Research Team

Environment, Metabolism, spermatogenesis, pathophysiology and inheritance

HomeTeamsEnvironment, Metabolism, spermatogenesis, pathophysiology and inheritance
Our team was created in January 2017. Our thematic is mainly focused on the links between altered bile acid metabolism, environmental exposures and testicular pathophysiologies leading to male fertility disorders with a focus on spermatogonial stem cell niche biology. This allows us to put forward new hypothesis and innovative research strategies on spermatogenesis, fertility disorders, testicular germ cell cancer and transgenerational inheritance of diseases.





61 publications

Increased coral biomineralization due to enhanced symbiotic activity upon volcanic ash exposure

Published on 01 Feb 2024 in Sci Total Environ

Förster F, Reynaud S, Sauzéat L , Ferrier-Pagès C, Samankassou E, Sheldrake TE


Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells.

Published on 01 Nov 2023 in Nanomaterials (Basel).

Bissardon C, Proux O, Gazze SA, Filhol O, Toubhans B, Sauzéat L , Bouchet S, Lewis AR, Maffeis T, Hazemann JL, Bayat S, Cloetens P, Conlan RS, Charlet L, Bohic S.


Metallome deregulation and health-related impacts due to long-term exposure to recent volcanic ash deposits: New chemical and isotopic insights.

Published on 10 Jul 2022 in The Science of the total environment , vol. 829 - pp 154383

Sauzéat L , Eychenne J , Gurioli L, Boyet M, Jessop DE, Moretti R, Monrose M , Holota H , Beaudoin C , Volle DH

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance.

Published on 30 Jun 2022 in Advanced science (Weinheim, Baden-Wurttemberg, Germany) , vol. 9 - pp e2200626

Thirouard L , Holota H , Monrose M , Garcia M , de Haze A , Damon-Soubeyrand C, Renaud Y , Saru JP , Perino A, Schoonjans K, Beaudoin C , Volle DH

When idiopathic male infertility is rooted in maternal malnutrition during the perinatal period in mice†.

Published on 19 Mar 2022 in Biology of reproduction , vol. 106 - pp 463-476

Muranishi Y, Parry L, Vachette-Dit-Martin M, Saez F , Coudy-Gandilhon C, Sauvanet P, Volle DH , Tournayre J, Bottari S, Carpentiero F, Martinez G, Muroňová J, Escoffier J, Bruhat A, Maurin AC, Averous J, Arnoult C, Fafournoux P, Jousse C


Editorial: Bisphenols and Male Reproductive Health.

Published on 01 Oct 2020 in Frontiers in endocrinology , vol. 11 - pp 597609

Barbonetti A, D'Andrea S, Bernabò N, Volle DH


Bile acids and male fertility: From mouse to human?

Published on 30 Aug 2017 in Molecular aspects of medicine , vol. 56 - pp 101-109

Sèdes L , Martinot E , Baptissart M , Baron S , Caira F , Beaudoin C , Volle DH

Bile acids and their receptors.

Published on 30 Aug 2017 in Molecular aspects of medicine , vol. 56 - pp 2-9

Martinot E , Sèdes L , Baptissart M , Lobaccaro JM , Caira F , Beaudoin C , Volle DH

Bile acids, roles in integrative physiology and pathophysiology.

Published on 30 Aug 2017 in Molecular aspects of medicine , vol. 56 - pp 1

Volle DH

The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate.

Published on 11 Jul 2017 in Stem cell reports , vol. 9 - pp 315-328

Martinot E , Sèdes L , Baptissart M , Holota H , Rouaisnel B , Damon-Soubeyrand C, De Haze A , Saru JP , Thibault-Carpentier C, Keime C, Lobaccaro JA, Baron S , Benoit G, Caira F , Beaudoin C , Volle DH

ERRα induces H3K9 demethylation by LSD1 to promote cell invasion.

Published on 11 Apr 2017 in Proceedings of the National Academy of Sciences of the United States of America , vol. 114 - pp 3909-3914

Carnesecchi J, Forcet C, Zhang L, Tribollet V, Barenton B, Boudra R , Cerutti C, Billas IM, Sérandour AA, Carroll JS, Beaudoin C , Vanacker JM


Nuclear receptors as pharmacological targets, where are we now?

