéen
Supervisor:
Realized by :
Christelle GROSS
Defense date:
12/12/2018
2017
Subject:
Rétinoïdes en intra-tracheal et occlusion de trachée dans le traitement anténatal de la hernie diaphragmatique congénitale
Supervisor:
Realized by :
Amélie DELABAERE
Defense date:
13/09/2017
2016
Subject:
Fonctions des rétinoïdes dans les membranes fœtales humaines : action pro-cicatrisante médiée par LOXL4
Supervisor:
Realized by :
Marion ROUZAIRE
Defense date:
22/09/2016
2015
Subject:
L’ATRA (Acide tout trans rétinoïque), dérivé actif de la vitamine A permet la cicatrisation de cellules épithéliales de cornée humaine HCE et de l’épithélium cornéen brulé par base chez le modèle souris
Supervisor:
Realized by :
Aurélie COMPTOUR
Defense date:
03/07/2015
2012
Subject:
Ontogénèse et régulation des aquaporines par les rétinoïdes dans ls membranes fœtales humaines
Supervisor:
Realized by :
Cécile PRAT
Defense date:
11/10/2012
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