Our team is interested in the membrane receptor called RAGE (advanced glycation end products receptor) which is a multi-ligand receptor (called alarmins) belonging to the immunoglobulin superfamily. The binding of one of its ligands will trigger at the cellular level signalling cascades leading to the arinsing of an inflammatory response. Our project is particularly interested in the involvement of this receptor in the lung and fetal membranes (water pocket) focusing on epithelial cells and their aggression as a result of 2 pathologies: acute respiratory distress syndrome and premature rupture of fetal membranes.
Following aggressions resulting from both exogenous and endogenous signals, the achievement of the integrity and functioning of the epithelial barrier is an essential element found in many human pathological situations. The abilities to repair such epithelial aggression condition the pejorative or favorable evolution of these clinical events. Located at the crossroads of many metabolic and/or inflammatory processes, the receptor for advanced glycation end-products (RAGE) appears to be a promising signaling pathway to be investigated in the context of this epithelial dysfunction. The team has begun to demonstrate this on two models of amniotic and pulmonary epithelial aggression present in the wake of two common and serious pathologies, respectively premature rupture of fetal membranes (PROM) and acute respiratory distress syndrome (ARDS). In view of the complexity of the possible combinations «ligands/ RAGE isoforms» associated with the pathological activation of the RAGE pathway, it appears essential to identify the relative importance of these different combinations and to determine whether new ligands cannot be specifically involved in PROM and/or ARDS. Using pharmacological and molecular approaches developed in parallel on our two models of epithelial aggression, this project also aims to identify abnormally modulated molecular pathways and target genes during the activation of the RAGE pathway that may be associated with the cascading of pathophysiological events encountered during these two pathologies. As the interaction of the epithelium with the cells of its immediate environment is a strong determinant of the evolution of aggression, our work also aims to demonstrate the impact of the RAGE pathway in cellular communications. Finally, the availability of KO mice for RAGE will allow to study in vivo, the impacts of a modulation of this route. Our results should make it possible to obtain diagnostic, prognostic and therapeutic advances focused on the RABIES signaling pathway during epithelial aggressions.
Published on 30 Oct 2019 in Reproductive sciences (Thousand Oaks, Calif.) , vol. 26 - pp 1351-1359
Published on 02 Mar 2019 in Respirology (Carlton, Vic.) , vol. 24 - pp 137-145
Blondonnet R , Joubert E, Godet T, Berthelin P, Pranal T, Roszyk L , Chabanne R, Eisenmann N, Lautrette A, Belville C , Cayot S, Gillart T, Souweine B, Bouvier D , Blanchon L , Sapin V , Pereira B, Constantin JM , Jabaudon M
Serum soluble receptor for advanced glycation end-products during acute bronchiolitis in infant: Prospective study in 93 cases.
Published on 30 Oct 2018 in Pediatric pulmonology , vol. 53 - pp 1429-1435
Clinical validation of S100B in the management of a mild traumatic brain injury: issues from an interventional cohort of 1449 adult patients.
Published on 25 Oct 2018 in Clinical chemistry and laboratory medicine , vol. 56 - pp 1897-1904
Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.
Published on 30 Sep 2018 in Intensive care medicine , vol. 44 - pp 1388-1399
Jabaudon M , Blondonnet R , Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V , Matthay MA, Constantin JM , Calfee CS
Understanding Macrophages in Acute Respiratory Distress Syndrome: From Pathophysiology to Precision Medicine.
Published on 30 Jul 2018 in Critical care medicine , vol. 46 - pp 1207-1208
Published on 30 Jun 2018 in Pediatrics , vol. 141
Clinical and Biological Predictors of Plasma Levels of Soluble RAGE in Critically Ill Patients: Secondary Analysis of a Prospective Multicenter Observational Study.
