Research Team

Nuclear Receptors and Pathophysiology

HomeTeamsNuclear Receptors and Pathophysiology

The NuReP group focuses its research activities on pathologies that involve lipid-sensitive nuclear receptors as well as steroid hormonal mediators. The team's goal is to improve understanding of the mechanisms linking metabolism and endocrine responses. Our attention focuses on several nuclear receptors: LXRalpha and LXRbeta, oxysterol receptors, both involved in the homeostasis of lipid metabolism, as well as AR and ER, androgen and estrogen receptors respectively, which represent master regulators of many tissues targeted by steroids. The team mainly focuses its research activity on two organs, the prostate and the ovary. In parallel, our team is developing numerous partnerships(academic, hospital, private companies, etc.) on topics of biomedical innovation concerning the pathologies that affect these two organs.


Capture d’écran 2023-04-04 à 15.35.59


Our scientific objectives aggregate around 5 points:

– Determine the pharmacological modulation potential of LXR in ovarian and prostate pathologies

– Understand the role of sterol metabolism in prostate cancer progression

– Explore how environmental disrupting chemical could influence the progression of prostate cancer

– Identify new selective modulators of LXRalpha and LXRbeta nuclear receptors

– Develop new non-mammalian in vivo models, in particular Drosophila melanogaster



70 publications

Persistent organic pollutants promote aggressiveness in prostate cancer.

Published on 01 Sep 2023 in Oncogene , vol. 42 - pp 2854-2867

Buñay J, Kossai M, Damon-Soubeyrant C, De Haze A , Saru JP , Trousson A , de Joussineau C , Bouchareb E , Kocer A , Vialat M , Dallel S , Degoul F , Bost F, Clavel S, Penault-Llorca F, Valli MP, Guy L, Matthews J, Renaud Y , Ittmann M, Jones J, Morel L , Lobaccaro JM , Baron S


Individual Comparison of Cholesterol Metabolism in Normal and Tumour Areas in Radical Prostatectomy Specimens from Patients with Prostate Cancer: Results of the CHOMECAP Study.

Published on 30 Mar 2019 in European urology oncology , vol. 2 - pp 198-206

Celhay O , Bousset L , Guy L, Kemeny JL, Leoni V, Caccia C, Trousson A , Damon-Soubeyrant C, De Haze A , Sabourin L, Godfraind C, de Joussineau C , Pereira B, Morel L , Lobaccaro JM , Baron S


Liver X Receptors: A Possible Link between Lipid Disorders and Female Infertility.

Published on 25 Jul 2018 in International journal of molecular sciences , vol. 19

Dallel S , Tauveron I , Brugnon F , Baron S , Lobaccaro JMA, Maqdasy S

Dual extraction of mRNA and lipids from a single biological sample.

Published on 04 May 2018 in Scientific reports , vol. 8 - pp 7019

Podechard N, Ducheix S, Polizzi A, Lasserre F, Montagner A, Legagneux V, Fouché E, Saez F , Lobaccaro JM , Lakhal L, Ellero-Simatos S, Martin PG, Loiseau N, Bertrand-Michel J, Guillou H


Role of the liver X receptors in skin physiology: Putative pharmacological targets in human diseases.

Published on 30 Oct 2017 in Chemistry and physics of lipids , vol. 207 - pp 59-68

Ouedraogo ZG, Fouache A , Trousson A , Baron S , Lobaccaro JA

Biological properties of propolis extracts: Something new from an ancient product.

Published on 30 Oct 2017 in Chemistry and physics of lipids , vol. 207 - pp 214-222

Zabaiou N , Fouache A , Trousson A , Baron S , Zellagui A, Lahouel M , Lobaccaro JA


mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.

Published on 18 May 2016 in Cell cycle (Georgetown, Tex.) , vol. 15 - pp 1352-62

Boudra R , Lagrafeuille R, Lours-Calet C, de Joussineau C , Loubeau-Legros G, Chaveroux C, Saru JP , Baron S , Morel L , Beaudoin C

Oxidative stress in benign prostate hyperplasia.

