Joel DREVETChef d'équipe
Background: Joël Drevet obtained his PhD in Cell Biology/Genetics and Immunology from Université Claude Bernard (Lyon1, France) in 1989. From 1990 to 1993, Joël Drevet spent four years at the Health Science Centre, Faculty of Medicine, University of Calgary (Alberta, Canada) as a postdoctoral researcher (1990-1991) and research associate (1992-1993). In September 1993, Joël Drevet was appointed Associate Professor at the Université Blaise Pascal (Clermont-Ferrand, France), now the Université Clermont Auvergne. In 1998, he was promoted to full professor and set-up his own research group in the field of mammalian reproductive physiology. From 1998 to 2023, his research team is supported by the CNRS. From 2008 to 2022, the team was also supported by the Institut National de la Recherche Médicale (INSERM). Since 2015, the team has been involved in clinical and veterinary valorization of its activities, supported by the Université Clermont Auvergne (UCA) and "Clermont Auvergne Innovation" (CAI). A diagnostics and R&D structure (EVALSEM) is being developed as a "Business Unit" under the guidance of the UCA Clermont Auvergne Innovation (CAI) valorisation unit. The service platform is attached to UCA-partner.
National/international outreach: Joël Drevet is a member of the European Academy of Andrology (EAA), the European Society of Human Reproduction and Embryology (ESHRE), the North American Society of Reproductive Studies (SSR) and the International Society of Andrology (ISA). J. Drevet is Managing Editor of BCA (Basic & Clinical Andrology), Associate Editor of the Asian Journal of Andrology and Academic Editor of PLoS ONE, Antioxidants, Frontiers in Reproductive Health and Oxidative Medicine & Cellular Longevity. Joël Drevet is also currently a member of the Editorial Board of Andrology. From 2011 to 2016, he was Associate Editor of Human Reproduction and a member of the editorial board of Biology of Reproduction. To date, Professor Drevet has an H-factor of 45 and a citation index > 7000. Throughout his career and to date, he has co-authored over 150 publications and supervised/co-supervised 17 doctoral theses.
Main research interests: Research led by Joël Drevet focuses on the post-testicular stages of mammalian sperm maturation during descent and storage in the epididymal tubule. Expertise focuses on aspects of oxidative stress and its impact on the fertilizing capacities of mammalian spermatozoa, the integrity of the paternal nucleus and potential transgenerational effects, both in natural reproduction and in assisted reproductive technologies (ART). Other aspects of epididymal physiology covered include cholesterol homeostasis and the control of immunity in the epididymis, at both fundamental and clinical levels.
Published on 06 Jun 2023 in Andrology
Yazdanpanah Ghadikolaei P, Ghaleno LR, Vesali S, Janzamin E, Gilani MAS, Sajadi H, Dizaj AVT, Shahverdi A, Drevet JR , Moghadam Masouleh AA
Published on 13 Jun 2023 in eLife , vol. 12
Damon-Soubeyrand C , Bongiovanni A, Chorfa A , Goubely C , Pirot N, Pardanaud L, Piboin-Fragner L, Vachias C , Bravard S , Guiton R , Thomas JL, Saez F , Kocer A , Tardivel M, Drevet JR , Henry-Berger J
Published on 10 Sep 2023 in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology
Published on 20 Jul 2023 in Basic and clinical andrology , vol. 33 - pp 19
Serum lipid profile levels and semen quality: new insights and clinical perpectives for male infertility and men’s health
Published on 20 Jul 2023 in Int Urol Nephrol
Andrade G, Iori I, Hsieh MK, Milani G, Zandona PCE, Teixeira TA, Drevet JR , Costa EM, Hallak J
Reactive Oxygen Species and Their Consequences on the Structure and Function of Mammalian Spermatozoa.
Published on 01 Sep 2022 in Antioxidants & redox signaling , vol. 37 - pp 481-500
Drevet JR , Hallak J, Nasr-Esfahani MH, Aitken RJ
Sperm motility in asthenozoospermic semen samples can be improved by incubation in a continuous single culture medium (CSCM®).