Published on 10 May 2018 in Disease markers , vol. 2018 - pp 7849675
Pranal T, Pereira B, Berthelin P, Roszyk L , Godet T, Chabanne R, Eisenmann N, Lautrette A, Belville C , Blondonnet R , Cayot S, Gillart T, Skrzypczak Y, Souweine B, Bouvier D , Blanchon L , Sapin V , Constantin JM , Jabaudon M
Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study.
Published on 08 Feb 2018 in Scientific reports , vol. 8 - pp 2603
Jabaudon M , Berthelin P, Pranal T, Roszyk L , Godet T, Faure JS, Chabanne R, Eisenmann N, Lautrette A, Belville C , Blondonnet R , Cayot S, Gillart T, Pascal J, Skrzypczak Y, Souweine B, Blanchon L , Sapin V , Pereira B, Constantin JM
Vitamin A status in healthy women eating traditionally prepared spirulina (Dihé) in the Chad Lake area.
Published on 29 Jan 2018 in PloS one , vol. 13 - pp e0191887
High frequency percussive ventilation increases alveolar recruitment in early acute respiratory distress syndrome: an experimental, physiological and CT scan study.
Published on 11 Jan 2018 in Critical care (London, England) , vol. 22 - pp 3
Rationale, study design and analysis plan of the lung imaging morphology for ventilator settings in acute respiratory distress syndrome study (LIVE study): Study protocol for a randomised controlled trial.
Published on 30 Oct 2017 in Anaesthesia, critical care & pain medicine , vol. 36 - pp 301-306
Published on 03 Aug 2017 in Scientific reports , vol. 7 - pp 7208
Blondonnet R , Audard J, Belville C , Clairefond G , Lutz J, Bouvier D , Roszyk L , Gross C , Lavergne M , Fournet M , Blanchon L , Vachias C , Damon-Soubeyrand C , Sapin V , Constantin JM , Jabaudon M
Published on 30 Jul 2017 in Annals of translational medicine , vol. 5 - pp 290
Retinoic Acid Engineered Amniotic Membrane Used as Graft or Homogenate: Positive Effects on Corneal Alkali Burns.
Published on 01 Jul 2017 in Investigative ophthalmology & visual science , vol. 58 - pp 3513-3518
[Premature rupture of membranes≥37 weeks of gestation: Predictive factors for labour onset within 24hours].
Published on 30 Jun 2017 in Gynecologie, obstetrique, fertilite & senologie , vol. 45 - pp 348-352
Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol.
Published on 29 May 2017 in BMJ open , vol. 7 - pp e015280
Bulyez S, Pereira B, Caumon E, Imhoff E, Roszyk L , Bernard L, Bühler L, Heidegger C, Jaber S, Lefrant JY, Chabanne R, Bertrand PM, Laterre PF, Guerci P, Danin PE, Escudier E, Sossou A, Morand D, Sapin V , Constantin JM , Jabaudon M , EPIPAN Study Group, AzuRea network
Published on 30 Apr 2017 in Sports medicine (Auckland, N.Z.) , vol. 47 - pp 781-789
Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study.
Published on 15 Mar 2017 in American journal of respiratory and critical care medicine , vol. 195 - pp 792-800
Jabaudon M , Boucher P, Imhoff E, Chabanne R, Faure JS, Roszyk L , Thibault S, Blondonnet R , Clairefond G , Guérin R, Perbet S , Cayot S, Godet T, Pereira B, Sapin V , Bazin JE, Futier E , Constantin JM
All-trans retinoic acid promotes wound healing of primary amniocytes through the induction of LOXL4, a member of the lysyl oxidase family.
Published on 30 Dec 2016 in The international journal of biochemistry & cell biology , vol. 81 - pp 10-19
Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS: A Prospective Multicenter Study.