Published on 01 Mar 2016 in Andrologia , vol. 48 - pp 69-73

Zabaiou N , Mabed D, Lobaccaro JM , Lahouel M

STAT3 Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma.

Published on 30 Jan 2016 in Brain pathology (Zurich, Switzerland) , vol. 26 - pp 18-30

Ouédraogo ZG, Müller-Barthélémy M, Kemeny JL, Dedieu V, Biau J, Khalil T, Raoelfils LI, Granzotto A, Pereira B, Beaudoin C , Guissou IP, Berger M, Morel L , Chautard E, Verrelle P

Lipid Homeostasis and Ligands for Liver X Receptors: Identification and Characterization.

Published on 01 Jan 2016 in Methods in molecular biology (Clifton, N.J.) , vol. 1443 - pp 13-9

Lobaccaro JM , Beaudoin C , Bayala B , Baron S , Trousson A


Comparaison appariée des flux du cholestérol cellulaire dans les tissus sains et cancéreux prostatiques : résultats de l’étude Chomecap.

Published on 30 Nov 2015 in Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie , vol. 25 - pp 727-8

Celhay O , Laurent G, Alioui A , Trousson A , Kemeny L, Pereira B, Leoni V, Lobaccaro J, Baron S

Enolase is regulated by Liver X Receptors.

Published on 30 Jul 2015 in Steroids , vol. 99 - pp 266-71

De Boussac H , Maqdasy S , Trousson A , Zelcer N, Volle DH , Lobaccaro JM , Baron S

Liver X receptor activation promotes polyunsaturated fatty acid synthesis in macrophages: relevance in the context of atherosclerosis.

Published on 30 Jun 2015 in Arteriosclerosis, thrombosis, and vascular biology , vol. 35 - pp 1357-65

Varin A, Thomas C, Ishibashi M, Ménégaut L, Gautier T, Trousson A , Bergas V, de Barros JP, Narce M, Lobaccaro JM , Lagrost L, Masson D


Anticancer activity of essential oils and their chemical components – a review.

Published on 19 Nov 2014 in American journal of cancer research , vol. 4 - pp 591-607

Bayala B , Bassole IH, Scifo R, Gnoula C, Morel L , Lobaccaro JM , Simpore J

Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.

Published on 30 Sep 2014 in Hepatology (Baltimore, Md.) , vol. 60 - pp 1054-65

Baptissart M , Vega A , Martinot E , Pommier AJ, Houten SM, Marceau G , de Haze A , Baron S , Schoonjans K, Lobaccaro JM , Volle DH

‘Auto-click’ functionalization for diversified copper(I) and gold(I) NHCs.

Published on 21 May 2014 in Dalton transactions (Cambridge, England : 2003) , vol. 43 - pp 6981-9

Ibrahim H, Gibard C, Hesling C , Guillot R, Morel L , Gautier A, Cisnetti F

NPM1 silencing reduces tumour growth and MAPK signalling in prostate cancer cells.

Published on 05 May 2014 in PloS one , vol. 9 - pp e96293

Loubeau G, Boudra R , Maquaire S, Lours-Calet C, Beaudoin C , Verrelle P, Morel L

Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.

Published on 11 Apr 2014 in Biochemical and biophysical research communications , vol. 446 - pp 656-62

Oumeddour A , Viennois E, Caira F , Decourbey C, Maqdasy S , Tahraoui A, Baron S , Volle DH , Lobaccaro JM

Chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils of plants from Burkina Faso.

Published on 24 Mar 2014 in PloS one , vol. 9 - pp e92122

Bayala B , Bassole IH, Gnoula C, Nebie R, Yonli A, Morel L , Figueredo G, Nikiema JB, Lobaccaro JM , Simpore J


Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?

Published on 30 Dec 2013 in Cellular and molecular life sciences : CMLS , vol. 70 - pp 4511-26

Baptissart M , Vega A , Martinot E , Baron S , Lobaccaro JM , Volle DH

Oxysterol receptors and their therapeutic applications in cancer conditions.