Published on 01 Feb 2022 in Systems biology in reproductive medicine , vol. 68 - pp 25-35
Ranéa C, Pariz JR, Drevet JR , Hallak J
Published on 02 Feb 2022 in Antioxidants (Basel, Switzerland) , vol. 11
Published on 01 Jan 2022 in Translational andrology and urology , vol. 11 - pp 110-115
The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review
Published on 30 May 2022 in Basic Clin Androl , vol. 32 - pp 8
Tavalaee M, Rahmani M, Drevet JR , Nasr-Esfahani MH
Published on 21 Jun 2022 in Scientific reports , vol. 12 - pp 10470
Safari H, Hajian M, Nasr-Esfahani MH, Forouzanfar M, Drevet JR
Published on 26 Oct 2022 in Reproduction (Cambridge, England) , vol. 164 - pp F125-F133
Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology.
Published on 31 Oct 2022 in Human reproduction (Oxford, England) , vol. 37 - pp 2497-2502
Björndahl L, Barratt CLR, Mortimer D, Agarwal A, Aitken RJ, Alvarez JG, Aneck-Hahn N, Arver S, Baldi E, Bassas L, Boitrelle F, Bornman R, Carrell DT, Castilla JA, Cerezo Parra G, Check JH, Cuasnicu PS, Darney SP, de Jager C, De Jonge CJ, Drevet JR , Drobnis EZ, Du Plessis SS, Eisenberg ML, Esteves SC, Evgeni EA, Ferlin A, Garrido N, Giwercman A, Goovaerts IGF, Haugen TB, Henkel R, Henningsohn L, Hofmann MC, Hotaling JM, Jedrzejczak P, Jouannet P, Jørgensen N, Kirkman Brown JC, Krausz C, Kurpisz M, Kvist U, Lamb DJ, Levine H, Loveland KL, McLachlan RI, Mahran A, Maree L, Martins da Silva S, Mbizvo MT, Meinhardt A, Menkveld R, Mortimer ST, Moskovtsev S, Muller CH, Munuce MJ, Muratori M, Niederberger C, O'Flaherty C, Oliva R, Ombelet W, Pacey AA, Palladino MA, Ramasamy R, Ramos L, Rives N, Roldan ER, Rothmann S, Sakkas D, Salonia A, Sánchez-Pozo MC, Sapiro R, Schlatt S, Schlegel PN, Schuppe HC, Shah R, Skakkebæk NE, Teerds K, Toskin I, Tournaye H, Turek PJ, van der Horst G, Vazquez-Levin M, Wang C, Wetzels A, Zeginiadou T, Zini A
Marijuana Is Associated With a Hormonal Imbalance Among Several Habits Related to Male Infertility: A Retrospective Study.
Published on 17 Feb 2022 in Frontiers in reproductive health , vol. 4 - pp 820451
Teixeira TA, Iori I, Andrade G, Saldiva PHN, Drevet JR , Costa EMF, Hallak J
Published on 08 Dec 2022 in PloS one , vol. 17 - pp e0271217
Aghajani R, Tavalaee M, Sadeghi N, Razi M, Gharagozloo P, Arbabian M, Drevet JR , Nasr-Esfahani MH
Published on 01 Jan 2021 in Asian journal of andrology , vol. 23 - pp 52-58
Ciccone IM, Costa EM, Pariz JR, Teixeira TA, Drevet JR , Gharagozloo P, Aitken RJ, Hallak J
Published on 01 Mar 2021 in Andrology , vol. 9 - pp 546-558
Published on 01 Jul 2021 in Asian journal of andrology , vol. 23 - pp 335-347
Teixeira TA, Oliveira YC, Bernardes FS, Kallas EG, Duarte-Neto AN, Esteves SC, Drevet JR , Hallak J
Dysplasia of the fibrous sheath with axonemal and centriolar defects combined with lack of mitochondrial activity as associated factors of ICSI failure in primary ciliary dyskinesia syndrome.