Published on 30 Oct 2016 in Cellular and molecular life sciences : CMLS , vol. 73 - pp 3777-80

Volle DH

mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.

Published on 18 May 2016 in Cell cycle (Georgetown, Tex.) , vol. 15 - pp 1352-62

Boudra R , Lagrafeuille R, Lours-Calet C, de Joussineau C , Loubeau-Legros G, Chaveroux C, Saru JP , Baron S , Morel L , Beaudoin C

STAT3 Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma.

Published on 30 Jan 2016 in Brain pathology (Zurich, Switzerland) , vol. 26 - pp 18-30

Ouédraogo ZG, Müller-Barthélémy M, Kemeny JL, Dedieu V, Biau J, Khalil T, Raoelfils LI, Granzotto A, Pereira B, Beaudoin C , Guissou IP, Berger M, Morel L , Chautard E, Verrelle P


Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.

Published on 30 Sep 2014 in Hepatology (Baltimore, Md.) , vol. 60 - pp 1054-65

Baptissart M , Vega A , Martinot E , Pommier AJ, Houten SM, Marceau G , de Haze A , Baron S , Schoonjans K, Lobaccaro JM , Volle DH

Levels of liver X receptors in testicular biopsies of patients with azoospermia.

Published on 30 Aug 2014 in Fertility and sterility , vol. 102 - pp 361-371.e5

Rondanino C , Ouchchane L, Chauffour C, Marceau G , Déchelotte P , Sion B, Pons-Rejraji H , Janny L , Volle DH , Lobaccaro JM , Brugnon F

NPM1 silencing reduces tumour growth and MAPK signalling in prostate cancer cells.

Published on 05 May 2014 in PloS one , vol. 9 - pp e96293

Loubeau G, Boudra R , Maquaire S, Lours-Calet C, Beaudoin C , Verrelle P, Morel L

Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.

Published on 11 Apr 2014 in Biochemical and biophysical research communications , vol. 446 - pp 656-62

Oumeddour A , Viennois E, Caira F , Decourbey C, Maqdasy S , Tahraoui A, Baron S , Volle DH , Lobaccaro JM


Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?

Published on 30 Dec 2013 in Cellular and molecular life sciences : CMLS , vol. 70 - pp 4511-26

Baptissart M , Vega A , Martinot E , Baron S , Lobaccaro JM , Volle DH

Oxysterol receptors and their therapeutic applications in cancer conditions.

Published on 30 Sep 2013 in Expert opinion on therapeutic targets , vol. 17 - pp 1029-38

De Boussac H , Alioui A , Viennois E, Dufour J , Trousson A , Vega A , Guy L, Volle DH , Lobaccaro JM , Baron S

Lipids, LXRs and prostate cancer: are HDACs a new link?

Published on 01 Jul 2013 in Biochemical pharmacology , vol. 86 - pp 168-74

Hoang JJ, Baron S , Volle DH , Lobaccaro JM , Trousson A

Emerging roles for LXRs and LRH-1 in female reproduction.

Published on 10 Apr 2013 in Molecular and cellular endocrinology , vol. 368 - pp 47-58

Mouzat K, Baron S , Marceau G , Caira F , Sapin V , Volle DH , Lumbroso S, Lobaccaro JM

Cholesterol and male fertility: what about orphans and adopted?

Published on 10 Apr 2013 in Molecular and cellular endocrinology , vol. 368 - pp 30-46

Maqdasy S , Baptissart M , Vega A , Baron S , Lobaccaro JM , Volle DH

Bile acids: from digestion to cancers.

Published on 30 Mar 2013 in Biochimie , vol. 95 - pp 504-17

Baptissart M , Vega A , Maqdasy S , Caira F , Baron S , Lobaccaro JM , Volle DH

LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.

Published on 01 Mar 2013 in American journal of cancer research , vol. 3 - pp 58-69

de Boussac H , Pommier AJ, Dufour J , Trousson A , Caira F , Volle DH , Baron S , Lobaccaro JM


Regenerating I messenger RNA and protein expression in the failing human testis: a potential molecular prognostic marker of seminoma.