Published on 30 Sep 2013 in Expert opinion on therapeutic targets , vol. 17 - pp 1029-38

De Boussac H , Alioui A , Viennois E, Dufour J , Trousson A , Vega A , Guy L, Volle DH , Lobaccaro JM , Baron S

Lipids, LXRs and prostate cancer: are HDACs a new link?

Published on 01 Jul 2013 in Biochemical pharmacology , vol. 86 - pp 168-74

Hoang JJ, Baron S , Volle DH , Lobaccaro JM , Trousson A

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

Published on 30 May 2013 in Journal of hepatology , vol. 58 - pp 984-92

Ducheix S, Montagner A, Polizzi A, Lasserre F, Marmugi A, Bertrand-Michel J, Podechard N, Al Saati T, Chétiveaux M, Baron S , Boué J, Dietrich G, Mselli-Lakhal L, Costet P, Lobaccaro JM , Pineau T, Theodorou V, Postic C, Martin PG, Guillou H

Emerging roles for LXRs and LRH-1 in female reproduction.

Published on 10 Apr 2013 in Molecular and cellular endocrinology , vol. 368 - pp 47-58

Mouzat K, Baron S , Marceau G , Caira F , Sapin V , Volle DH , Lumbroso S, Lobaccaro JM

Cholesterol and male fertility: what about orphans and adopted?

Published on 10 Apr 2013 in Molecular and cellular endocrinology , vol. 368 - pp 30-46

Maqdasy S , Baptissart M , Vega A , Baron S , Lobaccaro JM , Volle DH

A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα.

Published on 30 Mar 2013 in Biochimie , vol. 95 - pp 556-67

Ducheix S, Podechard N, Lasserre F, Polizzi A, Pommier A, Murzilli S, Di Lisio C, D'Amore S, Bertrand-Michel J, Montagner A, Pineau T, Loiseau N, Lobaccaro JM , Martin PG, Guillou H

Bile acids: from digestion to cancers.

Published on 30 Mar 2013 in Biochimie , vol. 95 - pp 504-17

Baptissart M , Vega A , Maqdasy S , Caira F , Baron S , Lobaccaro JM , Volle DH

LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.

Published on 01 Mar 2013 in American journal of cancer research , vol. 3 - pp 58-69

de Boussac H , Pommier AJ, Dufour J , Trousson A , Caira F , Volle DH , Baron S , Lobaccaro JM

Liver X Receptors and female reproduction: when cholesterol meets fertility!

Published on 30 Jan 2013 in Journal of endocrinological investigation , vol. 36 - pp 55-60

Lobaccaro JM , Gallot D , Lumbroso S, Mouzat K


Oxysterol receptors, AKT and prostate cancer.

Published on 30 Dec 2012 in Current opinion in pharmacology , vol. 12 - pp 724-8

Dufour J , Viennois E, De Boussac H , Baron S , Lobaccaro JM

Lxrα regulates the androgen response in prostate epithelium.

Published on 30 Jul 2012 in Endocrinology , vol. 153 - pp 3211-23

Viennois E, Esposito T, Dufour J , Pommier A, Fabre S, Kemeny JL, Guy L, Morel L , Lobaccaro JM , Baron S

Anticancer activity of silver-N-heterocyclic carbene complexes: caspase-independent induction of apoptosis via mitochondrial apoptosis-inducing factor (AIF).

Published on 30 May 2012 in ChemMedChem , vol. 7 - pp 805-14

Eloy L, Jarrousse AS, Teyssot ML, Gautier A, Morel L , Jolivalt C, Cresteil T, Roland S

Selective liver X receptor modulators (SLiMs): what use in human health?

Published on 04 Apr 2012 in Molecular and cellular endocrinology , vol. 351 - pp 129-41

Viennois E, Mouzat K, Dufour J , Morel L , Lobaccaro JM , Baron S


A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia.

Published on 26 Oct 2011 in BMC medical genetics , vol. 12 - pp 145

Mouzat K, Mercier E, Polge A, Evrard A, Baron S , Balducchi JP, Brouillet JP, Lumbroso S, Gris JC

Liver X Receptor: an oxysterol sensor and a major player in the control of lipogenesis.