Published on 01 May 2021 in International braz j urol : official journal of the Brazilian Society of Urology , vol. 47 - pp 617-626
Pariz JR, Rané C, Drevet J , Hallak J
Deferasirox, an Iron-Chelating Agent, Improves Testicular Morphometric and Sperm Functional Parameters in a Rat Model of Varicocele.
Published on 08 Apr 2021 in Oxidative medicine and cellular longevity , vol. 2021 - pp 6698482
LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames.
Published on 07 Jun 2021 in Communications biology , vol. 4 - pp 691
Blythe MJ, Kocer A , Rubio-Roldan A, Giles T, Abakir A, Ialy-Radio C, Wheldon LM, Bereshchenko O, Bruscoli S, Kondrashov A, Drevet JR , Emes RD, Johnson AD, McCarrey JR, Gackowski D, Olinski R, Cocquet J, Garcia-Perez JL, Ruzov A
Field study reveals morphological and neuroendocrine correlates of seasonal breeding in female water voles, Arvicola terrestris.
Published on 15 Sep 2021 in General and comparative endocrinology , vol. 311 - pp 113853
Apoptotic M540 bodies present in human semen interfere with flow cytometry-assisted assessment of sperm DNA fragmentation and oxidation.
Published on 21 Oct 2021 in Basic and clinical andrology , vol. 31 - pp 23
Beneficial effects of hypotaurine supplementation in preparation and freezing media on human sperm cryo-capacitation and DNA quality.
Published on 04 Nov 2021 in Basic and clinical andrology , vol. 31 - pp 26
Oxidation of Sperm Nucleus in Mammals: A Physiological Necessity to Some Extent with Adverse Impacts on Oocyte and Offspring.
Published on 23 Jan 2020 in Antioxidants (Basel, Switzerland) , vol. 9
Drevet JR , Aitken RJ
The Importance of Oxidative Stress in Determining the Functionality of Mammalian Spermatozoa: A Two-Edged Sword.
Published on 27 Jan 2020 in Antioxidants (Basel, Switzerland) , vol. 9
Aitken RJ, Drevet JR
Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.
Published on 01 Nov 2020 in Asian journal of andrology , vol. 22 - pp 590-601
Chu C, Yu L, Henry-Berger J , Ru YF, Kocer A , Champroux A , Li ZT, He M, Xie SS, Ma WB, Ni MJ, Ni ZM, Guo YL, Fei ZL, Gou LT, Liu Q, Sharma S, Zhou Y, Liu MF, Chen CD, Eamens AL, Nixon B, Zhou YC, Drevet JR , Zhang YL
Published on 13 Apr 2020 in Oxidative medicine and cellular longevity , vol. 2020 - pp 5140383
Sadeghi N, Erfani-Majd N, Tavalaee M, Tabandeh MR, Drevet JR , Nasr-Esfahani MH
Published on 01 Sep 2020 in Andrology , vol. 8 - pp 1442-1455
Shahreza FD, Hajian M, Gharagozloo P, Drevet JR , Nasr-Esfahani MH
Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model.
Published on 29 Jul 2020 in Oxidative medicine and cellular longevity , vol. 2020 - pp 5909306
Published on 13 Aug 2020 in Basic and clinical andrology , vol. 30 - pp 12
Mohammadi Z, Tavalaee M, Gharagozloo P, Drevet JR , Nasr-Esfahani MH
Published on 01 Sep 2019 in Andrology , vol. 7 - pp 681-689
Chu C, Zhang YL, Yu L, Sharma S, Fei ZL, Drevet JR
Paternal impacts on development: identification of genomic regions vulnerable to oxidative DNA damage in human spermatozoa.
Published on 02 Oct 2019 in Human reproduction (Oxford, England) , vol. 34 - pp 1876-1890
Xavier MJ, Nixon B, Roman SD, Scott RJ, Drevet JR , Aitken RJ
Peroxisome Proliferator-Activated Receptors (PPARs) levels in spermatozoa of normozoospermic and asthenozoospermic men.