Published on 30 Nov 2016 in Chest , vol. 150 - pp 998-1007
Mrozek S, Jabaudon M , Jaber S, Paugam-Burtz C, Lefrant JY, Rouby JJ, Asehnoune K, Allaouchiche B, Baldesi O, Leone M, Lu Q, Bazin JE, Roszyk L , Sapin V , Futier E , Pereira B, Constantin JM , Azurea network
Published on 30 Oct 2016 in Intensive care medicine , vol. 42 - pp 1546-1556
Haddam M, Zieleskiewicz L, Perbet S , Baldovini A, Guervilly C, Arbelot C, Noel A, Vigne C, Hammad E, Antonini F, Lehingue S, Peytel E, Lu Q, Bouhemad B, Golmard JL, Langeron O, Martin C, Muller L, Rouby JJ, Constantin JM , Papazian L, Leone M, CAR’Echo Collaborative Network, AzuRea Collaborative Network
Different dose rate-dependent responses of human melanoma cells and fibroblasts to low dose fast neutrons.
Published on 30 Sep 2016 in International journal of radiation biology , vol. 92 - pp 527-35
Effect of non-invasive oxygenation strategies in immunocompromised patients with severe acute respiratory failure: a post-hoc analysis of a randomised trial.
Published on 30 Aug 2016 in The Lancet. Respiratory medicine , vol. 4 - pp 646-652
Frat JP, Ragot S, Girault C, Perbet S , Prat G, Boulain T, Demoule A, Ricard JD, Coudroy R, Robert R, Mercat A, Brochard L, Thille AW, REVA network
Published on 30 May 2016 in Clinical chemistry and laboratory medicine , vol. 54 - pp 833-42
Net alveolar fluid clearance is associated with lung morphology phenotypes in acute respiratory distress syndrome.
Published on 30 Apr 2016 in Anaesthesia, critical care & pain medicine , vol. 35 - pp 81-6
Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery: A Randomized Clinical Trial.
Published on 05 Apr 2016 in JAMA , vol. 315 - pp 1345-53
Jaber S, Lescot T, Futier E , Paugam-Burtz C, Seguin P, Ferrandiere M, Lasocki S, Mimoz O, Hengy B, Sannini A, Pottecher J, Abback PS, Riu B, Belafia F, Constantin JM , Masseret E, Beaussier M, Verzilli D, De Jong A, Chanques G, Brochard L, Molinari N, NIVAS Study Group
Published on 01 Jan 2016 in Disease markers , vol. 2016 - pp 3501373
Association between intraoperative ventilator settings and plasma levels of soluble receptor for advanced glycation end-products in patients without pre-existing lung injury.
Published on 30 Oct 2015 in Respirology (Carlton, Vic.) , vol. 20 - pp 1131-8
Aquaporins and Fetal Membranes From Diabetic Parturient Women: Expression Abnormalities and Regulation by Insulin.
Published on 30 Oct 2015 in The Journal of clinical endocrinology and metabolism , vol. 100 - pp E1270-9
All-trans-retinoic acid regulates aquaporin-3 expression and related cellular membrane permeability in the human amniotic environment.
Published on 30 Aug 2015 in Placenta , vol. 36 - pp 881-7
Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study.
Published on 14 Aug 2015 in PloS one , vol. 10 - pp e0135857
Soluble Receptor for Advanced Glycation End-Products Predicts Impaired Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome.
Published on 15 Jul 2015 in American journal of respiratory and critical care medicine , vol. 192 - pp 191-9
Comment and reply on: Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth.
Published on 17 Jun 2015 in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - pp 1-2
Published on 04 Jun 2015 in The New England journal of medicine , vol. 372 - pp 2185-96
Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S , Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM , Tonnelier JM, Pierrot M, Mathonnet A, Béduneau G, Delétage-Métreau C, Richard JC, Brochard L, Robert R, FLORALI Study Group, REVA Network
Effects of a recruitment maneuver on plasma levels of soluble RAGE in patients with diffuse acute respiratory distress syndrome: a prospective randomized crossover study.
