Laurent MOREL
Professeur des Universités
MOREL
Laurent
Professeur des Universités
PU
Publications
LXR pathway drives hormonal response intensity in polycystic ovary syndrome.
Published on 21 May 2025 in EMBO molecular medicine
Dallel S , Despalles M , Tore M , Renaud Y , Kocer A , Damon-Soubeyrand C , Pouchin P , Vachias C , Boutourlinsky K , Gonthier-Gueret C, De Haze A , Sanchez P , Pointud JC , Bouchareb E , Vialat M , Lagarde A , Gulunga C, Chaput L, Vega A , Brugnon F , Tauveron I , Trousson A , de Joussineau C , Degoul F , Morel L , Lobaccaro JM , Maqdasy S , Baron S
Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis.
Published on 06 Jun 2024 in Cancers , vol. 16
Vialat M , Baabdaty E , Trousson A , Kocer A , Lobaccaro JA, Baron S , Morel L , de Joussineau C
Liver X Receptors Enhance Epithelial to Mesenchymal Transition in Metastatic Prostate Cancer Cells.
Published on 06 Aug 2024 in Cancers , vol. 16
Bouchareb E , Dallel S , De Haze A , Damon-Soubeyrand C , Renaud Y , Baabdaty E , Vialat M , Fabre J , Pouchin P , De Joussineau C , Degoul F , Sanmukh S , Gendronneau J , Sanchez P , Gonthier-Gueret C , Trousson A , Morel L , Lobaccaro JM , Kocer A , Baron S
Persistent organic pollutants promote aggressiveness in prostate cancer.
Published on 01 Sep 2023 in Oncogene , vol. 42 - pp 2854-2867
Buñay J, Kossai M, Damon-Soubeyrant C, De Haze A , Saru JP , Trousson A , de Joussineau C , Bouchareb E , Kocer A , Vialat M , Dallel S , Degoul F , Bost F, Clavel S, Penault-Llorca F, Valli MP, Guy L, Matthews J, Renaud Y , Ittmann M, Jones J, Morel L , Lobaccaro JM , Baron S
Screening for liver X receptor modulators: Where are we and for what use?
Published on 01 Aug 2021 in British journal of pharmacology , vol. 178 - pp 3277-3293
Buñay J, Fouache A , Trousson A , de Joussineau C , Bouchareb E , Zhu Z , Kocer A , Morel L , Baron S , Lobaccaro JA
MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin.
Published on 26 Aug 2021 in Journal of experimental & clinical cancer research : CR , vol. 40 - pp 270
Luo Y, Vlaeminck-Guillem V, Baron S , Dallel S , Zhang CX, Le Romancer M
Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer.
Published on 10 Sep 2021 in Cells , vol. 10
Rambur A , Vialat M , Beaudoin C , Lours-Calet C, Lobaccaro JM , Baron S , Morel L , de Joussineau C
Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia.
Published on 07 Dec 2020 in PLoS biology , vol. 18 - pp e3000948
Bousset L , Septier A , Bunay J, Voisin A , Guiton R , Damon-Soubeyrant C, Renaud Y , De Haze A , Sapin V , Fogli A , Rambur A , De Joussineau C , Kocer A , Trousson A , Henry-Berger J , Höring M, Liebisch G, Matysik S, Lobaccaro JA, Morel L , Baron S
Multiple functions of the scaffold protein Discs large 5 in the control of growth, cell polarity and cell adhesion in Drosophila melanogaster.
Published on 18 Jun 2020 in BMC developmental biology , vol. 20 - pp 10
Venugopal P , Veyssière H , Couderc JL , Richard G , Vachias C , Mirouse V
Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation.
Published on 08 Apr 2020 in Development (Cambridge, England) , vol. 147
Cerqueira Campos F , Dennis C , Alégot H , Fritsch C , Isabella A, Pouchin P , Bardot O , Horne-Badovinac S, Mirouse V
Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila.
Published on 08 May 2020 in Nature communications , vol. 11 - pp 2300
Rambur A , Lours-Calet C, Beaudoin C , Buñay J, Vialat M , Mirouse V , Trousson A , Renaud Y , Lobaccaro JA, Baron S , Morel L , de Joussineau C
Flavonoids differentially modulate liver X receptors activity-Structure-function relationship analysis.
Published on 01 Jun 2019 in The Journal of steroid biochemistry and molecular biology , vol. 190 - pp 173-182
Fouache A , Zabaiou N , De Joussineau C , Morel L , Silvente-Poirot S, Namsi A, Lizard G, Poirot M, Makishima M, Baron S , Lobaccaro JA, Trousson A
Individual Comparison of Cholesterol Metabolism in Normal and Tumour Areas in Radical Prostatectomy Specimens from Patients with Prostate Cancer: Results of the CHOMECAP Study.
Published on 30 Mar 2019 in European urology oncology , vol. 2 - pp 198-206
Celhay O , Bousset L , Guy L, Kemeny JL, Leoni V, Caccia C, Trousson A , Damon-Soubeyrant C, De Haze A , Sabourin L, Godfraind C, de Joussineau C , Pereira B, Morel L , Lobaccaro JM , Baron S
New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors.