Published on 01 Dec 2019 in Systems biology in reproductive medicine , vol. 65 - pp 409-419
Mousavi MS, Shahverdi A, Drevet J , Akbarinejad V, Esmaeili V, Sayahpour FA, Topraggaleh TR, Rahimizadeh P, Alizadeh A
Melatonin and Caffeine Supplementation Used, Respectively, as Protective and Stimulating Agents in the Cryopreservation of Human Sperm Improves Survival, Viability, and Motility after Thawing compared to Traditional TEST-Yolk Buffer.
Published on 23 Oct 2019 in Oxidative medicine and cellular longevity , vol. 2019 - pp 6472945
Pariz JR, Ranéa C, Monteiro RAC, Evenson DP, Drevet JR , Hallak J
Published on 01 Jan 2019 in Advances in experimental medicine and biology , vol. 1166 - pp 107-117
Drevet JR , Aitken RJ
Published on 01 Nov 2019 in Asian journal of andrology , vol. 21 - pp 531-539
Slc26a3 deficiency is associated with epididymis dysplasia and impaired sperm fertilization potential in the mouse.
Published on 01 Aug 2018 in Molecular reproduction and development , vol. 85 - pp 682-695
Comprehensive overview of murine epididymal mononuclear phagocytes and lymphocytes: Unexpected populations arise.
Published on 01 Apr 2018 in Journal of reproductive immunology , vol. 126 - pp 11-17
A Decade of Exploring the Mammalian Sperm Epigenome: Paternal Epigenetic and Transgenerational Inheritance.
Published on 15 May 2018 in Frontiers in cell and developmental biology , vol. 6 - pp 50
Male reproductive health statement (XIIIth international symposium on Spermatology, may 9th-12th 2018, Stockholm, Sweden.
Published on 29 Oct 2018 in Basic and clinical andrology , vol. 28 - pp 13
Levine H, Mohri H, Ekbom A, Ramos L, Parker G, Roldan E, Jovine L, Koelle S, Lindstrand A, Immler S, Mortimer S, Mortimer D, van der Horst G, Ishijima S, Aneck-Hahn N, Baldi E, Menkveld R, Rothmann SA, Giwercman A, Giwercman Y, Holmberg M, Kvist U, Björndahl L, Holmberg R, Arver S, Flanagan J, Drevet JR
Accuracy of human sperm DNA oxidation quantification and threshold determination using an 8-OHdG immuno-detection assay.
Published on 01 Apr 2018 in Human reproduction (Oxford, England) , vol. 33 - pp 553-562
Understanding Macrophages in Acute Respiratory Distress Syndrome: From Pathophysiology to Precision Medicine.
Published on 30 Jul 2018 in Critical care medicine , vol. 46 - pp 1207-1208
SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation.
Published on 01 Jun 2017 in Cell death and differentiation , vol. 24 - pp 1029-1044
A sequence of 28S rRNA-derived small RNAs is enriched in mature sperm and various somatic tissues and possibly associates with inflammation.
Published on 01 Jun 2017 in Journal of molecular cell biology , vol. 9 - pp 256-259
Chu C, Yu L, Wu B, Ma L, Gou LT, He M, Guo Y, Li ZT, Gao W, Shi H, Liu MF, Wang H, Chen CD, Drevet JR , Zhou Y, Zhang Y
Does sperm quality and DNA integrity differ in cryopreserved semen samples from young, adult, and aged Nellore bulls?
Published on 21 Jun 2017 in Basic and clinical andrology , vol. 27 - pp 12
Published on 01 Dec 2017 in Experimental eye research , vol. 165 - pp 99-104
Published on 01 Sep 2017 in Translational andrology and urology , vol. 6 - pp S590-S591
A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models.