Published on 30 Dec 2011 in Human pathology , vol. 42 - pp 1841-8

Mauro V, Volle DH , Chevallier D, Haudebourg J, Sénégas-Balas F, Pointis G

Liver X receptors, lipids and their reproductive secrets in the male.

Published on 30 Aug 2011 in Biochimica et biophysica acta , vol. 1812 - pp 974-81

El-Hajjaji FZ, Oumeddour A , Pommier AJ, Ouvrier A, Viennois E, Dufour J , Caira F , Drevet JR, Volle DH , Baron S , Saez F , Lobaccaro JM

Targeting liver X receptors in human health: deadlock or promising trail?

Published on 02 Mar 2011 in Expert opinion on therapeutic targets , vol. 15 - pp 219-32

Viennois E, Pommier AJ, Mouzat K, Oumeddour A , El Hajjaji FZ, Dufour J , Caira F , Volle DH , Baron S , Lobaccaro JM


[Endocrine disruptors and fertility: NR0B2, a new therapeutic target?].

Published on 30 Apr 2010 in Medecine sciences : M/S , vol. 26 - pp 359-61

Decourteix M, Volle DH


The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice.

Published on 30 Dec 2009 in The Journal of clinical investigation , vol. 119 - pp 3752-64

Volle DH , Decourteix M, Garo E, McNeilly J, Fenichel P, Auwerx J, McNeilly AS, Schoonjans K, Benahmed M

Metal-NHC complexes: a survey of anti-cancer properties.

Published on 21 Sep 2009 in Dalton transactions (Cambridge, England : 2003) - pp 6894-902

Teyssot ML, Jarrousse AS, Manin M, Chevry A, Roche S, Norre F, Beaudoin C , Morel L , Boyer D, Mahiou R, Gautier A

Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.

Published on 30 Jul 2009 in Endocrinology , vol. 150 - pp 3369-75

Mouzat K, Volat F, Baron S , Alves G, Pommier AJ, Volle DH , Marceau G , DeHaze A, Déchelotte P , Duggavathi R, Caira F , Lobaccaro JM

[NPM: a new player in prostate cancer?].

Published on 30 Jan 2009 in Medecine sciences : M/S , vol. 25 - pp 19-21

Beaudoin C , Maquaire S, Léotoing L, Allemand J, Lours-Calet C, Veyssière G, Manin M, Morel L

Toxicity of copper(I)-NHC complexes against human tumor cells: induction of cell cycle arrest, apoptosis, and DNA cleavage.

Published on 01 Jan 2009 in Chemistry (Weinheim an der Bergstrasse, Germany) , vol. 15 - pp 314-8

Teyssot ML, Jarrousse AS, Chevry A, De Haze A , Beaudoin C , Manin M, Nolan SP, Díez-González S, Morel L , Gautier A


Liver receptor homolog 1 is essential for ovulation.

Published on 15 Jul 2008 in Genes & development , vol. 22 - pp 1871-6

Duggavathi R, Volle DH , Mataki C, Antal MC, Messaddeq N, Auwerx J, Murphy BD, Schoonjans K

Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell.

Published on 01 May 2008 in Oncogene , vol. 27 - pp 2858-67

Léotoing L, Meunier L, Manin M, Mauduit C, Decaussin M, Verrijdt G, Claessens F, Benahmed M, Veyssière G, Morel L , Beaudoin C


5 theses
Etude des rôles du récepteur nucléaire CAR dans la physiologie et les physiopathologies testiculaires
Realized by :
Monrose Mélusine
Defense date:
Caractérisation du récepteur nucléaire FXRα dans les cancers germinaux du testicule et étude fonctionnelle d’un nouveau variant
Realized by :
Garcia Manon
Defense date:
Etude des rôles du récepteur membranaire des acides biliaires (TGR5) dans la physiologie et la physiopathologie testiculaires
Realized by :
Thirouard Laura
Defense date:
thèse suivante Etude du rôle du récepteur nucléaire FXRα dans la physiologie et la physiopathologie testiculaire
Realized by :
Martinot Emmanuelle
Defense date:
Impacts de concentrations supraphysiologiques d’acides biliaires sur la physiologie testiculaire et les fonctions de reproduction
Realized by :
Baptissart Marine
Defense date:
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