Published on 28 Aug 2018 in International journal of molecular sciences , vol. 19
Bousset L , Rambur A , Fouache A , Bunay J, Morel L , Lobaccaro JA, Baron S , Trousson A , de Joussineau C
STAT3 Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma.
Published on 30 Jan 2016 in Brain pathology (Zurich, Switzerland) , vol. 26 - pp 18-30
Ouédraogo ZG, Müller-Barthélémy M, Kemeny JL, Dedieu V, Biau J, Khalil T, Raoelfils LI, Granzotto A, Pereira B, Beaudoin C , Guissou IP, Berger M, Morel L , Chautard E, Verrelle P
mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.
Published on 18 May 2016 in Cell cycle (Georgetown, Tex.) , vol. 15 - pp 1352-62
Boudra R , Lagrafeuille R, Lours-Calet C, de Joussineau C , Loubeau-Legros G, Chaveroux C, Saru JP , Baron S , Morel L , Beaudoin C
Anticancer activity of essential oils and their chemical components – a review.
Published on 19 Nov 2014 in American journal of cancer research , vol. 4 - pp 591-607
Bayala B , Bassole IH, Scifo R, Gnoula C, Morel L , Lobaccaro JM , Simpore J
Chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils of plants from Burkina Faso.
Published on 24 Mar 2014 in PloS one , vol. 9 - pp e92122
Bayala B , Bassole IH, Gnoula C, Nebie R, Yonli A, Morel L , Figueredo G, Nikiema JB, Lobaccaro JM , Simpore J
NPM1 silencing reduces tumour growth and MAPK signalling in prostate cancer cells.
Published on 05 May 2014 in PloS one , vol. 9 - pp e96293
Loubeau G, Boudra R , Maquaire S, Lours-Calet C, Beaudoin C , Verrelle P, Morel L
‘Auto-click’ functionalization for diversified copper(I) and gold(I) NHCs.
Published on 21 May 2014 in Dalton transactions (Cambridge, England : 2003) , vol. 43 - pp 6981-9
Ibrahim H, Gibard C, Hesling C , Guillot R, Morel L , Gautier A, Cisnetti F
Selective liver X receptor modulators (SLiMs): what use in human health?
Published on 04 Apr 2012 in Molecular and cellular endocrinology , vol. 351 - pp 129-41
Viennois E, Mouzat K, Dufour J , Morel L , Lobaccaro JM , Baron S
Anticancer activity of silver-N-heterocyclic carbene complexes: caspase-independent induction of apoptosis via mitochondrial apoptosis-inducing factor (AIF).
Published on 30 May 2012 in ChemMedChem , vol. 7 - pp 805-14
Eloy L, Jarrousse AS, Teyssot ML, Gautier A, Morel L , Jolivalt C, Cresteil T, Roland S
Lxrα regulates the androgen response in prostate epithelium.
Published on 30 Jul 2012 in Endocrinology , vol. 153 - pp 3211-23
Viennois E, Esposito T, Dufour J , Pommier A, Fabre S, Kemeny JL, Guy L, Morel L , Lobaccaro JM , Baron S
A platinum Chugaev carbene complex as a potent anticancer agent.
Published on 21 Jul 2011 in Chemical communications (Cambridge, England) , vol. 47 - pp 7830-2
Alves G, Morel L , El-Ghozzi M, Avignant D, Legeret B, Nauton L, Cisnetti F, Gautier A
Akt signaling pathway: a target for radiosensitizing human malignant glioma.
Published on 30 May 2010 in Neuro-oncology , vol. 12 - pp 434-43
Chautard E, Loubeau G, Tchirkov A, Chassagne J, Vermot-Desroches C, Morel L , Verrelle P
Toxicity of copper(I)-NHC complexes against human tumor cells: induction of cell cycle arrest, apoptosis, and DNA cleavage.
Published on 01 Jan 2009 in Chemistry (Weinheim an der Bergstrasse, Germany) , vol. 15 - pp 314-8
Teyssot ML, Jarrousse AS, Chevry A, De Haze A , Beaudoin C , Manin M, Nolan SP, Díez-González S, Morel L , Gautier A
[NPM: a new player in prostate cancer?].
Published on 30 Jan 2009 in Medecine sciences : M/S , vol. 25 - pp 19-21
Beaudoin C , Maquaire S, Léotoing L, Allemand J, Lours-Calet C, Veyssière G, Manin M, Morel L
Metal-NHC complexes: a survey of anti-cancer properties.
Published on 21 Sep 2009 in Dalton transactions (Cambridge, England : 2003) - pp 6894-902
Teyssot ML, Jarrousse AS, Manin M, Chevry A, Roche S, Norre F, Beaudoin C , Morel L , Boyer D, Mahiou R, Gautier A
Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell.
Published on 01 May 2008 in Oncogene , vol. 27 - pp 2858-67
Léotoing L, Meunier L, Manin M, Mauduit C, Decaussin M, Verrijdt G, Claessens F, Benahmed M, Veyssière G, Morel L , Beaudoin C