Published on 01 Feb 2016 in Human reproduction (Oxford, England) , vol. 31 - pp 252-62
Published on 27 Sep 2016 in Basic and clinical andrology , vol. 26 - pp 11
Published on 21 Dec 2016 in Basic and clinical andrology , vol. 26 - pp 17
Published on 01 Jan 2016 in Reproduction, fertility, and development , vol. 28 - pp 1-10
Aitken RJ, Gibb Z, Baker MA, Drevet J , Gharagozloo P
Published on 01 Sep 2015 in Asian journal of andrology , vol. 17 - pp 742-8
Published on 01 Dec 2015 in Free radical biology & medicine , vol. 89 - pp 993-1002
Recent knowledge concerning mammalian sperm chromatin organization and its potential weaknesses when facing oxidative challenge.
Published on 01 Apr 2014 in Basic and clinical andrology , vol. 24 - pp 6
Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial.
Published on 12 Jul 2014 in Reproductive biology and endocrinology : RB&E , vol. 12 - pp 65
Published on 02 Oct 2013 in Basic and clinical andrology , vol. 23 - pp 8
Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment.
Published on 20 Jun 2013 in PloS one , vol. 8 - pp e66494
Published on 01 Dec 2013 in Free radical biology & medicine , vol. 65 - pp 719-723
Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.
Published on 01 Jan 2012 in PloS one , vol. 7 - pp e38565
Published on 30 May 2012 in Medecine sciences : M/S , vol. 28 - pp 519-25
Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability.
Published on 01 Nov 2011 in Journal of andrology , vol. 32 - pp 641-50
Published on 30 Jan 2011 in Asian journal of andrology , vol. 13 - pp 11-7
Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state.
Published on 11 Mar 2011 in The Journal of biological chemistry , vol. 286 - pp 8030-8042
Jrad-Lamine A , Henry-Berger J , Gourbeyre P, Damon-Soubeyrand C , Lenoir A , Combaret L, Saez F , Kocer A , Tone S, Fuchs D, Zhu W, Oefner PJ, Munn DH, Mellor AL, Gharbi N, Cadet R , Aitken RJ, Drevet JR
Transgenic tomatoes showing higher glutathione peroxydase antioxidant activity are more resistant to an abiotic stress but more susceptible to biotic stresses.
Published on 30 Mar 2011 in Plant science : an international journal of experimental plant biology , vol. 180 - pp 548-53
Herbette S, de Labrouhe DT, Drevet JR , Roeckel-Drevet P
LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner.
Published on 01 Sep 2009 in Journal of lipid research , vol. 50 - pp 1766-75
Published on 01 Jan 2009 in Folia histochemica et cytobiologica , vol. 47 - pp S75-9
Published on 30 Jun 2009 in Gynecologie, obstetrique & fertilite , vol. 37 - pp 529-35
Published on 30 Jul 2009 in The Journal of clinical investigation , vol. 119 - pp 2074-85
GPX5, the selenium-independent glutathione peroxidase-encoding single copy gene is differentially expressed in mouse epididymis.
Published on 01 Jan 2008 in Reproduction, fertility, and development , vol. 20 - pp 615-25
Published on 01 May 2007 in The FEBS journal , vol. 274 - pp 2163-80
Herbette S, Roeckel-Drevet P, Drevet JR
Identification of sperm antigens as a first step towards the generation of a contraceptive vaccine to decrease fossorial water vole Arvicola terrestris Scherman proliferations.
Published on 15 Sep 2007 in Theriogenology , vol. 68 - pp 779-95
Published on 16 May 2006 in Molecular and cellular endocrinology , vol. 250 - pp 70-9
Quantitative and spatial differences in the expression of tryptophan-metabolizing enzymes in mouse epididymis.
Published on 30 May 2006 in Cell and tissue research , vol. 324 - pp 301-10
Britan A, Maffre V, Tone S, Drevet JR
Published on 30 Jun 2006 in Biology of reproduction , vol. 74 - pp 1104-13
Rejraji H, Sion B, Prensier G, Carreras M, Motta C, Frenoux JM, Vericel E, Grizard G, Vernet P, Drevet JR
Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.
Published on 30 Oct 2004 in Journal of molecular endocrinology , vol. 33 - pp 361-75