Published on 30 Sep 2011 in Chemistry and physics of lipids , vol. 164 - pp 500-14

Ducheix S, Lobaccaro JM , Martin PG, Guillou H

A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity.

Published on 16 Sep 2011 in The Journal of biological chemistry , vol. 286 - pp 32277-88

Leotoing L, Chereau F, Baron S , Hube F, Valencia HJ, Bordereaux D, Demmers JA, Strouboulis J, Baud V

Liver X receptors, lipids and their reproductive secrets in the male.

Published on 30 Aug 2011 in Biochimica et biophysica acta , vol. 1812 - pp 974-81

El-Hajjaji FZ, Oumeddour A , Pommier AJ, Ouvrier A, Viennois E, Dufour J , Caira F , Drevet JR, Volle DH , Baron S , Saez F , Lobaccaro JM

Liver X receptors, lipids and their reproductive secrets in the male.

Published on 01 Aug 2011 in Biochimica et biophysica acta , vol. 1812 - pp 974-81

El-Hajjaji FZ, Oumeddour A , Pommier AJ, Ouvrier A, Viennois E, Dufour J , Caira F , Drevet JR , Volle DH, Baron S , Saez F , Lobaccaro JM

A platinum Chugaev carbene complex as a potent anticancer agent.

Published on 21 Jul 2011 in Chemical communications (Cambridge, England) , vol. 47 - pp 7830-2

Alves G, Morel L , El-Ghozzi M, Avignant D, Legeret B, Nauton L, Cisnetti F, Gautier A

Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols.

Published on 29 Jun 2011 in The Journal of neuroscience : the official journal of the Society for Neuroscience , vol. 31 - pp 9620-9

Makoukji J, Shackleford G, Meffre D, Grenier J, Liere P, Lobaccaro JM , Schumacher M, Massaad C

Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis.

Published on 09 Mar 2011 in The Journal of neuroscience : the official journal of the Society for Neuroscience , vol. 31 - pp 3729-42

Tawk M, Makoukji J, Belle M, Fonte C, Trousson A , Hawkins T, Li H, Ghandour S, Schumacher M, Massaad C

Targeting liver X receptors in human health: deadlock or promising trail?

Published on 02 Mar 2011 in Expert opinion on therapeutic targets , vol. 15 - pp 219-32

Viennois E, Pommier AJ, Mouzat K, Oumeddour A , El Hajjaji FZ, Dufour J , Caira F , Volle DH , Baron S , Lobaccaro JM


Estrogens repress PGC1-α expression in the uterus.

Published on 15 Dec 2010 in Molecular and cellular endocrinology , vol. 330 - pp 33-40

Macari C, Teyssier C, Tribollet V, Mouzat K, Forcet C, Horard B, Lobaccaro JM , Vanacker JM

Thyroid hormone receptor beta (TRbeta) and liver X receptor (LXR) regulate carbohydrate-response element-binding protein (ChREBP) expression in a tissue-selective manner.

Published on 03 Sep 2010 in The Journal of biological chemistry , vol. 285 - pp 28156-63

Gauthier K, Billon C, Bissler M, Beylot M, Lobaccaro JM , Vanacker JM, Samarut J

Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells.

Published on 30 Jun 2010 in The American journal of clinical nutrition , vol. 91 - pp 1716-24

Talvas J, Caris-Veyrat C, Guy L, Rambeau M, Lyan B, Minet-Quinard R , Lobaccaro JM , Vasson MP, Georgé S, Mazur A, Rock E

Akt signaling pathway: a target for radiosensitizing human malignant glioma.

Published on 30 May 2010 in Neuro-oncology , vol. 12 - pp 434-43

Chautard E, Loubeau G, Tchirkov A, Chassagne J, Vermot-Desroches C, Morel L , Verrelle P

Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.

Published on 06 May 2010 in Oncogene , vol. 29 - pp 2712-23

Pommier AJ, Alves G, Viennois E, Bernard S, Communal Y, Sion B, Marceau G , Damon C, Mouzat K, Caira F , Baron S , Lobaccaro JM


Metal-NHC complexes: a survey of anti-cancer properties.