Published on 30 May 2015 in Intensive care medicine , vol. 41 - pp 846-55
IFPA meeting 2014 workshop report: Animal models to study pregnancy pathologies; new approaches to study human placental exposure to xenobiotics; biomarkers of pregnancy pathologies; placental genetics and epigenetics; the placenta and stillbirth and fetal growth restriction.
Published on 30 Apr 2015 in Placenta , vol. 36 Suppl 1 - pp S5-10
Barbaux S, Erwich JJ, Favaron PO, Gil S, Gallot D , Golos TG, Gonzalez-Bulnes A, Guibourdenche J, Heazell AE, Jansson T, Laprévote O, Lewis RM, Miller RK, Monk D, Novakovic B, Oudejans C, Parast M, Peugnet P, Pfarrer C, Pinar H, Roberts CT, Robinson W, Saffery R, Salomon C, Sexton A, Staff AC, Suter M, Tarrade A, Wallace J, Vaillancourt C, Vaiman D, Worton SA, Lash GE
Published on 15 Jan 2015 in American journal of physiology. Lung cellular and molecular physiology , vol. 308 - pp L147-57
Published on 30 Dec 2014 in Development (Cambridge, England) , vol. 141 - pp 4526-36
The challenge of prenatal identification of congenital diaphragmatic hernia in the context of hydrops.
Published on 30 Nov 2014 in European journal of obstetrics, gynecology, and reproductive biology , vol. 182 - pp 238-9
Impact of the anesthetic conserving device on respiratory parameters and work of breathing in critically ill patients under light sedation with sevoflurane.
Published on 30 Oct 2014 in Anesthesiology , vol. 121 - pp 808-16
Endocrine gland-derived endothelial growth factor (EG-VEGF) is a potential novel regulator of human parturition.
Published on 30 Sep 2014 in Biology of reproduction , vol. 91 - pp 73
Published on 30 Aug 2014 in Acta ophthalmologica , vol. 92 - pp e366-71
Published on 07 Aug 2014 in Cell reports , vol. 8 - pp 743-53
Deplus R, Blanchon L , Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B , Berdasco M, Putmans P, Calonne E, Litchfield DW, de Launoit Y, Jurkowski TP, Stunnenberg HG, Bock C, Sotiriou C, Fraga MF, Esteller M, Jeltsch A, Fuks F
Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet – the RESOLVE trial.
Published on 11 Jul 2014 in Lipids in health and disease , vol. 13 - pp 112
Lung postmortem autopsy revealing extramedullary involvement in multiple myeloma causing acute respiratory distress syndrome.
Published on 01 Jan 2014 in Case reports in hematology , vol. 2014 - pp 635237
Plasma levels of sRAGE, loss of aeration and weaning failure in ICU patients: a prospective observational multicenter study.
Published on 27 May 2013 in PloS one , vol. 8 - pp e64083
[Coupling proteinemia and serum protein electrophoresis: evaluation of the capillary technique (Capillarys 2, Sebia), experience from Clermont-Ferrand].
Published on 01 Nov 2010 in Annales de biologie clinique , vol. 68 - pp 657-67
Fetal skin fibroblasts: a cell model for studying the retinoid pathway in congenital diaphragmatic hernia.
Published on 30 Mar 2010 in Birth defects research. Part A, Clinical and molecular teratology , vol. 88 - pp 195-200
Retinoid pathway and congenital diaphragmatic hernia: hypothesis from the analysis of chromosomal abnormalities.
Published on 01 Jan 2010 in Fetal diagnosis and therapy , vol. 28 - pp 129-39
Natural mutations of the anti-Mullerian hormone type II receptor found in persistent Mullerian duct syndrome affect ligand binding, signal transduction and cellular transport.
Published on 15 Aug 2009 in Human molecular genetics , vol. 18 - pp 3002-13
Belville C , Maréchal JD, Pennetier S, Carmillo P, Masgrau L, Messika-Zeitoun L, Galey J, Machado G, Treton D, Gonzalès J, Picard JY, Josso N, Cate RL, di Clemente N