Published on 21 Sep 2009 in Dalton transactions (Cambridge, England : 2003) - pp 6894-902

Teyssot ML, Jarrousse AS, Manin M, Chevry A, Roche S, Norre F, Beaudoin C , Morel L , Boyer D, Mahiou R, Gautier A

Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages.

Published on 14 Aug 2009 in Circulation research , vol. 105 - pp 393-401

Rébé C, Raveneau M, Chevriaux A, Lakomy D, Sberna AL, Costa A, Bessède G, Athias A, Steinmetz E, Lobaccaro JM , Alves G, Menicacci A, Vachenc S, Solary E, Gambert P, Masson D

Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.

Published on 30 Jul 2009 in Endocrinology , vol. 150 - pp 3369-75

Mouzat K, Volat F, Baron S , Alves G, Pommier AJ, Volle DH , Marceau G , DeHaze A, Déchelotte P , Duggavathi R, Caira F , Lobaccaro JM

25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.

Published on 30 May 2009 in Journal of neurochemistry , vol. 109 - pp 945-58

Trousson A , Bernard S, Petit PX, Liere P, Pianos A, El Hadri K, Lobaccaro JM , Ghandour MS, Raymondjean M, Schumacher M, Massaad C

[Nuclear liver X receptors are involved in the biology of reproduction].

Published on 02 Mar 2009 in Medecine sciences : M/S , vol. 25 - pp 141-4

Mouzat K, Alves G, Pommier A, Viennois E, Pihen T, Caira F , Baron S , A Lobaccaro JM

[NPM: a new player in prostate cancer?].

Published on 30 Jan 2009 in Medecine sciences : M/S , vol. 25 - pp 19-21

Beaudoin C , Maquaire S, Léotoing L, Allemand J, Lours-Calet C, Veyssière G, Manin M, Morel L

Toxicity of copper(I)-NHC complexes against human tumor cells: induction of cell cycle arrest, apoptosis, and DNA cleavage.

Published on 01 Jan 2009 in Chemistry (Weinheim an der Bergstrasse, Germany) , vol. 15 - pp 314-8

Teyssot ML, Jarrousse AS, Chevry A, De Haze A , Beaudoin C , Manin M, Nolan SP, Díez-González S, Morel L , Gautier A


Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell.

Published on 01 May 2008 in Oncogene , vol. 27 - pp 2858-67

Léotoing L, Meunier L, Manin M, Mauduit C, Decaussin M, Verrijdt G, Claessens F, Benahmed M, Veyssière G, Morel L , Beaudoin C

R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation.

Published on 02 Apr 2008 in BMC developmental biology , vol. 8 - pp 36

Kocer A , Pinheiro I, Pannetier M, Renault L, Parma P, Radi O, Kim KA, Camerino G, Pailhoux E

Differential aggregation and functional impairment induced by polyalanine expansions in FOXL2, a transcription factor involved in cranio-facial and ovarian development.

Published on 01 Apr 2008 in Human molecular genetics , vol. 17 - pp 1010-9

Moumné L, Dipietromaria A, Batista F, Kocer A , Fellous M, Pailhoux E, Veitia RA

A specialized cDNA microarray (Mouse Lipid Chip) reveals hepatic overexpression of serum amyloid a in high-fat diet-fed mice.

Published on 30 Mar 2008 in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme , vol. 40 - pp 228-30

Dejeans N, Auclair S, Henry-Berger J , Lobaccaro JM , Mazur A

Attempt to rescue sex-reversal by transgenic expression of the PISRT1 gene in XX PIS-/- goats.

Published on 01 Jan 2008 in Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation , vol. 2 - pp 142-51

Boulanger L, Kocer A , Daniel N, Pannetier M, Chesné P, Heyman Y, Renault L, Mandon-Pépin B, Chavatte-Palmer P, Vignon X, Vilotte JL, Cotinot C, Renard JP, Pailhoux E

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